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4QHU
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BU of 4qhu by Molmil
Crystal Structure of IL-17A/Fab6785 complex
Descriptor: CHLORIDE ION, Fab6785 heavy chain, Fab6785 light chain, ...
Authors:Luo, J, Gilliland, G.L, Malia, T, Obmolova, G, Teplyakov, A.
Deposit date:2014-05-29
Release date:2015-08-05
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:IL-17A Asymmetry in a Complex with a Neutralizing Antibody Fab6785 Reveals a Potential Mechanism of Receptor Differentiation
To be Published
6PPG
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BU of 6ppg by Molmil
Crystal structure of IL17FF bound to Fab fragments of MCAF5352A
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CADMIUM ION, Fab MCAF5352A heavy chain, ...
Authors:Huang, C.S, Yin, J.P, Hymowitz, S.G.
Deposit date:2019-07-06
Release date:2019-12-11
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Dissecting the molecular basis of high viscosity of monospecific and bispecific IgG antibodies.
Mabs, 12
2VXS
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BU of 2vxs by Molmil
Structure of IL-17A in complex with a potent, fully human neutralising antibody
Descriptor: FAB FRAGMENT, INTERLEUKIN-17A, SULFATE ION
Authors:Gerhardt, S, Hargreaves, D, Pauptit, R.A, Davies, R.A, Russell, C, Welsh, F, Tuske, S.J, Coales, S.J, Hamuro, Y, Needham, M.R.C, Langham, C, Barker, W, Bell, P, Aziz, A, Smith, M.J, Dawson, S, Abbott, W.M.
Deposit date:2008-07-09
Release date:2009-07-14
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.63 Å)
Cite:Structure of Il-17A in Complex with a Potent, Fully Human Neutralising Antibody.
J.Mol.Biol., 394, 2009
1JPY
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BU of 1jpy by Molmil
Crystal structure of IL-17F
Descriptor: 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Hymowitz, S.G, Filvaroff, E.H, Yin, J, Lee, J, Cai, L, Risser, P, Maruoka, M, Mao, W, Foster, J, Kelley, R, Pan, G, Gurney, A.L, de Vos, A.M, Starovasnik, M.A.
Deposit date:2001-08-03
Release date:2001-09-28
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:IL-17s adopt a cystine knot fold: structure and activity of a novel cytokine, IL-17F, and implications for receptor binding.
EMBO J., 20, 2001
5VB9
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BU of 5vb9 by Molmil
IL-17A in complex with peptide
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Interleukin-17A, ...
Authors:Antonysamy, S, Russell, M, Zhang, A, Groshong, C, Manglicmot, D, Lu, F, Benach, J, Wasserman, S.R, Zhang, F, Afshar, S, Bina, H, Broughton, H, Chalmers, M, Dodge, J, Espada, A, Jones, S, Ting, J.P, Woodman, M.
Deposit date:2017-03-28
Release date:2018-02-14
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Utilization of peptide phage display to investigate hotspots on IL-17A and what it means for drug discovery.
PLoS ONE, 13, 2018
8DY1
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BU of 8dy1 by Molmil
Crystal Structure of scFv CAT2200 LH in complex with IL-17A
Descriptor: Interleukin-17A, SULFATE ION, scFv CAT2200 LH
Authors:Luo, J, Armstrong, A.A.
Deposit date:2022-08-03
Release date:2023-05-03
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.68 Å)
Cite:"Stapling" scFv for multispecific biotherapeutics of superior properties.
Mabs, 15, 2023
8DY5
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BU of 8dy5 by Molmil
Crystal Structure of spFv CAT2200 LH in complex with IL-17A
Descriptor: CALCIUM ION, CHLORIDE ION, Interleukin-17A, ...
Authors:Luo, J, Boucher, L.E.
Deposit date:2022-08-03
Release date:2023-05-03
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:"Stapling" scFv for multispecific biotherapeutics of superior properties.
Mabs, 15, 2023
7Z2M
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BU of 7z2m by Molmil
Crystal Structure of the 11.003 Fab in complex with human IL-17A
Descriptor: 11.003 Fab heavy-chain, 11.003 Fab light-chain, GLYCEROL, ...
Authors:Rondeau, J.M, Lehmann, S.
Deposit date:2022-02-28
Release date:2023-02-08
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.899 Å)
Cite:"Redirecting an anti-IL-1 beta antibody to bind a new, unrelated and computationally predicted epitope on hIL-17A".
Commun Biol, 6, 2023
6WIO
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BU of 6wio by Molmil
Fab antigen complex
Descriptor: Fab Heavy chain, Fab Light chain, Interleukin-17A
Authors:Antonysamy, S.
