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1B7Y
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PHENYLALANYL TRNA SYNTHETASE COMPLEXED WITH PHENYLALANINYL-ADENYLATE
分子名称: ADENOSINE-5'-[PHENYLALANINOL-PHOSPHATE], MAGNESIUM ION, PROTEIN (PHENYLALANYL-TRNA SYNTHETASE)
著者Reshetnikova, L, Moor, N, Lavrik, O, Vassylyev, D.G.
登録日1999-01-26
公開日2000-01-26
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal structures of phenylalanyl-tRNA synthetase complexed with phenylalanine and a phenylalanyl-adenylate analogue.
J.Mol.Biol., 287, 1999
1B70
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PHENYLALANYL TRNA SYNTHETASE COMPLEXED WITH PHENYLALANINE
分子名称: MAGNESIUM ION, PHENYLALANINE, PHENYLALANYL-TRNA SYNTHETASE
著者Reshetnikova, L, Moor, N, Lavrik, O, Vassylyev, D.G.
登録日1999-01-26
公開日2000-02-09
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Crystal structures of phenylalanyl-tRNA synthetase complexed with phenylalanine and a phenylalanyl-adenylate analogue
J.Mol.Biol., 287, 1999
3CMQ
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Crystal structure of human mitochondrial phenylalanine tRNA synthetase
分子名称: ADENOSINE-5'-[PHENYLALANINYL-PHOSPHATE], MAGNESIUM ION, Phenylalanyl-tRNA synthetase, ...
著者Klipcan, L, Levin, I.L, Kessler, N, Moor, N, Finarov, I, Safro, M.
登録日2008-03-24
公開日2008-07-01
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献The tRNA-Induced Conformational Activation of Human Mitochondrial Phenylalanyl-tRNA Synthetase.
Structure, 16, 2008
1EIY
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THE CRYSTAL STRUCTURE OF PHENYLALANYL-TRNA SYNTHETASE FROM THERMUS THERMOPHILUS COMPLEXED WITH COGNATE TRNAPHE
分子名称: PHENYLALANYL-TRNA SYNTHETASE, TRNA(PHE)
著者Goldgur, Y, Mosyak, L, Reshetnikova, L, Ankilova, V, Safro, M.
登録日2000-02-29
公開日2000-03-06
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献The crystal structure of phenylalanyl-tRNA synthetase from thermus thermophilus complexed with cognate tRNAPhe.
Structure, 5, 1997
1JJC
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Crystal structure at 2.6A resolution of phenylalanyl-tRNA synthetase complexed with phenylalanyl-adenylate in the presence of manganese
分子名称: ADENOSINE-5'-[PHENYLALANINYL-PHOSPHATE], MANGANESE (II) ION, PHENYLALANYL-TRNA SYNTHETASE ALPHA CHAIN, ...
著者Safro, M.G, Fishman, R, Moor, N, Ankilova, V.
登録日2001-07-04
公開日2001-11-02
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structure at 2.6 A resolution of phenylalanyl-tRNA synthetase complexed with phenylalanyl-adenylate in the presence of manganese.
Acta Crystallogr.,Sect.D, 57, 2001
4TVA
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BU of 4tva by Molmil
Universal Pathway for Post-Transfer Editing Reactions: Insight from Crystal structure of TthPheRS with Puromycine
分子名称: PHENYLALANINE, PUROMYCIN, Phenylalanine--tRNA ligase alpha subunit, ...
著者Safro, M, Klipcan, L, Tworowski, D, Peretz, M.
登録日2014-06-26
公開日2015-03-18
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.597 Å)
主引用文献Universal pathway for posttransfer editing reactions: Insights from the crystal structure of TtPheRS with puromycin.
Proc.Natl.Acad.Sci.USA, 112, 2015
8P8X
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BU of 8p8x by Molmil
Crystal structure of a pathogenic mutant variant of human mitochodnrial PheRS
分子名称: PHENYLALANINE, Phenylalanine--tRNA ligase, mitochondrial
著者Chen, W, Kuhle, B.
