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4XQ2	Ensemble refinement of cystathione gamma lyase (CalE6) D7G from Micromonospora echinospora Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, CalE6, ... Authors: Wang, F, Yennamalli, R.M, Singh, S, Tan, K, Thorson, J.S, Phillips Jr, G.N, Enzyme Discovery for Natural Product Biosynthesis (NatPro) Deposit date: 2015-01-18 Release date: 2015-04-15 Method: X-RAY DIFFRACTION (2.1 Å) Cite: The crystal structure of cystathione gamma lyase (CalE6) from Micromonospora echinospora To Be Published
6S0C	Crystal structure of methionine gamma-lyase from Citrobacter freundii modified by dimethylthiosulfinate Descriptor: Cystathionine gamma-synthase, PYRIDOXAL-5'-PHOSPHATE, TRIETHYLENE GLYCOL Authors: Revtovich, S.V, Morozova, E.A, Nikulin, A.D, Demidkina, T.V. Deposit date: 2019-06-14 Release date: 2020-04-22 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.46 Å) Cite: Sulfoxides of sulfur-containing amino acids are suicide substrates of Citrobacter freundii methionine gamma-lyase. Structural bases of the enzyme inactivation. Biochimie, 168, 2020
5M3Z	Crystal structure of Citrobacter freundii methionine gamma-lyase with C115H replacement in the complex with L-norleucine Descriptor: 2-[O-PHOSPHONOPYRIDOXYL]-AMINO-HEXANOIC ACID, Methionine gamma-lyase, NORLEUCINE, ... Authors: Revtovich, S.V, Nikulin, A.D, Anufrieva, N.V, Morozova, E.A, Demidkina, T.V. Deposit date: 2016-10-17 Release date: 2017-06-28 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.45 Å) Cite: Crystal structure of mutant form Cys115His of Citrobacter freundii methionine gamma-lyase complexed with l-norleucine. Biochim. Biophys. Acta, 1865, 2017
7YEO	Crystal Structure of cystathionine gamma-synthase-like protein C23A1.14c Descriptor: MAGNESIUM ION, PYRIDOXAL-5'-PHOSPHATE, Uncharacterized trans-sulfuration enzyme C23A1.14c Authors: Zhang, S.J. Deposit date: 2022-07-06 Release date: 2023-01-11 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Crystal Structure of cystathionine gamma-synthase-like protein C23A1.14c To Be Published
7SWH	Crystal Structure of Putative cystathionine gamma-synthase from Burkholderia pseudomallei in Complex with PLP Descriptor: 1,2-ETHANEDIOL, Putative cystathionine gamma-synthase Authors: Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2021-11-19 Release date: 2021-12-01 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Crystal Structure of Putative cystathionine gamma-synthase from Burkholderia pseudomallei in Complex with PLP to be published
5X5H	Crystal structure of metB from Corynebacterium glutamicum Descriptor: Cystathionine beta-lyases/cystathionine gamma-synthases, GLYCEROL, MAGNESIUM ION, ... Authors: Sagong, H.-Y, Kim, K.-J. Deposit date: 2017-02-16 Release date: 2017-03-01 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.51 Å) Cite: Structural Insights into Substrate Specificity of Cystathionine gamma-Synthase from Corynebacterium glutamicum J. Agric. Food Chem., 65, 2017
5X2X	Crystal structure of Pseudomonas putida methionine gamma-lyase wild type with L-homocysteine intermediates Descriptor: (2E)-2-{[(1E)-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene]amino}but-2-enoic acid, HYDROSULFURIC ACID, L-methionine gamma-lyase Authors: Shiba, T, Sato, D, Harada, S. Deposit date: 2017-02-02 Release date: 2017-04-12 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural and mechanistic insights into homocysteine degradation by a mutant of methionine gamma-lyase based on substrate-assisted catalysis Protein Sci., 26, 2017
6NBA	Crystal structure of Human Cystathionine gamma lyase with S-3-Carboxpropyl-L-Cysteine Descriptor: 2-[({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)AMINO]ACRYLIC ACID, Cystathionine gamma-lyase Authors: Kim, H, Yadav, P.K, Banerjee, R, Cho, U.-S. Deposit date: 2018-12-06 Release date: 2019-06-12 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.495 Å) Cite: S-3-Carboxypropyl-l-cysteine specifically inhibits cystathionine gamma-lyase-dependent hydrogen sulfide synthesis. J.Biol.Chem., 294, 2019