Deposit date:2020-04-10
Release date:2020-09-23
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.17 Å)
Cite:Rapid and robust antibody Fab fragment crystallization utilizing edge-to-edge beta-sheet packing.
Plos One, 15, 2020
6WIR
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BU of 6wir by Molmil
Fab antigen complex
Descriptor: Fab heavy chain, Fab light chain, Interleukin-17A
Authors:Antonysamy, S.
Deposit date:2020-04-10
Release date:2020-09-23
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.96 Å)
Cite:Rapid and robust antibody Fab fragment crystallization utilizing edge-to-edge beta-sheet packing.
Plos One, 15, 2020
7AMG
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BU of 7amg by Molmil
IL-17A in complex with small molecule modulators
Descriptor: (3~{R})-4-[4-[[(2~{S})-2-[[2,2-bis(fluoranyl)-2-phenyl-ethanoyl]amino]-3-(2-chlorophenyl)propanoyl]amino]phenyl]-3-[[(2~{S})-3-methyl-2-[2-[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethoxy]ethanoylamino]butanoyl]amino]butanoic acid, Interleukin-17A
Authors:Hakansson, M, Kimbung, R, Logan, D, Walse, U.B, de Groot, M.J, Andrews, M.D, Dack, K.N, Lambert, M.
Deposit date:2020-10-08
Release date:2022-04-20
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (3.18 Å)
Cite:Discovery of an Oral, Rule of 5 Compliant, Interleukin 17A Protein-Protein Interaction Modulator for the Potential Treatment of Psoriasis and Other Inflammatory Diseases.
J.Med.Chem., 65, 2022
7AMA
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BU of 7ama by Molmil
IL-17A in complex with small molecule modulators
Descriptor: Interleukin-17A, ~{N}-[(2~{S})-1,1-dicyclopropyl-3-[[4-(3,5-dimethyl-1~{H}-pyrazol-4-yl)phenyl]amino]-3-oxidanylidene-propan-2-yl]-2-propan-2-yl-pyrazole-3-carboxamide
Authors:Hakansson, M, Kimbung, R, Logan, D, Walse, U.B, de Groot, M.J, Andrews, M.D, Dack, K.N, Lambert, M.
Deposit date:2020-10-08
Release date:2022-04-20
Last modified:2022-08-10
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:Discovery of an Oral, Rule of 5 Compliant, Interleukin 17A Protein-Protein Interaction Modulator for the Potential Treatment of Psoriasis and Other Inflammatory Diseases.
J.Med.Chem., 65, 2022
4HR9
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BU of 4hr9 by Molmil
Human interleukin 17A
Descriptor: Interleukin-17A
Authors:Liu, S.
Deposit date:2012-10-26
Release date:2013-05-22
Last modified:2013-06-19
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:Crystal structures of interleukin 17A and its complex with IL-17 receptor A.
Nat Commun, 4, 2013
6HGO
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BU of 6hgo by Molmil
Crystal Structure of human IL-17F
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-17F, ...
Authors:Rondeau, J.M, Goepfert, A.
Deposit date:2018-08-23
Release date:2019-11-20
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural Analysis Reveals that the Cytokine IL-17F Forms a Homodimeric Complex with Receptor IL-17RC to Drive IL-17RA-Independent Signaling.
Immunity, 52, 2020
5N7W
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BU of 5n7w by Molmil
Computationally designed functional antibody
Descriptor: Antibody Fragment Heavy Chain, Antibody Fragment Light Chain, Interleukin-17A
Authors:Hargreaves, D, Breed, J.
Deposit date:2017-02-21
Release date:2018-11-14
Last modified:2018-12-05
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Computational Design of Epitope-Specific Functional Antibodies.
Cell Rep, 25, 2018
5N92
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BU of 5n92 by Molmil
Crystal Structure of Human IL-17AF
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-17A, Interleukin-17F
Authors:Rondeau, J.-M, Goepfert, A.
Deposit date:2017-02-24
Release date:2017-09-06
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The human IL-17A/F heterodimer: a two-faced cytokine with unique receptor recognition properties.
Sci Rep, 7, 2017
5HI4
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BU of 5hi4 by Molmil
Binding site elucidation and structure guided design of macrocyclic IL-17A antagonists
Descriptor: (9'S,17'R)-6'-chloro-N-methyl-9'-{[(1-methyl-1H-pyrazol-5-yl)carbonyl]amino}-10',19'-dioxo-2'-oxa-11',18'-diazaspiro[cyclopentane-1,21'-tetracyclo[20.2.2.2~12,15~.1~3,7~]nonacosane]-1'(24'),3'(29'),4',6',12',14',22',25',27'-nonaene-17'-carboxamide, CAT-2000 FAB heavy chain, CAT-2000 FAB light chain, ...
Authors:Liu, S.
