5T19
| Structure of PTP1B complexed with N-(3'-(1,1-dioxido-4-oxo-1,2,5-thiadiazolidin-2-yl)-4'-methyl-[1,1'-biphenyl]-4-yl)acetamide | Descriptor: | 5-[4-methyl-4'-(methylamino)[1,1'-biphenyl]-3-yl]-1lambda~6~,2,5-thiadiazolidine-1,1,3-trione, CHLORIDE ION, MAGNESIUM ION, ... | Authors: | Laciak, A.R, Tanner, J.J. | Deposit date: | 2016-08-18 | Release date: | 2017-04-12 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.1001 Å) | Cite: | Covalent Allosteric Inactivation of Protein Tyrosine Phosphatase 1B (PTP1B) by an Inhibitor-Electrophile Conjugate. Biochemistry, 56, 2017
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1AAX
| CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH TWO BIS(PARA-PHOSPHOPHENYL)METHANE (BPPM) MOLECULES | Descriptor: | 4-PHOSPHONOOXY-PHENYL-METHYL-[4-PHOSPHONOOXY]BENZEN, MAGNESIUM ION, PROTEIN TYROSINE PHOSPHATASE 1B | Authors: | Puius, Y.A, Zhao, Y, Sullivan, M, Lawrence, D, Almo, S.C, Zhang, Z.-Y. | Deposit date: | 1997-01-16 | Release date: | 1998-03-04 | Last modified: | 2023-08-02 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Identification of a second aryl phosphate-binding site in protein-tyrosine phosphatase 1B: a paradigm for inhibitor design. Proc.Natl.Acad.Sci.USA, 94, 1997
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1A5Y
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7XC0
| Crystal structure of Human RPTPH | Descriptor: | PHOSPHATE ION, Receptor-type tyrosine-protein phosphatase H | Authors: | Kim, M, Ryu, S.E. | Deposit date: | 2022-03-22 | Release date: | 2022-07-06 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.56 Å) | Cite: | Crystal structure of the catalytic domain of human RPTPH. Acta Crystallogr.,Sect.F, 78, 2022
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8CT8
| Crystal structure of Drosophila melanogaster PRL/CBS-pair domain complex | Descriptor: | IODIDE ION, PRL-1 phosphatase, Unextended protein | Authors: | Fakih, R, Goldstein, R.H, Kozlov, G, Gehring, K. | Deposit date: | 2022-05-13 | Release date: | 2023-03-01 | Last modified: | 2023-04-05 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Burst kinetics and CNNM binding are evolutionarily conserved properties of phosphatases of regenerating liver. J.Biol.Chem., 299, 2023
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8DU7
| Room-temperature serial synchrotron crystallography (SSX) structure of apo PTP1B | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Tyrosine-protein phosphatase non-receptor type 1 | Authors: | Ebrahim, A, Sharma, S, Keedy, D.A. | Deposit date: | 2022-07-27 | Release date: | 2022-08-17 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Room-temperature serial synchrotron crystallography of the human phosphatase PTP1B. Acta Crystallogr.,Sect.F, 79, 2023
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6SUC
| Human PTPRU D1 domain, oxidised form | Descriptor: | Receptor-type tyrosine-protein phosphatase U | Authors: | Hay, I.M, Fearnley, G.W, Sharpe, H.J, Deane, J.E. | Deposit date: | 2019-09-13 | Release date: | 2020-07-08 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.97 Å) | Cite: | The receptor PTPRU is a redox sensitive pseudophosphatase. Nat Commun, 11, 2020
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6SUB
| Human PTPRU D1 domain, reduced form | Descriptor: | CHLORIDE ION, Receptor-type tyrosine-protein phosphatase U | Authors: | Hay, I.M, Fearnley, G.W, Sharpe, H.J, Deane, J.E. | Deposit date: | 2019-09-13 | Release date: | 2020-07-08 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.72 Å) | Cite: | The receptor PTPRU is a redox sensitive pseudophosphatase. Nat Commun, 11, 2020
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7S4F
| Protein Tyrosine Phosphatase 1B - F182Q mutant bound with Hepes | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, GLYCEROL, MAGNESIUM ION, ... | Authors: | Brandao, T.A.S, Hengge, A.C, Johnson, S.J. | Deposit date: | 2021-09-08 | Release date: | 2022-09-21 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Insights into the importance of WPD-loop sequence for activity and structure in protein tyrosine phosphatases. Chem Sci, 13, 2022
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6UZT
| Crystal Structure of RPTP alpha | Descriptor: | Receptor-type tyrosine-protein phosphatase alpha | Authors: | Santelli, E, Wen, Y, Yang, S, Svensson, M.N.D, Stanford, S.M, Bottini, N. | Deposit date: | 2019-11-15 | Release date: | 2020-03-18 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | RPTP alpha phosphatase activity is allosterically regulated by the membrane-distal catalytic domain. J.Biol.Chem., 295, 2020
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3H2X
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3I36
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7TVJ
| Crystal Structure of Monobody Mb(SHP2PTP_13)/SHP2 PTP Domain Complex | Descriptor: | CITRATE ANION, Mb(SHP2PTP_13), Tyrosine-protein phosphatase non-receptor type 11 | Authors: | Sha, F, Koide, S. | Deposit date: | 2022-02-05 | Release date: | 2023-02-15 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.39 Å) | Cite: | Monobody Inhibitor Selective to the Phosphatase Domain of SHP2 and its Use as a Probe for Quantifying SHP2 Allosteric Regulation. J.Mol.Biol., 435, 2023
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7UAD
