8FII
 
 | | Wild type APOBEC3A in complex with TT(FdZ)-hairpin inhibitor (crystal form 1) | | 分子名称: | DNA (5'-D(P*GP*CP*GP*CP*TP*TP*(UFP)P*GP*CP*GP*C)-3'), DNA dC->dU-editing enzyme APOBEC-3A, PHOSPHATE ION, ... | | 著者 | Harjes, S, Jameson, G.B, Harjes, E, Filichev, V.V, Kurup, H.M. | | 登録日 | 2022-12-16 | | 公開日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.94 Å) | | 主引用文献 | DNA-based inhibitors restrict mutagenic activity of APOBEC3 in cells
To Be Published
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8FIK
 | | APOBEC3A E72A inactive mutant in complex with ATTC-hairpin DNA substrate | | 分子名称: | CHLORIDE ION, DNA (5'-D(P*CP*CP*CP*AP*TP*CP*AP*TP*TP*CP*GP*AP*TP*GP*GP*G)-3'), DNA dC->dU-editing enzyme APOBEC-3A, ... | | 著者 | Harjes, S, Jameson, G.B, Harjes, E, Filichev, V.V, Kurup, H.M. | | 登録日 | 2022-12-16 | | 公開日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.912 Å) | | 主引用文献 | DNA-based inhibitors restrict mutagenic activity of APOBEC3 in cells
To Be Published
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8FIJ
 | | Wild type APOBEC3A in complex with TT(FdZ)-hairpin inhibitor (crystal form 2) | | 分子名称: | DNA (5'-D(*GP*CP*GP*CP*TP*TP*(UFP)P*GP*CP*GP*CP*T)-3'), DNA dC->dU-editing enzyme APOBEC-3A, PHOSPHATE ION, ... | | 著者 | Harjes, S, Jameson, G.B, Harjes, E, Filichev, V.V, Kurup, H.M. | | 登録日 | 2022-12-16 | | 公開日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.799 Å) | | 主引用文献 | DNA-based inhibitors restrict mutagenic activity of APOBEC3 in cells
To Be Published
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8FIL
 | | Zinc-free APOBEC3A (inactive E72A mutant) in complex with TTC-hairpin DNA substrate | | 分子名称: | CHLORIDE ION, DNA (5'-D(*TP*GP*CP*GP*CP*TP*TP*CP*GP*CP*GP*CP*T)-3'), DNA dC->dU-editing enzyme APOBEC-3A, ... | | 著者 | Harjes, S, Jameson, G.B, Harjes, E, Filichev, V.V, Kurup, H.M. | | 登録日 | 2022-12-16 | | 公開日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | | 主引用文献 | DNA-based inhibitors restrict mutagenic activity of APOBEC3 in cells
To Be Published
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8FIM
 | | Structure of APOBEC3A (E72A inactive mutant) in complex with TTC-hairpin DNA substrate | | 分子名称: | CHLORIDE ION, DNA (5'-D(*TP*GP*CP*GP*CP*TP*TP*CP*GP*CP*GP*CP*T)-3'), DNA dC->dU-editing enzyme APOBEC-3A, ... | | 著者 | Harjes, S, Jameson, G.B, Harjes, E, Filichev, V.V, Kurup, H.M. | | 登録日 | 2022-12-16 | | 公開日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.22 Å) | | 主引用文献 | DNA-based inhibitors restrict mutagenic activity of APOBEC3 in cells
To Be Published
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8J62
 | | Cryo-EM structure of APOBEC3G-Vif complex | | 分子名称: | APOBEC3G, Core binding factor beta, RNA (5'-R(*CP*GP*GP*UP*UP*GP*AP*UP*UP*GP*UP*UP*UP*UP*AP*AP*CP*AP*A)-3'), ... | | 著者 | Kouno, T, Shibata, S, Hyun, J, Kim, T.G, Wolf, M. | | 登録日 | 2023-04-24 | | 公開日 | 2023-07-19 | | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | | 主引用文献 | Structural insights into RNA bridging between HIV-1 Vif and antiviral factor APOBEC3G.
