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8U1N
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BU of 8u1n by Molmil
Cryo-EM structure of the cross-linked HSP90 dimer (NTD-MD) in the semi-open state
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Heat shock protein 83, MAGNESIUM ION
Authors:Finci, L.I, Simanshu, D.K.
Deposit date:2023-09-01
Release date:2024-03-13
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structural dynamics of RAF1-HSP90-CDC37 and HSP90 complexes reveal asymmetric client interactions and key structural elements.
Commun Biol, 7, 2024
8U1M
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BU of 8u1m by Molmil
Cryo-EM structure of the HSP90 dimer (NTD-MD) in the semi-open state
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Heat shock protein 83, MAGNESIUM ION
Authors:Finci, L.I, Simanshu, D.K.
Deposit date:2023-09-01
Release date:2024-03-13
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structural dynamics of RAF1-HSP90-CDC37 and HSP90 complexes reveal asymmetric client interactions and key structural elements.
Commun Biol, 7, 2024
8U1L
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BU of 8u1l by Molmil
Cryo-EM structure of the RAF1-HSP90-CDC37 complex in the closed state
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Heat shock protein 83, Hsp90 co-chaperone Cdc37, ...
Authors:Finci, L.I, Simanshu, D.K.
Deposit date:2023-09-01
Release date:2024-03-13
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Structural dynamics of RAF1-HSP90-CDC37 and HSP90 complexes reveal asymmetric client interactions and key structural elements.
Commun Biol, 7, 2024
8QMO
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BU of 8qmo by Molmil
Cryo-EM structure of the benzo[a]pyrene-bound Hsp90-XAP2-AHR complex
Descriptor: ADENOSINE-5'-DIPHOSPHATE, AH receptor-interacting protein, Aryl hydrocarbon receptor, ...
Authors:Kwong, H.S, Grandvuillemin, L, Sirounian, S, Ancelin, A, Lai-Kee-Him, J, Carivenc, C, Lancey, C, Ragan, T.J, Hesketh, E.L, Bourguet, W, Gruszczyk, J.
Deposit date:2023-09-24
Release date:2024-01-10
Last modified:2024-02-28
Method:ELECTRON MICROSCOPY (2.76 Å)
Cite:Structural Insights into the Activation of Human Aryl Hydrocarbon Receptor by the Environmental Contaminant Benzo[a]pyrene and Structurally Related Compounds.
J.Mol.Biol., 436, 2024
8OXU
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BU of 8oxu by Molmil
Crystal Structure of the Hsp90-LA1011 Complex
Descriptor: ATP-dependent molecular chaperone HSP82, dimethyl 2,6-bis[2-(dimethylamino)ethyl]-1-methyl-4-[4-(trifluoromethyl)phenyl]-4~{H}-pyridine-3,5-dicarboxylate
Authors:Roe, S.M, Prodromou, C.
Deposit date:2023-05-02
Release date:2023-07-12
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.94 Å)
Cite:The Crystal Structure of the Hsp90-LA1011 Complex and the Mechanism by Which LA1011 May Improve the Prognosis of Alzheimer's Disease.
Biomolecules, 13, 2023
8H77
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BU of 8h77 by Molmil
Hsp90-AhR-p23-XAP2 complex
Descriptor: ADENOSINE-5'-DIPHOSPHATE, AH receptor-interacting protein, Aryl hydrocarbon receptor, ...
Authors:Wen, Z.L, Zhai, Y.J, Zhu, Y, Sun, F.
Deposit date:2022-10-19
Release date:2023-01-04
Last modified:2023-03-22
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Cryo-EM structure of the cytosolic AhR complex.
Structure, 31, 2023
8GFT
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BU of 8gft by Molmil
Hsp90 provides platform for CRaf dephosphorylation by PP5
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Heat shock protein HSP 90-beta, ...
Authors:Jaime-Garza, M, Nowotny, C.A, Coutandin, D, Wang, F, Tabios, M, Agard, D.A.
Deposit date:2023-03-08
Release date:2023-05-03
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Hsp90 provides a platform for kinase dephosphorylation by PP5.
Nat Commun, 14, 2023
8GAE
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BU of 8gae by Molmil
Hsp90 provides platform for CRaf dephosphorylation by PP5
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Heat shock protein HSP 90-beta, ...
Authors:Jaime-Garza, M, Nowotny, C.A, Coutandin, D, Wang, F, Tabios, M, Agard, D.A.
Deposit date:2023-02-22
Release date:2023-04-26
Last modified:2023-05-03
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Hsp90 provides a platform for kinase dephosphorylation by PP5.
Nat Commun, 14, 2023
8FX4
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BU of 8fx4 by Molmil
GC-C-Hsp90-Cdc37 regulatory complex
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Guanylyl cyclase C, Heat shock protein HSP 90-beta, ...