| Crystal structure of human PTPN2 with inhibitor ABBV-CLS-484 | Descriptor: | 5-{(7R)-1-fluoro-3-hydroxy-7-[(3-methylbutyl)amino]-5,6,7,8-tetrahydronaphthalen-2-yl}-1lambda~6~,2,5-thiadiazolidine-1,1,3-trione, Tyrosine-protein phosphatase non-receptor type 2 | Authors: | Longenecker, K.L, Qiu, W, Sun, Q, Frost, J.M. | Deposit date: | 2022-03-12 | Release date: | 2023-07-26 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.044 Å) | Cite: | The PTPN2/PTPN1 inhibitor ABBV-CLS-484 unleashes potent anti-tumour immunity. Nature, 622, 2023
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6W30
| Protein Tyrosine Phosphatase 1B Bound to Amorphadiene | Descriptor: | Amorphadiene, GLYCEROL, MAGNESIUM ION, ... | Authors: | Sarkar, A, Kim, E.Y, Hongdusit, A, Sankaran, B, Fox, J. | Deposit date: | 2020-03-08 | Release date: | 2021-05-26 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Microbially Guided Discovery and Biosynthesis of Biologically Active Natural Products. Acs Synth Biol, 10, 2021
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3I7Z
| Protein Tyrosine Phosphatase 1B - Transition state analog for the first catalytic step | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, EGFR receptor fragment, GLYCEROL, ... | Authors: | Brandao, T.A.S, Johnson, S.J, Hengge, A.C. | Deposit date: | 2009-07-09 | Release date: | 2010-03-16 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Insights into the reaction of protein-tyrosine phosphatase 1B: crystal structures for transition state analogs of both catalytic steps. J.Biol.Chem., 285, 2010
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3I80
| Protein Tyrosine Phosphatase 1B - Transition state analog for the second catalytic step | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL, Tyrosine-protein phosphatase non-receptor type 1, ... | Authors: | Brandao, T.A.S, Johnson, S.J, Hengge, A.C. | Deposit date: | 2009-07-09 | Release date: | 2010-03-16 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Insights into the reaction of protein-tyrosine phosphatase 1B: crystal structures for transition state analogs of both catalytic steps. J.Biol.Chem., 285, 2010
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4Y14
| Structure of protein tyrosine phosphatase 1B complexed with inhibitor (PTP1B:CPT157633) | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 3-bromo-4-[difluoro(phosphono)methyl]-N-methyl-Nalpha-(methylsulfonyl)-L-phenylalaninamide, CHLORIDE ION, ... | Authors: | Choy, M.S, Connors, C, Page, R, Peti, W. | Deposit date: | 2015-02-06 | Release date: | 2015-08-05 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.898 Å) | Cite: | PTP1B inhibition suggests a therapeutic strategy for Rett syndrome. J.Clin.Invest., 125, 2015
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4YAA
| YopH W354Y Yersinia enterocolitica PTPase apo form | Descriptor: | ACETATE ION, SULFATE ION, Tyrosine-protein phosphatase YopH | Authors: | Moise, G.E, Johnson, S.J, Hengge, A.C. | Deposit date: | 2015-02-17 | Release date: | 2015-10-28 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.05 Å) | Cite: | Conservative Tryptophan Mutants of the Protein Tyrosine Phosphatase YopH Exhibit Impaired WPD-Loop Function and Crystallize with Divanadate Esters in Their Active Sites. Biochemistry, 54, 2015
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4ZI4
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4Z6B
| YopH W354H Yersinia enterocolitica PTPase in the apo form | Descriptor: | ACETATE ION, GLYCEROL, Tyrosine-protein phosphatase YopH | Authors: | Moise, G.E, Johnson, S.J, Hengge, A.C. | Deposit date: | 2015-04-04 | Release date: | 2015-10-28 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | Conservative Tryptophan Mutants of the Protein Tyrosine Phosphatase YopH Exhibit Impaired WPD-Loop Function and Crystallize with Divanadate Esters in Their Active Sites. Biochemistry, 54, 2015
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4ZN5
| YopH W354Y Yersinia enterocolitica PTPase bond with Divanadate glycerol ester in the active site | Descriptor: | ACETATE ION, Divanadate Glycerol ester, GLYCEROL, ... | Authors: | Moise, G.E, Johnson, S.J, Hengge, A.C. | Deposit date: | 2015-05-04 | Release date: | 2015-10-28 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.12 Å) | Cite: | Conservative Tryptophan Mutants of the Protein Tyrosine Phosphatase YopH Exhibit Impaired WPD-Loop Function and Crystallize with Divanadate Esters in Their Active Sites. Biochemistry, 54, 2015
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4ZRT
| PTP1BC215S bound to Nephrin peptide substrate | Descriptor: | CHLORIDE ION, GLY-PRO-LEU-PTR-ASP-GLU, GLYCEROL, ... | Authors: | Selner, N.G, Bell, C.E, Pei, D. | Deposit date: | 2015-05-12 | Release date: | 2015-06-24 | Last modified: | 2019-12-25 | Method: | X-RAY DIFFRACTION (1.74 Å) | Cite: | Diverse levels of sequence selectivity and catalytic efficiency of protein-tyrosine phosphatases. Biochemistry, 53, 2014
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5AWX
| Crystal structure of Human PTPRZ D1 domain | Descriptor: | BROMIDE ION, Receptor-type tyrosine-protein phosphatase zeta | Authors: | Sugawara, H. | Deposit date: | 2015-07-10 | Release date: | 2016-02-17 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.86 Å) | Cite: | Small-molecule inhibition of PTPRZ reduces tumor growth in a rat model of glioblastoma Sci Rep, 6, 2016
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5KA4
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