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9AXG
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BU of 9axg by Molmil
Human saposin B in the presence of globotriaosylceramide-NBD
Descriptor: MALONATE ION, Saposin-B
Authors:Sawyer, T.K, Garman, S.C.
Deposit date:2024-03-06
Release date:2024-03-13
Method:X-RAY DIFFRACTION (2.68 Å)
Cite:Human Saposin B Ligand Binding and Presentation to Alpha-Galactosidase A
To Be Published
4V2O
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BU of 4v2o by Molmil
Structure of saposin B in complex with chloroquine
Descriptor: N4-(7-CHLORO-QUINOLIN-4-YL)-N1,N1-DIETHYL-PENTANE-1,4-DIAMINE, SAPOSIN-B
Authors:Zubieta, C, Lai, X, Doyle, R.P.
Deposit date:2014-10-13
Release date:2015-12-09
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.13 Å)
Cite:The Lysosomal Protein Saposin B Binds Chloroquine.
Chemmedchem, 11, 2016
1L9L
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BU of 1l9l by Molmil
GRANULYSIN FROM HUMAN CYTOLYTIC T LYMPHOCYTES
Descriptor: 3[N-MORPHOLINO]PROPANE SULFONIC ACID, ETHANOL, Granulysin, ...
Authors:Anderson, D.H, Sawaya, M.R, Cascio, D, Ernst, W, Krensky, A, Modlin, R, Eisenberg, D.
Deposit date:2002-03-25
Release date:2002-11-06
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (0.92 Å)
Cite:Granulysin Crystal Structure and a Structure-Derived Lytic Mechanism
J.Mol.Biol., 325, 2002
6VZ0
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BU of 6vz0 by Molmil
C-terminal domain of mouse surfactant protein B crystallized at high pH
Descriptor: Pulmonary surfactant-associated protein B, ZINC ION
Authors:Rapoport, T.A, Bodnar, N.O.
Deposit date:2020-02-27
Release date:2020-11-25
Last modified:2021-01-20
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Mechanism of Lamellar Body Formation by Lung Surfactant Protein B.
Mol.Cell, 81, 2021
6SLR
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BU of 6slr by Molmil
Structure of saposin B in complex with atovaquone
Descriptor: 2-[trans-4-(4-chlorophenyl)cyclohexyl]-3-hydroxynaphthalene-1,4-dione, GLYCEROL, Prosaposin
Authors:Zubieta, C, Milliken, B, Doyle, R.
Deposit date:2019-08-20
Release date:2020-09-09
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:Structure of saposin B in complex with atovaquone
To Be Published
6VZE
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BU of 6vze by Molmil
C-terminal domain of mouse surfactant protein B crystallized at low pH
Descriptor: Pulmonary surfactant-associated protein B, SULFATE ION
Authors:Rapoport, T.A, Bodnar, N.O.
Deposit date:2020-02-28
Release date:2020-11-25
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Mechanism of Lamellar Body Formation by Lung Surfactant Protein B.
Mol.Cell, 81, 2021
2JSA
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BU of 2jsa by Molmil
Solution structure of Caenopore-5 (81 Pro Trans confomer)
Descriptor: Saposin-like protein family protein 5
Authors:Mysliwy, J, Grotzinger, J.
Deposit date:2007-07-02
Release date:2008-10-14
Last modified:2022-03-16
Method:SOLUTION NMR
Cite:Caenopore-5: the three-dimensional structure of an antimicrobial protein from Caenorhabditis elegans.
Dev.Comp.Immunol., 34, 2010
2JS9
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BU of 2js9 by Molmil
Structure of caenopore-5 (81 Pro cis conformer)
Descriptor: Saposin-like protein family protein 5
Authors:Mysliwy, J, Grotzinger, J.
Deposit date:2007-07-02
Release date:2008-10-14
Last modified:2022-03-16
Method:SOLUTION NMR
Cite:Caenopore-5: the three-dimensional structure of an antimicrobial protein from Caenorhabditis elegans.
