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4LNV
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BU of 4lnv by Molmil
Crystal Structure of TEP1s
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Thioester-containing protein I
Authors:Le, B.V, Williams, M, Logarajah, S, Baxter, R.H.G.
Deposit date:2013-07-12
Release date:2013-07-24
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:Molecular basis for genetic resistance of Anopheles gambiae to Plasmodium: structural analysis of TEP1 susceptible and resistant alleles.
Plos Pathog., 8, 2012
6TAV
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BU of 6tav by Molmil
Crystal structure of endopeptidase-induced alpha2-macroglobulin
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-2-macroglobulin, ...
Authors:Gomis-Ruth, F.X, Duquerroy, S, Trapani, S, Marrero, A, Goulas, T, Guevara, T, Andersen, G.A, Sottrup-Jensen, L, Navaza, J.
Deposit date:2019-10-30
Release date:2021-05-12
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (4.2 Å)
Cite:Cryo-EM structures shows the mechanistic basis of pan-peptidase inhibition by human alpha2-macroglobulin
Proc.Natl.Acad.Sci.USA, 2022
3T4A
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BU of 3t4a by Molmil
Structure of a truncated form of Staphylococcal Complement Inhibitor B bound to human C3c at 3.4 Angstrom resolution
Descriptor: Complement C3 beta chain, Complement C3c alpha' chain fragment 1, Complement C3c alpha' chain fragment 2, ...
Authors:Garcia, B.L, Geisbrecht, B.V, Summers, B.J.
Deposit date:2011-07-25
Release date:2011-11-23
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Diversity in the C3b Convertase Contact Residues and Tertiary Structures of the Staphylococcal Complement Inhibitor (SCIN) Protein Family.
J.Biol.Chem., 287, 2012
6EHG
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BU of 6ehg by Molmil
complement component C3b in complex with a nanobody
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C3, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Jensen, R.K, Andersen, K.R, Gadeberg, T.A.F, Laursen, N.S, Andersen, G.R.
Deposit date:2017-09-13
Release date:2018-02-14
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:A potent complement factor C3-specific nanobody inhibiting multiple functions in the alternative pathway of human and murine complement.
J. Biol. Chem., 293, 2018
5O35
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Structure of complement proteins complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C3, Complement factor H,Complement factor H
Authors:Xue, X, Wu, J, Forneris, F, Gros, P.
Deposit date:2017-05-23
Release date:2017-06-28
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (4.2 Å)
Cite:Regulator-dependent mechanisms of C3b processing by factor I allow differentiation of immune responses.
Nat. Struct. Mol. Biol., 24, 2017
7ZGJ
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BU of 7zgj by Molmil
Trypanosoma brucei gambiense ISG65 in complex with human complement component C3
Descriptor: 65 kDa invariant surface glycoprotein, putative, Complement C3, ...
Authors:Suelzen, H, Zoll, S.
Deposit date:2022-04-03
Release date:2023-04-05
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (3.58 Å)
Cite:Cryo-EM structures of Trypanosoma brucei gambiense ISG65 with human complement C3 and C3b and their roles in alternative pathway restriction.
Nat Commun, 14, 2023
7ZGK
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Trypanosoma brucei gambiense ISG65 in complex with human complement component C3b
Descriptor: 65 kDa invariant surface glycoprotein, putative, Complement C3 beta chain, ...
Authors:Suelzen, H, Zoll, S.
Deposit date:2022-04-03
Release date:2023-04-05
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (3.59 Å)
Cite:Cryo-EM structures of Trypanosoma brucei gambiense ISG65 with human complement C3 and C3b and their roles in alternative pathway restriction.
Nat Commun, 14, 2023
5O32
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BU of 5o32 by Molmil
The structure of complement complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Xue, X, Wu, J, Forneris, F, Gros, P.
Deposit date:2017-05-23
Release date:2017-06-28
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (4.206209 Å)
Cite:Regulator-dependent mechanisms of C3b processing by factor I allow differentiation of immune responses.
Nat. Struct. Mol. Biol., 24, 2017
8ENU
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BU of 8enu by Molmil
Structure of the C3bB proconvertase in complex with lufaxin
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C3 beta chain, Complement C3b alpha' chain, ...