Authors:Caveney, N.A, Garcia, K.C.
Deposit date:2023-01-23
Release date:2023-07-12
Last modified:2023-08-23
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structural insight into guanylyl cyclase receptor hijacking of the kinase-Hsp90 regulatory mechanism.
Elife, 12, 2023
8FFW
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BU of 8ffw by Molmil
Cryo-EM structure of the GR-Hsp90-FKBP51 complex
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, DEXAMETHASONE, Glucocorticoid receptor, ...
Authors:Noddings, C.M, Agard, D.A.
Deposit date:2022-12-10
Release date:2023-11-01
Last modified:2023-12-20
Method:ELECTRON MICROSCOPY (3.23 Å)
Cite:Cryo-EM reveals how Hsp90 and FKBP immunophilins co-regulate the glucocorticoid receptor.
Nat.Struct.Mol.Biol., 30, 2023
8FFV
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BU of 8ffv by Molmil
Cryo-EM structure of the GR-Hsp90-FKBP52 complex
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, DEXAMETHASONE, Glucocorticoid receptor, ...
Authors:Noddings, C.M, Agard, D.A.
Deposit date:2022-12-10
Release date:2023-11-01
Last modified:2023-12-20
Method:ELECTRON MICROSCOPY (3.01 Å)
Cite:Cryo-EM reveals how Hsp90 and FKBP immunophilins co-regulate the glucocorticoid receptor.
Nat.Struct.Mol.Biol., 30, 2023
8EOB
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BU of 8eob by Molmil
Cryo-EM structure of human HSP90B in the closed state
Descriptor: Heat shock protein HSP 90-beta, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Srivastava, D, Artemyev, N.O.
Deposit date:2022-10-02
Release date:2023-01-25
Last modified:2023-03-15
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Unique interface and dynamics of the complex of HSP90 with a specialized cochaperone AIPL1.
Structure, 31, 2023
8EOA
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BU of 8eoa by Molmil
Cryo-EM structure of human HSP90B-AIPL1 complex
Descriptor: Aryl-hydrocarbon-interacting protein-like 1, Heat shock protein HSP 90-beta, MAGNESIUM ION, ...
Authors:Srivastava, D, Artemyev, N.O.
Deposit date:2022-10-02
Release date:2023-01-25
Last modified:2023-03-15
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Unique interface and dynamics of the complex of HSP90 with a specialized cochaperone AIPL1.
Structure, 31, 2023
7ZUB
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BU of 7zub by Molmil
Cryo-EM structure of the indirubin-bound Hsp90-XAP2-AHR complex
Descriptor: (3~{Z})-3-(3-oxidanylidene-1~{H}-indol-2-ylidene)-1~{H}-indol-2-one, ADENOSINE-5'-DIPHOSPHATE, AH receptor-interacting protein, ...
Authors:Gruszczyk, J, Savva, C.G, Lai-Kee-Him, J, Bous, J, Ancelin, A, Kwong, H.S, Grandvuillemin, L, Bourguet, W.
Deposit date:2022-05-12
Release date:2022-11-23
Last modified:2022-12-07
Method:ELECTRON MICROSCOPY (2.85 Å)
Cite:Cryo-EM structure of the agonist-bound Hsp90-XAP2-AHR cytosolic complex.
Nat Commun, 13, 2022
7ZR6
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BU of 7zr6 by Molmil
CryoEM structure of HSP90-CDC37-BRAF(V600E)-PP5(open) complex
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Heat shock protein HSP 90-beta, Hsp90 co-chaperone Cdc37, ...
Authors:Oberoi, J, Pearl, L.H.
Deposit date:2022-05-03
Release date:2022-12-28
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:HSP90-CDC37-PP5 forms a structural platform for kinase dephosphorylation.
Nat Commun, 13, 2022
7ZR5
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BU of 7zr5 by Molmil
CryoEM structure of HSP90-CDC37-BRAF(V600E)-PP5(closed) complex
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Heat shock protein HSP 90-beta, Hsp90 co-chaperone Cdc37, ...
Authors:Oberoi, J, Pearl, L.H.
Deposit date:2022-05-03
Release date:2022-12-14
Last modified:2022-12-21
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:HSP90-CDC37-PP5 forms a structural platform for kinase dephosphorylation.
Nat Commun, 13, 2022
7ZR0
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BU of 7zr0 by Molmil
CryoEM structure of HSP90-CDC37-BRAF(V600E) complex.
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Heat shock protein HSP 90-beta, Hsp90 co-chaperone Cdc37, ...
Authors:Oberoi, J, Pearl, L.H.
Deposit date:2022-05-03
Release date:2022-12-14
Last modified:2023-01-11
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:HSP90-CDC37-PP5 forms a structural platform for kinase dephosphorylation.
