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7Z5L
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BU of 7z5l by Molmil
Crystal structure of human insulin, crystallised in the presence of macrophage migration inhibitory factor (MIF) and dimethyl sulfoxide (DMSO)
Descriptor: GLYCEROL, Insulin A chain, Insulin B chain, ...
Authors:van den Elsen, J.M.H, Wahid, A.A, Crennell, C.
Deposit date:2022-03-09
Release date:2023-03-22
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Dissociation of Hexameric Insulin Facilitated by Macrophage Migration Inhibitory Factor Indicates a Novel Role in Insulin Signalling
To Be Published
7Z5Q
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BU of 7z5q by Molmil
Crystal structure of human insulin, crystallised in the presence of macrophage migration inhibitory factor (MIF) and p-Hydroxyphenylpyruvate (HPP)
Descriptor: Insulin, Insulin A chain, SULFATE ION
Authors:van den Elsen, J.M.H, Wahid, A.A, Crennell, S.J.
Deposit date:2022-03-09
Release date:2023-03-22
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Dissociation of Hexameric Insulin Facilitated by Macrophage Migration Inhibitory Factor Indicates a Novel Role in Insulin Signalling
To Be Published
9INS
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BU of 9ins by Molmil
MONOVALENT CATION BINDING IN CUBIC INSULIN CRYSTALS
Descriptor: INSULIN (CHAIN A), INSULIN (CHAIN B)
Authors:Badger, J, Dodson, G.G.
Deposit date:1991-10-23
Release date:1991-11-07
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Monovalent cation binding to cubic insulin crystals
Biophys.J., 61, 1992
8SBD
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BU of 8sbd by Molmil
Cryo-EM structure of insulin amyloid-like fibril that is composed of two antiparallel protofilaments
Descriptor: Insulin A chain, Insulin B chain
Authors:Wang, L.W, Hall, C, Uchikawa, E, Chen, D.L, Choi, E, Zhang, X.W, Bai, X.C.
Deposit date:2023-04-03
Release date:2023-08-30
Last modified:2023-09-27
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structural basis of insulin fibrillation.
Sci Adv, 9, 2023
4XC4
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BU of 4xc4 by Molmil
Insulin co-crystallizes in the presence of it beta-cell chaperone sulfatide
Descriptor: CHLORIDE ION, Insulin, SODIUM ION, ...
Authors:Bracey, A.W, Magis, A.T, Buschard, K, Osterbye, T, Bailey, K.M, Ostrov, D.A.
Deposit date:2014-12-17
Release date:2015-02-11
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.499 Å)
Cite:Insulin co-crystallizes in the presence of it beta-cell chaperone sulfatide
To Be Published
6X4X
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BU of 6x4x by Molmil
B24Y DKP insulin
Descriptor: Insulin, Insulin chain A
Authors:Weiss, M.A, Yang, Y.
Deposit date:2020-05-24
Release date:2020-08-05
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Evolution of insulin at the edge of foldability and its medical implications.
Proc.Natl.Acad.Sci.USA, 117, 2020
7ELJ
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BU of 7elj by Molmil
Prion Derived Tetrapeptide Stabilizes Thermolabile Insulin via Conformational Trapping
Descriptor: IS1, Insulin A Chain, Insulin B chain
Authors:Banerjee, N.
Deposit date:2021-04-11
Release date:2021-04-28
Last modified:2021-07-07
Method:SOLUTION NMR
Cite:Prion-derived tetrapeptide stabilizes thermolabile insulin via conformational trapping.
Iscience, 24, 2021
6Z7Y
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BU of 6z7y by Molmil
Human insulin in complex with the analytical antibody OXI-005 Fab
Descriptor: Insulin, OXI-005 Fab Heavy chain, OXI-005 Fab Light chain
Authors:Johansson, E.
Deposit date:2020-06-02
Release date:2020-12-30
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Insulin binding to the analytical antibody sandwich pair OXI-005 and HUI-018: Epitope mapping and binding properties.
Protein Sci., 30, 2021
5AIY
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BU of 5aiy by Molmil
R6 HUMAN INSULIN HEXAMER (SYMMETRIC), NMR, 'RED' SUBSTATE, AVERAGE STRUCTURE
Descriptor: PHENOL, PROTEIN (INSULIN)
Authors:O'Donoghue, S.I, Chang, X, Abseher, R, Nilges, M, Led, J.J.
