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3TB8
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BU of 3tb8 by Molmil
Crystal structure of full-length myristoylated HIV-1 Nef
Descriptor: Protein Nef
Authors:Dennis, C.A, Harris, M, Jaeger, J.
Deposit date:2011-08-05
Release date:2012-10-03
Last modified:2022-12-21
Method:X-RAY DIFFRACTION (3.71 Å)
Cite:Crystal structure of full-length myristoylated HIV-1 Nef
To be Published
6K6N
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BU of 6k6n by Molmil
Crystal structure of SIVmac239 Nef protein
Descriptor: Protein Nef
Authors:Hirao, K, Andrews, S, Kuroki, K, Kusaka, H, Tadokoro, T, Kita, S, Ose, T, Rowland-Jones, S, Maenaka, K.
Deposit date:2019-06-04
Release date:2020-03-25
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.0002 Å)
Cite:Structure of HIV-2 Nef Reveals Features Distinct from HIV-1 Involved in Immune Regulation.
Iscience, 23, 2020
1AVV
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BU of 1avv by Molmil
HIV-1 NEF PROTEIN, UNLIGANDED CORE DOMAIN
Descriptor: NEGATIVE FACTOR
Authors:Arold, S, Franken, P, Dumas, C.
Deposit date:1997-09-21
Release date:1998-03-25
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (3 Å)
Cite:The crystal structure of HIV-1 Nef protein bound to the Fyn kinase SH3 domain suggests a role for this complex in altered T cell receptor signaling.
Structure, 5, 1997
2NEF
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BU of 2nef by Molmil
HIV-1 NEF (REGULATORY FACTOR), NMR, 40 STRUCTURES
Descriptor: NEGATIVE FACTOR (F-PROTEIN)
Authors:Grzesiek, S, Bax, A, Clore, G.M, Gronenborn, A.M, Hu, J.S, Kaufman, J, Palmer, I, Stahl, S.J, Tjandra, N, Wingfield, P.T.
Deposit date:1997-02-12
Release date:1997-07-07
Last modified:2017-11-29
Method:SOLUTION NMR
Cite:Refined solution structure and backbone dynamics of HIV-1 Nef.
Protein Sci., 6, 1997
2XI1
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BU of 2xi1 by Molmil
Crystal structure of the HIV-1 Nef sequenced from a patient's sample
Descriptor: NEF
Authors:Yadav, G.P, Singh, P, Gupta, S, Tripathi, A.K, Tripathi, R.K, Ramachandran, R.
Deposit date:2010-06-25
Release date:2011-08-10
Last modified:2011-11-23
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:A Novel Dimer-Tetramer Transition Captured by the Crystal Structure of the HIV-1 Nef.
Plos One, 6, 2011
6B72
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BU of 6b72 by Molmil
A novel HIV-1 Nef dimer interface induced by a single octyl-glucoside molecule
Descriptor: Protein Nef, octyl beta-D-glucopyranoside
Authors:Wu, M, Augelli-Szafran, C.E, Ptak, R.G, Smithgall, T.E.
Deposit date:2017-10-03
Release date:2018-02-21
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:A single beta-octyl glucoside molecule induces HIV-1 Nef dimer formation in the absence of partner protein binding.
PLoS ONE, 13, 2018
5NUI
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BU of 5nui by Molmil
Crystal structure of SIVmac239 Nef in an ExxxLM endocytic sorting motif bound state
Descriptor: Protein Nef, SER-GLN-ILE-LYS-ARG-LEU-LEU-SER
Authors:Manrique, S, Horenkamp, F.A, Anand, K, Geyer, M.
Deposit date:2017-04-30
Release date:2017-08-16
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Endocytic sorting motif interactions involved in Nef-mediated downmodulation of CD4 and CD3.
Nat Commun, 8, 2017
6OWT
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BU of 6owt by Molmil
Structure of SIVsmm Nef and SMM tetherin bound to the clathrin adaptor AP-2 complex
Descriptor: AP-2 complex subunit alpha, AP-2 complex subunit beta, AP-2 complex subunit sigma, ...
Authors:Buffalo, C.Z, Ren, X, Hurley, J.H.
Deposit date:2019-05-10
Release date:2019-09-25
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structural Basis for Tetherin Antagonism as a Barrier to Zoonotic Lentiviral Transmission.
Cell Host Microbe, 26, 2019
6URI
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BU of 6uri by Molmil
HIV-1 Nef in complex with the CD4 cytoplasmic domain and the AP2 clathrin adaptor complex
Descriptor: AP-2 complex subunit alpha, AP-2 complex subunit beta, AP-2 complex subunit mu, ...
