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7K17
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BU of 7k17 by Molmil
Re-refined crystal structure of DNA-dependent protein kinase catalytic subunit complexed with Ku80 C-terminal helix
Descriptor: DNA-dependent protein kinase catalytic subunit, X-ray repair cross-complementing protein 5
Authors:Chen, X, Gellert, M, Yang, W.
Deposit date:2020-09-07
Release date:2021-01-06
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (4.3 Å)
Cite:Structure of an activated DNA-PK and its implications for NHEJ.
Mol.Cell, 81, 2021
6ZHE
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BU of 6zhe by Molmil
Cryo-EM structure of DNA-PK dimer
Descriptor: DNA (25-MER), DNA (26-MER), DNA (27-MER), ...
Authors:Chaplin, A.K, Hardwick, S.W, Chirgadze, D.Y, Blundell, T.L.
Deposit date:2020-06-23
Release date:2020-10-21
Last modified:2021-01-20
Method:ELECTRON MICROSCOPY (7.24 Å)
Cite:Dimers of DNA-PK create a stage for DNA double-strand break repair.
Nat.Struct.Mol.Biol., 28, 2021
5Y3R
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BU of 5y3r by Molmil
Cryo-EM structure of Human DNA-PK Holoenzyme
Descriptor: DNA (34-MER), DNA (36-MER), DNA-dependent protein kinase catalytic subunit, ...
Authors:Yin, X, Liu, M, Tian, Y, Wang, J, Xu, Y.
Deposit date:2017-07-29
Release date:2017-09-06
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (6.6 Å)
Cite:Cryo-EM structure of human DNA-PK holoenzyme
Cell Res., 27, 2017
8EZB
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BU of 8ezb by Molmil
NHEJ Long-range complex with ATP
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, DNA (30-MER), DNA (31-MER), ...
Authors:Chen, S, He, Y.
Deposit date:2022-10-31
Release date:2023-06-14
Method:ELECTRON MICROSCOPY (8.9 Å)
Cite:Cryo-EM visualization of DNA-PKcs structural intermediates in NHEJ.
Sci Adv, 9, 2023
8EZA
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BU of 8eza by Molmil
NHEJ Long-range complex with PAXX
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, DNA (30-MER), DNA (31-MER), ...
Authors:Chen, S, He, Y.
Deposit date:2022-10-31
Release date:2023-06-14
Method:ELECTRON MICROSCOPY (4.39 Å)
Cite:Cryo-EM visualization of DNA-PKcs structural intermediates in NHEJ.
Sci Adv, 9, 2023
5Y58
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BU of 5y58 by Molmil
Crystal structure of Ku70/80 and TLC1
Descriptor: ATP-dependent DNA helicase II subunit 1, ATP-dependent DNA helicase II subunit 2, TLC1
Authors:Chen, H, Xue, J, Wu, J, Lei, M.
Deposit date:2017-08-08
Release date:2017-12-20
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Insights into Yeast Telomerase Recruitment to Telomeres
Cell, 172, 2018
1JEY
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BU of 1jey by Molmil
Crystal Structure of the Ku heterodimer bound to DNA
Descriptor: DNA (34-MER), DNA (5'-D(*GP*TP*TP*TP*TP*TP*AP*GP*TP*TP*TP*AP*TP*TP*GP*GP*GP*CP*GP*CP*G)-3'), Ku70, ...
Authors:Walker, J.R, Corpina, R.A, Goldberg, J.
Deposit date:2001-06-19
Release date:2001-08-10
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair.
Nature, 412, 2001
1JEQ
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BU of 1jeq by Molmil
Crystal Structure of the Ku Heterodimer
Descriptor: KU70, KU80
Authors:Walker, J.R, Corpina, R.A, Goldberg, J.
Deposit date:2001-06-18
Release date:2001-08-15
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair.
Nature, 412, 2001
6ZH6
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BU of 6zh6 by Molmil
Cryo-EM structure of DNA-PKcs:Ku80ct194
Descriptor: DNA-dependent protein kinase catalytic subunit,DNA-PKcs, X-ray repair cross-complementing protein 5
Authors:Chaplin, A.K, Hardwick, S.W, Chirgadze, D.Y, Blundell, T.L.
Deposit date:2020-06-21
Release date:2020-10-21
Last modified:2021-01-20
Method:ELECTRON MICROSCOPY (3.93 Å)
Cite:Dimers of DNA-PK create a stage for DNA double-strand break repair.
Nat.Struct.Mol.Biol., 28, 2021
6ZHA
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BU of 6zha by Molmil
Cryo-EM structure of DNA-PK monomer
Descriptor: DNA, DNA-dependent protein kinase catalytic subunit,DNA-dependent protein kinase catalytic subunit,DNA-dependent protein kinase catalytic subunit,DNA-PKcs, X-ray repair cross-complementing protein 5, ...
Authors:Chaplin, A.K, Hardwick, S.W, Chirgadze, D.Y, Blundell, T.L.
