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2WVJ
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BU of 2wvj by Molmil
Mutation of Thr163 to Ser in Human Thymidine Kinase Shifts the Specificity from Thymidine towards the Nucleoside Analogue Azidothymidine
Descriptor: MAGNESIUM ION, THYMIDINE KINASE, CYTOSOLIC, ...
Authors:Skovgaard, T, Uhlin, U, Munch-Petersen, B.
Deposit date:2009-10-17
Release date:2009-10-27
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Comparative Active-Site Mutation Study of Human and Caenorhabditis Elegans Thymidine Kinase 1.
FEBS J., 279, 2012
2B8T
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BU of 2b8t by Molmil
Crystal structure of Thymidine Kinase from U.urealyticum in complex with thymidine
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, THYMIDINE, Thymidine kinase, ...
Authors:Kosinska, U, Carnrot, C, Eriksson, S, Wang, L, Eklund, H.
Deposit date:2005-10-10
Release date:2005-12-20
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of the substrate complex of thymidine kinase from Ureaplasma urealyticum and investigations of possible drug targets for the enzyme
FEBS Lett., 272, 2005
4UXJ
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BU of 4uxj by Molmil
Leishmania major Thymidine Kinase in complex with dTTP
Descriptor: MAGNESIUM ION, THYMIDINE KINASE, THYMIDINE-5'-TRIPHOSPHATE, ...
Authors:Timm, J, Bosch-Navarrete, C, Recio, E, Nettleship, J.E, Rada, H, Gonzalez-Pacanowska, D, Wilson, K.S.
Deposit date:2014-08-22
Release date:2015-05-27
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural and Kinetic Characterization of Thymidine Kinase from Leishmania Major.
Plos Negl Trop Dis, 9, 2015
3E2I
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BU of 3e2i by Molmil
Crystal structure of Thymidine Kinase from S. aureus
Descriptor: GLYCEROL, Thymidine kinase, ZINC ION
Authors:Lam, R, Johns, K, Battaile, K.P, Romanov, V, Lam, K, Pai, E.F, Chirgadze, N.Y.
Deposit date:2008-08-05
Release date:2009-08-11
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Crystal structure of Thymidine Kinase from S. aureus
To be Published
4UXH
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BU of 4uxh by Molmil
Leishmania major Thymidine Kinase in complex with AP5dT
Descriptor: P1-(5'-ADENOSYL)P5-(5'-THYMIDYL)PENTAPHOSPHATE, THYMIDINE KINASE, ZINC ION
Authors:Timm, J, Bosch-Navarrete, C, Recio, E, Nettleship, J.E, Rada, H, Gonzalez-Pacanowska, D, Wilson, K.S.
Deposit date:2014-08-22
Release date:2015-05-27
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural and Kinetic Characterization of Thymidine Kinase from Leishmania Major.
Plos Negl Trop Dis, 9, 2015
4UXI
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BU of 4uxi by Molmil
Leishmania major Thymidine Kinase in complex with thymidine
Descriptor: PHOSPHATE ION, THYMIDINE, THYMIDINE KINASE, ...
Authors:Timm, J, Bosch-Navarrete, C, Recio, E, Nettleship, J.E, Rada, H, Gonzalez-Pacanowska, D, Wilson, K.S.
Deposit date:2014-08-22
Release date:2015-05-27
Last modified:2016-03-02
Method:X-RAY DIFFRACTION (2.74 Å)
Cite:Structural and Kinetic Characterization of Thymidine Kinase from Leishmania Major.
Plos Negl Trop Dis, 9, 2015
1W4R
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BU of 1w4r by Molmil
Structure of a type II thymidine kinase with bound dTTP
Descriptor: (2R,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, THYMIDINE KINASE, THYMIDINE-5'-TRIPHOSPHATE, ...
Authors:Birringer, M.S, Claus, M.T, Folkers, G, Kloer, D.P, Schulz, G.E, Scapozza, L.
Deposit date:2004-07-27
Release date:2005-02-01
Last modified:2013-03-06
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Structure of a Type II Thymidine Kinase with Bound Dttp
FEBS Lett., 579, 2005
2J87
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Structure of vaccinia virus thymidine kinase in complex with dTTP: insights for drug design
Descriptor: MAGNESIUM ION, THYMIDINE KINASE, THYMIDINE-5'-TRIPHOSPHATE, ...
Authors:El Omari, K, Solaroli, N, Karlsson, A, Balzarini, J, Stammers, D.K.
