PDB: 125 件ウェブページステータス検索Chemie searchBIRD

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1BJC	SOLUTION NMR STRUCTURE OF AMYLOID BETA[F16], RESIDUES 1-28, 15 STRUCTURES 分子名称: AMYLOID BETA-PEPTIDE 著者 Poulsen, S.-A, Watson, A.A, Craik, D.J. 登録日 1998-06-23 公開日 1998-11-18 最終更新日 2021-11-03 実験手法 SOLUTION NMR 主引用文献 Solution structures in aqueous SDS micelles of two amyloid beta peptides of A beta(1-28) mutated at the alpha-secretase cleavage site (K16E, K16F) J.Struct.Biol., 130, 2000
5OQV	Near-atomic resolution fibril structure of complete amyloid-beta(1-42) by cryo-EM 分子名称: Amyloid beta A4 protein 著者 Gremer, L, Schoelzel, D, Schenk, C, Reinartz, E, Labahn, J, Ravelli, R, Tusche, M, Lopez-Iglesias, C, Hoyer, W, Heise, H, Willbold, D, Schroeder, G.F. 登録日 2017-08-14 公開日 2017-09-13 最終更新日 2017-10-18 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 Fibril structure of amyloid-beta (1-42) by cryo-electron microscopy. Science, 358, 2017
3IFN	X-ray structure of amyloid beta peptide:antibody (Abeta1-40:12A11) complex 分子名称: 12A11 FAB antibody heavy chain, 12A11 FAB antibody light chain, Amyloid beta A4 protein 著者 Weis, W.I, Feinberg, H, Basi, G.S, Schenk, D. 登録日 2009-07-24 公開日 2009-11-17 最終更新日 2013-06-19 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Structural correlates of antibodies associated with acute reversal of amyloid beta-related behavioral deficits in a mouse model of Alzheimer disease. J.Biol.Chem., 285, 2010
2OTK	Structure of Alzheimer Ab peptide in complex with an engineered binding protein 分子名称: Amyloid beta A4 protein, ZAb3 Affibody dimer 著者 Hoyer, W, Hard, T. 登録日 2007-02-08 公開日 2008-02-12 最終更新日 2019-12-04 実験手法 SOLUTION NMR 主引用文献 Stabilization of a beta-hairpin in monomeric Alzheimer's amyloid-beta peptide inhibits amyloid formation. Proc.Natl.Acad.Sci.Usa, 105, 2008
2BEG	3D Structure of Alzheimer's Abeta(1-42) fibrils 分子名称: Amyloid beta A4 protein 著者 Luhrs, T, Ritter, C, Adrian, M, Riek-Loher, D, Bohrmann, B, Dobeli, H, Schubert, D, Riek, R. 登録日 2005-10-24 公開日 2005-11-22 最終更新日 2022-03-09 実験手法 SOLUTION NMR 主引用文献 3D structure of Alzheimer's amyloid-{beta}(1-42) fibrils. Proc.Natl.Acad.Sci.Usa, 102, 2005
5HOX	X-ray crystallographic structure of an A-beta 17_36 beta-hairpin. Synchrotron data set. (LVFFAEDCGSNKCAII(SAR)LMV). 分子名称: Amyloid beta A4 protein, O-(O-(2-AMINOPROPYL)-O'-(2-METHOXYETHYL)POLYPROPYLENE GLYCOL 500) 著者 Kreutzer, A.G, Nowick, J.S, Spencer, R.K. 登録日 2016-01-19 公開日 2016-03-23 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 X-ray Crystallographic Structures of a Trimer, Dodecamer, and Annular Pore Formed by an A beta 17-36 beta-Hairpin. J.Am.Chem.Soc., 138, 2016
1HZ3	ALZHEIMER'S DISEASE AMYLOID-BETA PEPTIDE (RESIDUES 10-35) 分子名称: A-BETA AMYLOID 著者 Zhang, S, Iwata, K, Lachenmann, M.J, Peng, J.W, Li, S, Stimson, E.R, Lu, Y, Felix, A.M, Maggio, J.E, Lee, J.P. 登録日 2001-01-23 公開日 2001-01-31 最終更新日 2022-02-23 実験手法 SOLUTION NMR 主引用文献 The Alzheimer's peptide a beta adopts a collapsed coil structure in water. J.Struct.Biol., 130, 2000
