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5T1J
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BU of 5t1j by Molmil
Crystal Structure of the Tbox DNA binding domain of the transcription factor T-bet
Descriptor: DNA, T-box transcription factor TBX21
Authors:Liu, C.F, Brandt, G.S, Hoang, Q, Hwang, E.S, Naumova, N, Lazarevic, V, Dekker, J, Glimcher, L.H, Ringe, D, Petsko, G.A.
Deposit date:2016-08-19
Release date:2016-10-26
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.947 Å)
Cite:Crystal structure of the DNA binding domain of the transcription factor T-bet suggests simultaneous recognition of distant genome sites.
Proc.Natl.Acad.Sci.USA, 113, 2016
6ZU8
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BU of 6zu8 by Molmil
Crystal structure of human Brachyury G177D variant in complex with Afatinib
Descriptor: Brachyury protein, N-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3S)-tetrahydrofuran-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)butanamide, ZINC ION
Authors:Newman, J.A, Gavard, A.E, Shrestha, L, Burgess-Brown, N.A, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O.
Deposit date:2020-07-21
Release date:2020-08-05
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal structure of human Brachyury G177D variant in complex with Afatinib
To Be Published
4A04
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BU of 4a04 by Molmil
Structure of the DNA-bound T-box domain of human TBX1, a transcription factor associated with the DiGeorge syndrome
Descriptor: DNA, T-BOX TRANSCRIPTION FACTOR TBX1
Authors:El Omari, K, De Mesmaeker, J, Karia, D, Ginn, H, Bhattacharya, S, Mancini, E.J.
Deposit date:2011-09-07
Release date:2011-10-12
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.58 Å)
Cite:Structure of the DNA-Bound T-Box Domain of Human Tbx1, a Transcription Factor Associated with the Digeorge Syndrome
Proteins, 80, 2012
8FMU
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BU of 8fmu by Molmil
Crystal structure of human Brachyury G177D variant in complex with SJF-4601
Descriptor: N-(3-chloro-4-fluorophenyl)-3-[4-(dimethylamino)butanamido]-4-methoxybenzamide, T-box transcription factor T
Authors:Bebenek, A, Linhares, B, Jaime-Figueroa, S, Butrin, A, Crews, C.
Deposit date:2022-12-24
Release date:2024-02-28
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Discovery and Development of the First Selective Brachyury Degrader
To Be Published
8CDN
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BU of 8cdn by Molmil
Crystal structure of human Brachyury in complex with a single T box binding element DNA
Descriptor: DNA (5'-D(*AP*GP*GP*CP*TP*CP*AP*CP*AP*CP*CP*T)-3'), DNA (5'-D(*AP*GP*GP*TP*GP*TP*GP*AP*GP*CP*CP*T)-3'), T-box transcription factor T
Authors:Newman, J.A, Gavard, A.E, von Delft, F, Gileadi, O, Bountra, C.
Deposit date:2023-01-31
Release date:2023-03-22
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Crystal structure of human Brachyury in complex with a single T box binding element DNA
To Be Published
1H6F
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BU of 1h6f by Molmil
Human TBX3, a transcription factor responsible for ulnar-mammary syndrome, bound to a palindromic DNA site
Descriptor: 5'-D(*TP*AP*AP*TP*TP*TP*CP*AP*CP*AP*CP*CP*TP* AP*GP*GP*TP*GP*TP*GP*AP*AP*AP*T)-3', MAGNESIUM ION, T-BOX TRANSCRIPTION FACTOR TBX3
Authors:Coll, M, Muller, C.W.
Deposit date:2001-06-13
Release date:2002-04-19
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure of the DNA-Bound T-Box Domain of Human Tbx3, a Transcription Factor Responsible for Ulnar- Mammary Syndrome
Structure, 10, 2002
1XBR
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BU of 1xbr by Molmil
T DOMAIN FROM XENOPUS LAEVIS BOUND TO DNA
Descriptor: DNA (5'-D(*AP*AP*TP*TP*TP*CP*AP*CP*AP*CP*CP*TP*AP*GP*GP*TP*G P*TP*GP*AP*AP*AP* TP*T)-3'), PROTEIN (T PROTEIN)
Authors:Muller, C.W.
Deposit date:1997-07-16
Release date:1998-01-16
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystallographic structure of the T domain-DNA complex of the Brachyury transcription factor.
Nature, 389, 1997
5BQD
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BU of 5bqd by Molmil
Crystal Structure of TBX5 (1-239) Dimer
Descriptor: MAGNESIUM ION, T-box transcription factor TBX5
Authors:Pradhan, L, Gopal, S, Patel, A, Kasahara, H, Nam, H.J.
Deposit date:2015-05-28
Release date:2016-03-16
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.583 Å)
Cite:Intermolecular Interactions of Cardiac Transcription Factors NKX2.5 and TBX5.