Deposit date:1998-12-29
Release date:2000-02-28
Last modified:2023-12-27
Method:SOLUTION NMR
Cite:Unraveling the symmetry ambiguity in a hexamer: calculation of the R6 human insulin structure.
J.Biomol.NMR, 16, 2000
7INS
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BU of 7ins by Molmil
STRUCTURE OF PORCINE INSULIN COCRYSTALLIZED WITH CLUPEINE Z
Descriptor: GENERAL PROTAMINE CHAIN, INSULIN (CHAIN A), INSULIN (CHAIN B), ...
Authors:Balschmidt, P, Hansen, F.B, Dodson, E, Dodson, G, Korber, F.
Deposit date:1991-09-03
Release date:1994-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of porcine insulin cocrystallized with clupeine Z.
Acta Crystallogr.,Sect.B, 47, 1991
7JP3
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BU of 7jp3 by Molmil
Des-B29,B30-insulin
Descriptor: CHLORIDE ION, Insulin B chain,Insulin A chain, PHENOL, ...
Authors:Yoder, J, Weiss, M.A, DiMarchi, R, Zaykov, A.
Deposit date:2020-08-07
Release date:2021-10-27
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Des-B29,B30-insulin
To Be Published
5WBT
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BU of 5wbt by Molmil
Solution Structure and Dynamics of an Ultra-Stable Single-Chain Insulin Analog STUDIES OF AN ENGINEERED MONOMER AND IMPLICATIONS FOR RECEPTOR BINDING
Descriptor: Insulin
Authors:Glidden, M.D, Yang, Y, Wickramasinghe, N.P, Weiss, M.A.
Deposit date:2017-06-29
Release date:2017-11-15
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Solution structure of an ultra-stable single-chain insulin analog connects protein dynamics to a novel mechanism of receptor binding.
J. Biol. Chem., 293, 2018
5HPU
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BU of 5hpu by Molmil
Insulin with proline analog HyP at position B28 in the R6 state
Descriptor: CHLORIDE ION, Insulin, chain A, ...
Authors:Lieblich, S.A, Fang, K.Y, Cahn, J.K.B, Tirrell, D.A.
Deposit date:2016-01-21
Release date:2017-01-25
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:4S-Hydroxylation of Insulin at ProB28 Accelerates Hexamer Dissociation and Delays Fibrillation.
J. Am. Chem. Soc., 139, 2017
5HRQ
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BU of 5hrq by Molmil
Insulin with proline analog HzP at position B28 in the R6 state
Descriptor: CHLORIDE ION, Insulin A-Chain, Insulin B-Chain, ...
Authors:Lieblich, S.A, Fang, K.Y, Cahn, J.K.B, Tirrell, D.A.
Deposit date:2016-01-24
Release date:2017-01-25
Last modified:2020-01-15
Method:X-RAY DIFFRACTION (1.28 Å)
Cite:4S-Hydroxylation of Insulin at ProB28 Accelerates Hexamer Dissociation and Delays Fibrillation.
J. Am. Chem. Soc., 139, 2017
5HPR
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BU of 5hpr by Molmil
Insulin with proline analog HyP at position B28 in the T2 state
Descriptor: GLYCEROL, Insulin A-Chain, Insulin B-Chain, ...
Authors:Lieblich, S.A, Fang, K.Y, Cahn, J.K.B, Tirrell, D.A.
Deposit date:2016-01-21
Release date:2017-01-25
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.33 Å)
Cite:4S-Hydroxylation of Insulin at ProB28 Accelerates Hexamer Dissociation and Delays Fibrillation.
J. Am. Chem. Soc., 139, 2017
5HQI
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BU of 5hqi by Molmil
Insulin with proline analog HzP at position B28 in the T2 state
Descriptor: Insulin A-Chain, Insulin B-Chain
Authors:Lieblich, S.A, Fang, K.Y, Cahn, J.K.B, Tirrell, D.A.
Deposit date:2016-01-21
Release date:2017-01-25
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (0.97 Å)
Cite:4S-Hydroxylation of Insulin at ProB28 Accelerates Hexamer Dissociation and Delays Fibrillation.
J. Am. Chem. Soc., 139, 2017
4RXW
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BU of 4rxw by Molmil
Crystal Structure of the cobalt human insulin derivative
Descriptor: COBALT (II) ION, Insulin A chain, Insulin B chain
Authors:Prugovecki, B, Ivetic, N, Matkovic-Calogovic, D.
