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8TF4
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BU of 8tf4 by Molmil
Wildtype rabbit TRPV5 into nanodiscs in the presence of PI(4,5)P2 and econazole
Descriptor: 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-[(2S)-2-[(4-CHLOROBENZYL)OXY]-2-(2,4-DICHLOROPHENYL)ETHYL]-1H-IMIDAZOLE, ERGOSTEROL, ...
Authors:De Jesus-Perez, J.J, Fluck, E.C, Moiseenkova-Bell, V.Y.
Deposit date:2023-07-07
Release date:2024-01-10
Last modified:2024-02-14
Method:ELECTRON MICROSCOPY (2.86 Å)
Cite:Structural mechanism of TRPV5 inhibition by econazole.
Structure, 32, 2024
8TF2
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BU of 8tf2 by Molmil
Wildtype rabbit TRPV5 into nanodiscs in Apo state
Descriptor: 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ERGOSTEROL, Transient receptor potential cation channel subfamily V member 5
Authors:De Jesus-Perez, J.J, Fluck, E.C, Moiseenkova-Bell, V.Y.
Deposit date:2023-07-07
Release date:2024-01-10
Last modified:2024-02-14
Method:ELECTRON MICROSCOPY (2.57 Å)
Cite:Structural mechanism of TRPV5 inhibition by econazole.
Structure, 32, 2024
8TF3
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BU of 8tf3 by Molmil
Wildtype rabbit TRPV5 into nanodiscs in complex with econazole
Descriptor: 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-[(2S)-2-[(4-CHLOROBENZYL)OXY]-2-(2,4-DICHLOROPHENYL)ETHYL]-1H-IMIDAZOLE, ERGOSTEROL, ...
Authors:De Jesus-Perez, J.J, Fluck, E.C, Moiseenkova-Bell, V.Y.
Deposit date:2023-07-07
Release date:2024-01-10
Last modified:2024-02-14
Method:ELECTRON MICROSCOPY (2.94 Å)
Cite:Structural mechanism of TRPV5 inhibition by econazole.
Structure, 32, 2024
8T1B
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BU of 8t1b by Molmil
Cryo-EM structure of full-length human TRPV4 in apo state
Descriptor: (2R)-2-{[(4-O-hexopyranosyl-beta-D-glucopyranosyl)oxy]methyl}-4-{[(25R)-5beta,14beta,17beta-spirostan-3beta-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside, SODIUM ION, Transient receptor potential cation channel subfamily V member 4/Enhanced green fluorescent protein chimera, ...
Authors:Nadezhdin, K.D, Talyzina, I.A, Neuberger, A, Sobolevsky, A.I.
Deposit date:2023-06-02
Release date:2023-07-05
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structure of human TRPV4 in complex with GTPase RhoA.
Nat Commun, 14, 2023
8T1C
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BU of 8t1c by Molmil
Cryo-EM structure of human TRPV4 ankyrin repeat domain in complex with GTPase RhoA
Descriptor: GUANOSINE-5'-DIPHOSPHATE, Transforming protein RhoA, Transient receptor potential cation channel subfamily V member 4-Enhanced green fluorescent protein chimera
Authors:Nadezhdin, K.D, Talyzina, I.A, Neuberger, A, Sobolevsky, A.I.
Deposit date:2023-06-02
Release date:2023-07-05
Method:ELECTRON MICROSCOPY (3.49 Å)
Cite:Structure of human TRPV4 in complex with GTPase RhoA.
Nat Commun, 14, 2023
8T1D
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BU of 8t1d by Molmil
Open-state cryo-EM structure of full-length human TRPV4 in complex with agonist 4a-PDD
Descriptor: (1aR,1bS,4aS,7aS,7bS,8R,9R,9aS)-9a-(decanoyloxy)-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-1H-cyclopropa[3,4]benzo[1,2-e]azulen-9-yl decanoate, Transient receptor potential cation channel subfamily V member 4/Enhanced green fluorescent protein chimera
Authors:Talyzina, I.A, Nadezhdin, K.D, Neuberger, A, Sobolevsky, A.I.
Deposit date:2023-06-02
Release date:2023-07-05
Method:ELECTRON MICROSCOPY (3.35 Å)
Cite:Structure of human TRPV4 in complex with GTPase RhoA.
Nat Commun, 14, 2023
8T1E
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BU of 8t1e by Molmil
Closed-state cryo-EM structure of full-length human TRPV4 in the presence of 4a-PDD
Descriptor: (2R)-2-{[(4-O-hexopyranosyl-beta-D-glucopyranosyl)oxy]methyl}-4-{[(25R)-5beta,14beta,17beta-spirostan-3beta-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside, SODIUM ION, Transient receptor potential cation channel subfamily V member 4,Enhanced green fluorescent protein, ...
Authors:Talyzina, I.A, Nadezhdin, K.D, Neuberger, A, Sobolevsky, A.I.
Deposit date:2023-06-02
Release date:2023-07-05
Method:ELECTRON MICROSCOPY (2.77 Å)
Cite:Structure of human TRPV4 in complex with GTPase RhoA.
