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2WJS
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BU of 2wjs by Molmil
Crystal structure of the LG1-3 region of the laminin alpha2 chain
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, LAMININ SUBUNIT ALPHA-2
Authors:Carafoli, F, Clout, N.J, Hohenester, E.
Deposit date:2009-05-28
Release date:2009-06-23
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal Structure of the Lg1-3 Region of the Laminin {Alpha}2 Chain.
J.Biol.Chem., 284, 2009
6ULB
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BU of 6ulb by Molmil
Sex Hormone-binding globulin mutant E176K in complex with Danazol
Descriptor: CALCIUM ION, Danazol, Sex hormone-binding globulin
Authors:Round, P.W, Das, S, Van Petegem, F.
Deposit date:2019-10-07
Release date:2020-10-21
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural and biochemical analyses of danazol interactions with sex hormone-binding globulin and effects on androgen action
To Be Published
3PVE
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BU of 3pve by Molmil
Crystal structure of the G2 domain of Agrin from Mus Musculus
Descriptor: Agrin, Agrin protein
Authors:Sampathkumar, P, Do, J, Bain, K, Freeman, J, Gheyi, T, Atwell, S, Thompson, D.A, Emtage, J.S, Wasserman, S, Sauder, J.M, Burley, S.K, New York SGX Research Center for Structural Genomics (NYSGXRC)
Deposit date:2010-12-07
Release date:2011-01-19
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Crystal structure of the G2 domain of Agrin from Mus Musculus
To be Published
1D2S
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BU of 1d2s by Molmil
CRYSTAL STRUCTURE OF THE N-TERMINAL LAMININ G-LIKE DOMAIN OF SHBG IN COMPLEX WITH DIHYDROTESTOSTERONE
Descriptor: 5-ALPHA-DIHYDROTESTOSTERONE, CALCIUM ION, SEX HORMONE-BINDING GLOBULIN
Authors:Grishkovskaya, I, Avvakumov, G.V, Sklenar, G, Dales, D, Hammond, G.L, Muller, Y.A.
Deposit date:1999-09-28
Release date:2000-06-28
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Crystal structure of human sex hormone-binding globulin: steroid transport by a laminin G-like domain.
EMBO J., 19, 2000
6PYA
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BU of 6pya by Molmil
Sex Hormone-binding globulin mutant E176K in complex with IPI
Descriptor: 3-[(1H-imidazol-1-yl)methyl]-2-phenyl-1H-indole, CALCIUM ION, Sex hormone-binding globulin
Authors:Round, P.W, Das, S, Van Petegem, F.
Deposit date:2019-07-29
Release date:2019-12-25
Last modified:2020-02-12
Method:X-RAY DIFFRACTION (1.71 Å)
Cite:Molecular interactions between sex hormone-binding globulin and nonsteroidal ligands that enhance androgen activity.
J.Biol.Chem., 295, 2020
6PYF
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BU of 6pyf by Molmil
Sex Hormone-binding globulin mutant E176K in complex with Estradiol
Descriptor: CALCIUM ION, ESTRADIOL, Sex hormone-binding globulin
Authors:Round, P.W, Wu, T.S, Das, S, Van Petegem, F.
Deposit date:2019-07-29
Release date:2019-12-25
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Molecular interactions between sex hormone-binding globulin and nonsteroidal ligands that enhance androgen activity.
J.Biol.Chem., 295, 2020
6PYB
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BU of 6pyb by Molmil
Sex Hormone-binding globulin mutant E176K in complex with DVT
Descriptor: 4,4'-[(3R,4R)-oxolane-3,4-diylbis(methylene)]bis(2-methoxyphenol), CALCIUM ION, Sex hormone-binding globulin
Authors:Round, P.W, Das, S, Van Petegem, F.
Deposit date:2019-07-29
Release date:2019-12-25
Last modified:2020-02-12
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Molecular interactions between sex hormone-binding globulin and nonsteroidal ligands that enhance androgen activity.
J.Biol.Chem., 295, 2020
1F5F
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BU of 1f5f by Molmil
CRYSTAL STRUCTURE OF THE N-TERMINAL G-DOMAIN OF SHBG IN COMPLEX WITH ZINC
Descriptor: 5-ALPHA-DIHYDROTESTOSTERONE, CALCIUM ION, ISOPROPYL ALCOHOL, ...
Authors:Avvakumov, V.A, Muller, Y.A, Hammond, G.L.
Deposit date:2000-06-14
Release date:2000-09-06
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Steroid-binding specificity of human sex hormone-binding globulin is influenced by occupancy of a zinc-binding site.
J.Biol.Chem., 275, 2000
1PZ7
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BU of 1pz7 by Molmil
Modulation of agrin function by alternative splicing and Ca2+ binding
Descriptor: Agrin, CALCIUM ION
Authors:Stetefeld, J, Alexandrescu, A.T, Maciejewski, M.W, Jenny, M, Rathgeb-Szabo, K, Schulthess, T, Landwehr, R, Frank, S, Ruegg, M.A, Kammerer, R.A.