Authors:Andersen, J.F, Lei, H.
Deposit date:2022-09-30
Release date:2023-08-09
Last modified:2024-02-21
Method:ELECTRON MICROSCOPY (3.22 Å)
Cite:A bispecific inhibitor of complement and coagulation blocks activation in complementopathy models via a novel mechanism.
Blood, 141, 2023
8EOK
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BU of 8eok by Molmil
Structure of the C3bB proconvertase in complex with lufaxin and factor Xa
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Activated factor Xa heavy chain, Complement C3 beta chain, ...
Authors:Andersen, J.F, Lei, H.
Deposit date:2022-10-03
Release date:2023-08-30
Method:ELECTRON MICROSCOPY (3.53 Å)
Cite:A bispecific inhibitor of complement and coagulation blocks activation in complementopathy models via a novel mechanism.
Blood, 141, 2023
6H03
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BU of 6h03 by Molmil
OPEN CONFORMATION OF THE MEMBRANE ATTACK COMPLEX
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C5,Complement C5, ...
Authors:Menny, A, Serna, M, Boyd, C.M, Gardner, S, Joseph, A.P, Topf, M, Bubeck, D.
Deposit date:2018-07-06
Release date:2018-12-19
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (5.6 Å)
Cite:CryoEM reveals how the complement membrane attack complex ruptures lipid bilayers.
Nat Commun, 9, 2018
6H04
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BU of 6h04 by Molmil
Closed conformation of the Membrane Attack Complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C5,Complement C5, ...
Authors:Menny, A, Serna, M, Boyd, C.M, Gardner, S, Joseph, A.P, Topf, M, Bubeck, D.
Deposit date:2018-07-06
Release date:2018-12-19
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (5.6 Å)
Cite:CryoEM reveals how the complement membrane attack complex ruptures lipid bilayers.
Nat Commun, 9, 2018
2A74
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BU of 2a74 by Molmil
Human Complement Component C3c
Descriptor: 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-alpha-D-glucopyranose, Complement Component C3c, GLYCEROL, ...
Authors:Janssen, B.J.C, Huizinga, E.G, Raaijmakers, H.C.A, Roos, A, Daha, M.R, Nilsson-Ekdahl, K, Nilsson, B, Gros, P.
Deposit date:2005-07-04
Release date:2005-09-27
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structures of complement component C3 provide insights into the function and evolution of immunity.
Nature, 437, 2005
2A73
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BU of 2a73 by Molmil
Human Complement Component C3
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C3, alpha-D-mannopyranose-(1-3)-[beta-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Janssen, B.J.C, Huizinga, E.G, Raaijmakers, H.C.A, Roos, A, Daha, M.R, Nilsson-Ekdahl, K, Nilsson, B, Gros, P.
Deposit date:2005-07-04
Release date:2005-09-27
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structures of complement component C3 provide insights into the function and evolution of immunity.
Nature, 437, 2005
7VOO
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BU of 7voo by Molmil
Induced alpha-2-macroglobulin monomer
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-2-macroglobulin, ...
Authors:Huang, X, Wang, Y, Ping, Z.
Deposit date:2021-10-14
Release date:2022-10-19
Last modified:2022-12-07
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Cryo-EM structures reveal the dynamic transformation of human alpha-2-macroglobulin working as a protease inhibitor.
Sci China Life Sci, 65, 2022
7VON
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BU of 7von by Molmil
Native alpha-2-macroglobulin monomer
Descriptor: Alpha-2-macroglobulin
Authors:Huang, X, Wang, Y.
Deposit date:2021-10-14
Release date:2022-11-16
Last modified:2022-12-07
Method:ELECTRON MICROSCOPY (5.2 Å)
Cite:Cryo-EM structures reveal the dynamic transformation of human alpha-2-macroglobulin working as a protease inhibitor.
Sci China Life Sci, 65, 2022
4ZIQ
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BU of 4ziq by Molmil
Crystal structure of trypsin activated alpha-2-macroglobulin from Escherichia coli.