1Z0Q	Aqueous Solution Structure of the Alzheimer's Disease Abeta Peptide (1-42) 分子名称: Alzheimer's disease amyloid 著者 Tomaselli, S, Esposito, V, Vangone, P, van Nuland, N.A, Bonvin, A.M, Guerrini, R, Tancredi, T, Temussi, P.A, Picone, D. 登録日 2005-03-02 公開日 2006-05-23 最終更新日 2022-03-02 実験手法 SOLUTION NMR 主引用文献 The alpha-to-beta Conformational Transition of Alzheimer's Abeta-(1-42) Peptide in Aqueous Media is Reversible: A Step by Step Conformational Analysis Suggests the Location of beta Conformation Seeding Chembiochem, 7, 2006
7RTZ	X-ray crystallographic structure of a beta-hairpin peptide derived from amyloid beta 14-40 分子名称: Amyloid-beta protein 40, CHLORIDE ION 著者 Samdin, T.D, Kreutzer, A.G, Nowick, J.S. 登録日 2021-08-16 公開日 2022-08-31 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 A beta-Barrel-Like Tetramer Formed by a beta-Hairpin Derived From A beta Chem Sci, 2023
1IYT	Solution structure of the Alzheimer's disease amyloid beta-peptide (1-42) 分子名称: Alzheimer's disease amyloid 著者 Crescenzi, O, Tomaselli, S, Guerrini, R, Salvadori, S, D'Ursi, A.M, Temussi, P.A, Picone, D. 登録日 2002-09-06 公開日 2003-02-11 最終更新日 2023-12-27 実験手法 SOLUTION NMR 主引用文献 Solution structure of the Alzheimer amyloid beta-peptide (1-42) in an apolar microenvironment. Similarity with a virus fusion domain. EUR.J.BIOCHEM., 269, 2002
7Q4M	Type II beta-amyloid 42 Filaments from Human Brain 分子名称: Amyloid-beta precursor protein, UNKNOWN ATOM OR ION 著者 Yang, Y, Arseni, D, Zhang, W, Huang, M, Lovestam, S.K.A, Schweighauser, M, Kotecha, A, Murzin, A.G, Peak-Chew, S.Y, Macdonald, J, Lavenir, I, Garringer, H.J, Gelpi, E, Newell, K.L, Kovacs, G.G, Vidal, R, Ghetti, B, Falcon, B, Scheres, S.H.W, Goedert, M. 登録日 2021-11-01 公開日 2021-11-24 最終更新日 2023-03-08 実験手法 ELECTRON MICROSCOPY (2.8 Å) 主引用文献 Cryo-EM structures of amyloid-beta 42 filaments from human brains. Science, 375, 2022
7Q4B	Type I beta-amyloid 42 Filaments from Human Brain 分子名称: Amyloid-beta precursor protein, UNKNOWN ATOM OR ION 著者 Yang, Y, Arseni, D, Zhang, W, Huang, M, Lovestam, S.K.A, Schweighauser, M, Kotecha, A, Murzin, A.G, Peak-Chew, S.Y, Macdonald, J, Lavenir, I, Garringer, H.J, Gelpi, E, Newell, K.L, Kovacs, G.G, Vidal, R, Ghetti, B, Falcon, B, Scheres, S.H.W, Goedert, M. 登録日 2021-10-30 公開日 2021-11-24 最終更新日 2023-03-08 実験手法 ELECTRON MICROSCOPY (2.5 Å) 主引用文献 Cryo-EM structures of amyloid-beta 42 filaments from human brains. Science, 375, 2022
5MYK	Structure of Pyroglutamate-Abeta-specific Fab c#17 in complex with murine Abeta-pE3-18PEGb 分子名称: Amyloid beta A4 protein, Fab c#17 heavy chain, Fab c#17 light chain 著者 Parthier, C, Piechotta, A, Stubbs, M.T. 登録日 2017-01-26 公開日 2017-06-28 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structural and functional analyses of pyroglutamate-amyloid-beta-specific antibodies as a basis for Alzheimer immunotherapy. J. Biol. Chem., 292, 2017
