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6YW8
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BU of 6yw8 by Molmil
NMR solution structure of unbound recombinant human Nerve Growth Factor (rhNGF)
Descriptor: Beta-nerve growth factor
Authors:Golic Grdadolnik, S, Paoletti, F.
Deposit date:2020-04-29
Release date:2021-05-12
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Endogenous modulators of neurotrophin signaling: Landscape of the transient ATP-NGF interactions.
Comput Struct Biotechnol J, 19, 2021
6XUO
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BU of 6xuo by Molmil
mature recombinant horse NGF
Descriptor: Nerve growth factor, ZINC ION
Authors:Kalnins, G.
Deposit date:2020-01-20
Release date:2020-01-29
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.803 Å)
Cite:Mature horse nerve growth factor at 2.8 angstrom resolution
To Be Published
5LSD
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BU of 5lsd by Molmil
recombinant mouse Nerve Growth Factor
Descriptor: Beta-nerve growth factor
Authors:Paoletti, F, de Chiara, C, Kelly, G, Lamba, D, Cattaneo, A, Pastore, A.
Deposit date:2016-08-25
Release date:2017-07-05
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Conformational Rigidity within Plasticity Promotes Differential Target Recognition of Nerve Growth Factor.
Front Mol Biosci, 3, 2016
5JZ7
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BU of 5jz7 by Molmil
NGF IN COMPLEX WITH MEDI578 scFv
Descriptor: Beta-nerve growth factor, MEDI578 scFv, heavy chain, ...
Authors:Olsson, L.-L, Aagaard, A.
Deposit date:2016-05-16
Release date:2017-01-11
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Engineering the surface properties of a human monoclonal antibody prevents self-association and rapid clearance in vivo.
Sci Rep, 6, 2016
1WWW
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BU of 1www by Molmil
NGF IN COMPLEX WITH DOMAIN 5 OF THE TRKA RECEPTOR
Descriptor: PROTEIN (NERVE GROWTH FACTOR), PROTEIN (TRKA RECEPTOR)
Authors:Wiesmann, C, Ultsch, M.H, De Vos, A.M.
Deposit date:1999-03-12
Release date:1999-09-15
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor.
Nature, 401, 1999
4EDW
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BU of 4edw by Molmil
Nerve Growth Factor in Complex with Fab from humanized version of mouse mAb 911 (tanezumab)
Descriptor: Beta-nerve growth factor, GLYCEROL, tanezumab Fab heavy chain, ...
Authors:Eigenbrot, C, Ultsch, M.
Deposit date:2012-03-27
Release date:2014-04-02
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:Generation of a high-fidelity antibody against nerve growth factor using library scanning mutagenesis and validation with structures of the initial and optimized Fab-antigen complexes.
MAbs, 6
4EFV
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BU of 4efv by Molmil
Crystal structure of OIF from Llama seminal plasma
Descriptor: CHLORIDE ION, Ovulation-inducing factor (OIF), PHOSPHATE ION
Authors:Van Straaten, K.E, Leduc, Y.A, Ratto, M.H, Valderrama, X.P, Delbaere, T.J, Pierson, R.A, Adams, G.P.
Deposit date:2012-03-30
Release date:2012-08-22
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.32 Å)
Cite:The nerve of ovulation-inducing factor in semen.
Proc.Natl.Acad.Sci.USA, 109, 2012
4XPJ
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BU of 4xpj by Molmil
Crystal structure of Nerve growth factor in complex with lysophosphatidylinositol
Descriptor: (2R)-2-hydroxy-3-{[(S)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propyl tridecanoate, Beta-nerve growth factor
Authors:Sun, H.L, Jiang, T.
Deposit date:2015-01-17
Release date:2015-07-15
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.605 Å)
Cite:The structure of nerve growth factor in complex with lysophosphatidylinositol
Acta Crystallogr.,Sect.F, 71, 2015
4ZBN
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BU of 4zbn by Molmil
Non-helical DNA Triplex Forms a Unique Aptamer Scaffold for High Affinity Recognition of Nerve Growth Factor
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Beta-nerve growth factor, DNA (28-MER)
Authors:Davies, D.R, Edwards, T.E.
Deposit date:2015-04-15
Release date:2015-06-10
Last modified:2015-07-15
Method:X-RAY DIFFRACTION (2.447 Å)
Cite:Non-helical DNA Triplex Forms a Unique Aptamer Scaffold for High Affinity Recognition of Nerve Growth Factor.
