8PAY
 
 | | Structure of the E.coli DNA polymerase sliding clamp with a covalently bound peptide 2. | | 分子名称: | ACE-GLN-ALC-GLC-LEU-PHE, Beta sliding clamp, GLYCEROL, ... | | 著者 | Compain, G, Monsarrat, C, Blagojevic, J, Brillet, K, Dumas, P, Hammann, P, Kuhn, L, Martiel, I, Engilberge, S, Olieric, V, Wolff, P, Burnouf, D, wagner, J, Guichard, G. | | 登録日 | 2023-06-08 | | 公開日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.21 Å) | | 主引用文献 | Peptide-Based Covalent Inhibitors Bearing Mild Electrophiles to Target a Conserved His Residue of the Bacterial Sliding Clamp.
Jacs Au, 4, 2024
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8PAT
 | | Structure of the E.coli DNA polymerase sliding clamp with a covalently bound peptide 3. | | 分子名称: | ACE-GLN-ALC-GLX-LEU-PHE, Beta sliding clamp | | 著者 | Compain, G, Monsarrat, C, Blagojevic, J, Brillet, K, Dumas, P, Hammann, P, Kuhn, L, Martiel, I, Engilberge, S, Olieric, V, Wolff, P, Burnouf, D, Guichard, G. | | 登録日 | 2023-06-08 | | 公開日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | | 主引用文献 | Peptide-Based Covalent Inhibitors Bearing Mild Electrophiles to Target a Conserved His Residue of the Bacterial Sliding Clamp.
Jacs Au, 4, 2024
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4TR6
 | | Crystal structure of DNA polymerase sliding clamp from Bacillus subtilis | | 分子名称: | DNA polymerase III subunit beta, SODIUM ION | | 著者 | Burnouf, D, Olieric, V, Ennifar, E, Wolff, P. | | 登録日 | 2014-06-14 | | 公開日 | 2014-09-10 | | 最終更新日 | 2014-11-19 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Differential Modes of Peptide Binding onto Replicative Sliding Clamps from Various Bacterial Origins.
J.Med.Chem., 57, 2014
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4K3L
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8CIY
 | | DNA-polymerase sliding clamp (DnaN) from Escherichia coli in complex with Cyclohexyl-Griselimycin. | | 分子名称: | ACETATE ION, Beta sliding clamp, CALCIUM ION, ... | | 著者 | Fu, C, Liu, Y, Walt, C, Bader, C, Rasheed, S, Lukat, P, Neuber, M, Blankenfeldt, W, Kalinina, O, Mueller, R. | | 登録日 | 2023-02-11 | | 公開日 | 2023-11-29 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | | 主引用文献 | Elucidation of unusual biosynthesis and DnaN-targeting mode of action of potent anti-tuberculosis antibiotics Mycoplanecins.
Nat Commun, 15, 2024
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7AZ8
 | | DNA polymerase sliding clamp from Escherichia coli with peptide 43 bound | | 分子名称: | Beta sliding clamp, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | | 著者 | Monsarrat, C, Compain, G, Andre, C, Martiel, I, Engilberge, S, Olieric, V, Wolff, P, Brillet, K, Landolfo, M, Silva da Veiga, C, Wagner, J, Guichard, G, Burnouf, D.Y. | | 登録日 | 2020-11-16 | | 公開日 | 2021-12-01 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.61 Å) | | 主引用文献 | Iterative Structure-Based Optimization of Short Peptides Targeting the Bacterial Sliding Clamp.
J.Med.Chem., 64, 2021
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4MJR
 | | E. coli sliding clamp in complex with (S)-Carprofen | | 分子名称: | (2S)-2-(6-chloro-9H-carbazol-2-yl)propanoic acid, CALCIUM ION, CHLORIDE ION, ... | | 著者 | Yin, Z, Oakley, A.J. | | 登録日 | 2013-09-04 | | 公開日 | 2013-09-18 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.62 Å) | | 主引用文献 | DNA replication is the target for the antibacterial effects of nonsteroidal anti-inflammatory drugs.