登録日2023-06-03
公開日2023-08-16
実験手法X-RAY DIFFRACTION (1.46 Å)
主引用文献Clinical and molecular characterization of novel FARS2 variants causing neonatal mitochondrial disease.
Mol.Genet.Metab., 140, 2023
1PYS
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PHENYLALANYL-TRNA SYNTHETASE FROM THERMUS THERMOPHILUS
分子名称: MAGNESIUM ION, PHENYLALANYL-TRNA SYNTHETASE
著者Safro, M, Mosyak, L, Goldgur, Y, Reshetnikova, L, Delarue, M.
登録日1996-11-14
公開日1997-11-19
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structure of phenylalanyl-tRNA synthetase from Thermus thermophilus.
Nat.Struct.Biol., 2, 1995
3PCO
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crystal structure of E. coli phenylalanine-tRNA synthetase complexed with phenylalanine and AMP
分子名称: ADENOSINE MONOPHOSPHATE, PHENYLALANINE, Phenylalanyl-tRNA synthetase, ...
著者Mermershtain, I, Finarov, I, Klipcan, L, Kessler, N, Rozenberg, H, Safro, M.G.
登録日2010-10-21
公開日2011-03-02
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (3.02 Å)
主引用文献Idiosyncrasy and identity in the prokaryotic phe-system: crystal structure of E. coli phenylalanyl-tRNA synthetase complexed with phenylalanine and AMP.
Protein Sci., 20, 2011
2IY5
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PHENYLALANYL-TRNA SYNTHETASE FROM THERMUS THERMOPHILUS complexed with tRNA and a phenylalanyl-adenylate analog
分子名称: ADENOSINE-5'-[PHENYLALANINOL-PHOSPHATE], MAGNESIUM ION, PHENYLALANYL-TRNA SYNTHETASE ALPHA CHAIN, ...
著者Moor, N, Kotik-Kogan, O, Tworowski, D, Sukhanova, M, Safro, M.
登録日2006-07-12
公開日2006-09-06
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献The crystal structure of the ternary complex of phenylalanyl-tRNA synthetase with tRNAPhe and a phenylalanyl-adenylate analogue reveals a conformational switch of the CCA end.
Biochemistry, 45, 2006
3HFV
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Crystal structure of human mitochondrial phenylalanyl-tRNA synthetase complexed with m-tyrosine
分子名称: META-TYROSINE, Phenylalanyl-tRNA synthetase, mitochondrial
著者Klipcan, L, Moor, N, Kessler, N, Safro, M.G.
登録日2009-05-12
公開日2009-07-21
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Eukaryotic cytosolic and mitochondrial phenylalanyl-tRNA synthetases catalyze the charging of tRNA with the meta-tyrosine
Proc.Natl.Acad.Sci.USA, 106, 2009
3HFZ
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Crystal structure of Thermus thermophilus Phenylalanyl-tRNA synthetase complexed with m-tyrosine
分子名称: META-TYROSINE, Phenylalanyl-tRNA synthetase alpha chain, Phenylalanyl-tRNA synthetase beta chain
著者Klipcan, L, Moor, N, Kessler, N, Safro, M.G.
登録日2009-05-13
公開日2009-07-21
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Eukaryotic cytosolic and mitochondrial phenylalanyl-tRNA synthetases catalyze the charging of tRNA with the meta-tyrosine
Proc.Natl.Acad.Sci.USA, 106, 2009
2RHS
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BU of 2rhs by Molmil
PheRS from Staphylococcus haemolyticus- rational protein engineering and inhibitor studies
分子名称: 1-{3-[(4-pyridin-2-ylpiperazin-1-yl)sulfonyl]phenyl}-3-(1,3-thiazol-2-yl)urea, Phenylalanyl-tRNA synthetase alpha chain, Phenylalanyl-tRNA synthetase beta chain, ...
著者Evdokimov, A.G, Mekel, M.