Dev.Comp.Immunol., 34, 2010
1N69
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BU of 1n69 by Molmil
Crystal structure of human saposin B
Descriptor: 1,2-Distearoyl-sn-glycerophosphoethanolamine, SAPOSIN B
Authors:Ahn, V.E, Faull, K.F, Whitelegge, J.P, Fluharty, A.L, Prive, G.G.
Deposit date:2002-11-08
Release date:2003-01-07
Last modified:2021-06-30
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal Structure of saposin B reveals a dimeric shell for lipid binding
Proc.Natl.Acad.Sci.USA, 100, 2003
1OF9
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BU of 1of9 by Molmil
Solution structure of the pore forming toxin of entamoeba histolytica (Amoebapore A)
Descriptor: PORE-FORMING PEPTIDE AMEOBAPORE A
Authors:Hecht, O, Schleinkofer, K, Bruhn, H, Leippe, M, Van Nuland, N, Dingley, A.J, Grotzinger, J.
Deposit date:2003-04-09
Release date:2004-02-26
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution Structure of the Pore-Forming Protein of Entamoeba Histolytica
J.Biol.Chem., 279, 2004
1SN6
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BU of 1sn6 by Molmil
NMR solution structure of human Saposin C in SDS micelles
Descriptor: Proactivator polypeptide
Authors:Hawkins, C.A, de Alba, E, Tjandra, N.
Deposit date:2004-03-10
Release date:2005-03-01
Last modified:2022-03-02
Method:SOLUTION NMR
Cite:Solution structure of human saposin C in a detergent environment.
J.Mol.Biol., 346, 2005
8EQU
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BU of 8equ by Molmil
Structure of SARS-CoV-2 Orf3a in late endosome/lysosome-like environment, Saposin A nanodisc
Descriptor: 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, ORF3a protein, Saposin A, ...
Authors:Miller, A.N, Houlihan, P.R, Matamala, E, Cabezas-Bratesco, D, Lee, G.Y, Cristofori-Armstrong, B, Dilan, T.L, Sanchez-Martinez, S, Matthies, D, Yan, R, Yu, Z, Ren, D, Brauchi, S.E, Clapham, D.E.
Deposit date:2022-10-09
Release date:2023-02-08
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:The SARS-CoV-2 accessory protein Orf3a is not an ion channel, but does interact with trafficking proteins.
Elife, 12, 2023
7MBK
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BU of 7mbk by Molmil
N-terminal domain of mouse surfactant protein B, 6W mutant
Descriptor: Pulmonary surfactant-associated protein B
Authors:Milicic, G, Rapoport, T.A.
Deposit date:2021-03-31
Release date:2021-04-14
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.17 Å)
Cite:Mechanism of Lamellar Body Formation by Lung Surfactant Protein B.
Mol.Cell, 81, 2021
7P4T
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BU of 7p4t by Molmil
Tetrameric structure of murine SapA
Descriptor: Saposin-A
Authors:Shamin, M, Deane, J.E.
Deposit date:2021-07-13
Release date:2022-05-25
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (3.17 Å)
Cite:A Tetrameric Assembly of Saposin A: Increasing Structural Diversity in Lipid Transfer Proteins.
Contact, 4, 2021
4UEX
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BU of 4uex by Molmil
Structure of human Saposin A at lysosomal pH
Descriptor: PROSAPOSIN
Authors:Hill, C.H, Read, R.J, Deane, J.E.
Deposit date:2014-12-20
Release date:2015-07-15
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of Human Saposin a at Lysosomal Ph.
Acta Crystallogr.,Sect.D, 71, 2015
4DDJ
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BU of 4ddj by Molmil
Crystal structure of saposin A in complex with lauryldimethylamine-N-oxide (LDAO)
Descriptor: LAURYL DIMETHYLAMINE-N-OXIDE, Saposin-A
Authors:Popovic, K, Prive, G.G.
Deposit date:2012-01-18
Release date:2012-02-15
Last modified:2020-01-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of saposin A lipoprotein discs.