Nat Commun, 14, 2023
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8H0I
 | | Cryo-EM structure of APOBEC3G-Vif complex | | 分子名称: | APOBEC3G, CHLORIDE ION, Core binding factor beta, ... | | 著者 | Kouno, T, Shibata, S, Hyun, J, Kim, T.G, Wolf, M. | | 登録日 | 2022-09-29 | | 公開日 | 2023-07-19 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Structural insights into RNA bridging between HIV-1 Vif and antiviral factor APOBEC3G.
Nat Commun, 14, 2023
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8CX1
 | | Cryo-EM structure of human APOBEC3G/HIV-1 Vif/CBFbeta/ELOB/ELOC dimeric complex in State 1 | | 分子名称: | Core-binding factor subunit beta, DNA dC->dU-editing enzyme APOBEC-3G, Elongin-B, ... | | 著者 | Li, Y, Langley, C, Azumaya, C.M, Echeverria, I, Chesarino, N.M, Emerman, M, Cheng, Y, Gross, J.D. | | 登録日 | 2022-05-19 | | 公開日 | 2023-02-15 | | 最終更新日 | 2023-04-05 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | The structural basis for HIV-1 Vif antagonism of human APOBEC3G.
Nature, 615, 2023
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8CX2
 | | Cryo-EM structure of human APOBEC3G/HIV-1 Vif/CBFbeta/ELOB/ELOC dimeric complex in State 2 | | 分子名称: | Core-binding factor subunit beta, DNA dC->dU-editing enzyme APOBEC-3G, Elongin-B, ... | | 著者 | Li, Y, Langley, C, Azumaya, C.M, Echeverria, I, Chesarino, N.M, Emerman, M, Cheng, Y, Gross, J.D. | | 登録日 | 2022-05-19 | | 公開日 | 2023-02-15 | | 最終更新日 | 2023-04-05 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | The structural basis for HIV-1 Vif antagonism of human APOBEC3G.
Nature, 615, 2023
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8CX0
 | | Cryo-EM structure of human APOBEC3G/HIV-1 Vif/CBFbeta/ELOB/ELOC monomeric complex | | 分子名称: | Core-binding factor subunit beta, DNA dC->dU-editing enzyme APOBEC-3G, Elongin-B, ... | | 著者 | Li, Y, Langley, C, Azumaya, C.M, Echeverria, I, Chesarino, N.M, Emerman, M, Cheng, Y, Gross, J.D. | | 登録日 | 2022-05-19 | | 公開日 | 2023-02-15 | | 最終更新日 | 2023-04-05 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | The structural basis for HIV-1 Vif antagonism of human APOBEC3G.
Nature, 615, 2023
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7UXD
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7RW6
 | | BORF2-APOBEC3Bctd Complex | | 分子名称: | DNA dC->dU-editing enzyme APOBEC-3B, Maltose/maltodextrin-binding periplasmic protein,Ribonucleoside-diphosphate reductase large subunit, ZINC ION | | 著者 | Shaban, N.M, Yan, R, Shi, K, McLellan, J.S, Yu, Z, Harris, R.S. | | 登録日 | 2021-08-19 | | 公開日 | 2022-04-27 | | 最終更新日 | 2022-05-04 | | 実験手法 | ELECTRON MICROSCOPY (2.55 Å) | | 主引用文献 | Cryo-EM structure of the EBV ribonucleotide reductase BORF2 and mechanism of APOBEC3B inhibition.
Sci Adv, 8, 2022
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7D3V
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7D3W
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7D3X
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6X91
 | | Crystal structure of MBP-fused human APOBEC1 | | 分子名称: | CACODYLATE ION, Maltodextrin-binding protein, C->U-editing enzyme APOBEC-1 chimera, ... | | 著者 | Wolfe, A.D, Li, S.-X, Chen, X.S. | | 登録日 | 2020-06-02 | | 公開日 | 2020-12-09 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (3.51 Å) | | 主引用文献 | The structure of APOBEC1 and insights into its RNA and DNA substrate selectivity.