Descriptor: CHLORIDE ION, GLYCEROL, Uncharacterized lipoprotein YfhM
Authors:Garcia-Ferrer, I, Arede, P, Gomez-Blanco, J, Luque, D, Duquerroy, S, Caston, J.R, Goulas, T, Gomis-Ruth, X.F.
Deposit date:2015-04-28
Release date:2015-06-10
Last modified:2015-07-15
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structural and functional insights into Escherichia coli alpha 2-macroglobulin endopeptidase snap-trap inhibition.
Proc.Natl.Acad.Sci.USA, 112, 2015
6YO6
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BU of 6yo6 by Molmil
Structure of iC3b1
Descriptor: hC3Nb1, iC3b1 alpha chain, iC3b1 beta chain
Authors:Jensen, R.K, Andersen, G.R.
Deposit date:2020-04-14
Release date:2021-02-24
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (6 Å)
Cite:Complement Receptor 3 Forms a Compact High-Affinity Complex with iC3b.
J Immunol., 206, 2021
8OQ3
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BU of 8oq3 by Molmil
Structure of methylamine treated human complement C3
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C3, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Gadeberg, T.A.F, Andersen, G.R.
Deposit date:2023-04-11
Release date:2024-02-21
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structure of methylamine treated human complement C3
To Be Published
8OVB
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BU of 8ovb by Molmil
Human Complement C3b in complex with Trypanosoma brucei ISG65.
Descriptor: Complement C3, Complement C3f fragment, ISG65 G
Authors:Cook, A.D, Higgins, M.K.
Deposit date:2023-04-25
Release date:2024-02-14
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Molecular mechanism of complement factor C3b inhibition by the trypanosome ISG65 receptor.
To be published
3CU7
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BU of 3cu7 by Molmil
Human Complement Component 5
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CADMIUM ION, ...
Authors:Fredslund, F, Andersen, G.R.
Deposit date:2008-04-16
Release date:2008-06-10
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (3.105 Å)
Cite:Structure of and influence of a tick complement inhibitor on human complement component 5
Nat.Immunol., 9, 2008
6YSQ
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BU of 6ysq by Molmil
The hC4Nb8 complement inhibitory nanobody in complex with C4b
Descriptor: Complement C4 beta chain, Complement C4 gamma chain, Complement C4-A alpha chain, ...
Authors:Zarantonello, A, Laursen, N.S, Andersen, G.R.
Deposit date:2020-04-23
Release date:2020-06-24
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:An Ultrahigh-Affinity Complement C4b-Specific Nanobody Inhibits In Vivo Assembly of the Classical Pathway Proconvertase.
J Immunol., 205, 2020
5A42
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BU of 5a42 by Molmil
Cryo-EM single particle 3D reconstruction of the native conformation of E. coli alpha-2-macroglobulin (ECAM)
Descriptor: UNCHARACTERIZED LIPOPROTEIN YFHM
Authors:Garcia-Ferrer, I, Arede, P, Gomez-Blanco, J, Luque, D, Duquerroy, S, Caston, J.R, Goulas, T, Gomis-Ruth, F.X.
Deposit date:2015-06-04
Release date:2015-07-29
Last modified:2017-08-23
Method:ELECTRON MICROSCOPY (16 Å)
Cite:Structural and Functional Insights Into Escherichia Coli Alpha2- Macroglobulin Endopeptidase Snap-Trap Inhibition.
Proc.Natl.Acad.Sci.USA, 112, 2015
2PN5
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BU of 2pn5 by Molmil
Crystal Structure of TEP1r
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, SODIUM ION, ...
Authors:Baxter, R.H.G.
Deposit date:2007-04-23
Release date:2007-07-24
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.698 Å)
Cite:Structural basis for conserved complement factor-like function in the antimalarial protein TEP1
Proc.Natl.Acad.Sci.Usa, 104, 2007
2QKI
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BU of 2qki by Molmil
Human C3c in complex with the inhibitor compstatin
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BROMIDE ION, Complement C3, ...
Authors:Janssen, B.J.C, Halff, E.F, Lambris, J.D, Gros, P.
Deposit date:2007-07-11
Release date:2007-08-14
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of compstatin in complex with complement component C3c reveals a new mechanism of complement inhibition.
J.Biol.Chem., 282, 2007

217705

건을2024-03-27부터공개중

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