Deposit date:2006-10-23
Release date:2006-11-13
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure of Vaccinia Virus Thymidine Kinase in Complex with Dttp: Insights for Drug Design.
Bmc Struct.Biol., 6, 2006
2JA1
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BU of 2ja1 by Molmil
Thymidine kinase from B. cereus with TTP bound as phosphate donor.
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, THYMIDINE KINASE, THYMIDINE-5'-TRIPHOSPHATE, ...
Authors:Kosinska, U, Carnrot, C, Sandrini, M.P.B, Clausen, A.R, Wang, L, Piskur, J, Eriksson, S, Eklund, H.
Deposit date:2006-11-17
Release date:2007-01-23
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Studies of Thymidine Kinases from Bacillus Anthracis and Bacillus Cereus Provide Insights Into Quaternary Structure and Conformational Changes Upon Substrate Binding
FEBS J., 274, 2007
1XBT
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BU of 1xbt by Molmil
Crystal Structure of Human Thymidine Kinase 1
Descriptor: MAGNESIUM ION, THYMIDINE-5'-TRIPHOSPHATE, Thymidine kinase, ...
Authors:Welin, M, Kosinska, U, Mikkelsen, N.E, Carnrot, C, Zhu, C, Wang, L, Eriksson, S, Munch-Petersen, B, Eklund, H.
Deposit date:2004-08-31
Release date:2004-12-14
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structures of thymidine kinase 1 of human and mycoplasmic origin
Proc.Natl.Acad.Sci.Usa, 101, 2004
2J9R
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BU of 2j9r by Molmil
Thymidine kinase from B. anthracis in complex with dT.
Descriptor: PHOSPHATE ION, THYMIDINE, THYMIDINE KINASE, ...
Authors:Kosinska, U, Carnrot, C, Sandrini, M.P.B, Clausen, A.R, Wang, L, Piskur, J, Eriksson, S, Eklund, H.
Deposit date:2006-11-15
Release date:2007-01-23
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural Studies of Thymidine Kinases from Bacillus Anthracis and Bacillus Cereus Provide Insights Into Quaternary Structure and Conformational Changes Upon Substrate Binding
FEBS J., 274, 2007
1XX6
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BU of 1xx6 by Molmil
X-ray structure of Clostridium acetobutylicum thymidine kinase with ADP. Northeast Structural Genomics Target CAR26.
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Thymidine kinase, ZINC ION
Authors:Kuzin, A.P, Abashidze, M, Forouhar, F, Vorobiev, S.M, Acton, T.B, Ma, L.-C, Xiao, R, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG)
Deposit date:2004-11-04
Release date:2004-12-21
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:X-ray structure of Clostridium acetobutylicum thymidine kinase with ADP. Northeast Structural Genomics Target CAR26.
To be Published
5FUX
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BU of 5fux by Molmil
catalytic domain of Thymidine kinase from Trypanosoma brucei with dTMP
Descriptor: MAGNESIUM ION, PHOSPHATE ION, THYMDINE KINASE, ...
Authors:Timm, J, Valente, M, Castillo-Acosta, V, Balzarini, T, Nettleship, J.E, Rada, H, Wilson, K.S, Gonzalez-Pacanowska, D.
Deposit date:2016-01-31
Release date:2016-07-27
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Cell Cycle Regulation and Novel Structural Features of Thymidine Kinase, an Essential Enzyme in Trypanosoma Brucei.
Mol.Microbiol., 102, 2016
5FUW
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BU of 5fuw by Molmil
catalytic domain of Thymidine kinase from Trypanosoma brucei with dTMP or dThd
Descriptor: PHOSPHATE ION, THYMDINE KINASE, THYMIDINE, ...
Authors:Timm, J, Valente, M, Castillo-Acosta, V, Balzarini, T, Nettleship, J.E, Rada, H, Wilson, K.S, Gonzalez-Pacanowska, D.
Deposit date:2016-01-31
Release date:2016-07-27
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Cell Cycle Regulation and Novel Structural Features of Thymidine Kinase, an Essential Enzyme in Trypanosoma Brucei.
Mol.Microbiol., 102, 2016
5FUV
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BU of 5fuv by Molmil
catalytic domain of Thymidine kinase from Trypanosoma brucei with dThd
Descriptor: GLYCEROL, PHOSPHATE ION, THYMDINE KINASE, ...
