6HAW
 
 | | Crystal structure of bovine cytochrome bc1 in complex with 2-pyrazolyl quinolone inhibitor WDH2G7 | | 分子名称: | 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHATE, ... | | 著者 | Amporndanai, K, Hong, W.D, O'Neill, P.M, Hasnain, S.S, Antonyuk, S.V. | | 登録日 | 2018-08-08 | | 公開日 | 2019-01-16 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (3.45 Å) | | 主引用文献 | Potent Antimalarial 2-Pyrazolyl Quinolonebc1(Qi) Inhibitors with Improved Drug-like Properties.
ACS Med Chem Lett, 9, 2018
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5GUP
 | | Cryo-EM structure of mammalian respiratory supercomplex I1III2IV1 | | 分子名称: | (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL, 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine, Acyl carrier protein, ... | | 著者 | Gu, J, Wu, M, Guo, R, Yang, M. | | 登録日 | 2016-08-30 | | 公開日 | 2017-03-29 | | 最終更新日 | 2019-11-06 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | Structure of Mammalian Respiratory Supercomplex I1III2IV1
Cell, 167, 2016
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6NHG
 | | Rhodobacter sphaeroides Mitochondrial respiratory chain complex | | 分子名称: | (2R)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(tetradecanoyloxy)propyl octadecanoate, 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, 1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE, ... | | 著者 | Xia, D, Zhou, F, Esser, L. | | 登録日 | 2018-12-21 | | 公開日 | 2019-06-19 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Crystal structure of bacterial cytochromebc1in complex with azoxystrobin reveals a conformational switch of the Rieske iron-sulfur protein subunit.
J.Biol.Chem., 294, 2019
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8Q1B
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3TGU
 | | Cytochrome bc1 complex from chicken with pfvs-designed moa inhibitor bound | | 分子名称: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, CARDIOLIPIN, Coenzyme Q10, ... | | 著者 | Huang, L.-S, Yang, G.-F, Berry, E.A. | | 登録日 | 2011-08-17 | | 公開日 | 2012-07-04 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Computational discovery of picomolar Q(o) site inhibitors of cytochrome bc1 complex.
J.Am.Chem.Soc., 134, 2012
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2YBB
 | | Fitted model for bovine mitochondrial supercomplex I1III2IV1 by single particle cryo-EM (EMD-1876) | | 分子名称: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, CALCIUM ION, CARDIOLIPIN, ... | | 著者 | Althoff, T, Mills, D.J, Popot, J.-L, Kuehlbrandt, W. | | 登録日 | 2011-03-02 | | 公開日 | 2011-10-19 | | 最終更新日 | 2019-10-23 | | 実験手法 | ELECTRON MICROSCOPY (19 Å) | | 主引用文献 | Arrangement of Electron Transport Chain Components in Bovine Mitochondrial Supercomplex I(1)III(2)Iv(1).
Embo J., 30, 2011
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8EC0
 | | III2IV respiratory supercomplex from Saccharomyces cerevisiae cardiolipin-lacking mutant | | 分子名称: | (1S)-2-{[{[(2R)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, 1,2-DIACYL-SN-GLYCERO-3-PHOSHOCHOLINE, 5-(3,7,11,15,19,23-HEXAMETHYL-TETRACOSA-2,6,10,14,18,22-HEXAENYL)-2,3-DIMETHOXY-6-METHYL-BENZENE-1,4-DIOL, ... | | 著者 | Hryc, C.F, Mileykovskaya, E, Baker, M, Dowhan, W. | | 登録日 | 2022-08-31 | | 公開日 | 2023-05-24 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Structural insights into cardiolipin replacement by phosphatidylglycerol in a cardiolipin-lacking yeast respiratory supercomplex.
