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7CIO
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BU of 7cio by Molmil
Molecular interactions of cytoplasmic region of CTLA-4 with SH2 domains of PI3-kinase
Descriptor: Cytotoxic T-lymphocyte protein 4, Phosphatidylinositol 3-kinase regulatory subunit alpha
Authors:Iiyama, M, Numoto, N, Ogawa, S, Kuroda, M, Morii, H, Abe, R, Ito, N, Oda, M.
Deposit date:2020-07-08
Release date:2020-12-09
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Molecular interactions of the CTLA-4 cytoplasmic region with the phosphoinositide 3-kinase SH2 domains.
Mol.Immunol., 131, 2021
4WWQ
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BU of 4wwq by Molmil
Apo structure of the Grb7 SH2 domain
Descriptor: Growth factor receptor-bound protein 7, MALONIC ACID
Authors:Watson, G.M, Ambaye, N.D, Wilce, M.C, Wilce, J.A.
Deposit date:2014-11-12
Release date:2015-09-23
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Cyclic Peptides Incorporating Phosphotyrosine Mimetics as Potent and Specific Inhibitors of the Grb7 Breast Cancer Target.
J.Med.Chem., 58, 2015
6SM5
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BU of 6sm5 by Molmil
MbC/SHP1-C-SH2 complex
Descriptor: MbC (monobody targeting SHP1-C-SH2), Tyrosine-protein phosphatase non-receptor type 6
Authors:Mann, G, Hantschel, O.
Deposit date:2019-08-21
Release date:2021-01-13
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:MbC/SHP1-C-SH2 complex
To Be Published
2VIF
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BU of 2vif by Molmil
Crystal structure of SOCS6 SH2 domain in complex with a c-KIT phosphopeptide
Descriptor: 1,2-ETHANEDIOL, MAST/STEM CELL GROWTH FACTOR RECEPTOR, SUPPRESSOR OF CYTOKINE SIGNALLING 6
Authors:Bullock, A, Pike, A.C.W, Savitsky, P, Keates, T, Pilka, E.S, von Delft, F, Edwards, A, Weigelt, J, Arrowsmith, C.H, Knapp, S.
Deposit date:2007-11-30
Release date:2007-12-25
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Structural Basis for C-Kit Inhibition by the Suppressor of Cytokine Signaling 6 (Socs6) Ubiquitin Ligase.
J.Biol.Chem., 286, 2011
2YU7
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BU of 2yu7 by Molmil
Solution structure of the SHP-1 C-terminal SH2 domain complexed with a tyrosine-phosphorylated peptide from NKG2A
Descriptor: Tyrosine-protein phosphatase non-receptor type 6, natural killer group 2A
Authors:Kasai, T, Koshiba, S, Inoue, M, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2007-04-05
Release date:2008-04-15
Last modified:2022-03-16
Method:SOLUTION NMR
Cite:Solution structure of the SHP-1 C-terminal SH2 domain complexed with a tyrosine-phosphorylated peptide from NKG2A
To be Published
2YSX
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BU of 2ysx by Molmil
Solution structure of the human SHIP SH2 domain
Descriptor: Signaling inositol polyphosphate phosphatase SHIP II
Authors:Kasai, T, Koshiba, S, Watanabe, S, Harada, T, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2007-04-04
Release date:2008-04-08
Last modified:2022-03-16
Method:SOLUTION NMR
Cite:Solution structure of the human SHIP SH2 domain
To be Published
5MTN
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BU of 5mtn by Molmil
Monobody Mb(Lck_1) bound to Lck-Sh2
Descriptor: Monobody Mb(Lck_1), SULFATE ION, Tyrosine-protein kinase Lck
Authors:Pojer, F, Kukenshoner, T, Koide, S, Hantschel, O.
Deposit date:2017-01-10
Release date:2017-04-05
Last modified:2019-10-16
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Selective Targeting of SH2 Domain-Phosphotyrosine Interactions of Src Family Tyrosine Kinases with Monobodies.
J. Mol. Biol., 429, 2017
5MTJ
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BU of 5mtj by Molmil
Yes1-SH2 in complex with monobody Mb(Yes_1)
Descriptor: 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, Monobody Mb(Yes_1), SULFATE ION, ...
Authors:Sha, F, Kukenshoner, T, Koide, S, Hantschel, O.
Deposit date:2017-01-09
Release date:2017-04-05
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.949 Å)
Cite:Selective Targeting of SH2 Domain-Phosphotyrosine Interactions of Src Family Tyrosine Kinases with Monobodies.
