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1W6J
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BU of 1w6j by Molmil
Structure of human OSC in complex with Ro 48-8071
Descriptor: LANOSTEROL SYNTHASE, TETRADECANE, [4-({6-[ALLYL(METHYL)AMINO]HEXYL}OXY)-2-FLUOROPHENYL](4-BROMOPHENYL)METHANONE, ...
Authors:Thoma, R, Schulz-Gasch, T, D'Arcy, B, Benz, J, Aebi, J, Dehmlow, H, Hennig, M, Ruf, A.
Deposit date:2004-08-18
Release date:2004-10-29
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Insight Into Steroid Scaffold Formation from the Structure of Human Oxidosqualene Cyclase
Nature, 432, 2004
1W6K
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BU of 1w6k by Molmil
Structure of human OSC in complex with Lanosterol
Descriptor: LANOSTEROL, LANOSTEROL SYNTHASE, octyl beta-D-glucopyranoside
Authors:Thoma, R, Schulz-Gasch, T, D'Arcy, B, Benz, J, Aebi, J, Dehmlow, H, Hennig, M, Ruf, A.
Deposit date:2004-08-19
Release date:2004-10-29
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Insight Into Steroid Scaffold Formation from the Structure of Human Oxidosqualene Cyclase
Nature, 432, 2004
6O60
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BU of 6o60 by Molmil
Crystal structure of GGTase3-FBXL2-SKP1 complex
Descriptor: F-box/LRR-repeat protein 2, Geranylgeranyl transferase type-2 subunit beta, Protein prenyltransferase alpha subunit repeat-containing protein 1, ...
Authors:Wang, H, Zheng, N.
Deposit date:2019-03-04
Release date:2019-06-26
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.503 Å)
Cite:GGTase3 is a newly identified geranylgeranyltransferase targeting a ubiquitin ligase.
Nat.Struct.Mol.Biol., 26, 2019
8E9E
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BU of 8e9e by Molmil
Rat protein farnesyltransferase in complex with FPP and inhibitor 2f
Descriptor: (5S)-4-({1-[(4-bromophenyl)methyl]-1H-imidazol-5-yl}methyl)-5-butyl-1-[3-(trifluoromethoxy)phenyl]piperazin-2-one, 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ...
Authors:Wang, Y, Shi, Y, Beese, L.S.
Deposit date:2022-08-26
Release date:2022-10-26
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.844 Å)
Cite:Structure-Guided Discovery of Potent Antifungals that Prevent Ras Signaling by Inhibiting Protein Farnesyltransferase.
J.Med.Chem., 65, 2022
5BP8
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BU of 5bp8 by Molmil
ent-Copalyl diphosphate synthase from Streptomyces platensis
Descriptor: 1,2-ETHANEDIOL, Ent-copalyl diphosphate synthase, SULFATE ION
Authors:Osipiuk, J, Hatzos-Skintges, C, Endres, M, Babnigg, G, Rudolf, J.D, Ma, M, Chang, C.-Y, Shen, B, Joachimiak, A, Enzyme Discovery for Natural Product Biosynthesis (NatPro), Midwest Center for Structural Genomics (MCSG)
Deposit date:2015-05-27
Release date:2015-06-10
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of the ent-Copalyl Diphosphate Synthase PtmT2 from Streptomyces platensis CB00739, a Bacterial Type II Diterpene Synthase.
J.Am.Chem.Soc., 138, 2016
3SQC
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BU of 3sqc by Molmil
SQUALENE-HOPENE CYCLASE
Descriptor: SQUALENE--HOPENE CYCLASE
Authors:Wendt, K.U, Schulz, G.E.
Deposit date:1998-09-04
Release date:1999-05-18
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The structure of the membrane protein squalene-hopene cyclase at 2.0 A resolution.
J.Mol.Biol., 286, 1999
2BED
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BU of 2bed by Molmil
Structure of FPT bound to inhibitor SCH207736
Descriptor: (11S)-8-CHLORO-11-[1-(METHYLSULFONYL)PIPERIDIN-4-YL]-6-PIPERAZIN-1-YL-11H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDINE, FARNESYL DIPHOSPHATE, Protein farnesyltransferase beta subunit, ...
