6DMM
 
 | | Crystal structure of the G23A mutant of human alpha defensin HNP4. | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, Neutrophil defensin 4, SULFATE ION | | Authors: | Gohain, N, Tolbert, W.D, Pazgier, M. | | Deposit date: | 2018-06-05 | | Release date: | 2019-01-30 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (1.67 Å) | | Cite: | Systematic mutational analysis of human neutrophil alpha-defensin HNP4.
Biochim Biophys Acta Biomembr, 1861, 2019
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4RBX
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1DFN
 | | CRYSTAL STRUCTURE OF DEFENSIN HNP-3, AN AMPHIPHILIC DIMER: MECHANISMS OF MEMBRANE PERMEABILIZATION | | Descriptor: | DEFENSIN HNP-3 | | Authors: | Hill, C.P, Yee, J, Selsted, M.E, Eisenberg, D. | | Deposit date: | 1991-01-18 | | Release date: | 1992-07-15 | | Last modified: | 2017-11-29 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Crystal structure of defensin HNP-3, an amphiphilic dimer: mechanisms of membrane permeabilization.
Science, 251, 1991
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7YOA
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6KRA
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3QTE
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6DMQ
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4RBW
 | | Crystal structure of human alpha-defensin 5, HD5 (Thr7Arg Glu21Arg mutant) | | Descriptor: | CHLORIDE ION, Defensin-5, SULFATE ION | | Authors: | Pazgier, M, Gohain, N, Tolbert, W.D. | | Deposit date: | 2014-09-13 | | Release date: | 2015-07-29 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Design of a potent antibiotic peptide based on the active region of human defensin 5.
J.Med.Chem., 58, 2015
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5CUJ
 | | Crystal structure of Human Defensin-5 Y27A mutant crystal form 2. | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, CALCIUM ION, CHLORIDE ION, ... | | Authors: | Tolbert, W.D, Gohain, N, Pazgier, M. | | Deposit date: | 2015-07-24 | | Release date: | 2016-07-27 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.08 Å) | | Cite: | Human Enteric alpha-Defensin 5 Promotes Shigella Infection by Enhancing Bacterial Adhesion and Invasion.
Immunity, 2018
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5CUI
 | | Crystal structure of Human Defensin-5 R28A mutant. | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2-(2-METHOXYETHOXY)ETHANOL, CHLORIDE ION, ... | | Authors: | Tolbert, W.D, Gohain, N, Pazgier, M. | | Deposit date: | 2015-07-24 | | Release date: | 2016-07-27 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.403 Å) | | Cite: | Human Enteric alpha-Defensin 5 Promotes Shigella Infection by Enhancing Bacterial Adhesion and Invasion.
Immunity, 2018
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5CUM
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2MXQ
 | | The solution structure of DEFA1, a highly potent antimicrobial peptide from the horse | | Descriptor: | Paneth cell-specific alpha-defensin 1 | | Authors: | Jung, S, Michalek, M, Shomali, M, Soennichsen, F.D. | | Deposit date: | 2015-01-12 | | Release date: | 2015-04-22 | | Last modified: | 2023-06-14 | | Method: | SOLUTION NMR | | Cite: | Solution structure and functional studies of the highly potent equine antimicrobial peptide DEFA1.
Biochem.Biophys.Res.Commun., 459, 2015
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2PM5
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2PM1
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2PM4
 | | Human alpha-defensin 1 (multiple Arg->Lys mutant) | | Descriptor: | Neutrophil defensin 1 (HNP-1) (HP-1) (HP1) (Defensin, alpha 1) | | Authors: | Lubkowski, J, Pazgier, M, Lu, W. | | Deposit date: | 2007-04-20 | | Release date: | 2007-05-29 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Toward understanding the cationicity of defensins. Arg and Lys versus their noncoded analogs.
J.Biol.Chem., 282, 2007
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4DU0
 | | Crystal structure of human alpha-defensin 1, HNP1 (G17A mutant) | | Descriptor: | CHLORIDE ION, GLYCEROL, Neutrophil defensin 1 | | Authors: | Wu, X, Lu, W, Pazgier, M. | | Deposit date: | 2012-02-21 | | Release date: | 2012-04-11 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Invariant gly residue is important for alpha-defensin folding, dimerization, and function: a case study of the human neutrophil alpha-defensin HNP1
J.Biol.Chem., 287, 2012
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2K1I
 | | Synthesis, Structure and Activities of an Oral Mucosal Alpha-Defensin from Rhesus Macaque | | Descriptor: | Mucosal Alpha-Defensin | | Authors: | Vasudevan, S.V, Yuan, J, Osapay, G, Tran, P, Tai, K, Selsted, M, Cocco, M.J. | | Deposit date: | 2008-03-05 | | Release date: | 2008-10-28 | | Last modified: | 2018-01-24 | | Method: | SOLUTION NMR | | Cite: | Synthesis, structure, and activities of an oral mucosal alpha-defensin from rhesus macaque.
J.Biol.Chem., 283, 2008
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2KHT
 | | NMR Structure of human alpha defensin HNP-1 | | Descriptor: | Neutrophil defensin 1 | | Authors: | Zhang, Y, Li, S, Doherty, T.F, Lubkowski, J, Lu, W, Li, J, Barinka, C, Hong, M. | | Deposit date: | 2009-04-11 | | Release date: | 2010-02-09 | | Last modified: | 2020-02-26 | | Method: | SOLID-STATE NMR | | Cite: | Resonance assignment and three-dimensional structure determination of a human alpha-defensin, HNP-1, by solid-state NMR.
J.Mol.Biol., 397, 2010
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4E86
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4E82
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4E83
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4LBF
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4LB1
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4LBB
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4LB7
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