Nat Commun, 14, 2023
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8E7S
 | | III2IV2 respiratory supercomplex from Saccharomyces cerevisiae with 4 bound UQ6 | | 分子名称: | (5S,11R)-5,8,11-trihydroxy-5,11-dioxido-17-oxo-4,6,10,12,16-pentaoxa-5,11-diphosphaoctadec-1-yl pentadecanoate, 1,2-DIACYL-SN-GLYCERO-3-PHOSHOCHOLINE, 5-(3,7,11,15,19,23-HEXAMETHYL-TETRACOSA-2,6,10,14,18,22-HEXAENYL)-2,3-DIMETHOXY-6-METHYL-BENZENE-1,4-DIOL, ... | | 著者 | Hryc, C.F, Mileykovskaya, E, Baker, M, Dowhan, W. | | 登録日 | 2022-08-24 | | 公開日 | 2023-05-24 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Structural insights into cardiolipin replacement by phosphatidylglycerol in a cardiolipin-lacking yeast respiratory supercomplex.
Nat Commun, 14, 2023
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5NMI
 | | Cytochrome bc1 bound to the inhibitor MJM170 | | 分子名称: | (4aS)-2-methyl-3-(4-phenoxyphenyl)-5,6,7,8-tetrahydroquinolin-4(4aH)-one, 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine, ARG-ASN-TRP-VAL-PRO-THR-ALA-GLN-LEU-TRP-GLY-ALA-VAL-GLY-ALA-VAL-GLY-LEU-VAL-SER-ALA-THR, ... | | 著者 | Capper, N.J, Antonyuk, S.V, Hasnain, S.S. | | 登録日 | 2017-04-05 | | 公開日 | 2017-06-14 | | 最終更新日 | 2018-12-19 | | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | | 主引用文献 | New paradigms for understanding and step changes in treating active and chronic, persistent apicomplexan infections.
Sci Rep, 6, 2016
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4PD4
 | | Structural analysis of atovaquone-inhibited cytochrome bc1 complex reveals the molecular basis of antimalarial drug action | | 分子名称: | 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-[trans-4-(4-chlorophenyl)cyclohexyl]-3-hydroxynaphthalene-1,4-dione, ... | | 著者 | Birth, D, Kao, W.-C, Hunte, C. | | 登録日 | 2014-04-17 | | 公開日 | 2014-06-11 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (3.04 Å) | | 主引用文献 | Structural analysis of atovaquone-inhibited cytochrome bc1 complex reveals the molecular basis of antimalarial drug action.
Nat Commun, 5, 2014
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5KLV
 | | Structure of bos taurus cytochrome bc1 with fenamidone inhibited | | 分子名称: | (2R)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(tetradecanoyloxy)propyl octadecanoate, (5S)-5-methyl-2-(methylsulfanyl)-5-phenyl-3-(phenylamino)-3,5-dihydro-4H-imidazol-4-one, 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, ... | | 著者 | Xia, D, Esser, L, Zhou, F, Zhou, Y, Xiao, Y, Tang, W.K, Yu, C.A, Qin, Z. | | 登録日 | 2016-06-25 | | 公開日 | 2016-10-12 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.652 Å) | | 主引用文献 | Hydrogen Bonding to the Substrate Is Not Required for Rieske Iron-Sulfur Protein Docking to the Quinol Oxidation Site of Complex III.
J.Biol.Chem., 291, 2016
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5OKD
 | | Crystal structure of bovine Cytochrome bc1 in complex with inhibitor SCR0911. | | 分子名称: | 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, ... | | 著者 | Amporndanai, K, O'Neill, P.M, Hasnain, S.S, Antonyuk, S.V. | | 登録日 | 2017-07-25 | | 公開日 | 2018-02-28 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | X-ray and cryo-EM structures of inhibitor-bound cytochromebc1complexes for structure-based drug discovery.