Deposit date:2016-01-11
Release date:2016-08-31
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Binding site elucidation and structure guided design of macrocyclic IL-17A antagonists.
Sci Rep, 6, 2016
5HHV
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BU of 5hhv by Molmil
Inhibiting complex IL-17A and IL-17RA interactions with a linear peptide
Descriptor: CAT-2000 FAB heavy chain, CAT-2000 FAB light chain, IL-17A peptide inhibitor, ...
Authors:Liu, S.
Deposit date:2016-01-11
Release date:2016-06-01
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Inhibiting complex IL-17A and IL-17RA interactions with a linear peptide.
Sci Rep, 6, 2016
5HI3
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BU of 5hi3 by Molmil
Binding site elucidation and structure guided design of macrocyclic IL-17A antagonists
Descriptor: CAT-2000 FAB heavy chain, CAT-2000 FAB light chain, Interleukin-17A, ...
Authors:Liu, S.
Deposit date:2016-01-11
Release date:2016-08-31
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Binding site elucidation and structure guided design of macrocyclic IL-17A antagonists.
Sci Rep, 6, 2016
5HHX
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BU of 5hhx by Molmil
Inhibiting complex IL-17A and IL-17RA interactions with a linear peptide
Descriptor: CAT-2000 FAB heavy chain, CAT-2000 FAB light chain, IL-17A peptide inhibitor, ...
Authors:Liu, S.
Deposit date:2016-01-11
Release date:2016-06-01
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3 Å)
Cite:Inhibiting complex IL-17A and IL-17RA interactions with a linear peptide.
Sci Rep, 6, 2016
5HI5
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BU of 5hi5 by Molmil
Binding site elucidation and structure guided design of macrocyclic IL-17A antagonists
Descriptor: (4S,20R)-7-chloro-N-methyl-4-{[(1-methyl-1H-pyrazol-5-yl)carbonyl]amino}-3,18-dioxo-2,19-diazatetracyclo[20.2.2.1~6,10~.1~11,15~]octacosa-1(24),6(28),7,9,11(27),12,14,22,25-nonaene-20-carboxamide, CAT-2000 FAB heavy chain, CAT-2000 light chain, ...
Authors:Liu, S.
Deposit date:2016-01-11
Release date:2016-08-31
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Binding site elucidation and structure guided design of macrocyclic IL-17A antagonists.
Sci Rep, 6, 2016
8B7W
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BU of 8b7w by Molmil
Complex IL-17A/anti-IL-17A-76
Descriptor: CHLORIDE ION, GLYCEROL, Interleukin-17A, ...
Authors:Kostareva, O.S, Svoeglazova, A, Kolyadenko, I.A, Dzhus, U.F, Tishchenko, S.V, Gabdulkhakov, A.G.
Deposit date:2022-10-03
Release date:2022-12-28
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Two Epitope Regions Revealed in the Complex of IL-17A and Anti-IL-17A V H H Domain.
Int J Mol Sci, 23, 2022
7WKX
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BU of 7wkx by Molmil
IL-17A in complex with the humanized antibody HB0017
Descriptor: ACETIC ACID, Heavy chain of HB0017 Fab, Interleukin-17A, ...
Authors:Xu, J, Zhu, X, He, Y.
Deposit date:2022-01-12
Release date:2022-03-23
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:Structural and functional insights into a novel pre-clinical-stage antibody targeting IL-17A for treatment of autoimmune diseases.
Int.J.Biol.Macromol., 202, 2022
8CDG
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BU of 8cdg by Molmil
Crystal structure of human IL-17A cytokine in complex with macrocycle
Descriptor: (9~{S},12~{R},19~{S})-9-[[4-[[(2~{S})-2-cyclohexyl-2-(2-phenylethanoylamino)ethanoyl]amino]phenyl]methyl]-12-methyl-7,10,13,21-tetrakis(oxidanylidene)-8,11,14,20-tetrazaspiro[4.17]docosane-19-carboxylic acid, Interleukin-17A
Authors:Schulze, M.-S.
Deposit date:2023-01-30
Release date:2023-12-06
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Modulation of IL-17 backbone dynamics reduces receptor affinity and reveals a new inhibitory mechanism.
Chem Sci, 14, 2023
8DYG
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BU of 8dyg by Molmil
IL17A homodimer bound to Compound 7
Descriptor: (5P)-2-hydroxy-5-(6-methylquinolin-5-yl)benzoic acid, Interleukin-17A
Authors:Argiriadi, M.A, Goedken, E.R.
Deposit date:2022-08-04
Release date:2022-09-07
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:Identification and structure-based drug design of cell-active inhibitors of interleukin 17A at a novel C-terminal site.
Sci Rep, 12, 2022

 

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