登録日2007-10-09
公開日2007-11-06
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Rational protein engineering in action: the first crystal structure of a phenylalanine tRNA synthetase from Staphylococcus haemolyticus.
J.Struct.Biol., 162, 2008
2RHQ
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PheRS from Staphylococcus haemolyticus- rational protein engineering and inhibitor studies
分子名称: 1-{3-[(4-pyridin-2-ylpiperazin-1-yl)sulfonyl]phenyl}-3-(1,3-thiazol-2-yl)urea, Phenylalanyl-tRNA synthetase alpha chain, Phenylalanyl-tRNA synthetase beta chain, ...
著者Evdokimov, A.G, Mekel, M.
登録日2007-10-09
公開日2007-11-06
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Rational protein engineering in action: the first crystal structure of a phenylalanine tRNA synthetase from Staphylococcus haemolyticus.
J.Struct.Biol., 162, 2008
7DB7
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BU of 7db7 by Molmil
Crystal structure of Mycobacterium tuberculosis phenylalanyl-tRNA synthetase in complex with compound GDI05-001
分子名称: 1-[3-[2-(1H-indol-3-yl)ethylsulfamoyl]phenyl]-3-(1,3-thiazol-2-yl)urea, Phenylalanine--tRNA ligase alpha subunit, Phenylalanine--tRNA ligase beta subunit, ...
著者Xu, M, Zhang, X, Xu, L, Chen, S.
登録日2020-10-19
公開日2021-01-13
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.71 Å)
主引用文献Re-discovery of PF-3845 as a new chemical scaffold inhibiting phenylalanyl-tRNA synthetase in Mycobacterium tuberculosis .
J.Biol.Chem., 2021
7DAW
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BU of 7daw by Molmil
Crystal structure of Mycobacterium tuberculosis phenylalanyl-tRNA synthetase
分子名称: Phenylalanine--tRNA ligase alpha subunit, Phenylalanine--tRNA ligase beta subunit, SULFATE ION
著者Xu, M, Zhang, X, Xu, L, Chen, S.
登録日2020-10-18
公開日2021-01-13
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.83 Å)
主引用文献Re-discovery of PF-3845 as a new chemical scaffold inhibiting phenylalanyl-tRNA synthetase in Mycobacterium tuberculosis .
J.Biol.Chem., 2021
7DB8
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Crystal structure of Mycobacterium tuberculosis phenylalanyl-tRNA synthetase in complex with compound PF-3845
分子名称: N-pyridin-3-yl-4-[[3-[5-(trifluoromethyl)pyridin-2-yl]oxyphenyl]methyl]piperidine-1-carboxamide, Phenylalanine--tRNA ligase alpha subunit, Phenylalanine--tRNA ligase beta subunit, ...
著者Xu, M, Zhang, X, Xu, L, Chen, S.
登録日2020-10-19
公開日2021-01-13
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Re-discovery of PF-3845 as a new chemical scaffold inhibiting phenylalanyl-tRNA synthetase in Mycobacterium tuberculosis .
J.Biol.Chem., 2021
3TEG
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Bacterial and Eukaryotic Phenylalanyl-tRNA Synthetases Catalyze Misaminoacylation of tRNAPhe with 3,4-Dihydroxy-L-Phenylalanine (L-Dopa)
分子名称: 3,4-DIHYDROXYPHENYLALANINE, Phenylalanyl-tRNA synthetase, mitochondrial
著者Moor, N, Klipcan, L, Safro, M.
登録日2011-08-14
公開日2011-11-23
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.2044 Å)
主引用文献Bacterial and Eukaryotic Phenylalanyl-tRNA Synthetases Catalyze Misaminoacylation of tRNA(Phe) with 3,4-Dihydroxy-L-Phenylalanine.
Chem.Biol., 18, 2011
3TEH
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Crystal structure of Thermus thermophilus Phenylalanyl-tRNA synthetase complexed with L-dopa
分子名称: 3,4-DIHYDROXYPHENYLALANINE, Phenylalanyl-tRNA synthetase alpha chain, Phenylalanyl-tRNA synthetase beta chain
著者Safro, M, Klipcan, L, Moor, N.
