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1B3U
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BU of 1b3u by Molmil
CRYSTAL STRUCTURE OF CONSTANT REGULATORY DOMAIN OF HUMAN PP2A, PR65ALPHA
Descriptor: PROTEIN (PROTEIN PHOSPHATASE PP2A)
Authors:Groves, M.R, Hanlon, N, Turowski, P, Hemmings, B, Barford, D.
Deposit date:1998-12-14
Release date:1999-04-12
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs.
Cell(Cambridge,Mass.), 96, 1999
6MQ5
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BU of 6mq5 by Molmil
Structure of human CLASP1 TOG1
Descriptor: CLIP-associating protein 1
Authors:Leano, J.B, Slep, K.C.
Deposit date:2018-10-09
Release date:2019-07-17
Last modified:2020-01-01
Method:X-RAY DIFFRACTION (2.146 Å)
Cite:Structures of TOG1 and TOG2 from the human microtubule dynamics regulator CLASP1.
Plos One, 14, 2019
7XVK
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BU of 7xvk by Molmil
Modularity of Phytophthora effectors enables host mimicry of a principal phosphatase
Descriptor: 1,2-ETHANEDIOL, RxLR effector protein PSR2, Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform
Authors:Wang, J, Wang, Y.
Deposit date:2022-05-24
Release date:2023-07-05
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:Pathogen protein modularity enables elaborate mimicry of a host phosphatase.
Cell, 186, 2023
7CYL
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BU of 7cyl by Molmil
Crystal structure of Karyopherin-beta2 in complex with FUS PY-NLS(P525L)
Descriptor: RNA-binding protein FUS, Transportin-1
Authors:Yoshizawa, T, Chook, Y.M.
Deposit date:2020-09-03
Release date:2021-02-24
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Mechanism of karyopherin-beta 2 binding and nuclear import of ALS variants FUS(P525L) and FUS(R495X).
Sci Rep, 11, 2021
5OWU
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BU of 5owu by Molmil
Kap95:Nup1 complex
Descriptor: Importin subunit beta-1, Nucleoporin NUP1
Authors:Stewart, M.
Deposit date:2017-09-04
Release date:2017-10-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for the high-affinity binding of nucleoporin Nup1p to the Saccharomyces cerevisiae importin-beta homologue, Kap95p.
J. Mol. Biol., 349, 2005
3ND2
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BU of 3nd2 by Molmil
Structure of Yeast Importin-beta (Kap95p)
Descriptor: Importin subunit beta-1
Authors:Forwood, J.K, Kobe, B.
Deposit date:2010-06-06
Release date:2010-07-07
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Quantitative Structural Analysis of Importin-beta Flexibility: Paradigm for Solenoid Protein Structures
Structure, 18, 2010
6EF4
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BU of 6ef4 by Molmil
Crystal structure of mouse PP2A Aalpha P179R mutant
Descriptor: Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
Authors:Wang, Z, Shen, G, Xu, W.
Deposit date:2018-08-16
Release date:2019-06-26
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:The Highly Recurrent PP2A A alpha-Subunit Mutation P179R Alters Protein Structure and Impairs PP2A Enzyme Function to Promote Endometrial Tumorigenesis.
Cancer Res., 79, 2019
6IUR
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BU of 6iur by Molmil
A phosphatase complex STRN3-PP2Aa
Descriptor: PP2A scaffolding subunit, PROPANE, Striatin-3
Authors:Tang, Y, Zhou, Z.C.
Deposit date:2018-11-30
Release date:2019-12-04
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (3.33 Å)
Cite:Selective Inhibition of STRN3-Containing PP2A Phosphatase Restores Hippo Tumor-Suppressor Activity in Gastric Cancer.
Cancer Cell, 38, 2020
6XTE
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BU of 6xte by Molmil
Human karyopherin RanBP5 (isoform-1)
Descriptor: Antipain, CHLORIDE ION, Importin-5, ...
Authors:Swale, C, McCarthy, A.A, Ruigrok, R.W.H, Crepin, T.
