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7ZYI
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BU of 7zyi by Molmil
Structure of the human sodium/bile acid cotransporter (NTCP) in complex with Fab and nanobody
Descriptor: CHOLESTEROL, GLYCOCHENODEOXYCHOLIC ACID, Nanobody, ...
Authors:Liu, H, Irobalieva, R.N, Bang-Sorensen, R, Nosol, K, Mukherjee, S, Agrawal, P, Stieger, B, Kossiakoff, A.A, Locher, K.P.
Deposit date:2022-05-24
Release date:2022-07-13
Last modified:2022-08-10
Method:ELECTRON MICROSCOPY (2.88 Å)
Cite:Structure of human NTCP reveals the basis of recognition and sodium-driven transport of bile salts into the liver.
Cell Res., 32, 2022
3ZUX
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BU of 3zux by Molmil
Crystal structure of a bacterial homologue of the bile acid sodium symporter ASBT.
Descriptor: LAURYL DIMETHYLAMINE-N-OXIDE, MERCURY (II) ION, PHOSPHATIDYLETHANOLAMINE, ...
Authors:Hu, N.-J, Iwata, S, Cameron, A.D, Drew, D.
Deposit date:2011-07-21
Release date:2011-10-12
Last modified:2023-05-31
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal Structure of a Bacterial Homologue of the Bile Acid Sodium Symporter Asbt.
Nature, 478, 2011
3ZUY
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BU of 3zuy by Molmil
Crystal structure of a bacterial homologue of the bile acid sodium symporter ASBT.
Descriptor: LAURYL DIMETHYLAMINE-N-OXIDE, PHOSPHATIDYLETHANOLAMINE, SODIUM ION, ...
Authors:Hu, N.-J, Iwata, S, Cameron, A.D, Drew, D.
Deposit date:2011-07-21
Release date:2011-10-12
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal Structure of a Bacterial Homologue of the Bile Acid Sodium Symporter Asbt.
Nature, 478, 2011
7PQG
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BU of 7pqg by Molmil
Structure of thermostabilised human NTCP in complex with nanobody 87
Descriptor: Nanobody 87, Sodium/bile acid cotransporter
Authors:Goutam, K, Reyes, N.
Deposit date:2021-09-21
Release date:2022-05-18
Last modified:2022-07-06
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Structural basis of sodium-dependent bile salt uptake into the liver.
Nature, 606, 2022
7CYG
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BU of 7cyg by Molmil
Crystal structure of a cysteine-pair mutant (Y113C-P190C) of a bacterial bile acid transporter before disulfide bond formation
Descriptor: Transporter, sodium/bile acid symporter family
Authors:Wang, X, Lyu, Y, Ji, Y, Sun, Z, Zhou, X.
Deposit date:2020-09-03
Release date:2021-01-13
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (3.198 Å)
Cite:An engineered disulfide bridge traps and validates an outward-facing conformation in a bile acid transporter.
Acta Crystallogr D Struct Biol, 77, 2021
7CYK
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BU of 7cyk by Molmil
Crystal structure of a second cysteine-pair mutant (V110C-I197C) of a bacterial bile acid transporter before disulfide bond formation
Descriptor: MERCURY (II) ION, Transporter, sodium/bile acid symporter family
Authors:Wang, X, Lyu, Y, Ji, Y, Sun, Z, Zhou, X.
Deposit date:2020-09-03
Release date:2021-01-13
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.785 Å)
Cite:An engineered disulfide bridge traps and validates an outward-facing conformation in a bile acid transporter.
Acta Crystallogr D Struct Biol, 77, 2021
7FCI
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BU of 7fci by Molmil
human NTCP in complex with YN69083 Fab
Descriptor: Fab Heavy chain, Fab Light chain, Sodium/bile acid cotransporter
Authors:Park, J.H, Iwamoto, M, Yun, J.H, Uchikubo-Kamo, T, Son, D, Jin, Z, Yoshida, H, Ohki, M, Ishimoto, N, Mizutani, K, Oshima, M, Muramatsu, M, Wakita, T, Shirouzu, M, Liu, K, Uemura, T, Nomura, N, Iwata, S, Watashi, K, Tame, J.R.H, Nishizawa, T, Lee, W, Park, S.Y.
Deposit date:2021-07-14
Release date:2022-05-25
Last modified:2022-07-13
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structural insights into the HBV receptor and bile acid transporter NTCP.