Chem.Biol., 21, 2014
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6FVM
 | | Mutant DNA polymerase sliding clamp from Escherichia coli with bound P7 peptide | | 分子名称: | Beta sliding clamp, CALCIUM ION, GLYCEROL, ... | | 著者 | Martiel, I, Andre, C, Olieric, V, Guichard, G, Burnouf, D. | | 登録日 | 2018-03-04 | | 公開日 | 2019-04-10 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.631 Å) | | 主引用文献 | Peptide Interactions on Bacterial Sliding Clamps.
Acs Infect Dis., 2019
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3D1G
 | | Structure of a small molecule inhibitor bound to a DNA sliding clamp | | 分子名称: | DNA polymerase III subunit beta, [(5R)-5-(2,3-dibromo-5-ethoxy-4-hydroxybenzyl)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid | | 著者 | Georgescu, R.E, Yurieva, O, Seung-Sup, K, Kuriyan, J, Kong, X.-P, O'Donnell, M. | | 登録日 | 2008-05-05 | | 公開日 | 2008-07-29 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.64 Å) | | 主引用文献 | Structure of a small-molecule inhibitor of a DNA polymerase sliding clamp.
Proc.Natl.Acad.Sci.Usa, 105, 2008
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7AZ7
 | | DNA polymerase sliding clamp from Escherichia coli with peptide 37 bound | | 分子名称: | Beta sliding clamp, FORMIC ACID, PENTAETHYLENE GLYCOL, ... | | 著者 | Monsarrat, C, Compain, G, Andre, C, Martiel, I, Engilberge, S, Olieric, V, Wolff, P, Brillet, K, Landolfo, M, Silva da Veiga, C, Wagner, J, Guichard, G, Burnouf, D.Y. | | 登録日 | 2020-11-16 | | 公開日 | 2021-12-01 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Iterative Structure-Based Optimization of Short Peptides Targeting the Bacterial Sliding Clamp.
J.Med.Chem., 64, 2021
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1OK7
 | | A Conserved protein binding-site on Bacterial Sliding Clamps | | 分子名称: | DNA POLYMERASE III, DNA POLYMERASE IV | | 著者 | Burnouf, D.Y, Olieric, V, Wagner, J, Fujii, S, Reinbolt, J, Fuchs, R.P.P, Dumas, P. | | 登録日 | 2003-07-18 | | 公開日 | 2004-07-15 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Structural and Biochemical Analysis of Sliding Clamp/Ligand Interactions Suggest a Competition between Replicative and Translesion DNA Polymerases
J.Mol.Biol., 335, 2004
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4N96
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4N98
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5W7Z
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4MJQ
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4N94
 | | E. coli sliding clamp in complex with 3,4-difluorobenzamide | | 分子名称: | 1,2-ETHANEDIOL, 3,4-difluorobenzamide, CALCIUM ION, ... | | 著者 | Yin, Z, Oakley, A.J. | | 登録日 | 2013-10-19 | | 公開日 | 2013-11-06 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | | 主引用文献 | Discovery of lead compounds targeting the bacterial sliding clamp using a fragment-based approach.
J.Med.Chem., 57, 2014
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6PTR
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4K3S
 | | E. coli sliding clamp in P1 crystal space group | | 分子名称: | CALCIUM ION, DNA polymerase III subunit beta, O-ACETALDEHYDYL-HEXAETHYLENE GLYCOL, ... | | 著者 | Yin, Z, Oakley, A.J. | | 登録日 | 2013-04-11 | | 公開日 | 2013-05-01 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Structural and Thermodynamic Dissection of Linear Motif Recognition by the E. coli Sliding Clamp
J.Med.Chem., 56, 2013
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8CIX
 | | DNA-polymerase sliding clamp (DnaN) from Escherichia coli in complex with Griselimycin. | | 分子名称: | ACETATE ION, Beta sliding clamp, CALCIUM ION, ... | | 著者 | Fu, C, Liu, Y, Walt, C, Bader, C, Rasheed, S, Lukat, P, Neuber, M, Blankenfeldt, W, Kalinina, O, Mueller, R. | | 登録日 | 2023-02-11 | | 公開日 | 2023-11-29 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | | 主引用文献 | Elucidation of unusual biosynthesis and DnaN-targeting mode of action of potent anti-tuberculosis antibiotics Mycoplanecins.