Authors:Strickland, C.
Deposit date:2005-10-24
Release date:2006-08-08
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Enhanced FTase activity achieved via piperazine interaction with catalytic zinc.
Bioorg.Med.Chem.Lett., 16, 2006
6VPT
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BU of 6vpt by Molmil
Crystal structure and mechanistic molecular modeling studies of Rv3377c: the Mycobacterium tuberculosis diterpene cyclase
Descriptor: Cyclase
Authors:Zhang, T, Prach, L, DiMaio, F, Siegel, J.
Deposit date:2020-02-04
Release date:2020-12-02
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.718 Å)
Cite:Crystal Structure and Mechanistic Molecular Modeling Studies of Mycobacterium tuberculosis Diterpene Cyclase Rv3377c.
Biochemistry, 59, 2020
4EHM
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BU of 4ehm by Molmil
RabGGTase in complex with covalently bound Psoromic acid
Descriptor: 4-formyl-3-hydroxy-8-methoxy-1,9-dimethyl-11-oxo-11H-dibenzo[b,e][1,4]dioxepine-6-carboxylic acid, CALCIUM ION, Geranylgeranyl transferase type-2 subunit alpha, ...
Authors:Guo, Z, Deraeve, C, Bon, R.S, Alexandrov, K, Waldmann, H, Wu, Y.W, Goody, R.S, Blankenfeldt, W.
Deposit date:2012-04-02
Release date:2012-05-30
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Psoromic Acid is a Selective and Covalent Rab-Prenylation Inhibitor Targeting Autoinhibited RabGGTase
J.Am.Chem.Soc., 134, 2012
8RDX
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BU of 8rdx by Molmil
PGGtase I in complex with probe BAY-6092
Descriptor: (5~{R})-5-(2-methoxyphenyl)-9-[(2~{R})-3,3,3-tris(fluoranyl)-2-methoxy-2-phenyl-propanoyl]-3,9-diazaspiro[5.5]undecan-2-one, CHLORIDE ION, DIPHOSPHATE, ...
Authors:Steuber, H.
Deposit date:2023-12-08
Release date:2024-02-14
Method:X-RAY DIFFRACTION (3.67 Å)
Cite:Novel YAP1/TAZ pathway inhibitors identified through phenotypic screening with potent anti-tumor activity via blockade of GGTase-I / Rho-GTPase signaling
Cell Chem Biol, 2024
8T70
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BU of 8t70 by Molmil
Cryptococcus neoformans protein farnesyltransferase in complex with FPTII and TKCMIIM peptide
Descriptor: (2R)-3-(cyclohexylamino)-2-hydroxypropane-1-sulfonic acid, 1,2-ETHANEDIOL, MET-ILE-ILE-MET, ...
Authors:Wang, Y, Beese, L.S.
Deposit date:2023-06-19
Release date:2023-08-09
Method:X-RAY DIFFRACTION (1.892 Å)
Cite:Cryptococcus neoformans protein farnesyltransferase in complex with FPTII and TKCMIIM peptide
To Be Published
2ZIS
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BU of 2zis by Molmil
Crystal Structure of rat protein farnesyltransferase complexed with a bezoruran inhibitor and FPP
Descriptor: 3-{2-[(S)-(4-cyanophenyl)(hydroxy)(1-methyl-1H-imidazol-5-yl)methyl]-5-nitro-1-benzofuran-7-yl}benzonitrile, ACETIC ACID, FARNESYL DIPHOSPHATE, ...
Authors:Fukami, T.A, Sogabe, S, Nagata, Y, Kondoh, O, Ishii, N.
Deposit date:2008-02-22
Release date:2009-02-24
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Synthesis and structure-activity relationships of novel benzofuran farnesyltransferase inhibitors
Bioorg.Med.Chem.Lett., 19, 2009
2ZIR
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BU of 2zir by Molmil
Crystal Structure of rat protein farnesyltransferase complexed with a benzofuran inhibitor and FPP
Descriptor: 2-[(S)-(4-chlorophenyl)(hydroxy)(1-methyl-1H-imidazol-5-yl)methyl]-N-morpholin-4-yl-7-phenyl-1-benzofuran-5-carboxamide, FARNESYL DIPHOSPHATE, GLYCEROL, ...