Deposit date:2003-07-10
Release date:2004-04-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.421 Å)
Cite:Modulation of agrin function by alternative splicing and Ca2+ binding.
STRUCTURE, 12, 2004
1PZ9
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BU of 1pz9 by Molmil
Modulation of agrin function by alternative splicing and Ca2+ binding
Descriptor: Agrin
Authors:Stetefeld, J, Alexandrescu, A.T, Maciejewski, M.W, Jenny, M, Rathgeb-Szabo, K, Schulthess, T, Landwehr, R, Frank, S, Ruegg, M.A, Kammerer, R.A.
Deposit date:2003-07-10
Release date:2004-04-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Modulation of agrin function by alternative splicing and Ca2+ binding.
STRUCTURE, 12, 2004
1Q56
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BU of 1q56 by Molmil
NMR structure of the B0 isoform of the agrin G3 domain in its Ca2+ bound state
Descriptor: Agrin
Authors:Stetefeld, J, Alexandrescu, A.T, Maciejewski, M.W, Jenny, M, Rathgeb-Szabo, K, Schulthess, T, Landwehr, R, Frank, S, Ruegg, M.A, Kammerer, R.A.
Deposit date:2003-08-06
Release date:2004-04-13
Last modified:2022-03-02
Method:SOLUTION NMR
Cite:Modulation of agrin function by alternative splicing and Ca2+ binding
Structure, 12, 2004
1PZ8
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BU of 1pz8 by Molmil
Modulation of agrin function by alternative splicing and Ca2+ binding
Descriptor: Agrin, CALCIUM ION
Authors:Stetefeld, J, Alexandrescu, A.T, Maciejewski, M.W, Jenny, M, Rathgeb-Szabo, K, Schulthess, T, Landwehr, R, Frank, S, Ruegg, M.A, Kammerer, R.A.
Deposit date:2003-07-10
Release date:2004-04-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Modulation of agrin function by alternative splicing and Ca2+ binding.
STRUCTURE, 12, 2004
1KDM
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BU of 1kdm by Molmil
THE CRYSTAL STRUCTURE OF THE HUMAN SEX HORMONE-BINDING GLOBULIN (TETRAGONAL CRYSTAL FORM)
Descriptor: 5-ALPHA-DIHYDROTESTOSTERONE, CALCIUM ION, sex hormone-binding globulin
Authors:Grishkovskaya, I, Avvakumov, G.V, Hammond, G.L, Muller, Y.A.
Deposit date:2001-11-13
Release date:2002-05-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Resolution of a disordered region at the entrance of the human sex hormone-binding globulin steroid-binding site.
J.Mol.Biol., 318, 2002
1KDK
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BU of 1kdk by Molmil
THE STRUCTURE OF THE N-TERMINAL LG DOMAIN OF SHBG IN CRYSTALS SOAKED WITH EDTA
Descriptor: 5-ALPHA-DIHYDROTESTOSTERONE, Sex Hormone-Binding Globulin
Authors:Grishkovskaya, I, Avvakumov, G.V, Hammond, G.L, Muller, Y.A.
Deposit date:2001-11-13
Release date:2002-05-15
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Resolution of a disordered region at the entrance of the human sex hormone-binding globulin steroid-binding site.
J.Mol.Biol., 318, 2002
1LHW
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BU of 1lhw by Molmil
CRYSTAL STRUCTURE OF THE N-TERMINAL LG-DOMAIN OF SHBG IN COMPLEX WITH 2-METHOXYESTRADIOL
Descriptor: 1,3,5(10)-ESTRATRIEN-2,3,17-BETA-TRIOL 2-METHYL ETHER, CALCIUM ION, ISOPROPYL ALCOHOL, ...
Authors:Avvakumov, G.V, Grishkovskaya, I, Muller, Y.A, Hammond, G.L.
Deposit date:2002-04-17
Release date:2002-10-23
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Crystal structure of human sex hormone-binding globulin in complex with 2-methoxyestradiol reveals the molecular basis for high affinity interactions with C-2 derivatives of estradiol.
J.Biol.Chem., 277, 2002
1LHU
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BU of 1lhu by Molmil
CRYSTAL STRUCTURE OF THE N-TERMINAL LG-DOMAIN OF SHBG IN COMPLEX WITH ESTRADIOL
Descriptor: CALCIUM ION, ESTRADIOL, SEX HORMONE-BINDING GLOBULIN
Authors:Grishkovskaya, I, Avvakumov, G.V, Hammond, G.L, Catalano, M.G, Muller, Y.A.
Deposit date:2002-04-17
Release date:2002-10-23
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Steroid Ligands Bind Human Sex Hormone-binding Globulin in Specific Orientations and Produce Distinct Changes in Protein Conformation
J.Biol.Chem., 277, 2002
1LHO
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BU of 1lho by Molmil
CRYSTAL STRUCTURE OF THE N-TERMINAL LG-DOMAIN OF SHBG IN COMPLEX WITH 5ALPHA-ANDROSTANE-3BETA,17BETA-DIOL
Descriptor: 5-ALPHA-ANDROSTANE-3-BETA,17BETA-DIOL, CALCIUM ION, SEX HORMONE-BINDING GLOBULIN
Authors:Grishkovskaya, I, Avvakumov, G.V, Hammond, G.L, Catalano, M.G, Muller, Y.A.
