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2L95
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BU of 2l95 by Molmil
Solution Structure of Cytotoxic T-Lymphocyte Antigent-2(Ctla protein), Crammer at pH 6.0
Descriptor: Crammer
Authors:Tseng, T.S, Cheng, C.S, Liu, Y.N, Lyu, P.C.
Deposit date:2011-01-31
Release date:2011-12-21
Last modified:2020-01-01
Method:SOLUTION NMR
Cite:A molten globule-to-ordered structure transition of Drosophila melanogaster crammer is required for its ability to inhibit cathepsin.
Biochem.J., 442, 2012
5JT8
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Structural basis for the limited antibody cross reactivity between the mite allergens Blo t 1 and Der p 1
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Blo t 1 allergen, ...
Authors:Meno, K, Kastrup, J.S, Gajhede, M.
Deposit date:2016-05-09
Release date:2017-05-24
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The structure of the mite allergen Blo t 1 explains the limited antibody cross-reactivity to Der p 1.
Allergy, 72, 2017
8GX2
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BU of 8gx2 by Molmil
The crystal structure of human CtsL in complex with 14c
Descriptor: DIMETHYL SULFOXIDE, N-[(2S)-3-cyclohexyl-1-[[(2S,3S)-4-(cyclopropylamino)-3-oxidanyl-4-oxidanylidene-1-[(3S)-2-oxidanylidenepiperidin-3-yl]butan-2-yl]amino]-1-oxidanylidene-propan-2-yl]-1-benzofuran-2-carboxamide, Procathepsin L
Authors:Zhao, Y, Shao, M, Zhao, J, Yang, H, Rao, Z.
Deposit date:2022-09-18
Release date:2023-09-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:The crystal structure of human CtsL in complex with 14a
To Be Published
1BY8
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BU of 1by8 by Molmil
THE CRYSTAL STRUCTURE OF HUMAN PROCATHEPSIN K
Descriptor: PROTEIN (PROCATHEPSIN K)
Authors:Lalonde, J.M, Zhao, B, Smith, W.W, Janson, C.A, Desjarlais, R.L, Tomaszek, T.A, Carr, T.J, Thompson, S.K, Yamashita, D.S, Veber, D.F, Abdel-Mequid, S.S.
Deposit date:1998-10-27
Release date:1999-10-24
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The crystal structure of human procathepsin K.
Biochemistry, 38, 1999
7AVM
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BU of 7avm by Molmil
Crystal Structure of Pro-Rhodesain C150A
Descriptor: Cysteine protease, GLYCEROL
Authors:Johe, P, Jaenicke, E, Neuweiler, H, Schirmeister, T, Kersten, C, Hellmich, U.
Deposit date:2020-11-05
Release date:2020-11-25
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure, interdomain dynamics, and pH-dependent autoactivation of pro-rhodesain, the main lysosomal cysteine protease from African trypanosomes.
J.Biol.Chem., 296, 2021
6U7D
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BU of 6u7d by Molmil
Recombinant stem bromelain precursor
Descriptor: FBSB
Authors:Yongqing, T, Pike, R.N, Wijeyewickrema, L.C.
Deposit date:2019-09-02
Release date:2019-09-18
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal Structure of a Recombinant Stem Bromelain Precursor
To be published
2O6X
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BU of 2o6x by Molmil
Crystal Structure of ProCathepsin L1 from Fasciola hepatica
Descriptor: Secreted cathepsin L 1
Authors:Brinen, L.S, Dalton, J.P, Geiger, S, Marion, R, Stack, C.M.
Deposit date:2006-12-08
Release date:2007-12-18
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structural and functional relationships in the virulence-associated cathepsin L proteases of the parasitic liver fluke, Fasciola hepatica.
J.Biol.Chem., 283, 2008
1PCI
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BU of 1pci by Molmil
PROCARICAIN
Descriptor: PROCARICAIN
Authors:Groves, M.R, Taylor, M.A.J, Scott, M, Cummings, N.J, Pickersgill, R.W, Jenkins, J.A.
Deposit date:1996-06-28
Release date:1997-04-01
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:The prosequence of procaricain forms an alpha-helical domain that prevents access to the substrate-binding cleft.