Deposit date:2020-01-16
Release date:2020-04-22
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:X-ray Structure of the Human Karyopherin RanBP5, an Essential Factor for Influenza Polymerase Nuclear Trafficking.
J.Mol.Biol., 432, 2020
6XU2
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BU of 6xu2 by Molmil
Human karyopherin RanBP5 (isoform-3)
Descriptor: Antipain, Importin-5, NICKEL (II) ION
Authors:Swale, C, McCarthy, A.A, Berger, I, Bieniossek, C, Delmas, B, Ruigrok, R.W.H, Crepin, T.
Deposit date:2020-01-17
Release date:2020-04-22
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.834 Å)
Cite:X-ray Structure of the Human Karyopherin RanBP5, an Essential Factor for Influenza Polymerase Nuclear Trafficking.
J.Mol.Biol., 432, 2020
5J3V
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BU of 5j3v by Molmil
Crystal structure of human Karyopherin-beta2 bound to the histone H3 tail
Descriptor: Histone H3, Transportin-1,Transportin-1
Authors:Soniat, M, Chook, Y.M.
Deposit date:2016-03-31
Release date:2016-09-21
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:Karyopherin-beta 2 Recognition of a PY-NLS Variant that Lacks the Proline-Tyrosine Motif.
Structure, 24, 2016
4OO6
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BU of 4oo6 by Molmil
Crystal structure of human KAP-beta2 bound to the NLS of HCC1 (Hepato Cellular Carcinoma protein 1)
Descriptor: RNA-binding protein 39, Transportin-1
Authors:Sampathkumar, P, Brower, A, Soniat, M, Bonanno, J, Hillerich, B, Seidel, R.D, Rout, M.P, Chook, Y.M, Almo, S.C, New York Structural Genomics Research Consortium (NYSGRC), Nucleocytoplasmic Transport: a Target for Cellular Control (NPCXstals)
Deposit date:2014-01-30
Release date:2014-02-12
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of human KAP-beta2 bound to the NLS of HCC1 (Hepato Cellular Carcinoma protein 1)
to be published
2DB0
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BU of 2db0 by Molmil
Crystal structure of PH0542
Descriptor: 253aa long hypothetical protein
Authors:Nishino, A, Handa, N, Kishishita, S, Murayama, K, Shirouzu, M, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2005-12-14
Release date:2006-06-14
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of PH0542
To be Published
2H4M
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BU of 2h4m by Molmil
Karyopherin Beta2/Transportin-M9NLS
Descriptor: Heterogeneous nuclear ribonucleoprotein A1, Transportin-1
Authors:Chook, Y.M, Cansizoglu, A.E.
Deposit date:2006-05-24
Release date:2006-10-24
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:Rules for nuclear localization sequence recognition by karyopherin beta 2.
Cell(Cambridge,Mass.), 126, 2006
4FDD
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BU of 4fdd by Molmil
Crystal structure of KAP beta2-PY-NLS
Descriptor: RNA-binding protein FUS, Transportin-1
Authors:Zhang, Z.C, Chook, Y.M.
Deposit date:2012-05-28
Release date:2012-07-18
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural and energetic basis of ALS-causing mutations in the atypical proline-tyrosine nuclear localization signal of the Fused in Sarcoma protein (FUS).
Proc.Natl.Acad.Sci.USA, 109, 2012
4FQ3
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BU of 4fq3 by Molmil
Crystal structure of transportin/FUS-NLS
Descriptor: Fusion (Involved in t(12;16) in malignant liposarcoma), Transportin-1
Authors:Gong, W, Niu, C, Jia, M, Gao, F.
Deposit date:2012-06-25
Release date:2013-08-21
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of transportin/FUS-NLS
To be Published
5TQC
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BU of 5tqc by Molmil
Crystal structure of transport factor karyopherin-beta 2 in complex with the PY-NLS of ribosomal protein L4 (RpL4)
Descriptor: 60S ribosomal protein L4-like protein, Transportin-1,Transportin-1
Authors:Huber, F.M, Hoelz, A.