Authors:Jia, X, Kwon, Y.
Deposit date:2019-10-23
Release date:2020-07-29
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural basis of CD4 downregulation by HIV-1 Nef.
Nat.Struct.Mol.Biol., 27, 2020
3IK5
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BU of 3ik5 by Molmil
SIVmac239 Nef in complex with TCR zeta ITAM 1 polypeptide (A63-R80)
Descriptor: Protein Nef, T-cell surface glycoprotein CD3 zeta chain
Authors:Kim, W.M, Sigalov, A.B, Stern, L.J.
Deposit date:2009-08-05
Release date:2010-02-02
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Pseudo-merohedral twinning and noncrystallographic symmetry in orthorhombic crystals of SIVmac239 Nef core domain bound to different-length TCRzeta fragments.
Acta Crystallogr.,Sect.D, 66, 2010
4NEE
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BU of 4nee by Molmil
crystal structure of AP-2 alpha/simga2 complex bound to HIV-1 Nef
Descriptor: AP-2 complex subunit alpha-2, AP-2 complex subunit sigma, Protein Nef
Authors:Hurley, J.H, Bonifacino, J.S, Ren, X, Park, S.Y.
Deposit date:2013-10-29
Release date:2014-01-29
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.8841 Å)
Cite:How HIV-1 Nef hijacks the AP-2 clathrin adaptor to downregulate CD4.
Elife, 3, 2014
3IOZ
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BU of 3ioz by Molmil
SIVmac239 Nef in complex with a TCR zeta polypeptide DP1 (L51-D93)
Descriptor: Protein Nef, T-cell surface glycoprotein CD3 zeta chain
Authors:Kim, W.M, Sigalov, A.B, Stern, L.J.
Deposit date:2009-08-15
Release date:2010-02-02
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (3.699 Å)
Cite:Pseudo-merohedral twinning and noncrystallographic symmetry in orthorhombic crystals of SIVmac239 Nef core domain bound to different-length TCRzeta fragments.
Acta Crystallogr.,Sect.D, 66, 2010
4EN2
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BU of 4en2 by Molmil
HIV-1 Nef in complex with MHC-I cytoplasmic domain and Mu1 adaptin subunit of AP1 adaptor (second domain)
Descriptor: AP-1 complex subunit mu-1, MHC-I, Protein Nef
Authors:Jia, X, Xiong, Y.
Deposit date:2012-04-12
Release date:2012-06-20
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.58 Å)
Cite:Structural basis of evasion of cellular adaptive immunity by HIV-1 Nef.
Nat.Struct.Mol.Biol., 19, 2012
4EMZ
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BU of 4emz by Molmil
HIV-1 Nef in complex with MHC-I cytoplasmic domain and Mu1 adaptin subunit of AP1 adaptor (second domain)
Descriptor: AP-1 complex subunit mu-1, MHC-I, Protein Nef
Authors:Jia, X, Xiong, Y.
Deposit date:2012-04-12
Release date:2012-06-20
Last modified:2012-07-25
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis of evasion of cellular adaptive immunity by HIV-1 Nef.
Nat.Struct.Mol.Biol., 19, 2012
1AVZ
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BU of 1avz by Molmil
V-1 NEF PROTEIN IN COMPLEX WITH WILD TYPE FYN SH3 DOMAIN
Descriptor: FYN TYROSINE KINASE, NEGATIVE FACTOR
Authors:Arold, S, Franken, P, Dumas, C.
Deposit date:1997-09-23
Release date:1998-03-25
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (3 Å)
Cite:The crystal structure of HIV-1 Nef protein bound to the Fyn kinase SH3 domain suggests a role for this complex in altered T cell receptor signaling.
Structure, 5, 1997
7D7S
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BU of 7d7s by Molmil
HIV-1 SF2 Nef in complex with the Fyn SH3 R96I mutant
Descriptor: Protein Nef, Tyrosine-protein kinase Fyn
Authors:Aldehaiman, A, Shahul Hamed, U.F, Arold, S.T.
Deposit date:2020-10-05
Release date:2020-11-18
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (3.32 Å)
Cite:Synergy and allostery in ligand binding by HIV-1 Nef.
Biochem.J., 478, 2021
7UX3
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BU of 7ux3 by Molmil
Asymmetric unit of AP-1, Arf1, Nef lattice on MHC-I lipopeptide incorporated narrow membrane tubes
Descriptor: ADP-ribosylation factor 1, AP-1 complex subunit beta-1, AP-1 complex subunit gamma-1, ...
Authors:Hooy, R.M, Hurley, J.H.