Biochemistry, 55, 2016
8A10
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BU of 8a10 by Molmil
Crystal Structure of human Brachyury G177D variant in complex with Molpolrt-020-049-143
Descriptor: T-box transcription factor T, UNKNOWN LIGAND
Authors:Newman, J.A, Gavard, A, Aitkenhead, H, Imprachim, N, Sherestha, L, Burgess-Brown, N.A, von Delft, F, Bountra, C, Gileadi, O.
Deposit date:2022-05-30
Release date:2022-07-13
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Crystal Structure of human Brachyury G177D variant in complex with Molpolrt-020-049-143
To Be Published
8A7N
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BU of 8a7n by Molmil
Crystal Structure of human Brachyury G177D variant in complex with (S)-N-(3-aminopropyl)-3-((1-(2-fluorophenyl)-2-oxopyrrolidin-3-yl)amino)-N-methylbenzamide (CF-2-125)
Descriptor: N-(3-azanylpropyl)-3-[[(3S)-1-(2-fluorophenyl)-2-oxidanylidene-pyrrolidin-3-yl]amino]-N-methyl-benzamide, PHOSPHATE ION, T-box transcription factor T
Authors:Newman, J.A, Gavard, A, Aitkenhead, H, Imprachim, N, Sherestha, L, Burgess-Brown, N.A, von Delft, F, Bountra, C, Gileadi, O.
Deposit date:2022-06-21
Release date:2022-10-05
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal Structure of human Brachyury G177D variant in complex with (S)-N-(3-aminopropyl)-3-((1-(2-fluorophenyl)-2-oxopyrrolidin-3-yl)amino)-N-methylbenzamide (CF-2-125)
To Be Published
2X6U
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BU of 2x6u by Molmil
Crystal structure of human TBX5 in the DNA-free form
Descriptor: 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, MAGNESIUM ION, T-BOX TRANSCRIPTION FACTOR TBX5
Authors:Stirnimann, C.U, Mueller, C.W.
Deposit date:2010-02-22
Release date:2010-04-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural Basis of Tbx5-DNA Recognition: The T-Box Domain in its DNA-Bound and -Unbound Form.
J.Mol.Biol., 400, 2010
2X6V
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BU of 2x6v by Molmil
Crystal structure of human TBX5 in the DNA-bound and DNA-free form
Descriptor: 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, 5'-D(*TP*AP*AP*GP*GP*TP*GP*TP*GP*AP*GP)-3', 5'-D(*TP*CP*TP*CP*AP*CP*AP*CP*CP*TP*TP)-3', ...
Authors:Ptchelkine, D, Stirnimann, C.U, Grimm, C, Mueller, C.W.
Deposit date:2010-02-22
Release date:2010-04-28
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Basis of Tbx5-DNA Recognition: The T-Box Domain in its DNA-Bound and -Unbound Form.
J.Mol.Biol., 400, 2010
6F59
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BU of 6f59 by Molmil
Crystal structure of human Brachyury (T) G177D variant in complex with DNA
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, Brachyury protein, DNA (26-MER), ...
Authors:Newman, J.A, Gavard, A.E, Krojer, T, Shrestha, L, Burgess-Brown, N.A, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O.
Deposit date:2017-12-01
Release date:2017-12-13
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.151 Å)
Cite:Crystal structure of human Brachyury (T) G177D variant in complex with DNA
To Be Published
6F58
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BU of 6f58 by Molmil
Crystal structure of human Brachyury (T) in complex with DNA
Descriptor: Brachyury protein, DNA (5'-D(*AP*AP*TP*TP*TP*CP*AP*CP*AP*CP*CP*TP*AP*GP*GP*TP*GP*TP*GP*AP*AP*AP*TP*T)-3'), SODIUM ION
Authors:Newman, J.A, Gavard, A.E, Krojer, T, Shrestha, L, Burgess-Brown, N.A, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O.
Deposit date:2017-12-01
Release date:2017-12-13
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.253 Å)
Cite:Crystal structure of human Brachyury (T) in complex with DNA
To Be Published
7ZK2
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BU of 7zk2 by Molmil
Crystal Structure of human Brachyury G177D variant in complex with CSC027898502
Descriptor: N-[4-(2-morpholin-4-yl-1,3-thiazol-4-yl)phenyl]ethanamide, PHOSPHATE ION, T-box transcription factor T
Authors:Newman, J.A, Gavard, A, Aitkenhead, H, Imprachim, N, Sherestha, L, Burgess-Brown, N.A, von Delft, F, Bountra, C, Gileadi, O.
Deposit date:2022-04-12
Release date:2022-06-22
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal Structure of human Brachyury G177D variant in complex with CSC027898502
To Be Published
7ZL2
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BU of 7zl2 by Molmil
Crystal Structure of human Brachyury G177D variant in complex with Molpolrt-039-246-810
Descriptor: T-box transcription factor T, UNKNOWN LIGAND
Authors:Newman, J.A, Gavard, A, Aitkenhead, H, Imprachim, N, Sherestha, L, Burgess-Brown, N.A, von Delft, F, Bountra, C, Gileadi, O.