Nat Commun, 15, 2024
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7AZC
 | | DNA polymerase sliding clamp from Escherichia coli with peptide 22 bound | | 分子名称: | Beta sliding clamp, GLYCEROL, Peptide 22 | | 著者 | Monsarrat, C, Compain, G, Andre, C, Martiel, I, Engilberge, S, Olieric, V, Wolff, P, Brillet, K, Landolfo, M, Silva da Veiga, C, Wagner, J, Guichard, G, Burnouf, D.Y. | | 登録日 | 2020-11-16 | | 公開日 | 2021-12-01 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.77 Å) | | 主引用文献 | Iterative Structure-Based Optimization of Short Peptides Targeting the Bacterial Sliding Clamp.
J.Med.Chem., 64, 2021
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3F1V
 | | E. coli Beta Sliding Clamp, 148-153 Ala Mutant | | 分子名称: | CALCIUM ION, CHLORIDE ION, DNA polymerase III subunit beta | | 著者 | Cody, V. | | 登録日 | 2008-10-28 | | 公開日 | 2009-09-01 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.77 Å) | | 主引用文献 | Sliding clamp-DNA interactions are required for viability and contribute to DNA polymerase management in Escherichia coli.
J.Mol.Biol., 387, 2009
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4TR8
 | | Crystal structure of DNA polymerase sliding clamp from Pseudomonas aeruginosa | | 分子名称: | DNA polymerase III subunit beta, SODIUM ION | | 著者 | Olieric, V, Burnouf, D, Ennifar, E, Wolff, P. | | 登録日 | 2014-06-15 | | 公開日 | 2014-09-10 | | 最終更新日 | 2014-12-24 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Differential Modes of Peptide Binding onto Replicative Sliding Clamps from Various Bacterial Origins.
J.Med.Chem., 57, 2014
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4N95
 | | E. coli sliding clamp in complex with 5-chloroindoline-2,3-dione | | 分子名称: | 5-chloro-1H-indole-2,3-dione, CALCIUM ION, CHLORIDE ION, ... | | 著者 | Yin, Z, Oakley, A.J. | | 登録日 | 2013-10-19 | | 公開日 | 2013-11-06 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Discovery of lead compounds targeting the bacterial sliding clamp using a fragment-based approach.
J.Med.Chem., 57, 2014
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7AZE
 | | DNA polymerase sliding clamp from Escherichia coli with peptide 18 bound | | 分子名称: | Beta sliding clamp, GLYCEROL, MALONATE ION, ... | | 著者 | Monsarrat, C, Compain, G, Andre, C, Martiel, I, Engilberge, S, Olieric, V, Wolff, P, Brillet, K, Landolfo, M, Silva da Veiga, C, Wagner, J, Guichard, G, Burnouf, D.Y. | | 登録日 | 2020-11-16 | | 公開日 | 2021-12-01 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.82 Å) | | 主引用文献 | Iterative Structure-Based Optimization of Short Peptides Targeting the Bacterial Sliding Clamp.
J.Med.Chem., 64, 2021
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1MMI
 | | E. COLI DNA POLYMERASE BETA SUBUNIT | | 分子名称: | DNA polymerase III, beta chain | | 著者 | Oakley, A.J, Prosselkov, P, Wijffels, G, Beck, J.L, Wilce, M.C.J, Dixon, N.E. | | 登録日 | 2002-09-04 | | 公開日 | 2003-09-04 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.848 Å) | | 主引用文献 | Flexibility revealed by the 1.85 A crystal structure of the beta sliding-clamp subunit of Escherichia coli DNA polymerase III.
Acta Crystallogr.,Sect.D, 59, 2003
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