IUCrJ, 5, 2018
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7TAY
 | | Bos Taurus Mitochondrial BC1 in complex with Pyramoxadone | | 分子名称: | (2R)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(tetradecanoyloxy)propyl octadecanoate, (5S)-3-anilino-5-methyl-5-(6-phenoxypyridin-3-yl)-1,3-oxazolidine-2,4-dione, 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, ... | | 著者 | Xia, D, Zhou, F, Esser, L. | | 登録日 | 2021-12-21 | | 公開日 | 2023-01-18 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | | 主引用文献 | Conformation Switch of Rieske ISP subunit is revealed by the Crystal Structure of Bacterial Cytochrome bc1 in Complex with Azoxystrobin
to be published
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7JRG
 | | Plant Mitochondrial complex III2 from Vigna radiata | | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, Alpha-MPP, ... | | 著者 | Maldonado, M, Letts, J.A. | | 登録日 | 2020-08-12 | | 公開日 | 2021-01-20 | | 最終更新日 | 2021-02-03 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Atomic structures of respiratory complex III 2 , complex IV, and supercomplex III 2 -IV from vascular plants.
Elife, 10, 2021
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7JRP
 | | Plant Mitochondrial complex SC III2+IV from Vigna radiata | | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, Alpha-MPP, ... | | 著者 | Maldonado, M, Letts, J.A. | | 登録日 | 2020-08-12 | | 公開日 | 2021-01-20 | | 最終更新日 | 2021-02-03 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Atomic structures of respiratory complex III 2 , complex IV, and supercomplex III 2 -IV from vascular plants.
Elife, 10, 2021
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5LUF
 | | Cryo-EM of bovine respirasome | | 分子名称: | COPPER (II) ION, Cytochrome b, Cytochrome b-c1 complex subunit 1, ... | | 著者 | Sousa, J.S, Mills, D.J, Vonck, J, Kuehlbrandt, W. | | 登録日 | 2016-09-08 | | 公開日 | 2016-11-30 | | 最終更新日 | 2019-12-11 | | 実験手法 | ELECTRON MICROSCOPY (9.1 Å) | | 主引用文献 | Functional asymmetry and electron flow in the bovine respirasome.
Elife, 5, 2016
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7TZ6
 | | Structure of mitochondrial bc1 in complex with ck-2-68 | | 分子名称: | 7-chloranyl-3-methyl-2-[4-[[4-(trifluoromethyloxy)phenyl]methyl]phenyl]-1~{H}-quinolin-4-one, Cytochrome b, Cytochrome b-c1 complex subunit 1, ... | | 著者 | Xia, D, Esser, L, Zhou, F, Huang, R. | | 登録日 | 2022-02-15 | | 公開日 | 2023-02-22 | | 最終更新日 | 2023-09-06 | | 実験手法 | ELECTRON MICROSCOPY (2.88 Å) | | 主引用文献 | Structure of complex III with bound antimalarial agent CK-2-68 provides insights into selective inhibition of Plasmodium cytochrome bc 1 complexes.
J.Biol.Chem., 299, 2023
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6T0B
 | | The III2-IV(5B)2 respiratory supercomplex from S. cerevisiae | | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSHOCHOLINE, CALCIUM ION, CARDIOLIPIN, ... | | 著者 | Marechal, A, Pinotsis, N, Hartley, A. | | 登録日 | 2019-10-02 | | 公開日 | 2020-04-22 | | 最終更新日 | 2020-05-06 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Rcf2 revealed in cryo-EM structures of hypoxic isoforms of mature mitochondrial III-IV supercomplexes.
Proc.Natl.Acad.Sci.USA, 117, 2020
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2A06
 | | Bovine cytochrome bc1 complex with stigmatellin bound | | 分子名称: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, AZIDE ION, CARDIOLIPIN, ... | | 著者 | Huang, L.S, Cobessi, D, Tung, E.Y, Berry, E.A. | | 登録日 | 2005-06-16 | | 公開日 | 2005-06-21 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Binding of the Respiratory Chain Inhibitor Antimycin to the Mitochondrial bc(1) Complex: A New Crystal Structure Reveals an Altered Intramolecular Hydrogen-bonding Pattern.
