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5KUY	Influenza hemagglutinin H3 A/Hong Kong/1/1968 in complex with designed inhibitor protein HSB.2A Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Designed influenza inhibitor HSB.2A, ... Authors: Bernard, S.M, Wilson, I.A. Deposit date: 2016-07-13 Release date: 2017-06-14 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.598 Å) Cite: Computational design of trimeric influenza-neutralizing proteins targeting the hemagglutinin receptor binding site. Nat. Biotechnol., 35, 2017
8PK3	CryoEM reconstruction of hemagglutinin HK68 of Influenza A virus bound to an Affimer reagent Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Affimer molecule (A31), ... Authors: Debski-Antoniak, O, Flynn, A, Klebl, D.P, Tiede, C, Muench, S, Tomlinson, D, Fontana, J. Deposit date: 2023-06-24 Release date: 2024-01-03 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Exploiting the Affimer platform against influenza A virus To Be Published
2FK0	Crystal Structure of a H5N1 influenza virus hemagglutinin. Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, hemagglutinin Authors: Stevens, J, Wilson, I.A. Deposit date: 2006-01-03 Release date: 2006-05-02 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.95 Å) Cite: Structure and Receptor Specificity of the Hemagglutinin from an H5N1 Influenza Virus. Science, 312, 2006
7QA4	Crystal structure of stabilized H3N2 A/Hong Kong/1/1968 Hemagglutinin at 2.2 Angstrom Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, ... Authors: Milder, F.J, Langedijk, J.P.M. Deposit date: 2021-11-16 Release date: 2022-02-02 Last modified: 2022-03-30 Method: X-RAY DIFFRACTION (2.19 Å) Cite: Universal stabilization of the influenza hemagglutinin by structure-based redesign of the pH switch regions. Proc.Natl.Acad.Sci.USA, 119, 2022
2HMG	REFINEMENT OF THE INFLUENZA VIRUS HEMAGGLUTININ BY SIMULATED ANNEALING Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, HEMAGGLUTININ (HA1 CHAIN), HEMAGGLUTININ (HA2 CHAIN), ... Authors: Weis, W.I, Bruenger, A.T, Skehel, J.J, Wiley, D.C. Deposit date: 1989-09-11 Release date: 1991-01-15 Last modified: 2020-07-29 Method: X-RAY DIFFRACTION (3 Å) Cite: Refinement of the influenza virus hemagglutinin by simulated annealing. J.Mol.Biol., 212, 1990
2IBX	Influenza virus (VN1194) H5 HA Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin Authors: Yamada, S, Russell, R.J, Gamblin, S.J, Skehel, J.J, Kawaoka, Y. Deposit date: 2006-09-12 Release date: 2006-11-28 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Haemagglutinin mutations responsible for the binding of H5N1 influenza A viruses to human-type receptors. Nature, 444, 2006
8D21	Cryo-EM structure of the VRC321 clinical trial, vaccine-elicited, human antibody 1B06 in complex with a stabilized NC99 HA trimer Descriptor: 1B06 Heavy Chain, 1B06 Light Chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Gorman, J, Kwong, P.D. Deposit date: 2022-05-27 Release date: 2023-04-12 Last modified: 2023-05-03 Method: ELECTRON MICROSCOPY (3.96 Å) Cite: An influenza H1 hemagglutinin stem-only immunogen elicits a broadly cross-reactive B cell response in humans. Sci Transl Med, 15, 2023
7RCR	Crystal Structure of the refolded Hemagglutinin head domain of Influenza A virus A/Ohio/09/2015 Descriptor: 1,2-ETHANEDIOL, Hemagglutinin Authors: Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2021-07-08 Release date: 2021-08-04 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Crystal Structure of the refolded Hemagglutinin head domain of Influenzavirus A Influenza A virus A/Ohio/09/2015 to be published
8DIM	CryoEM structure of Influenza A virus A/Ohio/09/2015 hemagglutinin bound to CR6261 Fab Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CR6261 Fab heavy chain, CR6261 Fab light chain, ... Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2022-06-29 Release date: 2022-11-16 Method: ELECTRON MICROSCOPY (2.62 Å) Cite: CryoEM structure of Influenza A virus A/Ohio/09/2015 hemagglutinin bound to CR6261 Fab To Be Published
