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5F1C
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BU of 5f1c by Molmil
Crystal structure of an invertebrate P2X receptor from the Gulf Coast tick in the presence of ATP and Zn2+ ion at 2.9 Angstroms
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-TRIPHOSPHATE, Putative uncharacterized protein, ...
Authors:Kasuya, G, Hattori, M, Ishitani, R, Nureki, O.
Deposit date:2015-11-30
Release date:2016-03-16
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural Insights into Divalent Cation Modulations of ATP-Gated P2X Receptor Channels
Cell Rep, 14, 2016
3H9V
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BU of 3h9v by Molmil
Crystal structure of the ATP-gated P2X4 ion channel in the closed, apo state at 3.1 Angstroms
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GADOLINIUM ATOM, P2X purinoceptor
Authors:Kawate, T, Michel, J.C, Gouaux, E.
Deposit date:2009-04-30
Release date:2009-07-28
Last modified:2021-10-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Crystal structure of the ATP-gated P2X(4) ion channel in the closed state.
Nature, 460, 2009
3I5D
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BU of 3i5d by Molmil
Crystal structure of the ATP-gated P2X4 ion channel in the closed, apo state at 3.5 Angstroms (R3)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, P2X purinoceptor
Authors:Kawate, T, Michel, J.C, Gouaux, E.
Deposit date:2009-07-05
Release date:2009-08-04
Last modified:2021-10-13
Method:X-RAY DIFFRACTION (3.46 Å)
Cite:Crystal structure of the ATP-gated P2X(4) ion channel in the closed state.
Nature, 460, 2009
4DW0
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BU of 4dw0 by Molmil
Crystal structure of the ATP-gated P2X4 ion channel in the closed, apo state at 2.9 Angstroms
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, GADOLINIUM ATOM, GLYCEROL, ...
Authors:Hattori, M, Gouaux, E.
Deposit date:2012-02-24
Release date:2012-04-25
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Molecular mechanism of ATP binding and ion channel activation in P2X receptors.
Nature, 485, 2012
4DW1
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BU of 4dw1 by Molmil
Crystal structure of the ATP-gated P2X4 ion channel in the ATP-bound, open state at 2.8 Angstroms
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-TRIPHOSPHATE, GLYCEROL, ...
Authors:Hattori, M, Gouaux, E.
Deposit date:2012-02-24
Release date:2012-04-25
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Molecular mechanism of ATP binding and ion channel activation in P2X receptors.
Nature, 485, 2012
5WZY
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BU of 5wzy by Molmil
Crystal structure of the P2X4 receptor from zebrafish in the presence of CTP at 2.8 Angstroms
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CYTIDINE-5'-TRIPHOSPHATE, GLYCEROL, ...
Authors:Kasuya, G, Hattori, M, Nureki, O.
Deposit date:2017-01-19
Release date:2017-04-05
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.799 Å)
Cite:Structural insights into the nucleotide base specificity of P2X receptors
Sci Rep, 7, 2017
8JV5
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BU of 8jv5 by Molmil
Cryo-EM structure of the zebrafish P2X4 receptor in complex with BX430
Descriptor: 1-[2,6-bis(bromanyl)-4-propan-2-yl-phenyl]-3-pyridin-3-yl-urea, 2-acetamido-2-deoxy-beta-D-glucopyranose, P2X purinoceptor
Authors:Hattori, M, Shen, C.
Deposit date:2023-06-27
Release date:2023-10-18
Last modified:2023-10-25
Method:ELECTRON MICROSCOPY (3.23 Å)
Cite:Structural insights into the allosteric inhibition of P2X4 receptors.
Nat Commun, 14, 2023
8JV6
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BU of 8jv6 by Molmil
Cryo-EM structures of the zebrafish P2X4 receptor in complex with BAY-1797
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, N-[4-(3-chloranylphenoxy)-3-sulfamoyl-phenyl]-2-phenyl-ethanamide, P2X purinoceptor
Authors:Hattori, M, Shen, C.
Deposit date:2023-06-27
Release date:2023-10-18
Last modified:2023-10-25
Method:ELECTRON MICROSCOPY (3.43 Å)
Cite:Structural insights into the allosteric inhibition of P2X4 receptors.
Nat Commun, 14, 2023
8JV7
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BU of 8jv7 by Molmil
Cryo-EM structures of the panda P2X7 receptor in complex with PPADS
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-[(E)-[4-methanoyl-6-methyl-5-oxidanyl-3-(phosphonooxymethyl)pyridin-2-yl]diazenyl]benzene-1,3-disulfonic acid, P2X purinoceptor
Authors:Sheng, D, Hattori, M.