J. Mol. Biol., 429, 2017
5MTM
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BU of 5mtm by Molmil
Monobody Mb(Lck_3) bound to Lck-SH2 domain
Descriptor: Monobody Mb(Lck_3), Tyrosine-protein kinase Lck, ZINC ION
Authors:Pojer, F, Kukenshoner, T, Koide, S, Hantschel, O.
Deposit date:2017-01-10
Release date:2017-04-05
Last modified:2019-10-16
Method:X-RAY DIFFRACTION (2.405 Å)
Cite:Selective Targeting of SH2 Domain-Phosphotyrosine Interactions of Src Family Tyrosine Kinases with Monobodies.
J. Mol. Biol., 429, 2017
4QSY
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BU of 4qsy by Molmil
SHP2 SH2 domain in complex with GAB1 peptide
Descriptor: GRB2-associated-binding protein 1, Tyrosine-protein phosphatase non-receptor type 11
Authors:Gogl, G, Remenyi, A.
Deposit date:2014-07-06
Release date:2015-07-08
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Selective targeting of GAB adapter protein SHP2 tyrosine phosphatase interaction attenuates ERK signaling
To be Published
4ROJ
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BU of 4roj by Molmil
Crystal Structure of the VAV2 SH2 domain in complex with TXNIP phosphorylated peptide
Descriptor: Guanine nucleotide exchange factor VAV2, Thioredoxin-interacting protein, UNKNOWN ATOM OR ION
Authors:Liu, Y, Tempel, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC)
Deposit date:2014-10-28
Release date:2014-12-10
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal Structure of the VAV2 SH2 domain in complex with TXNIP phosphorylated peptide
TO BE PUBLISHED
4TZI
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BU of 4tzi by Molmil
Structure of unliganded Lyn SH2 domain
Descriptor: Tyrosine-protein kinase Lyn
Authors:Wybenga-Groot, L.E.
Deposit date:2014-07-10
Release date:2015-01-21
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Tyrosine Phosphorylation of the Lyn Src Homology 2 (SH2) Domain Modulates Its Binding Affinity and Specificity.
Mol.Cell Proteomics, 14, 2015
4U1P
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BU of 4u1p by Molmil
Human Fyn-SH2 domain in complex with a synthetic high-affinity phospho-peptide
Descriptor: Middle T antigen, POLYETHYLENE GLYCOL (N=34), SODIUM ION, ...
Authors:Garcia-Pino, A, Huculeci, R, Lenaerts, T, van Nuland, N.A.J.
Deposit date:2014-07-16
Release date:2015-07-29
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Human Fyn-SH2 domain in complex with a synthetic high-affinity phospho-peptide
To Be Published
4U17
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BU of 4u17 by Molmil
Swapped dimer of the human Fyn-SH2 domain
Descriptor: 1,2-ETHANEDIOL, PHOSPHATE ION, Tyrosine-protein kinase Fyn
Authors:Garcia-Pino, A, Huculeci, R, Lenaerts, T, van Nuland, N.A.J.
Deposit date:2014-07-15
Release date:2015-07-29
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Swapped dimer of the human Fyn-SH2 domain
To Be Published
4EIH
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BU of 4eih by Molmil
Crystal structure of Arg SH2 domain
Descriptor: Abelson tyrosine-protein kinase 2, CHLORIDE ION
Authors:Liu, W, MacGrath, S.M, Koleske, A.J, Boggon, T.J.
Deposit date:2012-04-05
Release date:2013-04-10
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Two Amino Acid Residues Confer Different Binding Affinities of Abelson Family Kinase Src Homology 2 Domains for Phosphorylated Cortactin.
J.Biol.Chem., 289, 2014
6WAY
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BU of 6way by Molmil
C-terminal SH2 domain of p120RasGAP in complex with p190RhoGAP phosphotyrosine peptide
Descriptor: Ras GTPase-activating protein 1, Rho GTPase-activating protein 35
Authors:Jaber Chehayeb, R, Wang, J, Stiegler, A.L, Boggon, T.J.
Deposit date:2020-03-26
Release date:2020-06-17
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:The GTPase-activating protein p120RasGAP has an evolutionarily conserved "FLVR-unique" SH2 domain.
J.Biol.Chem., 295, 2020
6WAX
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BU of 6wax by Molmil
C-terminal SH2 domain of p120RasGAP
Descriptor: 1,2-ETHANEDIOL, Ras GTPase-activating protein 1, SULFATE ION
Authors:Jaber Chehayeb, R, Wang, J, Stiegler, A.L, Boggon, T.J.
Deposit date:2020-03-26
Release date:2020-06-17
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:The GTPase-activating protein p120RasGAP has an evolutionarily conserved "FLVR-unique" SH2 domain.