Structure, 23, 2015
1B98
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BU of 1b98 by Molmil
NEUROTROPHIN 4 (HOMODIMER)
Descriptor: CHLORIDE ION, PROTEIN (NEUROTROPHIN-4)
Authors:Robinson, R.C, Radziejewski, C, Stuart, D.I, Jones, E.Y, Choe, S.
Deposit date:1999-02-22
Release date:1999-02-26
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:The structures of the neurotrophin 4 homodimer and the brain-derived neurotrophic factor/neurotrophin 4 heterodimer reveal a common Trk-binding site.
Protein Sci., 8, 1999
1BTG
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BU of 1btg by Molmil
CRYSTAL STRUCTURE OF BETA NERVE GROWTH FACTOR AT 2.5 A RESOLUTION IN C2 SPACE GROUP WITH ZN IONS BOUND
Descriptor: BETA NERVE GROWTH FACTOR, ZINC ION
Authors:Holland, D.R, Matthews, B.W.
Deposit date:1995-08-29
Release date:1996-03-08
Last modified:2020-07-22
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Nerve growth factor in different crystal forms displays structural flexibility and reveals zinc binding sites.
J.Mol.Biol., 239, 1994
1BND
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BU of 1bnd by Molmil
STRUCTURE OF THE BRAIN-DERIVED NEUROTROPHIC FACTOR(SLASH)NEUROTROPHIN 3 HETERODIMER
Descriptor: BRAIN DERIVED NEUROTROPHIC FACTOR, ISOPROPYL ALCOHOL, NEUROTROPHIN 3
Authors:Robinson, R.C, Radziejewski, C, Stuart, D.I, Jones, E.Y.
Deposit date:1994-12-12
Release date:1996-04-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of the brain-derived neurotrophic factor/neurotrophin 3 heterodimer.
Biochemistry, 34, 1995
1NT3
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BU of 1nt3 by Molmil
HUMAN NEUROTROPHIN-3
Descriptor: PROTEIN (NEUROTROPHIN-3)
Authors:Butte, M.J, Hwang, P.K, Mobley, W.C, Fletterick, R.J.
Deposit date:1999-05-17
Release date:1999-06-06
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of neurotrophin-3 homodimer shows distinct regions are used to bind its receptors.
Biochemistry, 37, 1998
1B8K
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BU of 1b8k by Molmil
Neurotrophin-3 from Human
Descriptor: PROTEIN (NEUROTROPHIN-3)
Authors:Robinson, R.C, Radziejewski, C, Stuart, D.I, Jones, E.Y, Choe, S.
Deposit date:1999-02-01
Release date:1999-02-09
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:The structures of the neurotrophin 4 homodimer and the brain-derived neurotrophic factor/neurotrophin 4 heterodimer reveal a common Trk-binding site.
Protein Sci., 8, 1999
1B8M
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BU of 1b8m by Molmil
BRAIN DERIVED NEUROTROPHIC FACTOR, NEUROTROPHIN-4
Descriptor: PROTEIN (BRAIN DERIVED NEUROTROPHIC FACTOR), PROTEIN (NEUROTROPHIN-4)
Authors:Robinson, R.C, Radziejewski, C, Stuart, D.I, Jones, E.Y, Choe, S.
Deposit date:1999-02-01
Release date:1999-02-09
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:The structures of the neurotrophin 4 homodimer and the brain-derived neurotrophic factor/neurotrophin 4 heterodimer reveal a common Trk-binding site.
Protein Sci., 8, 1999
1BET
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BU of 1bet by Molmil
NEW PROTEIN FOLD REVEALED BY A 2.3 ANGSTROM RESOLUTION CRYSTAL STRUCTURE OF NERVE GROWTH FACTOR
Descriptor: BETA-NERVE GROWTH FACTOR
Authors:Mcdonald, N.Q, Lapatto, R, Murray-Rust, J, Gunning, J, Wlodawer, A, Blundell, T.L.
Deposit date:1993-04-08
Release date:1994-05-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:New protein fold revealed by a 2.3-A resolution crystal structure of nerve growth factor.
Nature, 354, 1991
4EC7
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BU of 4ec7 by Molmil
Cobra NGF in complex with lipid
Descriptor: (2S)-1-hydroxy-3-(tetradecanoyloxy)propan-2-yl docosanoate, Venom nerve growth factor
Authors:Jiang, T, Wang, F, Tong, Q.