7L0L	Cryo-EM structure of the VRC316 clinical trial, vaccine-elicited, human antibody 316-310-1B11 in complex with an H2 CAN05 HA trimer Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 316-310-1B11 Heavy Chain, 316-310-1B11 Light Chain, ... Authors: Gorman, J, Kwong, P.D. Deposit date: 2020-12-11 Release date: 2021-11-03 Last modified: 2022-03-09 Method: ELECTRON MICROSCOPY (2.85 Å) Cite: A single residue in influenza virus H2 hemagglutinin enhances the breadth of the B cell response elicited by H2 vaccination. Nat Med, 28, 2022
7MEM	CryoEM structure of monoclonal Fab 045-09 2B05 binding the lateral patch of influenza virus H1 HA Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of monoclonal antibody 045-09 2B05, ... Authors: Han, J, Ward, A. Deposit date: 2021-04-06 Release date: 2021-07-28 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: First exposure to the pandemic H1N1 virus induced broadly neutralizing antibodies targeting hemagglutinin head epitopes. Sci Transl Med, 13, 2021
7MFG	Cryo-EM structure of the VRC310 clinical trial, vaccine-elicited, human antibody 310-030-1D06 Fab in complex with an H1 NC99 HA trimer Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 310-030-1D06 Heavy, 310-030-1D06 Light, ... Authors: Gorman, J, Kwong, P.D. Deposit date: 2021-04-09 Release date: 2021-11-03 Last modified: 2022-03-09 Method: ELECTRON MICROSCOPY (3.87 Å) Cite: A single residue in influenza virus H2 hemagglutinin enhances the breadth of the B cell response elicited by H2 vaccination. Nat Med, 28, 2022
7DEB	Structure of an avian influenza H5 hemagglutinin from the influenza virus A/duck/Eastern China/L0230/2010 (H5N2) Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, ... Authors: Sun, H, Sun, H, Song, J, Zhang, W, Qi, J, Gao, G.F, Liu, J. Deposit date: 2020-11-03 Release date: 2021-11-03 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Haemagglutinin and neuraminidase acid stability in H5N6 avian influenza virus confers infection adaptation in mammals To Be Published
7DEA	Structure of an avian influenza H5 hemagglutinin from the influenza virus A/duck Northern China/22/2017 (H5N6) Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin Authors: Sun, H, Sun, H, Song, J, Zhang, W, Wei, X, Qi, J, Gao, G.F, Liu, J. Deposit date: 2020-11-03 Release date: 2021-11-03 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.84 Å) Cite: Haemagglutinin and neuraminidase acid stability in H5N6 avian influenza virus confers infection adaptation in mammals To Be Published
7DKJ	Hemagglutinin Influenza A virus (A/Okuda/1957(H2N2) bound with a neutralizing antibody Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Fv-clasp heavy chain, Fv-clasp light chain, ... Authors: Shirouzu, M. Deposit date: 2020-11-24 Release date: 2021-11-24 Last modified: 2023-06-14 Method: ELECTRON MICROSCOPY (3.7 Å) Cite: Hemagglutinin Influenza A virus (A/Okuda/1957(H2N2) bound with a neutralizing antibody To Be Published
6Q0I	Inferred intermediate I-7 (I-7-6) of the human antibody lineage 652 in complex with influenza hemagglutinin head domain of A/Beijing/262/95(H1N1) Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Fab heavy chain, Fab lambda chain, ... Authors: McCarthy, K.R, Harrison, S.C. Deposit date: 2019-08-01 Release date: 2019-12-18 Last modified: 2020-07-29 Method: X-RAY DIFFRACTION (2.702 Å) Cite: Affinity maturation in a human humoral response to influenza hemagglutinin. Proc.Natl.Acad.Sci.USA, 2019
6TJY	Crystal structure of haemagglutinin from (A/seal/Germany/1/2014) seal H10N7 influenza virus Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... Authors: Zhang, J, Xiong, X, Purkiss, A, Walker, P, Gamblin, S, Skehel, J.J. Deposit date: 2019-11-27 Release date: 2020-10-21 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.82 Å) Cite: Hemagglutinin Traits Determine Transmission of Avian A/H10N7 Influenza Virus between Mammals. Cell Host Microbe, 28, 2020