NAR Cancer, 2, 2020
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6NFK
 | | Crystal Structure of the Cancer Genomic DNA Mutator APOBEC3B with loop 7 from APOBEC3G bound to iodide | | 分子名称: | 1,2-ETHANEDIOL, DNA dC->dU-editing enzyme APOBEC-3B, IODIDE ION | | 著者 | Shi, K, Orellana, K, Aihara, H. | | 登録日 | 2018-12-20 | | 公開日 | 2019-12-25 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | | 主引用文献 | Active site plasticity and possible modes of chemical inhibition of the human DNA deaminase APOBEC3B
Faseb Bioadv, 2, 2020
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6NFM
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6NFL
 | | Crystal Structure of the Cancer Genomic DNA Mutator APOBEC3B with loop 7 from APOBEC3G complexed with 2-HP | | 分子名称: | 1,2-ETHANEDIOL, 1,3-diazinan-2-one, CHLORIDE ION, ... | | 著者 | Shi, K, Orellana, K, Aihara, H. | | 登録日 | 2018-12-20 | | 公開日 | 2019-12-25 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.731 Å) | | 主引用文献 | Active site plasticity and possible modes of chemical inhibition of the human DNA deaminase APOBEC3B
Faseb Bioadv, 2, 2020
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6K3K
 | | Solution structure of APOBEC3G-CD2 with ssDNA, Product B | | 分子名称: | DNA dC->dU-editing enzyme APOBEC-3G, DNA/RNA (5'-D(*AP*TP*TP*CP*UP*(ICY)P*AP*AP*TP*T)-3'), ZINC ION | | 著者 | Cao, C, Yan, X, Lan, W, Wang, C. | | 登録日 | 2019-05-19 | | 公開日 | 2019-06-12 | | 最終更新日 | 2023-06-14 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural Investigations on the Interactions between Cytidine Deaminase Human APOBEC3G and DNA.
Chem Asian J, 14, 2019
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6K3J
 | | Solution structure of APOBEC3G-CD2 with ssDNA, Product A | | 分子名称: | DNA (5'-D(*AP*TP*TP*CP*UP*(IUR)P*AP*AP*TP*T)-3'), DNA dC->dU-editing enzyme APOBEC-3G, ZINC ION | | 著者 | Cao, C, Yan, X, Lan, W, Wang, C. | | 登録日 | 2019-05-19 | | 公開日 | 2019-06-12 | | 最終更新日 | 2023-06-14 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural Investigations on the Interactions between Cytidine Deaminase Human APOBEC3G and DNA.
Chem Asian J, 14, 2019
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6BUX
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6BWY
 | | DNA substrate selection by APOBEC3G | | 分子名称: | DNA (30-MER), PHOSPHATE ION, Protection of telomeres protein 1, ... | | 著者 | Ziegler, S.J, Buzovetsky, O. | | 登録日 | 2017-12-15 | | 公開日 | 2018-04-18 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Insights into DNA substrate selection by APOBEC3G from structural, biochemical, and functional studies.
PLoS ONE, 13, 2018
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5SXG
 | | Crystal Structure of the Cancer Genomic DNA Mutator APOBEC3B | | 分子名称: | 1,3-PROPANDIOL, DNA dC->dU-editing enzyme APOBEC-3B, IMIDAZOLE, ... | | 著者 | Shi, K, Kurahashi, K, Aihara, H. | | 登録日 | 2016-08-09 | | 公開日 | 2017-12-27 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | | 主引用文献 | Conformational Switch Regulates the DNA Cytosine Deaminase Activity of Human APOBEC3B.
Sci Rep, 7, 2017
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5SXH
 | | Crystal Structure of the Cancer Genomic DNA Mutator APOBEC3B | | 分子名称: | 1,2-ETHANEDIOL, DNA dC->dU-editing enzyme APOBEC-3B, ZINC ION | | 著者 | Shi, K, Kurahashi, K, Aihara, H. | | 登録日 | 2016-08-09 | | 公開日 | 2017-12-27 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | | 主引用文献 | Conformational Switch Regulates the DNA Cytosine Deaminase Activity of Human APOBEC3B.
Sci Rep, 7, 2017
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