J.Mol.Biol., 351, 2005
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6T15
 | | The III2-IV(5B)1 respiratory supercomplex from S. cerevisiae | | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSHOCHOLINE, CARDIOLIPIN, COPPER (II) ION, ... | | 著者 | Marechal, A, Pinotsis, N, Hartley, A. | | 登録日 | 2019-10-03 | | 公開日 | 2020-04-22 | | 最終更新日 | 2020-05-06 | | 実験手法 | ELECTRON MICROSCOPY (3.29 Å) | | 主引用文献 | Rcf2 revealed in cryo-EM structures of hypoxic isoforms of mature mitochondrial III-IV supercomplexes.
Proc.Natl.Acad.Sci.USA, 117, 2020
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2FYU
 | | Crystal structure of bovine heart mitochondrial bc1 with jg144 inhibitor | | 分子名称: | (5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE, Cytochrome b, Cytochrome c1, ... | | 著者 | Xia, D, Esser, L. | | 登録日 | 2006-02-08 | | 公開日 | 2006-08-29 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.26 Å) | | 主引用文献 | Surface-modulated motion switch: Capture and release of iron-sulfur protein in the cytochrome bc1 complex.
Proc.Natl.Acad.Sci.Usa, 103, 2006
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4U3F
 | | Cytochrome bc1 complex from chicken with designed inhibitor bound | | 分子名称: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CARDIOLIPIN, ... | | 著者 | Huang, L.-S, Zhu, X.-L, Yang, G.F, Berry, E.A. | | 登録日 | 2014-07-21 | | 公開日 | 2015-07-29 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (3.2312 Å) | | 主引用文献 | Rational Design of Highly Potent and Slow-Binding Cytochrome bc1 Inhibitor as Fungicide by Computational Substitution Optimization
Sci Rep, 5, 2015
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2BCC
 | | STIGMATELLIN-BOUND CYTOCHROME BC1 COMPLEX FROM CHICKEN | | 分子名称: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, FE2/S2 (INORGANIC) CLUSTER, PROTOPORPHYRIN IX CONTAINING FE, ... | | 著者 | Zhang, Z, Huang, L, Shulmeister, V.M, Chi, Y.I, Kim, K.K, Hung, L.W, Crofts, A.R, Berry, E.A, Kim, S.H. | | 登録日 | 1998-09-18 | | 公開日 | 1999-08-02 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | | 主引用文献 | Electron Transfer by Domain Movement in Cytochrome Bc1
Nature, 392, 1998
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2IBZ
 | | Yeast Cytochrome BC1 Complex with Stigmatellin | | 分子名称: | 5-(3,7,11,15,19,23-HEXAMETHYL-TETRACOSA-2,6,10,14,18,22-HEXAENYL)-2,3-DIMETHOXY-6-METHYL-BENZENE-1,4-DIOL, Cytochrome b, Cytochrome c1, ... | | 著者 | Hunte, C. | | 登録日 | 2006-09-12 | | 公開日 | 2007-03-20 | | 最終更新日 | 2021-03-03 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | A Comparison of Stigmatellin Conformations, Free and Bound to the Photosynthetic Reaction Center and the Cytochrome bc(1) Complex.
J.Mol.Biol., 368, 2007
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4D6U
 | | Cytochrome bc1 bound to the 4(1H)-pyridone GSK932121 | | 分子名称: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, 3-chloro-6-(hydroxymethyl)-2-methyl-5-{4-[3-(trifluoromethoxy)phenoxy]phenyl}pyridin-4-ol, CARDIOLIPIN, ... | | 著者 | Capper, M.J, ONeill, P.M, Fisher, N, Strange, R.W, Moss, D, Ward, S.A, Berry, N.G, Lawrenson, A.S, Hasnain, S.S, Biagini, G.A, Antonyuk, S.V. | | 登録日 | 2014-11-14 | | 公開日 | 2015-01-14 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (4.09 Å) | | 主引用文献 | Antimalarial 4(1H)-Pyridones Bind to the Qi Site of Cytochrome Bc1.
Proc.Natl.Acad.Sci.USA, 112, 2015
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