Authors:Timm, J, Valente, M, Castillo-Acosta, V, Balzarini, T, Nettleship, J.E, Rada, H, Wilson, K.S, Gonzalez-Pacanowska, D.
Deposit date:2016-01-31
Release date:2016-07-27
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Cell Cycle Regulation and Novel Structural Features of Thymidine Kinase, an Essential Enzyme in Trypanosoma Brucei.
Mol.Microbiol., 102, 2016
5FUY
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BU of 5fuy by Molmil
catalytic domain of Thymidine kinase from Trypanosoma brucei with dTMP
Descriptor: PHOSPHATE ION, THYMDINE KINASE, ZINC ION, ...
Authors:Timm, J, Valente, M, Castillo-Acosta, V, Balzarini, T, Nettleship, J.E, Rada, H, Wilson, K.S, Gonzalez-Pacanowska, D.
Deposit date:2016-01-31
Release date:2016-07-27
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Cell Cycle Regulation and Novel Structural Features of Thymidine Kinase, an Essential Enzyme in Trypanosoma Brucei.
Mol.Microbiol., 102, 2016
2ORV
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BU of 2orv by Molmil
human Thymidine Kinase 1 in complex with TP4A
Descriptor: P1-(5'-ADENOSYL)P4-(5'-(2'-DEOXY-THYMIDYL))TETRAPHOSPHATE, Thymidine kinase, ZINC ION
Authors:Segura-Pena, D, Lutz, S, Monnerjahn, C, Konrad, M, Lavie, A.
Deposit date:2007-02-04
Release date:2007-03-27
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Binding of ATP to TK1-like Enzymes Is Associated with a Conformational Change in the Quaternary Structure.
J.Mol.Biol., 369, 2007
2ORW
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BU of 2orw by Molmil
Thermotoga maritima thymidine kinase 1 like enzyme in complex with TP4A
Descriptor: MAGNESIUM ION, P1-(5'-ADENOSYL)P4-(5'-(2'-DEOXY-THYMIDYL))TETRAPHOSPHATE, Thymidine kinase, ...
Authors:Segura-Pena, D, Lutz, S, Monnerjahn, C, Konrad, M, Lavie, A.
Deposit date:2007-02-04
Release date:2007-03-27
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Binding of ATP to TK1-like Enzymes Is Associated with a Conformational Change in the Quaternary Structure.
J.Mol.Biol., 369, 2007
2QQE
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BU of 2qqe by Molmil
Thymidine Kinase from Thermotoga Maritima in complex with Thymidine
Descriptor: THYMIDINE, Thymidine kinase, ZINC ION
Authors:Segura-Pena, D, Lichter, J, Trani, M, Konrad, M, Lavie, A, Lutz, S.
Deposit date:2007-07-26
Release date:2007-10-16
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Quaternary structure change as a mechanism for the regulation of thymidine kinase 1-like enzymes.
Structure, 15, 2007
2QPO
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BU of 2qpo by Molmil
Thermotoga Maritima Thymidine Kinase in the apo form
Descriptor: SULFATE ION, Thymidine kinase, ZINC ION
Authors:Segura-Pena, D, Lichter, J, Trani, M, Konrad, M, Lavie, A, Lutz, S.
Deposit date:2007-07-24
Release date:2007-10-16
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Quaternary structure change as a mechanism for the regulation of thymidine kinase 1-like enzymes.
Structure, 15, 2007
2QQ0
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BU of 2qq0 by Molmil
Thymidine Kinase from Thermotoga Maritima in complex with thymidine + AppNHp
Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Segura-Pena, D, Lichter, J, Trani, M, Konrad, M, Lavie, A, Lutz, S.
Deposit date:2007-07-25
Release date:2007-10-16
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Quaternary structure change as a mechanism for the regulation of thymidine kinase 1-like enzymes.
Structure, 15, 2007
2UZ3
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BU of 2uz3 by Molmil
Crystal Structure of Thymidine Kinase with dTTP from U. urealyticum
Descriptor: MAGNESIUM ION, THYMIDINE KINASE, THYMIDINE-5'-TRIPHOSPHATE, ...
Authors:Welin, M, Kosinska, U, Mikkelsen, N.E, Carnrot, C, Zhu, C, Wang, L, Eriksson, S, Munch-Petersen, B, Eklund, H.
Deposit date:2007-04-24
Release date:2007-05-29
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structures of Thymidine Kinase 1 of Human and Mycoplasmic Origin
Proc.Natl.Acad.Sci.USA, 101, 2004

217705

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