2FQ6	Cystathionine beta-lyase (cbl) from escherichia coli in complex with n-hydrazinocarbonylmethyl-2-trifluoromethyl-benzamide Descriptor: Cystathionine beta-lyase, PHOSPHORIC ACID MONO-(5-HYDROXY-6-METHYL-4-{[2-(2-TRIFLUOROMETHYL-BENZOYLAMINO)-ACETYL]-HYDRAZONOMETHYL}-PYRIDIN-3-YLMETHYL)ESTER Authors: Junop, M.S. Deposit date: 2006-01-17 Release date: 2006-12-26 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.78 Å) Cite: Inhibitors of bacterial cystathionine beta-lyase: leads for new antimicrobial agents and probes of enzyme structure and function. J.Med.Chem., 50, 2007
6OVG	L-Methionine Depletion with an Engineered Human Enzyme Disrupts Prostate Cancer Metabolism Descriptor: Cystathionine gamma-lyase, SULFATE ION Authors: Yan, W, Irani, S, Zhang, J. Deposit date: 2019-05-07 Release date: 2020-04-22 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.719 Å) Cite: Enzyme-mediated depletion of serum l-Met abrogates prostate cancer growth via multiple mechanisms without evidence of systemic toxicity. Proc.Natl.Acad.Sci.USA, 117, 2020
5IJG	Crystal structure of O-acetylhomoserine sulfhydrolase from Brucella melitensis at 2.0 A resolution Descriptor: Cys/Met metabolism pyridoxal-phosphate-dependent enzyme, GLYCEROL, PYRIDOXAL-5'-PHOSPHATE Authors: Boyko, K.M, Nikolaeva, A.Y, Koolikova, V.V, Kotlov, M.I, Demidkina, T.V, Popov, V.O. Deposit date: 2016-03-02 Release date: 2017-04-05 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal structure of O-acetylhomoserine sulfhydrolase from Brucella melitensis at 2.0 A resolution To Be Published
1UKJ	Detailed structure of L-Methionine-Lyase from Pseudomonas putida Descriptor: Methionine gamma-lyase, SULFATE ION Authors: Misaki, S, Takimoto, A, Takakura, T, Yoshioka, T, Yamashita, M, Tamura, T, Tanaka, H, Inagaki, K. Deposit date: 2003-08-24 Release date: 2004-10-19 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Detailed structure of L-Methionine -Lyase from Pseudomonas putida To be Published
2GQN	Cystathionine Beta-Lyase (CBL) from Escherichia Coli in complex with N-Hydrazinocarbonylmethyl-2-Nitro-Benzamide Descriptor: (5-HYDROXY-6-METHYL-4-((2-(2-(2-NITROBENZAMIDO)ACETYL)HYDRAZINYL)METHYL)PYRIDIN-3-YL)METHYL DIHYDROGEN PHOSPHATE, Cystathionine beta-lyase Authors: Summerfield, R, Junop, M.S. Deposit date: 2006-04-21 Release date: 2007-03-06 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Inhibitors of Bacterial Cystathionine beta-Lyase: Leads for New Antimicrobial Agents and Probes of Enzyme Structure and Function. J.Med.Chem., 50, 2007
5K30	Crystal structure of methionine gamma-lyase from Citrobacter freundii modified by S-Ethyl-L-cysteine sulfoxide Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DI(HYDROXYETHYL)ETHER, Methionine gamma-lyase, ... Authors: Revtovich, S.V, Nikulin, A.D, Morozova, E.A, Demidkina, T.V. Deposit date: 2016-05-19 Release date: 2017-07-12 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.59 Å) Cite: Sulfoxides of sulfur-containing amino acids are suicide substrates of Citrobacter freundii methionine gamma-lyase. Structural bases of the enzyme inactivation. Biochimie, 168, 2020
2CB1	Crystal Structure of O-actetyl Homoserine Sulfhydrylase From Thermus Thermophilus HB8,OAH2. Descriptor: O-ACETYL HOMOSERINE SULFHYDRYLASE, PYRIDOXAL-5'-PHOSPHATE Authors: Imagawa, T, Utsunomiya, H, Tsuge, H, Ebihara, A, Kanagawa, M, Nakagawa, N, Kuroishi, C, Agari, Y, Kuramitsu, S, Yokoyama, S. Deposit date: 2005-12-28 Release date: 2007-01-03 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2 Å) Cite: The Crystal Structure of O-Acetyl Homoserine Sulfhydrylase To be Published
2CTZ	Crystal structure of o-acetyl homoserine sulfhydrylase from Thermus thermophilus HB8 Descriptor: O-acetyl-L-homoserine sulfhydrylase, PYRIDOXAL-5'-PHOSPHATE Authors: Imagawa, T, Kousumi, Y, Tsuge, H, Utsunomiya, H, Ebihara, A, Nakagawa, N, Yokoyama, S, Kuramitsu, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2005-05-24 Release date: 2005-11-24 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Crystal structure of o-acetyl homoserine sulfhydrylase from Thermus thermophilus HB8 To be Published