Deposit date:2022-05-04
Release date:2023-05-10
Last modified:2023-06-14
Method:ELECTRON MICROSCOPY (9.6 Å)
Cite:Self-assembly and structure of a clathrin-independent AP-1:Arf1 tubular membrane coat.
Sci Adv, 8, 2022
8F2P
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BU of 8f2p by Molmil
Nef SF2 dimerization mutant bound to Hck SH3
Descriptor: C-terminal core protein, Tyrosine-protein kinase HCK
Authors:Thomas, C.E, Alvarado, J.J, Smithgall, T.E.
Deposit date:2022-11-08
Release date:2023-02-22
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.63 Å)
Cite:Neutron Reflectometry and Molecular Simulations Demonstrate HIV-1 Nef Homodimer Formation on Model Lipid Bilayers.
J.Mol.Biol., 435, 2023
1EFN
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BU of 1efn by Molmil
HIV-1 NEF PROTEIN IN COMPLEX WITH R96I MUTANT FYN SH3 DOMAIN
Descriptor: FYN TYROSINE KINASE, HIV-1 NEF PROTEIN, TRIMETHYL LEAD ION
Authors:Lee, C.-H, Kuriyan, J.
Deposit date:1996-06-29
Release date:1997-01-11
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of the conserved core of HIV-1 Nef complexed with a Src family SH3 domain.
Cell(Cambridge,Mass.), 85, 1996
4U5W
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BU of 4u5w by Molmil
Crystal Structure of HIV-1 Nef-SF2 Core Domain in Complex with the Src Family Kinase Hck SH3-SH2 Tandem Regulatory Domains
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, IODIDE ION, Protein Nef, ...
Authors:Alvarado, J.J, Yeh, J.I, Smithgall, T.E.
Deposit date:2014-07-25
Release date:2014-08-20
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Interaction with the Src Homology (SH3-SH2) Region of the Src-family Kinase Hck Structures the HIV-1 Nef Dimer for Kinase Activation and Effector Recruitment.
J.Biol.Chem., 289, 2014
3REB
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BU of 3reb by Molmil
HIV-1 Nef protein in complex with engineered Hck-SH3 domain
Descriptor: Protein Nef, Tyrosine-protein kinase HCK
Authors:Schulte, A, Blankenfeldt, W, Geyer, M.
Deposit date:2011-04-04
Release date:2011-06-01
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3.45 Å)
Cite:Molecular design, functional characterization and structural basis of a protein inhibitor against the HIV-1 pathogenicity factor Nef.
PLoS ONE, 6, 2011
5NUH
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BU of 5nuh by Molmil
Crystal structure of SIVmac239 Nef bound to an engineered Hck SH3 domain
Descriptor: Protein Nef, Tyrosine-protein kinase HCK,Tyrosine-protein kinase HCK
Authors:Horenkamp, F.A, Anand, K, Geyer, M.
Deposit date:2017-04-30
Release date:2017-08-16
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.78 Å)
Cite:Endocytic sorting motif interactions involved in Nef-mediated downmodulation of CD4 and CD3.
Nat Commun, 8, 2017
4ORZ
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BU of 4orz by Molmil
HIV-1 Nef protein in complex with single domain antibody sdAb19 and an engineered Hck SH3 domain
Descriptor: Protein Nef, Tyrosine-protein kinase HCK, single domain antibody sdAb19
Authors:Geyer, M, Lulf, S.
Deposit date:2014-02-12
Release date:2014-03-26
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for the inhibition of HIV-1 Nef by a high-affinity binding single-domain antibody.
Retrovirology, 11, 2014
3RBB
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BU of 3rbb by Molmil
HIV-1 NEF protein in complex with engineered HCK SH3 domain
Descriptor: 1,2-ETHANEDIOL, Protein Nef, Tyrosine-protein kinase HCK
Authors:Horenkamp, F.A, Schulte, A, Weyand, M, Geyer, M.
Deposit date:2011-03-29
Release date:2011-04-27
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Conformation of the Dileucine-Based Sorting Motif in HIV-1 Nef Revealed by Intermolecular Domain Assembly.
Traffic, 12, 2011
3REA
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BU of 3rea by Molmil
HIV-1 Nef protein in complex with engineered Hck-SH3 domain
Descriptor: Protein Nef, Tyrosine-protein kinase HCK
Authors:Schulte, A, Blankenfeldt, W, Geyer, M.
Deposit date:2011-04-04
Release date:2011-06-01
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Molecular design, functional characterization and structural basis of a protein inhibitor against the HIV-1 pathogenicity factor Nef.
PLoS ONE, 6, 2011

 

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