Structure, 4, 1996
5Z5O
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Structure of Pycnonodysostosis disease related I249T mutant of human cathepsin K
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 1,2-ETHANEDIOL, CHLORIDE ION, ...
Authors:Biswas, S, Roy, S.
Deposit date:2018-01-19
Release date:2018-09-26
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Not all pycnodysostosis-related mutants of human cathepsin K are inactive - crystal structure and biochemical studies of an active mutant I249T.
FEBS J., 285, 2018
2C0Y
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BU of 2c0y by Molmil
THE CRYSTAL STRUCTURE OF A CYS25ALA MUTANT OF HUMAN PROCATHEPSIN S
Descriptor: PROCATHEPSIN S
Authors:Kaulmann, G, Palm, G.J, Schilling, K, Hilgenfeld, R, Wiederanders, B.
Deposit date:2005-09-08
Release date:2006-11-08
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The Crystal Structure of a Cys25 -> Ala Mutant of Human Procathepsin S Elucidates Enzyme-Prosequence Interactions.
Protein Sci., 15, 2006
3F75
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BU of 3f75 by Molmil
Activated Toxoplasma gondii cathepsin L (TgCPL) in complex with its propeptide
Descriptor: 1,2-ETHANEDIOL, BROMIDE ION, CHLORIDE ION, ...
Authors:Larson, E.T, Merritt, E.A, Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
Deposit date:2008-11-07
Release date:2008-11-25
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Toxoplasma gondii cathepsin L is the primary target of the invasion-inhibitory compound morpholinurea-leucyl-homophenyl-vinyl sulfone phenyl.
J.Biol.Chem., 284, 2009
1CS8
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BU of 1cs8 by Molmil
CRYSTAL STRUCTURE OF PROCATHEPSIN L
Descriptor: HUMAN PROCATHEPSIN L
Authors:Cygler, M, Coulombe, R.
Deposit date:1999-08-17
Release date:1999-08-23
Last modified:2021-11-03
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of human procathepsin L reveals the molecular basis of inhibition by the prosegment.
EMBO J., 15, 1996
6CZS
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BU of 6czs by Molmil
Crystal structure of human pro-cathepsin H C26S mutant
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Pro-cathepsin H, ...
Authors:Huang, X, Hao, Y.
Deposit date:2018-04-09
Release date:2018-08-08
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:Crystal structures of human procathepsin H.
PLoS ONE, 13, 2018
1CJL
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BU of 1cjl by Molmil
CRYSTAL STRUCTURE OF A CYSTEINE PROTEASE PROFORM
Descriptor: PROCATHEPSIN L
Authors:Coulombe, R, Grochulski, P, Sivaraman, J, Cygler, M.
Deposit date:1996-07-24
Release date:1997-08-12
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of human procathepsin L reveals the molecular basis of inhibition by the prosegment.
EMBO J., 15, 1996
6CZK
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BU of 6czk by Molmil
Crystal structure of wild-type human pro-cathepsin H
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Pro-cathepsin H, ...
Authors:Huang, X, Hao, Y.
Deposit date:2018-04-09
Release date:2018-08-08
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.001 Å)
Cite:Crystal structures of human procathepsin H.
PLoS ONE, 13, 2018
7W33
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BU of 7w33 by Molmil
The crystal structure of human CtsL in complex with 14a
Descriptor: N-[(2S)-3-(4-fluorophenyl)-1-oxidanylidene-1-[[(2R,3S)-3-oxidanyl-4-oxidanylidene-1-[(3S)-2-oxidanylidenepiperidin-3-yl]-4-[(phenylmethyl)amino]butan-2-yl]amino]propan-2-yl]-1-benzofuran-2-carboxamide, Procathepsin L
Authors:Zhao, Y, Shao, M, Zhao, J, Yang, H, Rao, Z.
Deposit date:2021-11-25
Release date:2023-05-31
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:The crystal structure of human CtsL in complex with 14a
To Be Published
7W34
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The crystal structure of human CtsL in complex with 14b
Descriptor: N-[(2S)-3-cyclohexyl-1-oxidanylidene-1-[[(2S,3S)-3-oxidanyl-4-oxidanylidene-1-[(3S)-2-oxidanylidenepiperidin-3-yl]-4-[(phenylmethyl)amino]butan-2-yl]amino]propan-2-yl]-1-benzofuran-2-carboxamide, Procathepsin L
Authors:Zhao, Y, Shao, M, Zhao, J, Yang, H, Rao, Z.