登録日2011-08-14
公開日2011-11-23
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.8524 Å)
主引用文献Bacterial and Eukaryotic Phenylalanyl-tRNA Synthetases Catalyze Misaminoacylation of tRNA(Phe) with 3,4-Dihydroxy-L-Phenylalanine.
Chem.Biol., 18, 2011
2AKW
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Crystal Structure of T.Thermophilus Phenylalanyl-tRNA synthetase complexed with p-Cl-Phenylalanine
分子名称: 4-CHLORO-L-PHENYLALANINE, MANGANESE (II) ION, Phenylalanyl-tRNA synthetase alpha chain, ...
著者Kotik-Kogan, O.M, Moor, N.A, Tworowski, D.E, Safro, M.G.
登録日2005-08-04
公開日2005-12-27
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structural Basis for Discrimination of L-Phenylalanine from L-Tyrosine by Phenylalanyl-tRNA Synthetase
Structure, 13, 2005
2ALY
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Crystal Structure of T.Thermophilus Phenylalanyl-tRNA synthetase complexed with 5'-O-[N-(L-tyrosyl)sulphamoyl]adenosine
分子名称: 5'-O-[N-(L-TYROSYL)SULFAMOYL]ADENOSINE, MANGANESE (II) ION, Phenylalanyl-tRNA synthetase alpha chain, ...
著者Kotik-Kogan, O.M, Moor, N.A, Tworowski, D.E, Safro, M.G.
登録日2005-08-04
公開日2005-12-27
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural Basis for Discrimination of L-Phenylalanine from L-Tyrosine by Phenylalanyl-tRNA Synthetase
Structure, 13, 2005
2AMC
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Crystal structure of Phenylalanyl-tRNA synthetase complexed with L-tyrosine
分子名称: MAGNESIUM ION, Phenylalanyl-tRNA synthetase alpha chain, Phenylalanyl-tRNA synthetase beta chain, ...
著者Kotik-Kogan, O, Moor, N, Tworowski, D, Safro, M.
登録日2005-08-09
公開日2005-12-20
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structural Basis for Discrimination of L-Phenylalanine from L-Tyrosine by Phenylalanyl-tRNA Synthetase
Structure, 13, 2005
3TUP
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Crystal structure of human mitochondrial PheRS complexed with tRNAPhe in the active open state
分子名称: Phenylalanyl-tRNA synthetase, mitochondrial, Thermus thermophilus tRNAPhe
著者Safro, M, Klipcan, L, Moor, N, Finarov, I, Kessler, N, Sukhanova, M.
登録日2011-09-17
公開日2011-11-23
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (3.05 Å)
主引用文献Crystal Structure of Human Mitochondrial PheRS Complexed with tRNA(Phe) in the Active "Open" State.
J.Mol.Biol., 415, 2012
6P26
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Escherichia coli tRNA synthetase in complex with compound 1
分子名称: N-benzyl-2-(cyclohex-1-en-1-yl)ethan-1-amine, Phenylalanine--tRNA ligase alpha subunit, Phenylalanine--tRNA ligase beta subunit
著者Kahne, D, Baidin, V, Owens, T.W.
登録日2019-05-21
公開日2020-11-18
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.16 Å)
主引用文献Simple Secondary Amines Inhibit Growth of Gram-Negative Bacteria through Highly Selective Binding to Phenylalanyl-tRNA Synthetase.
J.Am.Chem.Soc., 143, 2021
6P24
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Escherichia coli tRNA synthetase
分子名称: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, ...
著者Kahne, D, Baidin, V, Owens, T.W.
登録日2019-05-20
公開日2020-11-18
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.12 Å)
主引用文献Simple Secondary Amines Inhibit Growth of Gram-Negative Bacteria through Highly Selective Binding to Phenylalanyl-tRNA Synthetase.
J.Am.Chem.Soc., 143, 2021

 

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