Deposit date:2016-10-23
Release date:2017-02-15
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3 Å)
Cite:Molecular basis for protection of ribosomal protein L4 from cellular degradation.
Nat Commun, 8, 2017
5YVI
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BU of 5yvi by Molmil
Crystal structure of Karyopherin beta2 in complex with FUS(456-526)
Descriptor: RNA-binding protein FUS, Transportin-1
Authors:Yoshizawa, T, Fung, H.Y.J, Chook, Y.M.
Deposit date:2017-11-25
Release date:2018-05-16
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Nuclear Import Receptor Inhibits Phase Separation of FUS through Binding to Multiple Sites.
Cell, 173, 2018
5VCH
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BU of 5vch by Molmil
Crystal structure of full-length Kluyveromyces lactis Kap123
Descriptor: Kap123
Authors:An, S, Yoon, J, Song, J.-J, Cho, U.-S.
Deposit date:2017-03-31
Release date:2017-11-01
Last modified:2022-03-16
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structure-based nuclear import mechanism of histones H3 and H4 mediated by Kap123.
Elife, 6, 2017
5VE8
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BU of 5ve8 by Molmil
Crystal structure of full-length Kluyveromyces lactis Kap123 with histone H3 1-28
Descriptor: Histone H3, Kap123
Authors:An, S, Yoon, J, Song, J.-J, Cho, U.-S.
Deposit date:2017-04-04
Release date:2017-11-01
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure-based nuclear import mechanism of histones H3 and H4 mediated by Kap123.
Elife, 6, 2017
5W0V
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BU of 5w0v by Molmil
Crystal structure of full-length Kluyveromyces lactis Kap123 with histone H4 1-34
Descriptor: Histone H4 1-34, Kap123
Authors:An, S, Yoon, J, Song, J.-J, Cho, U.-S.
Deposit date:2017-05-31
Release date:2017-11-01
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.821 Å)
Cite:Structure-based nuclear import mechanism of histones H3 and H4 mediated by Kap123.
Elife, 6, 2017
2Z5N
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BU of 2z5n by Molmil
Complex of Transportin 1 with hnRNP D NLS
Descriptor: Heterogeneous nuclear ribonucleoprotein D0, Transportin-1
Authors:Imasaki, T, Shimizu, T, Hashimoto, H, Hidaka, Y, Kose, S, Imamoto, N, Yamada, M, Sato, M.
Deposit date:2007-07-14
Release date:2007-10-23
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural basis for substrate recognition and dissociation by human transportin 1
Mol.Cell, 28, 2007
2Z5J
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BU of 2z5j by Molmil
Free Transportin 1
Descriptor: Transportin-1
Authors:Imasaki, T, Shimizu, T, Hashimoto, H, Hidaka, Y, Yamada, M, Sato, M.
Deposit date:2007-07-13
Release date:2007-10-23
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Structural basis for substrate recognition and dissociation by human transportin 1
Mol.Cell, 28, 2007
2Z5O
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BU of 2z5o by Molmil
Complex of Transportin 1 with JKTBP NLS
Descriptor: Heterogeneous nuclear ribonucleoprotein D-like, Transportin-1
Authors:Imasaki, T, Shimizu, T, Hashimoto, H, Hidaka, Y, Kose, S, Imamoto, N, Yamada, M, Sato, M.
Deposit date:2007-07-14
Release date:2007-10-23
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural basis for substrate recognition and dissociation by human transportin 1
Mol.Cell, 28, 2007
2Z5K
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BU of 2z5k by Molmil
Complex of Transportin 1 with TAP NLS
Descriptor: Nuclear RNA export factor 1, PHOSPHATE ION, Transportin-1
Authors:Imasaki, T, Shimizu, T, Hashimoto, H, Hidaka, Y, Yamada, M, Kose, S, Imamoto, N, Sato, M.
Deposit date:2007-07-14
Release date:2007-10-23
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural basis for substrate recognition and dissociation by human transportin 1
Mol.Cell, 28, 2007

 

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