Deposit date:2014-12-12
Release date:2015-01-21
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Crystal Structure of the cobalt human insulin derivative
TO BE PUBLISHED
4UNE
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BU of 4une by Molmil
Human insulin B26Phe mutant crystal structure
Descriptor: INSULIN A CHAIN, INSULIN B CHAIN, SULFATE ION
Authors:Zakova, L, Klevtikova, E, Lepsik, M, Collinsova, M, Watson, C.J, Turkenburg, J.P, Jiracek, J, Brzozowski, A.M.
Deposit date:2014-05-28
Release date:2014-10-15
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:Human Insulin Analogues Modified at the B26 Site Reveal a Hormone Conformation that is Undetected in the Receptor Complex
Acta Crystallogr.,Sect.D, 70, 2014
4UNH
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BU of 4unh by Molmil
Human insulin B26Gly mutant crystal structure
Descriptor: INSULIN A CHAIN, INSULIN B CHAIN, SULFATE ION
Authors:Zakova, L, Klevtikova, E, Lepsik, M, Collinsova, M, Watson, C.J, Turkenburg, J.P, Jiracek, J, Brzozowski, A.M.
Deposit date:2014-05-28
Release date:2014-10-15
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Human Insulin Analogues Modified at the B26 Site Reveal a Hormone Conformation that is Undetected in the Receptor Complex
Acta Crystallogr.,Sect.D, 70, 2014
4UNG
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BU of 4ung by Molmil
Human insulin B26Asn mutant crystal structure
Descriptor: INSULIN A CHAIN, INSULIN B CHAIN, SULFATE ION
Authors:Zakova, L, Klevtikova, E, Lepsik, M, Collinsova, M, Watson, C.J, Turkenburg, J.P, Jiracek, J, Brzozowski, A.M.
Deposit date:2014-05-28
Release date:2014-10-15
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Human Insulin Analogues Modified at the B26 Site Reveal a Hormone Conformation that is Undetected in the Receptor Complex
Acta Crystallogr.,Sect.D, 70, 2014
7NHU
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BU of 7nhu by Molmil
Crystal structure of desB30 insulin produced by cell free protein synthesis
Descriptor: Insulin
Authors:Johansson, E.
Deposit date:2021-02-11
Release date:2021-06-16
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Cell free protein synthesis versus yeast expression - A comparison using insulin as a model protein.
Protein Expr.Purif., 186, 2021
8GSG
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BU of 8gsg by Molmil
T3R3 form of Human insulin with single Zn
Descriptor: CHLORIDE ION, Insulin A chain, Insulin B chain, ...
Authors:Zhu, Z.L.
Deposit date:2022-09-06
Release date:2023-03-15
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:T3R3 insulin with single Zn
To Be Published
6K59
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BU of 6k59 by Molmil
Structure of Glargine insulin in 20% acetic acid-d4 (pH 1.9)
Descriptor: Glargine Insulin Chain-A, Glargine insulin Chain-B
Authors:Ratha, B.N, Kar, R.K, Bhunia, A.
Deposit date:2019-05-28
Release date:2020-05-06
Method:SOLUTION NMR
Cite:Molecular Details of a Salt Bridge and Its Role in Insulin Fibrillation by NMR and Raman Spectroscopic Analysis.
J.Phys.Chem.B, 124, 2020
3LRI
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BU of 3lri by Molmil
Solution structure and backbone dynamics of long-[Arg(3)]insulin-like growth factor-I
Descriptor: PROTEIN (INSULIN-LIKE GROWTH FACTOR I)
Authors:Laajoki, L.G, Francis, G.L, Wallace, J.C, Carver, J.A, Keniry, M.A.
Deposit date:1999-04-13
Release date:2000-05-23
Last modified:2023-12-27
Method:SOLUTION NMR
Cite:Solution structure and backbone dynamics of long-[Arg(3)]insulin-like growth factor-I
J.Biol.Chem., 275, 2000
6KH8
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BU of 6kh8 by Molmil
Solution structure of Zn free Bovine Pancreatic Insulin in 20% acetic acid-d4 (pH 1.9)
Descriptor: Insulin A Chain, Insulin B chain
Authors:Bhunia, A, Ratha, B.N, Kar, R.K, Brender, J.R.
Deposit date:2019-07-14
Release date:2020-10-07
Last modified:2020-11-18
Method:SOLUTION NMR
Cite:High-resolution structure of a partially folded insulin aggregation intermediate.
Proteins, 88, 2020

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数据于2024-03-27公开中

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