6TJW	Crystal structure of the haemagglutinin mutant (Gln226Leu, Del228) from an H10N7 seal influenza virus isolated in Germany Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Zhang, J, Xiong, X, Purkiss, A, Walker, P, Gamblin, S, Skehel, J.J. Deposit date: 2019-11-27 Release date: 2020-10-21 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.31 Å) Cite: Hemagglutinin Traits Determine Transmission of Avian A/H10N7 Influenza Virus between Mammals. Cell Host Microbe, 28, 2020
6TVB	Crystal structure of the haemagglutinin from a transmissible H10N7 seal influenza virus isolated in Netherland in complex with human receptor analogue 6'-SLN Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin HA1, ... Authors: Zhang, J, Xiong, X, Purkiss, A, Walker, P, Gamblin, S, Skehel, J.J. Deposit date: 2020-01-09 Release date: 2020-10-21 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Hemagglutinin Traits Determine Transmission of Avian A/H10N7 Influenza Virus between Mammals. Cell Host Microbe, 28, 2020
6TY1	Crystal structure of the haemagglutinin mutant (Gln226Leu, Gly228Ser) from an H10N7 seal influenza virus isolated in Germany in complex with human receptor analogue 6'-SLN Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, Hemagglutinin HA2, ... Authors: Zhang, J, Xiong, X, Purkiss, A, Walker, P, Gamblin, S, Skehel, J.J. Deposit date: 2020-01-15 Release date: 2020-10-21 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Hemagglutinin Traits Determine Transmission of Avian A/H10N7 Influenza Virus between Mammals. Cell Host Microbe, 28, 2020
2RFU	Crystal structure of influenza B virus hemagglutinin in complex with LSTc receptor analog Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Influenza B hemagglutinin (HA), ... Authors: Wang, Q, Tian, X, Chen, X, Ma, J. Deposit date: 2007-10-01 Release date: 2008-02-05 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Structural basis for receptor specificity of influenza B virus hemagglutinin. Proc.Natl.Acad.Sci.Usa, 104, 2007
2RFT	Crystal structure of influenza B virus hemagglutinin in complex with LSTa receptor analog Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Influenza B hemagglutinin (HA), ... Authors: Wang, Q, Tian, X, Chen, X, Ma, J. Deposit date: 2007-10-01 Release date: 2008-02-05 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Structural basis for receptor specificity of influenza B virus hemagglutinin. Proc.Natl.Acad.Sci.Usa, 104, 2007
2VIU	INFLUENZA VIRUS HEMAGGLUTININ Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, HEMAGGLUTININ, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose Authors: Bizebard, T, Fleury, D, Gigant, B, Wharton, S.A, Skehel, J.J, Knossow, M. Deposit date: 1997-12-22 Release date: 1998-04-29 Last modified: 2021-11-03 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Antigen distortion allows influenza virus to escape neutralization. Nat.Struct.Biol., 5, 1998
3BT6	Crystal Structure of Influenza B Virus Hemagglutinin Descriptor: 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Wang, Q, Cheng, F, Lu, M, Tian, X, Ma, J. Deposit date: 2007-12-27 Release date: 2008-05-27 Last modified: 2020-07-29 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Crystal structure of unliganded influenza B virus hemagglutinin. J.Virol., 82, 2008
3EYM	Structure of Influenza Haemagglutinin in complex with an inhibitor of membrane fusion Descriptor: 2-tert-butylbenzene-1,4-diol, Hemagglutinin HA1 chain, Hemagglutinin HA2 chain Authors: Russell, R.J, Kerry, P.S, Stevens, D.A, Steinhauer, D.A, Martin, S.R, Gamblin, S.J, Skehel, J.J. Deposit date: 2008-10-21 Release date: 2009-01-13 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Structure of influenza hemagglutinin in complex with an inhibitor of membrane fusion Proc.Natl.Acad.Sci.USA, 105, 2008

 

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