Nat Commun, 13, 2022
7Z38
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BU of 7z38 by Molmil
Structure of the RAF1-HSP90-CDC37 complex (RHC-I)
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Heat shock protein HSP 90-beta, Hsp90 co-chaperone Cdc37, ...
Authors:Mesa, P, Garcia-Alonso, S, Barbacid, M, Montoya, G.
Deposit date:2022-03-01
Release date:2022-09-14
Last modified:2022-09-28
Method:ELECTRON MICROSCOPY (3.16 Å)
Cite:Structure of the RAF1-HSP90-CDC37 complex reveals the basis of RAF1 regulation.
Mol.Cell, 82, 2022
7Z37
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BU of 7z37 by Molmil
Structure of the RAF1-HSP90-CDC37 complex (RHC-II)
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Heat shock protein HSP 90-beta, Hsp90 co-chaperone Cdc37, ...
Authors:Mesa, P, Garcia-Alonso, S, Barbacid, M, Montoya, G.
Deposit date:2022-03-01
Release date:2022-09-14
Last modified:2022-09-28
Method:ELECTRON MICROSCOPY (3.67 Å)
Cite:Structure of the RAF1-HSP90-CDC37 complex reveals the basis of RAF1 regulation.
Mol.Cell, 82, 2022
7Y04
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BU of 7y04 by Molmil
Hsp90-AhR-p23 complex
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Aryl hydrocarbon receptor, BERYLLIUM TRIFLUORIDE ION, ...
Authors:Wen, Z.L, Zhai, Y.J, Zhu, Y, Sun, F.
Deposit date:2022-06-03
Release date:2023-01-04
Last modified:2023-03-22
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Cryo-EM structure of the cytosolic AhR complex.
Structure, 31, 2023
7ULK
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BU of 7ulk by Molmil
Human TRAP1 NM in complex with 42C
Descriptor: CALCIUM ION, Heat shock protein 75 kDa, mitochondrial, ...
Authors:Stachowski, T.R, Nithianantham, S, Vanarotti, M, Fischer, M.
Deposit date:2022-04-05
Release date:2023-04-12
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:Pan-HSP90 ligand binding reveals isoform-specific differences in plasticity and water networks.
Protein Sci., 32, 2023
7U8X
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BU of 7u8x by Molmil
hTRAP1 with inhibitors
Descriptor: Heat shock protein 75 kDa, mitochondrial, [5-(4-fluoro-2H-isoindole-2-carbonyl)-2-hydroxyphenyl](5-methoxy-2H-isoindol-2-yl)methanone
Authors:Deng, J, Matts, R, Peng, S.
Deposit date:2022-03-09
Release date:2023-08-16
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Elucidation of novel TRAP1-Selective inhibitors that regulate mitochondrial processes.
Eur.J.Med.Chem., 258, 2023
7U8W
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BU of 7u8w by Molmil
hTRAP1 with inhibitors
Descriptor: Heat shock protein 75 kDa, mitochondrial, [5-(4-fluoro-2H-isoindole-2-carbonyl)-2-hydroxyphenyl](5-fluoro-2H-isoindol-2-yl)methanone
Authors:Deng, J, Matts, R, Peng, S.
Deposit date:2022-03-09
Release date:2023-08-16
Method:X-RAY DIFFRACTION (1.706 Å)
Cite:Elucidation of novel TRAP1-Selective inhibitors that regulate mitochondrial processes.
Eur.J.Med.Chem., 258, 2023
7U8V
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BU of 7u8v by Molmil
hTRAP1 with inhibitors
Descriptor: (4-hydroxy-1,3-phenylene)bis[(2H-isoindol-2-yl)methanone], Heat shock protein 75 kDa, mitochondrial
Authors:Deng, J, Matts, R, Peng, S.
Deposit date:2022-03-09
Release date:2023-08-16
Method:X-RAY DIFFRACTION (1.448 Å)
Cite:Elucidation of novel TRAP1-Selective inhibitors that regulate mitochondrial processes.
Eur.J.Med.Chem., 258, 2023
7U8U
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BU of 7u8u by Molmil
hTRAP1 with inhibitors
Descriptor: Heat shock protein 75 kDa, mitochondrial, [2-hydroxy-5-(2H-isoindole-2-carbonyl)phenyl]{5-[3-(triphenyl-lambda~5~-phosphanyl)propoxy]-2H-isoindol-2-yl}methanone
Authors:Deng, J, Matts, R, Peng, S.
Deposit date:2022-03-09
Release date:2023-08-16
Method:X-RAY DIFFRACTION (3.065 Å)
Cite:Elucidation of novel TRAP1-Selective inhibitors that regulate mitochondrial processes.
Eur.J.Med.Chem., 258, 2023

 

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數據於2024-03-27公開中

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