J.Biol.Chem., 295, 2020
6VK2
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BU of 6vk2 by Molmil
NMR solution structure of Grb2-SH2 domain at pH 7
Descriptor: Growth factor receptor-bound protein 2
Authors:Sanches, K, Caruso, I.P, Melo, F.A, Almeida, F.C.L.
Deposit date:2020-01-18
Release date:2020-07-29
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:The dynamics of free and phosphopeptide-bound Grb2-SH2 reveals two dynamically independent subdomains and an encounter complex with fuzzy interactions.
Sci Rep, 10, 2020
6WM1
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BU of 6wm1 by Molmil
Crystal structure of the Grb2 SH2 domain in complex with a tripeptide: Ac-pY-Ac6c-N-phenylpropyl
Descriptor: ACE-PTR-02K-ASN-PRA, CALCIUM ION, CHLORIDE ION, ...
Authors:Martin, S.F, Clements, J.H.
Deposit date:2020-04-20
Release date:2020-09-02
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Some thermodynamic effects of varying nonpolar surfaces in protein-ligand interactions.
Eur.J.Med.Chem., 208, 2020
6WO2
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BU of 6wo2 by Molmil
Crystal Structure of the Grb2 SH2 Domain in Complex with a Tripeptide: Ac-pY-Ac6c-N-isohexyl
Descriptor: ACE-PTR-02K-ASN-U67, CALCIUM ION, Growth factor receptor-bound protein 2, ...
Authors:Martin, S.F, Clements, J.H.
Deposit date:2020-04-24
Release date:2020-09-02
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:Some thermodynamic effects of varying nonpolar surfaces in protein-ligand interactions.
Eur.J.Med.Chem., 208, 2020
6PXC
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BU of 6pxc by Molmil
N-Terminal SH2 domain of the p120RasGAP bound to a p190RhoGAP phosphotyrosine peptide
Descriptor: Ras GTPase-activating protein 1, phosphopeptide of p190RhoGAP
Authors:Jaber Chehayeb, R, Stiegler, A.L, Boggon, T.J.
Deposit date:2019-07-25
Release date:2019-12-18
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structures of p120RasGAP N-terminal SH2 domain in its apo form and in complex with a p190RhoGAP phosphotyrosine peptide.
Plos One, 14, 2019
6HTF
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BU of 6htf by Molmil
Crystal structure of human Btk SH2 domain bound to rF10 repebody
Descriptor: Tyrosine-protein kinase BTK, rF10 repebody
Authors:Duarte, D.P, Pojer, F, Hantschel, O.
Deposit date:2018-10-04
Release date:2020-05-20
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.102 Å)
Cite:Btk SH2-kinase interface is critical for allosteric kinase activation and its targeting inhibits B-cell neoplasms.
Nat Commun, 11, 2020
6PXB
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BU of 6pxb by Molmil
N-Terminal SH2 domain of the p120RasGAP
Descriptor: Ras GTPase-activating protein 1
Authors:Jaber Chehayeb, R, Stiegler, A.L, Boggon, T.J.
Deposit date:2019-07-25
Release date:2019-12-18
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.747 Å)
Cite:Crystal structures of p120RasGAP N-terminal SH2 domain in its apo form and in complex with a p190RhoGAP phosphotyrosine peptide.
Plos One, 14, 2019
7MPH
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BU of 7mph by Molmil
GRB2 SH2 Domain with Compound 7
Descriptor: (4-{(10R,11E,14S,18S)-18-(2-amino-2-oxoethyl)-14-[(naphthalen-1-yl)methyl]-8,17,20-trioxo-7,16,19-triazaspiro[5.14]icos-11-en-10-yl}phenyl)acetic acid, 1,2-ETHANEDIOL, Growth factor receptor-bound protein 2, ...
Authors:Sun, L, Schonbrunn, E.
Deposit date:2021-05-04
Release date:2021-09-22
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:Synthesis and structural characterization of a monocarboxylic inhibitor for GRB2 SH2 domain.
Bioorg.Med.Chem.Lett., 51, 2021
6ICH
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BU of 6ich by Molmil
Grb2 SH2 domain in domain swapped dimer form
Descriptor: Growth factor receptor-bound protein 2
Authors:Hosoe, Y, Numoto, N, Inaba, S, Ogawa, S, Morii, H, Abe, R, Ito, N, Oda, M.
Deposit date:2018-09-06
Release date:2019-07-17
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural and functional properties of Grb2 SH2 dimer in CD28 binding.
Biophys Physicobio., 16, 2019

217705

數據於2024-03-27公開中

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