Nat Commun, 14, 2023
8T1F
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BU of 8t1f by Molmil
Cryo-EM structure of full-length human TRPV4 in complex with antagonist HC-067047
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-methyl-1-[3-(morpholin-4-yl)propyl]-5-phenyl-N-[3-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide, Transient receptor potential cation channel subfamily V member 4/Enhanced green fluorescent protein chimera
Authors:Talyzina, I.A, Nadezhdin, K.D, Neuberger, A, Sobolevsky, A.I.
Deposit date:2023-06-02
Release date:2023-07-05
Method:ELECTRON MICROSCOPY (3.49 Å)
Cite:Structure of human TRPV4 in complex with GTPase RhoA.
Nat Commun, 14, 2023
8JKM
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BU of 8jkm by Molmil
RN-1747 bound state of mTRPV4
Descriptor: Transient receptor potential cation channel subfamily V member 4
Authors:Zhen, W.X, Yang, F.
Deposit date:2023-06-01
Release date:2023-12-13
Method:ELECTRON MICROSCOPY (3.98 Å)
Cite:Structural basis of ligand activation and inhibition in a mammalian TRPV4 ion channel.
Cell Discov, 9, 2023
8SWI
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BU of 8swi by Molmil
Crystal structure of legAS4 from Legionella pneumophila subsp. pneumophila with histone H3 (1-12)peptide
Descriptor: Eukaryotic huntingtin interacting protein B, Histone H3 peptided, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Xu, C, Chung, I.Y.W, Cygler, M.
Deposit date:2023-05-18
Release date:2023-12-27
Method:X-RAY DIFFRACTION (3 Å)
Cite:The SET and ankyrin domains of the secreted Legionella pneumophila histone methyltransferase work together to modify host chromatin.
Mbio, 14, 2023
8JEU
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BU of 8jeu by Molmil
Conformation 2 of the plant potassium channel SKOR
Descriptor: Potassium channel SKOR
Authors:Liu, S, Li, S, Sun, D, Tian, C.
Deposit date:2023-05-16
Release date:2023-08-30
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Cryo-EM structure reveals a symmetry reduction of the plant outward-rectifier potassium channel SKOR.
Cell Discov, 9, 2023
8JET
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BU of 8jet by Molmil
Conformation 1 of the plant potassium channel SKOR
Descriptor: Potassium channel SKOR
Authors:Liu, S, Li, S, Sun, D, Tian, C.
Deposit date:2023-05-16
Release date:2023-08-30
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Cryo-EM structure reveals a symmetry reduction of the plant outward-rectifier potassium channel SKOR.
Cell Discov, 9, 2023
8JEC
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BU of 8jec by Molmil
plant potassium channel SKOR mutant - L271P/D312N
Descriptor: Potassium channel SKOR
Authors:Liu, S, Li, S, Tian, C.
Deposit date:2023-05-15
Release date:2023-08-30
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Cryo-EM structure reveals a symmetry reduction of the plant outward-rectifier potassium channel SKOR.
Cell Discov, 9, 2023
8SR6
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BU of 8sr6 by Molmil
Crystal structure of legAS4 from Legionella pneumophila subsp. pneumophila with histone H3 (3-17)peptide
Descriptor: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Eukaryotic huntingtin interacting protein B, ...
Authors:Xu, C, Chung, I.Y.W, Cygler, M.
Deposit date:2023-05-05
Release date:2024-03-13
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:Histone methyltransferase activity of the secreted Legionella pneumophila SET-domain effector RomA/LegAS4 depends on its ankyrin domain
To Be Published
8SP8
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BU of 8sp8 by Molmil
Human TRP channel TRPV6 in cNW30 nanodiscs inhibited by tetrahydrocannabivarin (THCV)
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CALCIUM ION, CHLORIDE ION, ...
Authors:Neuberger, A, Yelshanskaya, M.V, Nadezhdin, K.D, Sobolevsky, A.I.
Deposit date:2023-05-02
Release date:2023-08-23
Method:ELECTRON MICROSCOPY (2.79 Å)
Cite:Molecular pathway and structural mechanism of human oncochannel TRPV6 inhibition by the phytocannabinoid tetrahydrocannabivarin.
Nat Commun, 14, 2023
8J1B
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BU of 8j1b by Molmil
GSK101 and Ruthenium Red bound state of mTRPV4
Descriptor: N-[(2S)-1-{4-[N-(2,4-dichlorobenzene-1-sulfonyl)-L-seryl]piperazin-1-yl}-4-methyl-1-oxopentan-2-yl]-1-benzothiophene-2-carboxamide, Transient receptor potential cation channel subfamily V member 4, ruthenium(6+) azanide pentaamino(oxido)ruthenium (1/4/2)
Authors:Zhen, W.X, Yang, F.
Deposit date:2023-04-12
Release date:2023-08-09
Method:ELECTRON MICROSCOPY (3.72 Å)
Cite:Structural basis of ligand activation and inhibition in a mammalian TRPV4 ion channel.