Deposit date:2020-06-21
Release date:2020-10-21
Last modified:2021-01-20
Method:ELECTRON MICROSCOPY (3.91 Å)
Cite:Dimers of DNA-PK create a stage for DNA double-strand break repair.
Nat.Struct.Mol.Biol., 28, 2021
7SGL
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BU of 7sgl by Molmil
DNA-PK complex of DNA end processing
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, DNA-dependent protein kinase catalytic subunit, Hairpin_1, ...
Authors:Liu, L, Li, J, Chen, X, Yang, W, Gellert, M.
Deposit date:2021-10-06
Release date:2022-01-12
Last modified:2022-01-19
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Autophosphorylation transforms DNA-PK from protecting to processing DNA ends.
Mol.Cell, 82, 2022
7SU3
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BU of 7su3 by Molmil
CryoEM structure of DNA-PK complex VII
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, DNA (5'-D(*AP*AP*GP*CP*AP*GP*TP*AP*GP*AP*G)-3'), DNA (5'-D(*GP*CP*AP*TP*GP*CP*TP*CP*TP*AP*CP*TP*GP*CP*TP*TP*CP*GP*AP*TP*AP*TP*CP*G)-3'), ...
Authors:Chen, X, Liu, L, Gellert, M, Yang, W.
Deposit date:2021-11-16
Release date:2022-01-12
Last modified:2022-01-19
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Autophosphorylation transforms DNA-PK from protecting to processing DNA ends.
Mol.Cell, 82, 2022
7SUD
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BU of 7sud by Molmil
CryoEM structure of DNA-PK complex VIII
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, DNA-dependent protein kinase catalytic subunit, MAGNESIUM ION, ...
Authors:Chen, X, Liu, L, Gellert, M, Yang, W.
Deposit date:2021-11-16
Release date:2022-01-12
Last modified:2022-01-19
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Autophosphorylation transforms DNA-PK from protecting to processing DNA ends.
Mol.Cell, 82, 2022
7AXZ
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BU of 7axz by Molmil
Ku70/80 complex apo form
Descriptor: X-ray repair cross-complementing protein 5, X-ray repair cross-complementing protein 6
Authors:Hnizda, A, Tesina, P, Novak, P, Blundell, T.L.
Deposit date:2020-11-10
Release date:2021-02-10
Last modified:2021-07-28
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:SAP domain forms a flexible part of DNA aperture in Ku70/80.
Febs J., 288, 2021
6ERG
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BU of 6erg by Molmil
Complex of XLF and heterodimer Ku bound to DNA
Descriptor: DNA (21-MER), DNA (34-MER), Non-homologous end-joining factor 1, ...
Authors:Nemoz, C, Legrand, P, Ropars, V, Charbonnier, J.B.
Deposit date:2017-10-18
Release date:2018-10-17
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:XLF and APLF bind Ku80 at two remote sites to ensure DNA repair by non-homologous end joining.
Nat. Struct. Mol. Biol., 25, 2018
6ERH
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BU of 6erh by Molmil
Complex of XLF and heterodimer Ku bound to DNA
Descriptor: DNA (21-MER), DNA (34-MER), Non-homologous end-joining factor 1, ...
Authors:Nemoz, C, Legrand, P, Ropars, V, Charbonnier, J.B.
Deposit date:2017-10-18
Release date:2018-10-17
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:XLF and APLF bind Ku80 at two remote sites to ensure DNA repair by non-homologous end joining.
Nat. Struct. Mol. Biol., 25, 2018
6ERF
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BU of 6erf by Molmil
Complex of APLF factor and Ku heterodimer bound to DNA
Descriptor: Aprataxin and PNK-like factor, DNA (34-MER), DNA (5'-D(*GP*TP*TP*TP*TP*TP*AP*GP*TP*TP*TP*AP*TP*TP*GP*GP*GP*CP*GP*CP*G)-3'), ...
Authors:Nemoz, C, Legrand, P, Ropars, V, Charbonnier, J.B.
Deposit date:2017-10-18
Release date:2018-10-17
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.01 Å)
Cite:XLF and APLF bind Ku80 at two remote sites to ensure DNA repair by non-homologous end joining.
Nat.Struct.Mol.Biol., 25, 2018
7LT3
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BU of 7lt3 by Molmil
NHEJ Long-range synaptic complex
Descriptor: ADENOSINE-5'-DIPHOSPHATE, DNA (30-MER), DNA (31-MER), ...
Authors:He, Y, Chen, S.
Deposit date:2021-02-18
Release date:2021-04-14
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (4.6 Å)
Cite:Structural basis of long-range to short-range synaptic transition in NHEJ.
Nature, 593, 2021
7LSY
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BU of 7lsy by Molmil
NHEJ Short-range synaptic complex
Descriptor: DNA (26-MER), DNA (5'-D(P*CP*AP*AP*TP*GP*AP*AP*AP*CP*GP*GP*AP*AP*CP*AP*GP*TP*CP*AP*G)-3'), DNA (5'-D(P*GP*TP*TP*CP*TP*TP*AP*GP*TP*AP*TP*AP*TP*A)-3'), ...