Deposit date:2023-06-27
Release date:2023-11-29
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structural insights into the orthosteric inhibition of P2X receptors by non-ATP-analog antagonists
Elife, 2023
8JV8
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BU of 8jv8 by Molmil
Cryo-EM structures of the panda P2X7 receptor in complex with PPNDS
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-[(E)-{4-formyl-5-hydroxy-6-methyl-3-[(phosphonooxy)methyl]pyridin-2-yl}diazenyl]-7-nitronaphthalene-1,5-disulfonic acid, P2X purinoceptor
Authors:Sheng, D, Hattori, M.
Deposit date:2023-06-27
Release date:2023-11-29
Method:ELECTRON MICROSCOPY (3.34 Å)
Cite:Structural insights into the orthosteric inhibition of P2X receptors by non-ATP-analog antagonists
Elife, 2023
5YVE
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BU of 5yve by Molmil
Crystal structure of human P2X3 receptor in complex with the AF-219 negative allosteric modulator
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-[2,4-bis(azanyl)pyrimidin-5-yl]oxy-2-methoxy-4-propan-2-yl-benzenesulfonamide, MAGNESIUM ION, ...
Authors:Wang, Y, Hattori, M.
Deposit date:2017-11-25
Release date:2018-04-04
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Druggable negative allosteric site of P2X3 receptors.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6AH5
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BU of 6ah5 by Molmil
Structure of human P2X3 receptor in complex with ATP and Mg2+ ion
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Hattori, M.
Deposit date:2018-08-16
Release date:2019-06-12
Last modified:2020-12-23
Method:X-RAY DIFFRACTION (3.819 Å)
Cite:Molecular mechanisms of human P2X3 receptor channel activation and modulation by divalent cation bound ATP.
Elife, 8, 2019
6AH4
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BU of 6ah4 by Molmil
Structure of human P2X3 receptor in complex with ATP and Ca2+ ion
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Hattori, M.
Deposit date:2018-08-16
Release date:2019-06-12
Last modified:2020-12-23
Method:X-RAY DIFFRACTION (3.296 Å)
Cite:Molecular mechanisms of human P2X3 receptor channel activation and modulation by divalent cation bound ATP.
Elife, 8, 2019
5SVR
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BU of 5svr by Molmil
Crystal structure of the ATP-gated human P2X3 ion channel bound to competitive antagonist A-317491
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-{[(3-phenoxyphenyl)methyl][(1S)-1,2,3,4-tetrahydronaphthalen-1-yl]carbamoyl}benzene-1,2,4-tricarboxylic acid, MAGNESIUM ION, ...
Authors:Mansoor, S.E, Lu, W, Oosterheert, W, Shekhar, M, Tajkhorshid, E, Gouaux, E.
Deposit date:2016-08-07
Release date:2016-10-05
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3.13 Å)
Cite:X-ray structures define human P2X3 receptor gating cycle and antagonist action.
Nature, 538, 2016
5SVJ
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BU of 5svj by Molmil
Crystal structure of the ATP-gated human P2X3 ion channel in the closed, apo state
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, MAGNESIUM ION, ...
Authors:Mansoor, S.E, Lu, W, Oosterheert, W, Shekhar, M, Tajkhorshid, E, Gouaux, E.
Deposit date:2016-08-06
Release date:2016-09-28
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.984 Å)
Cite:X-ray structures define human P2X3 receptor gating cycle and antagonist action.
Nature, 538, 2016
5SVQ
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BU of 5svq by Molmil
Crystal structure of the ATP-gated human P2X3 ion channel bound to competitive antagonist TNP-ATP
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, MAGNESIUM ION, P2X purinoceptor 3, ...
Authors:Mansoor, S.E, Lu, W, Oosterheert, W, Shekhar, M, Tajkhorshid, E, Gouaux, E.
Deposit date:2016-08-07
Release date:2016-10-05
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:X-ray structures define human P2X3 receptor gating cycle and antagonist action.
Nature, 538, 2016
5SVM
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BU of 5svm by Molmil
Crystal structure of the ATP-gated human P2X3 ion channel bound to agonist 2-methylthio-ATP in the desensitized state
Descriptor: 1,2-ETHANEDIOL, 2-(methylsulfanyl)adenosine 5'-(tetrahydrogen triphosphate), 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ...
Authors:Mansoor, S.E, Lu, W, Oosterheert, W, Shekhar, M, Tajkhorshid, E, Gouaux, E.