Authors:Fukami, T.A, Sogabe, S, Nagata, Y, Kondoh, O, Ishii, N.
Deposit date:2008-02-22
Release date:2009-02-24
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Synthesis and structure-activity relationships of novel benzofuran farnesyltransferase inhibitors
Bioorg.Med.Chem.Lett., 19, 2009
2R2L
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BU of 2r2l by Molmil
Structure of Farnesyl Protein Transferase bound to PB-93
Descriptor: FARNESYL DIPHOSPHATE, Farnesyltransferase subunit alpha, Farnesyltransferase subunit beta, ...
Authors:Strickland, C.O, Voorhis, W.
Deposit date:2007-08-27
Release date:2008-03-11
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:Efficacy, pharmacokinetics, and metabolism of tetrahydroquinoline inhibitors of Plasmodium falciparum protein farnesyltransferase.
Antimicrob.Agents Chemother., 51, 2007
2SQC
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BU of 2sqc by Molmil
SQUALENE-HOPENE CYCLASE FROM ALICYCLOBACILLUS ACIDOCALDARIUS
Descriptor: (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, SQUALENE-HOPENE CYCLASE
Authors:Wendt, K.U, Schulz, G.E.
Deposit date:1998-08-02
Release date:1999-04-27
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2 Å)
Cite:The structure of the membrane protein squalene-hopene cyclase at 2.0 A resolution.
J.Mol.Biol., 286, 1999
4L9P
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BU of 4l9p by Molmil
Crystal structure of Aspergillus fumigatus protein farnesyltransferase complexed with the FII analog, FPT-II, and the KCVVM peptide
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, CaaX farnesyltransferase alpha subunit Ram2, ...
Authors:Mabanglo, M.F, Hast, M.A, Beese, L.S.
Deposit date:2013-06-18
Release date:2014-01-01
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Crystal structures of the fungal pathogen Aspergillus fumigatus protein farnesyltransferase complexed with substrates and inhibitors reveal features for antifungal drug design.
Protein Sci., 23, 2014
4LNG
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BU of 4lng by Molmil
Aspergillus fumigatus protein farnesyltransferase complex with farnesyldiphosphate and tipifarnib
Descriptor: 1,2-ETHANEDIOL, 6-[(S)-AMINO(4-CHLOROPHENYL)(1-METHYL-1H-IMIDAZOL-5-YL)METHYL]-4-(3-CHLOROPHENYL)-1-METHYLQUINOLIN-2(1H)-ONE, CaaX farnesyltransferase alpha subunit Ram2, ...
Authors:Mabanglo, M.F, Hast, M.A, Beese, L.S.
Deposit date:2013-07-11
Release date:2014-01-01
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.905 Å)
Cite:Crystal structures of the fungal pathogen Aspergillus fumigatus protein farnesyltransferase complexed with substrates and inhibitors reveal features for antifungal drug design.
Protein Sci., 23, 2014
4LNB
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BU of 4lnb by Molmil
Aspergillus fumigatus protein farnesyltransferase ternary complex with farnesyldiphosphate and ethylenediamine scaffold inhibitor 5
Descriptor: 1,2-ETHANEDIOL, CaaX farnesyltransferase alpha subunit Ram2, CaaX farnesyltransferase beta subunit Ram1, ...
Authors:Mabanglo, M.F, Hast, M.A, Beese, L.S.
Deposit date:2013-07-11
Release date:2014-01-01
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.752 Å)
Cite:Crystal structures of the fungal pathogen Aspergillus fumigatus protein farnesyltransferase complexed with substrates and inhibitors reveal features for antifungal drug design.
Protein Sci., 23, 2014
4MBG
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BU of 4mbg by Molmil
Crystal structure of Aspergillus fumigatus protein farnesyltransferase binary complex with farnesyldiphosphate
Descriptor: 1,2-ETHANEDIOL, CaaX farnesyltransferase alpha subunit Ram2, CaaX farnesyltransferase beta subunit Ram1, ...