6W0O	Amyloid-beta(1-40) fibril derived from Alzheimer's disease cortical tissue 分子名称: Amyloid-beta precursor protein 著者 Ghosh, U, Thurber, K.R, Tycko, R. 登録日 2020-03-02 公開日 2021-01-13 最終更新日 2023-06-14 実験手法 ELECTRON MICROSCOPY (2.77 Å), SOLID-STATE NMR 主引用文献 Molecular structure of a prevalent amyloid-beta fibril polymorph from Alzheimer's disease brain tissue. Proc.Natl.Acad.Sci.USA, 118, 2021
5MYX	Structure of Pyroglutamate-Abeta-specific Fab c#24 in complex with human Abeta-pE3-18 分子名称: Fab c#24 heavy chain, Fab c#24 light chain, Pyroglutamate-Abeta pE3-18 著者 Parthier, C, Piechotta, A, Stubbs, M.T. 登録日 2017-01-30 公開日 2017-06-28 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.492 Å) 主引用文献 Structural and functional analyses of pyroglutamate-amyloid-beta-specific antibodies as a basis for Alzheimer immunotherapy. J. Biol. Chem., 292, 2017
6WXM	X-ray crystallographic structure of a beta-hairpin peptide derived from amyloid beta 16-36 分子名称: Amyloid-beta protein, HEXANE-1,6-DIOL 著者 Kreutzer, A.G, Nowick, J.S. 登録日 2020-05-11 公開日 2020-07-08 最終更新日 2020-08-26 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 X-ray Crystallography Reveals Parallel and Antiparallel beta-Sheet Dimers of a beta-Hairpin Derived from A beta16-36that Assemble to Form Different Tetramers. Acs Chem Neurosci, 11, 2020
7U4P	Covalently stabilized triangular trimer composed of Abeta17-36 beta-hairpins 分子名称: Amyloid-beta 17-36 peptide 著者 Kreutzer, A.G, Haerianardakani, S, Nowick, J.S. 登録日 2022-02-28 公開日 2023-03-15 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (1.803 Å) 主引用文献 Antibodies Raised Against an A beta Oligomer Mimic Recognize Pathological Features in Alzheimer's Disease and Associated Amyloid-Disease Brain Tissue. Acs Cent.Sci., 10, 2024
7Y8Q	Amyloid-beta assemblage on GM1-containing membranes 分子名称: Amyloid-beta protein 40 著者 Yagi-Utsumi, M, Itoh, S.G, Okumura, H, Yanagisawa, K, Kato, K, Nishimura, K. 登録日 2022-06-24 公開日 2023-07-05 最終更新日 2023-09-20 実験手法 SOLID-STATE NMR 主引用文献 The Double-Layered Structure of Amyloid-beta Assemblage on GM1-Containing Membranes Catalytically Promotes Fibrillization. Acs Chem Neurosci, 14, 2023
1NMJ	The Solution Structure of Rat Ab-(1-28) and its Interaction with Zinc: Insights into the Scarity of Amyloid Deposition in Aged Rat Brain 分子名称: amyloid beta-peptide from Alzheimer's disease amyloid A4 protein homolog 著者 Huang, J, Yao, Y, Tang, W.X. 登録日 2003-01-10 公開日 2003-01-28 最終更新日 2022-02-23 実験手法 SOLUTION NMR 主引用文献 The solution structure of rat Abeta-(1-28) and its interaction with zinc ion: insights into the scarcity of amyloid deposition in aged rat brain J.Biol.Inorg.Chem., 9, 2004