Deposit date:2016-08-06
Release date:2016-09-28
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3.093 Å)
Cite:X-ray structures define human P2X3 receptor gating cycle and antagonist action.
Nature, 538, 2016
5SVP
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BU of 5svp by Molmil
Anomalous sulfur signal reveals the position of agonist 2-methylthio-ATP bound to the ATP-gated human P2X3 ion channel in the desensitized state
Descriptor: 1,2-ETHANEDIOL, 2-(methylsulfanyl)adenosine 5'-(tetrahydrogen triphosphate), 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ...
Authors:Mansoor, S.E, Lu, W, Oosterheert, W, Shekhar, M, Tajkhorshid, E, Gouaux, E.
Deposit date:2016-08-07
Release date:2016-09-28
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3.298 Å)
Cite:X-ray structures define human P2X3 receptor gating cycle and antagonist action.
Nature, 538, 2016
5SVL
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BU of 5svl by Molmil
Crystal structure of the ATP-gated human P2X3 ion channel in the ATP-bound, closed (desensitized) state
Descriptor: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Mansoor, S.E, Lu, W, Oosterheert, W, Shekhar, M, Tajkhorshid, E, Gouaux, E.
Deposit date:2016-08-06
Release date:2016-10-05
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:X-ray structures define human P2X3 receptor gating cycle and antagonist action.
Nature, 538, 2016
5SVS
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BU of 5svs by Molmil
Anomalous Mn2+ signal reveals a divalent cation-binding site in the head domain of the ATP-gated human P2X3 ion channel
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, MAGNESIUM ION, ...
Authors:Mansoor, S.E, Lu, W, Oosterheert, W, Shekhar, M, Tajkhorshid, E, Gouaux, E.
Deposit date:2016-08-07
Release date:2016-09-28
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (4.025 Å)
Cite:X-ray structures define human P2X3 receptor gating cycle and antagonist action.
Nature, 538, 2016
5SVK
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BU of 5svk by Molmil
Crystal structure of the ATP-gated human P2X3 ion channel in the ATP-bound, open state
Descriptor: (CARBAMOYLMETHYL-CARBOXYMETHYL-AMINO)-ACETIC ACID, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Mansoor, S.E, Lu, W, Oosterheert, W, Shekhar, M, Tajkhorshid, E, Gouaux, E.
Deposit date:2016-08-06
Release date:2016-09-28
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.773 Å)
Cite:X-ray structures define human P2X3 receptor gating cycle and antagonist action.
Nature, 538, 2016
5SVT
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BU of 5svt by Molmil
Anomalous Cs+ signal reveals the site of Na+ ion entry to the channel pore of the human P2X3 ion channel through the extracellular fenestrations
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, MAGNESIUM ION, P2X purinoceptor 3, ...
Authors:Mansoor, S.E, Lu, W, Oosterheert, W, Shekhar, M, Tajkhorshid, E, Gouaux, E.
Deposit date:2016-08-07
Release date:2016-09-28
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3.794 Å)
Cite:X-ray structures define human P2X3 receptor gating cycle and antagonist action.
Nature, 538, 2016
5U2H
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BU of 5u2h by Molmil
Crystal structure of the ATP-gated P2X7 ion channel bound to ATP and allosteric antagonist A804598
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Karasawa, A, Kawate, T.
Deposit date:2016-11-30
Release date:2017-01-04
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3.903 Å)
Cite:Structural basis for subtype-specific inhibition of the P2X7 receptor.
Elife, 5, 2016
5U1U
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BU of 5u1u by Molmil
Crystal structure of the ATP-gated P2X7 ion channel bound to allosteric antagonist A740003
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, N-{(1R)-1-[N''-cyano-N'-(quinolin-5-yl)carbamimidamido]-2,2-dimethylpropyl}-2-(3,4-dimethoxyphenyl)acetamide, P2X purinoceptor
Authors:Karasawa, A, Kawate, T.
Deposit date:2016-11-29
Release date:2017-01-11
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.604 Å)
Cite:Structural basis for subtype-specific inhibition of the P2X7 receptor.
Elife, 5, 2016
5U1Y
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BU of 5u1y by Molmil
Crystal structure of the ATP-gated P2X7 ion channel bound to allosteric antagonist GW791343
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, N~2~-(3,4-difluorophenyl)-N-{2-methyl-5-[(piperazin-1-yl)methyl]phenyl}glycinamide, P2X purinoceptor
Authors:Karasawa, A, Kawate, T.
Deposit date:2016-11-29
Release date:2017-01-04
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structural basis for subtype-specific inhibition of the P2X7 receptor.
Elife, 5, 2016

 

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