Authors:Mabanglo, M.F, Hast, M.A, Beese, L.S.
Deposit date:2013-08-19
Release date:2014-01-01
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Crystal structures of the fungal pathogen Aspergillus fumigatus protein farnesyltransferase complexed with substrates and inhibitors reveal features for antifungal drug design.
Protein Sci., 23, 2014
6J6X
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BU of 6j6x by Molmil
Crystal structure of apo GGTaseIII
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, Geranylgeranyl transferase type-2 subunit beta, MAGNESIUM ION, ...
Authors:Goto-Ito, S, Yamagata, A, Sato, Y, Fukai, S.
Deposit date:2019-01-16
Release date:2020-01-22
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.962 Å)
Cite:Crystal structure of apo GGTaseIII
To Be Published
6J74
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BU of 6j74 by Molmil
Complex of GGTaseIII and full-length Ykt6
Descriptor: Geranylgeranyl transferase type-2 subunit beta, PHOSPHATE ION, Protein prenyltransferase alpha subunit repeat-containing protein 1, ...
Authors:Goto-Ito, S, Yamagata, A, Sato, Y, Fukai, S.
Deposit date:2019-01-16
Release date:2020-01-22
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (3.212 Å)
Cite:Complex of GGTaseIII and full-length Ykt6
To Be Published
6J7F
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BU of 6j7f by Molmil
Complex of GGTaseIII, farnesyl-Ykt6 (C-terminal methylated), and GGPP
Descriptor: DIPHOSPHATE, FARNESYL, GERAN-8-YL GERAN, ...
Authors:Goto-Ito, S, Yamagata, A, Sato, Y, Fukai, S.
Deposit date:2019-01-18
Release date:2020-01-22
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.883 Å)
Cite:Complex of GGTaseIII, farnesyl-Ykt6 (C-terminal methylated), and GGPP
To Be Published
6J7X
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BU of 6j7x by Molmil
Complex of GGTaseIII, farnesyl-Ykt6, and GGPP
Descriptor: FORMIC ACID, GERANYLGERANYL DIPHOSPHATE, Geranylgeranyl transferase type-2 subunit beta, ...
Authors:Goto-Ito, S, Yamagata, A, Sato, Y, Fukai, S.
Deposit date:2019-01-18
Release date:2020-01-22
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Complex of GGTaseIII, farnesyl-Ykt6 (C-terminal methylated), and GGPP
To Be Published
3PZ4
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BU of 3pz4 by Molmil
Crystal structure of FTase(ALPHA-subunit; BETA-subunit DELTA C10) in complex with BMS3 and lipid substrate FPP
Descriptor: (3R)-3-benzyl-4-[(4-methoxyphenyl)sulfonyl]-1-[(1-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine-7-carbonitrile, FARNESYL DIPHOSPHATE, Protein farnesyltransferase subunit beta, ...
Authors:Guo, Z, Bon, R.S, Stigter, E.A, Waldmann, H, Alexandrov, K, Blankenfeldt, W, Goody, R.S.
Deposit date:2010-12-14
Release date:2011-05-11
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure-Guided Development of Selective RabGGTase Inhibitors.
Angew.Chem.Int.Ed.Engl., 50, 2011
3PZ3
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BU of 3pz3 by Molmil
Crystal structure of RabGGTase(DELTA LRR; DELTA IG) in Complex with BMS-analogue 14
Descriptor: 4-({(3R)-7-(5-formylfuran-2-yl)-4-[(4-methoxyphenyl)sulfonyl]-1-[(1-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-3-yl}methyl)phenyl benzylcarbamate, CALCIUM ION, Geranylgeranyl transferase type-2 subunit alpha, ...
Authors:Guo, Z, Bon, R.S, Stigter, E.A, Waldmann, H, Alexandrov, K, Blankenfeldt, W, Goody, R.S.
Deposit date:2010-12-14
Release date:2011-05-11
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure-Guided Development of Selective RabGGTase Inhibitors.
Angew.Chem.Int.Ed.Engl., 50, 2011

217705

数据于2024-03-27公开中

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