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1PB5
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BU of 1pb5 by Molmil
NMR Structure of a Prototype LNR Module from Human Notch1
Descriptor: CALCIUM ION, Neurogenic locus notch homolog protein 1
Authors:Vardar, D, North, C.L, Sanchez-Irizarry, C, Aster, J.C, Blacklow, S.C.
Deposit date:2003-05-14
Release date:2003-06-17
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:Nuclear Magnetic Resonance Structure of a Prototype Lin12-Notch Repeat Module from Human Notch1
Biochemistry, 42, 2003
7ABV
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BU of 7abv by Molmil
Structure of the S1-cleaved mouse Notch1 Negative Regulatory Region (NRR)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Neurogenic locus notch homolog protein 1
Authors:Zeronian, M.R, Janssen, B.J.C.
Deposit date:2020-09-08
Release date:2021-07-07
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.065 Å)
Cite:Notch-Jagged signaling complex defined by an interaction mosaic.
Proc.Natl.Acad.Sci.USA, 118, 2021
7DXI
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BU of 7dxi by Molmil
Structure of Drosophila melanogaster GlcNAc-1-phosphotransferase
Descriptor: CALCIUM ION, FI02838p
Authors:Du, S, Xiao, J, Guopeng, W.
Deposit date:2021-01-19
Release date:2022-02-02
Last modified:2022-08-17
Method:ELECTRON MICROSCOPY (3.53 Å)
Cite:Structural insights into how GlcNAc-1-phosphotransferase directs lysosomal protein transport.
J.Biol.Chem., 298, 2022
6XSW
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BU of 6xsw by Molmil
Structure of the Notch3 NRR in complex with an antibody Fab Fragment
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Anti-N3 Fab Heavy Chain, ...
Authors:Bard, J.
Deposit date:2020-07-16
Release date:2021-07-21
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.98 Å)
Cite:NOTCH3-targeted antibody drug conjugates regress tumors by inducing apoptosis in receptor cells and through transendocytosis into ligand cells.
Cell Rep Med, 2, 2021
4ZLP
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BU of 4zlp by Molmil
Crystal Structure of Notch3 Negative Regulatory Region
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, CALCIUM ION, ...
Authors:Xu, X, Blacklow, S.C.
Deposit date:2015-05-01
Release date:2015-08-19
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.479 Å)
Cite:Insights into Autoregulation of Notch3 from Structural and Functional Studies of Its Negative Regulatory Region.
Structure, 23, 2015
2OO4
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BU of 2oo4 by Molmil
Structure of LNR-HD (Negative Regulatory Region) from human Notch 2
Descriptor: CALCIUM ION, GLYCEROL, Neurogenic locus notch homolog protein 2, ...
Authors:Gordon, W.R, Vardar-Ulu, D, Histen, G, Sanchez-Irizarry, C, Aster, J.C, Blacklow, S.C.
Deposit date:2007-01-25
Release date:2007-04-03
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.003 Å)
Cite:Structural basis for autoinhibition of Notch
Nat.Struct.Mol.Biol., 14, 2007
3ETO
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BU of 3eto by Molmil
2 Angstrom Xray structure of the NOTCH1 Negative Regulatory Region (NRR)
Descriptor: CALCIUM ION, CHLORIDE ION, GLYCEROL, ...
Authors:Gordon, W.R, Blacklow, S.C.
Deposit date:2008-10-08
Release date:2008-12-23
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of the Notch1-negative regulatory region: implications for normal activation and pathogenic signaling in T-ALL.
Blood, 113, 2009
7S05
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BU of 7s05 by Molmil
Cryo-EM structure of human GlcNAc-1-phosphotransferase A2B2 subcomplex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Li, H, Li, H.
Deposit date:2021-08-30
Release date:2022-03-30
Last modified:2022-04-27
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structure of the human GlcNAc-1-phosphotransferase alpha beta subunits reveals regulatory mechanism for lysosomal enzyme glycan phosphorylation.
Nat.Struct.Mol.Biol., 29, 2022
7S06
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BU of 7s06 by Molmil
Cryo-EM structure of human GlcNAc-1-phosphotransferase A2B2 subcomplex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, N-acetylglucosamine-1-phosphotransferase subunits alpha/beta
Authors:Li, H, Li, H.
Deposit date:2021-08-30
Release date:2022-03-30
Last modified:2022-04-27
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structure of the human GlcNAc-1-phosphotransferase alpha beta subunits reveals regulatory mechanism for lysosomal enzyme glycan phosphorylation.
Nat.Struct.Mol.Biol., 29, 2022
5CZX
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BU of 5czx by Molmil
Crystal structure of Notch3 NRR in complex with 20358 Fab
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 20358 Fab heavy chain, ...
Authors:Hu, T, Fryer, C, Chopra, R, Clark, K.
Deposit date:2015-08-01
Release date:2016-06-01
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Characterization of activating mutations of NOTCH3 in T-cell acute lymphoblastic leukemia and anti-leukemic activity of NOTCH3 inhibitory antibodies.
Oncogene, 35, 2016
5CZV
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BU of 5czv by Molmil
Crystal structure of Notch3 NRR in complex with 20350 Fab
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Fab 20350 heavy chain, ...
Authors:Hu, T, Fryer, C, Chopra, R, Clark, K.
Deposit date:2015-08-01
Release date:2016-06-01
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.19 Å)
Cite:Characterization of activating mutations of NOTCH3 in T-cell acute lymphoblastic leukemia and anti-leukemic activity of NOTCH3 inhibitory antibodies.
Oncogene, 35, 2016
3I08
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BU of 3i08 by Molmil
Crystal structure of the S1-cleaved Notch1 Negative Regulatory Region (NRR)
Descriptor: CALCIUM ION, CHLORIDE ION, Neurogenic locus notch homolog protein 1
Authors:Gordon, W.R, Blacklow, S.C.
Deposit date:2009-06-24
Release date:2009-09-01
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Effects of S1 cleavage on the structure, surface export, and signaling activity of human Notch1 and Notch2.
Plos One, 4, 2009
3L95
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BU of 3l95 by Molmil
Crystal structure of the human Notch1 Negative Regulatory Region (NRR) bound to the fab fragment of an antagonist antibody
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Neurogenic locus notch homolog protein 1, ...
Authors:Hymowitz, S.G, de Leon, G.P.
Deposit date:2010-01-04
Release date:2010-03-09
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:Therapeutic antibody targeting of individual Notch receptors.
Nature, 464, 2010

217705

數據於2024-03-27公開中

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