Nature, 606, 2022
8HRY
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BU of 8hry by Molmil
Cryo-EM structure of human NTCP-myr-preS1-YN9016Fab complex
Descriptor: Fab heavy chain from antibody IgG clone number YN9016, Fab light chain from antibody IgG clone number YN9016, Large S protein (Fragment), ...
Authors:Asami, J, Shimizu, T, Ohto, U.
Deposit date:2022-12-16
Release date:2024-01-17
Last modified:2024-01-31
Method:ELECTRON MICROSCOPY (3.11 Å)
Cite:Structural basis of hepatitis B virus receptor binding.
Nat.Struct.Mol.Biol., 2024
8OYF
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BU of 8oyf by Molmil
Crystal structure of ASBTNM in lipidic cubic phase without substrate bound
Descriptor: (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, NICKEL (II) ION, PHOSPHATIDYLETHANOLAMINE, ...
Authors:Becker, P, Cameron, A.D.
Deposit date:2023-05-04
Release date:2023-07-12
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Mechanism of substrate binding and transport in BASS transporters.
Biorxiv, 2023
8OYG
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BU of 8oyg by Molmil
Crystal structure of ASBTNM in complex with pantoate
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, CADMIUM ION, PANTOATE, ...
Authors:Becker, P, Cameron, A.D.
Deposit date:2023-05-04
Release date:2023-07-12
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Mechanism of substrate binding and transport in BASS transporters.
Biorxiv, 2023
7VAF
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BU of 7vaf by Molmil
Cryo-EM structure of Rat NTCP complexed with YN69202Fab
Descriptor: Fab heavy chain from antibody IgG clone number YN69202, Fab light chain from antibody IgG clone number YN69202, Sodium/bile acid cotransporter
Authors:Asami, J, Shimizu, T, Ohto, U.
Deposit date:2021-08-29
Release date:2022-05-25
Last modified:2022-07-13
Method:ELECTRON MICROSCOPY (3.11 Å)
Cite:Structure of the bile acid transporter and HBV receptor NTCP.
Nature, 606, 2022
7VAE
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BU of 7vae by Molmil
Cryo-EM structure of bovine NTCP complexed with YN69202Fab
Descriptor: Fab heavy chain from antibody IgG clone number YN69202, Fab light chain from antibody IgG clone number YN69202, Solute carrier family 10 (Sodium/bile acid cotransporter family), ...
Authors:Asami, J, Shimizu, T, Ohto, U.
Deposit date:2021-08-29
Release date:2022-05-25
Last modified:2022-07-13
Method:ELECTRON MICROSCOPY (3.55 Å)
Cite:Structure of the bile acid transporter and HBV receptor NTCP.
Nature, 606, 2022
7VAD
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BU of 7vad by Molmil
Cryo-EM structure of human NTCP complexed with YN69202Fab
Descriptor: Fab heavy chain from antibody IgG clone number YN69202, Fab light chain from antibody IgG clone number YN69202, Sodium/bile acid cotransporter
Authors:Asami, J, Shimizu, T, Ohto, U.
Deposit date:2021-08-29
Release date:2022-05-25
Last modified:2022-07-13
Method:ELECTRON MICROSCOPY (3.41 Å)
Cite:Structure of the bile acid transporter and HBV receptor NTCP.
Nature, 606, 2022
7VAG
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BU of 7vag by Molmil
Cryo-EM structure of human NTCP complexed with YN69202Fab in the presence of myristoylated preS1 peptide
Descriptor: Fab heavy chain from antibody IgG clone number YN69202, Fab light chain from antibody IgG clone number YN69202, Sodium/bile acid cotransporter
Authors:Asami, J, Shimizu, T, Ohto, U.
Deposit date:2021-08-29
Release date:2022-05-25
Last modified:2022-07-13
Method:ELECTRON MICROSCOPY (3.32 Å)
Cite:Structure of the bile acid transporter and HBV receptor NTCP.
Nature, 606, 2022
6LGY
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BU of 6lgy by Molmil
Crystal structure of a cysteine-pair mutant (P10C-S291C) of a bacterial bile acid transporter in an inward-facing state complexed with glycine and sodium
Descriptor: 2,3-dihydroxypropyl (9Z)-octadec-9-enoate, GLYCINE, NONAETHYLENE GLYCOL, ...
Authors:Wang, X, Lyu, Y, Ji, Y, Sun, Z, Zhou, X.
Deposit date:2019-12-06
Release date:2020-12-09
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.247 Å)
Cite:Substrate binding in the bile acid transporter ASBT Yf from Yersinia frederiksenii.