Deposit date:2002-04-17
Release date:2002-10-23
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2 Å)
Cite:Steroid Ligands Bind Human Sex Hormone-binding Globulin in Specific Orientations and Produce Distinct Changes in Protein Conformation
J.Biol.Chem., 277, 2002
1LHV
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BU of 1lhv by Molmil
CRYSTAL STRUCTURE OF THE N-TERMINAL LG-DOMAIN OF SHBG IN COMPLEX WITH NORGESTREL
Descriptor: 13-BETA-ETHYL-17-ALPHA-ETHYNYL-17-BETA-HYDROXYGON-4-EN-3-ONE, CALCIUM ION, ISOPROPYL ALCOHOL, ...
Authors:Grishkovskaya, I, Avvakumov, G.V, Hammond, G.L, Catalano, M.G, Muller, Y.A.
Deposit date:2002-04-17
Release date:2002-10-23
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2 Å)
Cite:Steroid Ligands Bind Human Sex Hormone-binding Globulin in Specific Orientations and Produce Distinct Changes in Protein Conformation
J.Biol.Chem., 277, 2002
1LHN
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BU of 1lhn by Molmil
CRYSTAL STRUCTURE OF THE N-TERMINAL LG-DOMAIN OF SHBG IN COMPLEX WITH 5ALPHA-ANDROSTANE-3BETA,17ALPHA-DIOL
Descriptor: 5-ALPHA-ANDROSTANE-3-BETA,17-ALPHA-DIOL, CALCIUM ION, SEX HORMONE-BINDING GLOBULIN, ...
Authors:Grishkovskaya, I, Avvakumov, G.V, Hammond, G.L, Catalano, M.G, Muller, Y.A.
Deposit date:2002-04-17
Release date:2002-10-23
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2 Å)
Cite:Steroid Ligands Bind Human Sex Hormone-binding Globulin in Specific Orientations and Produce Distinct Changes in Protein Conformation
J.Biol.Chem., 277, 2002
7CEC
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BU of 7cec by Molmil
Structure of alpha6beta1 integrin in complex with laminin-511
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Arimori, T, Miyazaki, N, Takagi, J.
Deposit date:2020-06-22
Release date:2021-06-23
Last modified:2021-07-14
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structural mechanism of laminin recognition by integrin.
Nat Commun, 12, 2021
4RA0
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BU of 4ra0 by Molmil
An engineered Axl 'decoy receptor' effectively silences the Gas6-Axl signaling axis
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, CHLORIDE ION, ...
Authors:Kariolis, M.S, Kapur, S, Mathews, I.I, Cochran, J.R.
Deposit date:2014-09-09
Release date:2014-09-24
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.07 Å)
Cite:An engineered Axl 'decoy receptor' effectively silences the Gas6-Axl signaling axis.
Nat.Chem.Biol., 10, 2014
5XAU
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BU of 5xau by Molmil
Crystal structure of integrin binding fragment of laminin-511
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Takizawa, M, Arimori, T, Kitago, Y, Takagi, J, Sekiguchi, K.
Deposit date:2017-03-15
Release date:2017-09-20
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Mechanistic basis for the recognition of laminin-511 by alpha 6 beta 1 integrin.
Sci Adv, 3, 2017
5MC9
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BU of 5mc9 by Molmil
Crystal structure of the heterotrimeric integrin-binding region of laminin-111
Descriptor: CALCIUM ION, Laminin subunit alpha-1, Laminin subunit beta-1, ...
Authors:Pulido, D, Hohenester, E.
Deposit date:2016-11-09
Release date:2017-02-08
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.13 Å)
Cite:Crystal Structure of the Heterotrimeric Integrin-Binding Region of Laminin-111.
Structure, 25, 2017
2C5D
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BU of 2c5d by Molmil
Structure of a minimal Gas6-Axl complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, GROWTH-ARREST-SPECIFIC PROTEIN 6 PRECURSOR, ...
Authors:Sasaki, T, Knyazev, P.G, Clout, N.J, Cheburkin, Y, Goehring, W, Ullrich, A, Timpl, R, Hohenester, E.
Deposit date:2005-10-26
Release date:2005-12-19
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structural Basis for Gas6-Axl Signalling.
Embo J., 25, 2006
5VXZ
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BU of 5vxz by Molmil
High-affinity AXL decoy receptor
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, CHLORIDE ION, ...
Authors:Mathrews, I.I, Kapur, S, Kariolis, M.S, Cochran, J.R.
Deposit date:2017-05-24
Release date:2017-06-21
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Inhibition of the GAS6/AXL pathway augments the efficacy of chemotherapies.
J. Clin. Invest., 127, 2017

 

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