Deposit date:2022-04-13
Release date:2022-06-22
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal Structure of human Brachyury G177D variant in complex with Molpolrt-039-246-810
To Be Published
7ZKF
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BU of 7zkf by Molmil
Crystal Structure of human Brachyury G177D variant in complex with CF-5-86
Descriptor: PHOSPHATE ION, T-box transcription factor T, UNKNOWN LIGAND
Authors:Newman, J.A, Gavard, A, Aitkenhead, H, Imprachim, N, Sherestha, L, Burgess-Brown, N.A, von Delft, F, Bountra, C, Gileadi, O.
Deposit date:2022-04-12
Release date:2022-06-22
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:Crystal Structure of human Brachyury G177D variant in complex with CF-5-86
To Be Published
5QSL
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BU of 5qsl by Molmil
PanDDA analysis group deposition -- Crystal Structure of human Brachyury in complex with Z1273312153
Descriptor: CADMIUM ION, N-methyl-1H-indole-7-carboxamide, T-box transcription factor T
Authors:Newman, J.A, Gavard, A.E, Fernandez-Cid, A, Sherestha, L, Burgess-Brown, N.A, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O.
Deposit date:2019-05-25
Release date:2019-07-10
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:PanDDA analysis group deposition
To Be Published
5QRH
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BU of 5qrh by Molmil
PanDDA analysis group deposition -- Crystal Structure of human Brachyury in complex with Z32327641
Descriptor: CADMIUM ION, T-box transcription factor T, [4-(cyclopropanecarbonyl)piperazin-1-yl](furan-2-yl)methanone
Authors:Newman, J.A, Gavard, A.E, Fernandez-Cid, A, Sherestha, L, Burgess-Brown, N.A, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O.
Deposit date:2019-05-25
Release date:2019-07-10
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:PanDDA analysis group deposition
To Be Published
5QS6
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BU of 5qs6 by Molmil
PanDDA analysis group deposition -- Crystal Structure of human Brachyury G177D variant in complex with Z44592329
Descriptor: N-phenyl-N'-pyridin-3-ylurea, T-box transcription factor T
Authors:Newman, J.A, Gavard, A.E, Sherestha, L, Fernandez-Cid, A, Burgess-Brown, N.A, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O.
Deposit date:2019-06-19
Release date:2019-08-21
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:PanDDA analysis group deposition
To Be Published
5QSK
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BU of 5qsk by Molmil
PanDDA analysis group deposition -- Crystal Structure of human Brachyury G177D variant in complex with Z2856434906
Descriptor: (benzyloxy)acetic acid, T-box transcription factor T
Authors:Newman, J.A, Gavard, A.E, Sherestha, L, Burgess-Brown, N.A, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O.
Deposit date:2019-05-25
Release date:2019-08-21
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:PanDDA analysis group deposition
To Be Published
5QS7
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BU of 5qs7 by Molmil
PanDDA analysis group deposition -- Crystal Structure of human Brachyury G177D variant in complex with Z32327641
Descriptor: T-box transcription factor T, [4-(cyclopropanecarbonyl)piperazin-1-yl](furan-2-yl)methanone
Authors:Newman, J.A, Gavard, A.E, Sherestha, L, Burgess-Brown, N.A, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O.
Deposit date:2019-05-25
Release date:2019-08-21
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:PanDDA analysis group deposition
To Be Published
5QRM
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BU of 5qrm by Molmil
PanDDA analysis group deposition -- Crystal Structure of human Brachyury in complex with Z1899842917
Descriptor: 3-[(3,5-dimethyl-1,2-oxazol-4-yl)methyl]-5-methyl-1,3,4-thiadiazol-2(3H)-one, CADMIUM ION, T-box transcription factor T
Authors:Newman, J.A, Gavard, A.E, Fernandez-Cid, A, Sherestha, L, Burgess-Brown, N.A, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O.
Deposit date:2019-05-25
Release date:2019-07-10
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:PanDDA analysis group deposition
To Be Published
5QSD
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BU of 5qsd by Molmil
PanDDA analysis group deposition -- Crystal Structure of human Brachyury G177D variant in complex with Z54571979
Descriptor: N-{4-[(pyrimidin-2-yl)oxy]phenyl}acetamide, T-box transcription factor T
Authors:Newman, J.A, Gavard, A.E, Sherestha, L, Burgess-Brown, N.A, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O.
Deposit date:2019-05-25
Release date:2019-08-21
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:PanDDA analysis group deposition
To Be Published
5QRI
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BU of 5qri by Molmil
PanDDA analysis group deposition -- Crystal Structure of human Brachyury in complex with Z2856434826
Descriptor: CADMIUM ION, T-box transcription factor T, [4-(propan-2-yl)piperazin-1-yl](thiophen-2-yl)methanone
Authors:Newman, J.A, Gavard, A.E, Fernandez-Cid, A, Sherestha, L, Burgess-Brown, N.A, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O.
Deposit date:2019-05-25
Release date:2019-07-10
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:PanDDA analysis group deposition
To Be Published

 

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217705

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