1Y4I	Crystal structure of Citrobacter Freundii L-methionine-lyase Descriptor: SULFATE ION, methionine gamma-lyase Authors: Revtovich, S.V, Mamaeva, D.V, Morozova, E.A, Nikulin, A.D, Nikonov, S.V, Garber, M.B, Demidkina, T.V. Deposit date: 2004-12-01 Release date: 2005-06-14 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structure of Citrobacter freundii L-methionine gamma-lyase. Acta Crystallogr.,Sect.F, 61, 2005
6CJA	Crystal structure of Cystathionine beta-lyase from Legionella pneumophila Philadelphia 1 in complex with Alanyl-PLP and Serine Descriptor: (E)-N-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)-L-alanine, Cystathionine beta-lyase, GLYCEROL, ... Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2018-02-26 Release date: 2018-03-21 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Crystal structure of Cystathionine beta-lyase from Legionella pneumophila Philadelphia 1 in complex with Alanyl-PLP and Serine to be published
6CJB	Crystal structure of Cystathionine beta-lyase from Legionella pneumophila Philadelphia 1 covalently bound to Pyridoxal phosphate Descriptor: Cystathionine beta-lyase, FORMIC ACID, GLYCEROL Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2018-02-26 Release date: 2018-03-21 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Crystal structure of Cystathionine beta-lyase from Legionella pneumophila Philadelphia 1 covalently bound to Pyridoxal phosphate to be published
8ERB	Crystal structure of Fub7 in complex with vinylglycine ketimine Descriptor: (2E)-2-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)imino]but-3-enoic acid, Sulfhydrylase FUB7 Authors: Hai, Y. Deposit date: 2022-10-11 Release date: 2023-10-18 Last modified: 2024-03-27 Method: X-RAY DIFFRACTION (1.98 Å) Cite: Molecular and Structural Basis for C gamma-C Bond Formation by PLP-Dependent Enzyme Fub7. Angew.Chem.Int.Ed.Engl., 63, 2024
8EQW	Crystal structure of Fub7 Descriptor: Sulfhydrylase FUB7 Authors: Hai, Y. Deposit date: 2022-10-10 Release date: 2023-10-11 Last modified: 2024-03-27 Method: X-RAY DIFFRACTION (1.76 Å) Cite: Molecular and Structural Basis for C gamma-C Bond Formation by PLP-Dependent Enzyme Fub7. Angew.Chem.Int.Ed.Engl., 63, 2024
8ERJ	Crystal structure of Fub7 in complex with E-2-aminocrotonate Descriptor: (2E)-2-{[(1E)-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene]amino}but-2-enoic acid, (2S)-2-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]but-3-enoic acid, Sulfhydrylase FUB7 Authors: Hai, Y. Deposit date: 2022-10-12 Release date: 2023-10-25 Last modified: 2024-03-27 Method: X-RAY DIFFRACTION (2.16 Å) Cite: Molecular and Structural Basis for C gamma-C Bond Formation by PLP-Dependent Enzyme Fub7. Angew.Chem.Int.Ed.Engl., 63, 2024
4Q31	The crystal structure of cystathione gamma lyase (CalE6) from Micromonospora echinospora Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, FORMIC ACID, ... Authors: Tan, K, Bigelow, L, Jedrzejczak, R, Babnigg, G, Bingman, C.A, Yennamalli, R.M, Singh, S, Kharel, M.K, Thorson, J.S, Phillips Jr, G.N, Joachimiak, A, Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro) Deposit date: 2014-04-10 Release date: 2014-05-07 Last modified: 2017-03-08 Method: X-RAY DIFFRACTION (2.099 Å) Cite: Structural dynamics of a methionine gamma-lyase for calicheamicin biosynthesis: Rotation of the conserved tyrosine stacking with pyridoxal phosphate. Struct Dyn, 3, 2016
7BQW	Crystal structure of Methionine gamma-lyase from Fusobacterium nucleatum Descriptor: L-methionine gamma-lyase Authors: Lan, J, Chen, Y, Liu, W, Xu, Y. Deposit date: 2020-03-25 Release date: 2020-04-15 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Crystal structure of Methionine gamma-lyase from Fusobacterium nucleatum To Be Published
7BA4	Structure of Cystathionine gamma-lyase from Pseudomonas aeruginosa Descriptor: Cystathionine gamma-lyase, PYRIDOXAL-5'-PHOSPHATE Authors: Fernandez-Rodriguez, C, Oyenarte, I, Gonzalez-Recio, I, Majtan, T, Astegno, A, Martinez-Cruz, L.A. Deposit date: 2020-12-15 Release date: 2021-09-29 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2 Å) Cite: Structure of Cystathionine gamma-lyase from Pseudomonas aeruginosa To Be Published

 

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