Deposit date:2012-03-26
Release date:2012-09-12
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural and functional insights into lipid-bound nerve growth factors
Faseb J., 26, 2012
4EDX
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BU of 4edx by Molmil
Nerve Growth Factor in Complex with Fab from mouse mAb 911
Descriptor: Beta-nerve growth factor, heavy chain of Fab of murine anti-NGF, light chain of FAB of murine anti-NGF
Authors:Eigenbrot, C, Ultsch, M.
Deposit date:2012-03-27
Release date:2014-04-02
Last modified:2014-08-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Generation of a high-fidelity antibody against nerve growth factor using library scanning mutagenesis and validation with structures of the initial and optimized Fab-antigen complexes.
MAbs, 6
4EAX
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BU of 4eax by Molmil
Mouse NGF in complex with Lyso-PS
Descriptor: Beta-nerve growth factor, O-[(S)-hydroxy{[(2S)-2-hydroxy-3-(octadec-9-enoyloxy)propyl]oxy}phosphoryl]-L-serine
Authors:Jiang, T, Tong, Q.
Deposit date:2012-03-23
Release date:2012-09-12
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural and functional insights into lipid-bound nerve growth factors
Faseb J., 26, 2012
1HCF
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BU of 1hcf by Molmil
Crystal structure of TrkB-d5 bound to neurotrophin-4/5
Descriptor: BDNF/NT-3 GROWTH FACTORS RECEPTOR, NEUROTROPHIN-4, SULFATE ION
Authors:Banfield, M.J, Naylor, R.L, Robertson, A.G.S, Allen, S.J, Dawbarn, D, Brady, R.L.
Deposit date:2001-05-03
Release date:2001-12-06
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Specificity in Trk-Receptor:Neurotrophin Interaction: The Crystal Structure of Trkb-D5 in Complex with Neurotrophin-4/5
Structure, 9, 2001
2IFG
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BU of 2ifg by Molmil
Structure of the extracellular segment of human TRKA in complex with nerve growth factor
Descriptor: 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-nerve growth factor, High affinity nerve growth factor receptor, ...
Authors:He, X, Garcia, K.C.
Deposit date:2006-09-20
Release date:2007-02-13
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Structural and mechanistic insights into nerve growth factor interactions with the TrkA and p75 receptors.
Neuron, 53, 2007
6FFY
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BU of 6ffy by Molmil
Structure of the mouse SorCS2-NGF complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-nerve growth factor, VPS10 domain-containing receptor SorCS2, ...
Authors:Leloup, N.O.L, Janssen, B.J.C.
Deposit date:2018-01-09
Release date:2018-08-01
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.9 Å)
Cite:Structural insights into SorCS2-Nerve Growth Factor complex formation.
Nat Commun, 9, 2018
3BUK
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BU of 3buk by Molmil
Crystal Structure of the Neurotrophin-3 and p75NTR Symmetrical Complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Neurotrophin-3, Tumor necrosis factor receptor superfamily member 16
Authors:Jiang, T, Gong, Y, Cao, P, Yu, H.J.
Deposit date:2008-01-02
Release date:2008-07-15
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of the neurotrophin-3 and p75NTR symmetrical complex.
Nature, 454, 2008
3IJ2
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BU of 3ij2 by Molmil
Ligand-receptor structure
Descriptor: Beta-nerve growth factor, Nerve growth factor receptor (TNFR superfamily, member 16)
Authors:Feng, D, Garcia, K.C.
Deposit date:2009-08-03
Release date:2010-01-12
Last modified:2021-10-13
Method:X-RAY DIFFRACTION (3.75 Å)
Cite:Molecular and structural insight into proNGF engagement of p75NTR and sortilin.
J.Mol.Biol., 396, 2010
1SG1
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BU of 1sg1 by Molmil
Crystal Structure of the Receptor-Ligand Complex between Nerve Growth Factor and the Common Neurotrophin Receptor p75
Descriptor: Beta-nerve growth factor, CHLORIDE ION, Tumor necrosis factor receptor superfamily member 16
Authors:He, X.L, Garcia, K.C.
Deposit date:2004-02-22
Release date:2004-06-01
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of nerve growth factor complexed with the shared neurotrophin receptor p75
Science, 304, 2004

 

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