Acta Crystallogr D Struct Biol, 77, 2021
6LH0
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BU of 6lh0 by Molmil
Crystal structure of a cysteine-pair mutant (P10C-S291C) of a bacterial bile acid transporter in an inward-facing apo-state
Descriptor: 2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Transporter, sodium/bile acid symporter family
Authors:Wang, X, Lyu, Y, Ji, Y, Sun, Z, Zhou, X.
Deposit date:2019-12-06
Release date:2020-12-09
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.812 Å)
Cite:Substrate binding in the bile acid transporter ASBT Yf from Yersinia frederiksenii.
Acta Crystallogr D Struct Biol, 77, 2021
6LGZ
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BU of 6lgz by Molmil
Crystal structure of a cysteine-pair mutant (P10C-S291C) of a bacterial bile acid transporter in an inward-facing state complexed with sulfate
Descriptor: 2,3-dihydroxypropyl (9Z)-octadec-9-enoate, SULFATE ION, Transporter, ...
Authors:Wang, X, Lyu, Y, Ji, Y, Sun, Z, Zhou, X.
Deposit date:2019-12-06
Release date:2020-12-09
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.428 Å)
Cite:Substrate binding in the bile acid transporter ASBT Yf from Yersinia frederiksenii.
Acta Crystallogr D Struct Biol, 77, 2021
6LH1
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BU of 6lh1 by Molmil
Crystal structure of a cysteine-pair mutant (Y113C-P190C) of a bacterial bile acid transporter trapped in an outward-facing conformation
Descriptor: 2,3-dihydroxypropyl (9Z)-octadec-9-enoate, CITRIC ACID, Transporter, ...
Authors:Wang, X, Lyu, Y, Ji, Y, Sun, Z, Zhou, X.
Deposit date:2019-12-06
Release date:2020-12-09
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.861 Å)
Cite:An engineered disulfide bridge traps and validates an outward-facing conformation in a bile acid transporter.
Acta Crystallogr D Struct Biol, 77, 2021
6LGV
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BU of 6lgv by Molmil
Crystal structure of a cysteine-pair mutant (P10C-S291C) of a bacterial bile acid transporter in an inward-facing state complexed with citrate
Descriptor: 2,3-dihydroxypropyl (9Z)-octadec-9-enoate, CITRIC ACID, Transporter, ...
Authors:Wang, X, Lyu, Y, Ji, Y, Sun, Z, Zhou, X.
Deposit date:2019-12-06
Release date:2020-12-09
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.847 Å)
Cite:Substrate binding in the bile acid transporter ASBT Yf from Yersinia frederiksenii.
Acta Crystallogr D Struct Biol, 77, 2021
7WSI
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BU of 7wsi by Molmil
Cryo-EM structure of human NTCP (wild-type) complexed with YN69202Fab
Descriptor: Fab heavy chain from antibody IgG clone number YN69202, Fab light chain from antibody IgG clone number YN69202, Sodium/bile acid cotransporter
Authors:Asami, J, Shimizu, T, Ohto, U.
Deposit date:2022-01-29
Release date:2022-05-25
Last modified:2022-07-13
Method:ELECTRON MICROSCOPY (3.32 Å)
Cite:Structure of the bile acid transporter and HBV receptor NTCP.
Nature, 606, 2022
7PQQ
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BU of 7pqq by Molmil
Structure of thermostabilised human NTCP in complex with Megabody 91
Descriptor: Anti-RON nanobody,Megabody 91,Glucosidase YgjK, Sodium/bile acid cotransporter
Authors:Goutam, K, Reyes, N.
Deposit date:2021-09-18
Release date:2022-05-18
Last modified:2022-07-06
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structural basis of sodium-dependent bile salt uptake into the liver.
Nature, 606, 2022
8HRX
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BU of 8hrx by Molmil
Cryo-EM structure of human NTCP-myr-preS1-YN9048Fab complex
Descriptor: Fab heavy chain from antibody IgG clone number YN9048, Fab light chain from antibody IgG clone number YN9048, PreS1 protein (Fragment), ...
Authors:Asami, J, Shimizu, T, Ohto, U.
Deposit date:2022-12-16
Release date:2024-01-17
Last modified:2024-01-31
Method:ELECTRON MICROSCOPY (2.89 Å)
Cite:Structural basis of hepatitis B virus receptor binding.
Nat.Struct.Mol.Biol., 2024

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