Authors:He, Y, Chen, S.
Deposit date:2021-02-18
Release date:2021-04-14
Last modified:2023-08-16
Method:ELECTRON MICROSCOPY (8.4 Å)
Cite:Structural basis of long-range to short-range synaptic transition in NHEJ.
Nature, 593, 2021
7NFC
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BU of 7nfc by Molmil
Cryo-EM structure of NHEJ super-complex (dimer)
Descriptor: DNA (27-MER), DNA (28-MER), DNA ligase 4, ...
Authors:Chaplin, A.K, Hardwick, S.W, Kefala Stavridi, A, Chirgadze, D.Y, Blundell, T.L.
Deposit date:2021-02-05
Release date:2021-08-18
Last modified:2021-09-22
Method:ELECTRON MICROSCOPY (4.14 Å)
Cite:Cryo-EM of NHEJ supercomplexes provides insights into DNA repair.
Mol.Cell, 81, 2021
7NFE
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BU of 7nfe by Molmil
Cryo-EM structure of NHEJ super-complex (monomer)
Descriptor: DNA (5'-D(P*AP*AP*TP*AP*AP*AP*CP*TP*AP*AP*AP*AP*AP*CP*TP*AP*TP*TP*AP*TP*TP*AP*TP*G)-3'), DNA (5'-D(P*TP*AP*AP*TP*AP*AP*TP*AP*GP*TP*TP*TP*TP*TP*AP*GP*TP*TP*TP*AP*TP*TP*AP*G)-3'), DNA ligase 4, ...
Authors:Chaplin, A.K, Hardwick, S.W, Kefala Stavridi, A, Chirgadze, D.Y, Blundell, T.L.
Deposit date:2021-02-06
Release date:2021-08-18
Last modified:2021-09-22
Method:ELECTRON MICROSCOPY (4.29 Å)
Cite:Cryo-EM of NHEJ supercomplexes provides insights into DNA repair.
Mol.Cell, 81, 2021
7Z88
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BU of 7z88 by Molmil
DNA-PK in the intermediate state
Descriptor: (~{S})-[2-chloranyl-4-fluoranyl-5-(7-morpholin-4-ylquinazolin-4-yl)phenyl]-(6-methoxypyridazin-3-yl)methanol, DNA (26-MER), DNA-dependent protein kinase catalytic subunit, ...
Authors:Liang, S, Blundell, T.L.
Deposit date:2022-03-16
Release date:2023-01-18
Last modified:2023-03-01
Method:ELECTRON MICROSCOPY (3.33 Å)
Cite:Human DNA-dependent protein kinase activation mechanism.
Nat.Struct.Mol.Biol., 30, 2023
7Z87
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BU of 7z87 by Molmil
DNA-PK in the active state
Descriptor: (~{S})-[2-chloranyl-4-fluoranyl-5-(7-morpholin-4-ylquinazolin-4-yl)phenyl]-(6-methoxypyridazin-3-yl)methanol, DNA (26-MER), DNA-dependent protein kinase catalytic subunit, ...
Authors:Liang, S, Blundell, T.L.
Deposit date:2022-03-16
Release date:2023-01-18
Last modified:2023-03-01
Method:ELECTRON MICROSCOPY (2.91 Å)
Cite:Human DNA-dependent protein kinase activation mechanism.
Nat.Struct.Mol.Biol., 30, 2023
7Z6O
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BU of 7z6o by Molmil
X-Ray studies of Ku70/80 reveal the binding site for IP6
Descriptor: DNA (5'-D(*GP*TP*TP*TP*TP*TP*AP*GP*TP*TP*TP*AP*T)-3'), DNA (5'-D(P*AP*AP*AP*TP*AP*AP*AP*CP*TP*AP*AP*AP*AP*AP*C)-3'), INOSITOL HEXAKISPHOSPHATE, ...
Authors:Varela, P.F, Charbonnier, J.B.
Deposit date:2022-03-14
Release date:2023-08-30
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:Structural and functional basis of inositol hexaphosphate stimulation of NHEJ through stabilization of Ku-XLF interaction.
Nucleic Acids Res., 51, 2023
8AG4
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BU of 8ag4 by Molmil
Vaccinia C16 protein bound to Ku70/Ku80
Descriptor: Protein C10, X-ray repair cross-complementing protein 5, X-ray repair cross-complementing protein 6
Authors:Rivera-Calzada, A, Arribas-Bosacoma, R, Pearl, L.H, Llorca, O.
Deposit date:2022-07-19
Release date:2022-11-09
Last modified:2022-11-30
Method:ELECTRON MICROSCOPY (2.46 Å)
Cite:Structural basis for the inactivation of cytosolic DNA sensing by the vaccinia virus.
Nat Commun, 13, 2022

 

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