Proc.Natl.Acad.Sci.USA, 109, 2012
2Z9A
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BU of 2z9a by Molmil
Crystal Structure of Human Saposin C Dimer in Open Conformation
Descriptor: GLYCEROL, Proactivator polypeptide
Authors:Rossmann, M, Saenger, W, Maier, T.
Deposit date:2007-09-18
Release date:2008-04-29
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structures of human saposins C and d: implications for lipid recognition and membrane interactions.
Structure, 16, 2008
2DOB
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BU of 2dob by Molmil
Crystal Structure of Human Saposin A
Descriptor: CALCIUM ION, Proactivator polypeptide
Authors:Prive, G.G, Ahn, V.E.
Deposit date:2006-04-28
Release date:2006-07-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structures of saposins A and C.
Protein Sci., 15, 2006
3RFI
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BU of 3rfi by Molmil
Crystal structure of the saposin-like domain of plant aspartic protease from Solanum tuberosum
Descriptor: Asp
Authors:Bhaumik, P, Wlodawer, A.
Deposit date:2011-04-06
Release date:2011-06-15
Last modified:2011-08-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure and Mechanism of the Saposin-like Domain of a Plant Aspartic Protease.
J.Biol.Chem., 286, 2011
3BQP
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BU of 3bqp by Molmil
Crystal Structure of Human Saposin D (orthorhombic)
Descriptor: MAGNESIUM ION, Proactivator polypeptide
Authors:Prive, G.G, Popovic, K.
Deposit date:2007-12-20
Release date:2008-02-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Structures of the human ceramide activator protein saposin D.
Acta Crystallogr.,Sect.D, 64, 2008
3BQQ
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BU of 3bqq by Molmil
Crystal Structure of Human Saposin D (triclinic)
Descriptor: PROACTIVATOR POLYPEPTIDE
Authors:Prive, G.G, Popovic, K.
Deposit date:2007-12-20
Release date:2008-02-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structures of the human ceramide activator protein saposin D.
Acta Crystallogr.,Sect.D, 64, 2008
1M12
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BU of 1m12 by Molmil
NMR solution structure of human Saposin C
Descriptor: SAPOSIN C
Authors:de Alba, E, Weiler, S, Tjandra, N.
Deposit date:2002-06-17
Release date:2003-07-29
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:Solution structure of human saposin C: pH-dependent interaction with phospholipid vesicles.
Biochemistry, 42, 2003
6VYN
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BU of 6vyn by Molmil
N-terminal domain of mouse surfactant protein B with bound lipid, wild type
Descriptor: (7Z,19R,22R)-25-amino-22-hydroxy-16,22-dioxo-17,21,23-trioxa-22lambda~5~-phosphapentacos-7-en-19-yl (9Z)-octadec-9-enoate, Pulmonary surfactant-associated protein B
Authors:Rapoport, T.A, Bodnar, N.O.
Deposit date:2020-02-27
Release date:2020-11-25
Last modified:2021-01-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Mechanism of Lamellar Body Formation by Lung Surfactant Protein B.
Mol.Cell, 81, 2021
6W1B
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BU of 6w1b by Molmil
N-terminal domain of mouse surfactant protein B with bound lipid, Y59A/H79A mutant
Descriptor: 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, Pulmonary surfactant-associated protein B
Authors:Rapoport, T.A, Bodnar, N.O.
Deposit date:2020-03-04
Release date:2020-11-25
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Mechanism of Lamellar Body Formation by Lung Surfactant Protein B.
Mol.Cell, 81, 2021
5U85
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BU of 5u85 by Molmil
Murine saposin-D (SapD), open conformation
Descriptor: Saposin-D
Authors:Gebai, A, Gorelik, A, Illes, K, Nagar, B.
Deposit date:2016-12-13
Release date:2018-06-13
Last modified:2019-05-22
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Crystal structure of saposin D in an open conformation.
J. Struct. Biol., 204, 2018

 

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