7B3K	Dynamic complex between all-D-enantiomeric peptide D3 with L723P mutant of amyloid precursor protein (APP) 672-726 fragment (amyloid beta 1-55) 分子名称: D3 all D-enantimeric peptide, Isoform L-APP677 of Amyloid-beta precursor protein 著者 Bocharov, E.V, Volynsky, P.E, Okhrimenko, I.S, Urban, A.S. 登録日 2020-12-01 公開日 2021-01-13 最終更新日 2023-06-14 実験手法 SOLUTION NMR 主引用文献 All - d - Enantiomeric Peptide D3 Designed for Alzheimer's Disease Treatment Dynamically Interacts with Membrane-Bound Amyloid-beta Precursors. J.Med.Chem., 64, 2021
7B3J	Dynamic complex between all-D-enantiomeric peptide D3 with wild-type amyloid precursor protein 672-726 fragment (amyloid beta 1-55) 分子名称: D3 all D-enantimeric peptide, Isoform L-APP677 of Amyloid-beta precursor protein 著者 Bocharov, E.V, Volynsky, P.E, Okhrimenko, I.S, Urban, A.S. 登録日 2020-12-01 公開日 2021-01-13 最終更新日 2021-12-08 実験手法 SOLUTION NMR 主引用文献 All - d - Enantiomeric Peptide D3 Designed for Alzheimer's Disease Treatment Dynamically Interacts with Membrane-Bound Amyloid-beta Precursors. J.Med.Chem., 64, 2021
5HOW	X-ray crystallographic structure of an Abeta 17-36 beta-hairpin. LV(PHI)FAEDCGSNKCAII(SAR)L(ORN)V 分子名称: Amyloid beta A4 protein 著者 Kreutzer, A.G, Nowick, J.S, Spencer, R.K. 登録日 2016-01-19 公開日 2016-03-23 最終更新日 2019-12-25 実験手法 X-RAY DIFFRACTION (2.295 Å) 主引用文献 X-ray Crystallographic Structures of a Trimer, Dodecamer, and Annular Pore Formed by an A beta 17-36 beta-Hairpin. J.Am.Chem.Soc., 138, 2016
6NB9	Amyloid-Beta (20-34) with L-isoaspartate 23 分子名称: Amyloid-beta A4 protein 著者 Sawaya, M.R, Warmack, R.A, Boyer, D.R, Zee, C.T, Richards, L.S, Cascio, D, Gonen, T, Clarke, S.G, Eisenberg, D.S. 登録日 2018-12-06 公開日 2019-08-07 最終更新日 2022-09-07 実験手法 ELECTRON CRYSTALLOGRAPHY (1.05 Å) 主引用文献 Structure of amyloid-beta (20-34) with Alzheimer's-associated isomerization at Asp23 reveals a distinct protofilament interface. Nat Commun, 10, 2019
5HOY	X-ray crystallographic structure of an A-beta 17_36 beta-hairpin. X-ray diffractometer data set. (LVFFAEDCGSNKCAII(SAR)LMV). 分子名称: Amyloid beta A4 protein, O-(O-(2-AMINOPROPYL)-O'-(2-METHOXYETHYL)POLYPROPYLENE GLYCOL 500) 著者 Kreutzer, A.G, Spencer, R.K, Nowick, J.S. 登録日 2016-01-19 公開日 2016-03-23 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.295 Å) 主引用文献 X-ray Crystallographic Structures of a Trimer, Dodecamer, and Annular Pore Formed by an A beta 17-36 beta-Hairpin. J.Am.Chem.Soc., 138, 2016
7F29	Cryo-EM structure of the fibril formed by disaccharide-modified amyloid-beta(1-42) 分子名称: ACETIC ACID, Amyloid-beta A4 protein, beta-D-galactopyranose-(1-3)-2-amino-2-deoxy-alpha-D-galactopyranose 著者 Xia, W.C, Sun, Y.P, Liu, C. 登録日 2021-06-10 公開日 2022-07-13 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 O-Glycosylation Induces Amyloid-beta To Form New Fibril Polymorphs Vulnerable for Degradation J.Am.Chem.Soc., 143, 2021

 

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