Cell Discov, 9, 2023
8J1H
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BU of 8j1h by Molmil
Agonist1 and Ruthenium Red bound state of mTRPV4
Descriptor: 8-fluoranyl-3-[4-(4-fluoranylphenoxy)phenyl]-2-(4-methylpiperazin-1-yl)quinazolin-4-one, Transient receptor potential cation channel subfamily V member 4
Authors:Zhen, W.X, Yang, F.
Deposit date:2023-04-12
Release date:2023-08-09
Method:ELECTRON MICROSCOPY (3.88 Å)
Cite:Structural basis of ligand activation and inhibition in a mammalian TRPV4 ion channel.
Cell Discov, 9, 2023
8J1D
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BU of 8j1d by Molmil
Cryo-EM structure of apo state mTRPV4
Descriptor: Transient receptor potential cation channel subfamily V member 4
Authors:Zhen, W.X, Yang, F.
Deposit date:2023-04-12
Release date:2023-08-09
Method:ELECTRON MICROSCOPY (3.59 Å)
Cite:Structural basis of ligand activation and inhibition in a mammalian TRPV4 ion channel.
Cell Discov, 9, 2023
8J1F
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BU of 8j1f by Molmil
GSK101 bound state of mTRPV4
Descriptor: N-[(2S)-1-{4-[N-(2,4-dichlorobenzene-1-sulfonyl)-L-seryl]piperazin-1-yl}-4-methyl-1-oxopentan-2-yl]-1-benzothiophene-2-carboxamide, Transient receptor potential cation channel subfamily V member 4
Authors:Zhen, W.X, Yang, F.
Deposit date:2023-04-12
Release date:2023-08-09
Method:ELECTRON MICROSCOPY (3.62 Å)
Cite:Structural basis of ligand activation and inhibition in a mammalian TRPV4 ion channel.
Cell Discov, 9, 2023
8GKG
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BU of 8gkg by Molmil
Human TRPV3 pentamer structure
Descriptor: Transient receptor potential cation channel subfamily V member 3
Authors:Lansky, S, Betancourt, J.M, Scheuring, S.
Deposit date:2023-03-18
Release date:2023-09-06
Last modified:2023-09-20
Method:ELECTRON MICROSCOPY (4.38 Å)
Cite:A pentameric TRPV3 channel with a dilated pore.
Nature, 621, 2023
8GKA
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BU of 8gka by Molmil
Human TRPV3 tetramer structure, closed conformation
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, SODIUM ION, Transient receptor potential cation channel subfamily V member 3
Authors:Lansky, S, Betancourt, J.M, Scheuring, S.
Deposit date:2023-03-17
Release date:2023-09-06
Last modified:2023-09-20
Method:ELECTRON MICROSCOPY (2.55 Å)
Cite:A pentameric TRPV3 channel with a dilated pore.
Nature, 621, 2023
8GF9
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BU of 8gf9 by Molmil
Cryo-EM structure of human TRPV1 in cNW11 nanodisc and POPC:POPE:POPG lipids
Descriptor: (2R)-3-{[(R)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctadecanoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, SODIUM ION, ...
Authors:Neuberger, A, Nadezhdin, K.D, Sobolevsky, A.I.
Deposit date:2023-03-07
Release date:2023-05-10
Method:ELECTRON MICROSCOPY (2.58 Å)
Cite:Human TRPV1 structure and inhibition by the analgesic SB-366791.
Nat Commun, 14, 2023
8GFA
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BU of 8gfa by Molmil
Cryo-EM structure of human TRPV1 in complex with the analgesic drug SB-366791
Descriptor: (2E)-3-(4-chlorophenyl)-N-(3-methoxyphenyl)prop-2-enamide, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-[2-[(1~{S},2~{S},4~{S},5'~{R},6~{R},7~{S},8~{R},9~{S},12~{S},13~{R},16~{S})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol, ...
Authors:Neuberger, A, Nadezhdin, K.D, Sobolevsky, A.I.
Deposit date:2023-03-07
Release date:2023-05-10
Method:ELECTRON MICROSCOPY (2.29 Å)
Cite:Human TRPV1 structure and inhibition by the analgesic SB-366791.
Nat Commun, 14, 2023
8GF8
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BU of 8gf8 by Molmil
Cryo-EM structure of human TRPV1 in cNW11 nanodisc and soybean lipids
Descriptor: (2R)-3-{[(R)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctadecanoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, SODIUM ION, ...
Authors:Neuberger, A, Nadezhdin, K.D, Sobolevsky, A.I.
Deposit date:2023-03-07
Release date:2023-05-10
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Human TRPV1 structure and inhibition by the analgesic SB-366791.
Nat Commun, 14, 2023
8FOA
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BU of 8foa by Molmil
Cryo-EM structure of human TRPV6 in complex with the natural phytoestrogen genistein
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CALCIUM ION, CHOLESTEROL HEMISUCCINATE, ...
Authors:Neuberger, A, Yelshanskaya, M.V, Nadezhdin, K.D, Sobolevsky, A.I.
Deposit date:2022-12-30
Release date:2023-05-24
Method:ELECTRON MICROSCOPY (2.66 Å)
Cite:Structural mechanism of human oncochannel TRPV6 inhibition by the natural phytoestrogen genistein.
Nat Commun, 14, 2023

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