Deposit date:2021-11-25
Release date:2023-05-31
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.89 Å)
Cite:The crystal structure of human CtsL in complex with 14a
To Be Published
3TNX
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BU of 3tnx by Molmil
Structure of the precursor of a thermostable variant of papain at 2.6 Angstroem resolution
Descriptor: CHLORIDE ION, Papain
Authors:Roy, S, Choudhury, D, Dattagupta, J.K, Biswas, S.
Deposit date:2011-09-02
Release date:2012-09-12
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:The structure of a thermostable mutant of pro-papain reveals its activation mechanism
Acta Crystallogr.,Sect.D, 68, 2012
3USV
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BU of 3usv by Molmil
Structure of the precursor of a thermostable variant of papain at 3.8 A resolution from a crystal soaked at pH 4
Descriptor: Papain
Authors:Roy, S, Choudhury, D, Biswas, S, Dattagupta, J.K.
Deposit date:2011-11-24
Release date:2012-11-28
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:Crystallographic analysis of pro-papain variant elucidates the structural basis of the step-wise activation mechanism of the zymogen
To be Published
5EGW
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BU of 5egw by Molmil
2.70 A crystal structure of the Amb a 11 cysteine protease, a major ragweed pollen allergen, in its proform
Descriptor: Cysteine protease
Authors:Briozzo, P, Kopecny, D.
Deposit date:2015-10-27
Release date:2016-04-27
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural and Functional Characterization of the Major Allergen Amb a 11 from Short Ragweed Pollen.
J.Biol.Chem., 291, 2016
5EF4
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2.05 A crystal structure of the Amb a 11 cysteine protease, a major ragweed pollen allergen, in its proform
Descriptor: Cysteine protease, GLYCEROL
Authors:Briozzo, P, Kopecny, D, Savko, M.
Deposit date:2015-10-23
Release date:2016-04-27
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structural and Functional Characterization of the Major Allergen Amb a 11 from Short Ragweed Pollen.
J.Biol.Chem., 291, 2016
6JD8
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BU of 6jd8 by Molmil
Structure of a proline specific mutant of human cathepsin L
Descriptor: 1,2-ETHANEDIOL, Cathepsin L1, DI(HYDROXYETHYL)ETHER, ...
Authors:Choudhury, D, Biswas, S.
Deposit date:2019-01-31
Release date:2020-02-05
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.457 Å)
Cite:Structure-guided protein engineering of human cathepsin L for efficient collagenolytic activity.
Protein Eng.Des.Sel., 34, 2021
6JD0
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BU of 6jd0 by Molmil
Structure of mutant human cathepsin L, engineered for GAG binding
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Cathepsin L1, ...
Authors:Choudhury, D, Biswas, S.
Deposit date:2019-01-30
Release date:2020-02-05
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.805 Å)
Cite:Structure-guided protein engineering of human cathepsin L for efficient collagenolytic activity.
Protein Eng.Des.Sel., 34, 2021
3QT4
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BU of 3qt4 by Molmil
Structure of digestive procathepsin L 3 of Tenebrio molitor larval midgut
Descriptor: 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE, Cathepsin-L-like midgut cysteine proteinase, PHOSPHATE ION, ...
Authors:Beton, D, Guzzo, C.R, Terra, W.R, Farah, C.S.
Deposit date:2011-02-22
Release date:2012-02-22
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.11 Å)
Cite:The 3D structure and function of digestive cathepsin L-like proteinases of Tenebrio molitor larval midgut.
Insect Biochem.Mol.Biol., 42, 2012
3QJ3
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BU of 3qj3 by Molmil
Structure of digestive procathepsin L2 proteinase from Tenebrio molitor larval midgut
Descriptor: ACETATE ION, Cathepsin L-like protein
Authors:Beton, D, Guzzo, C.R, Terra, W.R, Farah, C.S.
Deposit date:2011-01-28
Release date:2012-02-01
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:The 3D structure and function of digestive cathepsin L-like proteinases of Tenebrio molitor larval midgut.
Insect Biochem.Mol.Biol., 42, 2012

 

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