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5Y58
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BU of 5y58 by Molmil
Crystal structure of Ku70/80 and TLC1
分子名称: ATP-dependent DNA helicase II subunit 1, ATP-dependent DNA helicase II subunit 2, TLC1
著者Chen, H, Xue, J, Wu, J, Lei, M.
登録日2017-08-08
公開日2017-12-20
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structural Insights into Yeast Telomerase Recruitment to Telomeres
Cell, 172, 2018
6ERG
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BU of 6erg by Molmil
Complex of XLF and heterodimer Ku bound to DNA
分子名称: DNA (21-MER), DNA (34-MER), Non-homologous end-joining factor 1, ...
著者Nemoz, C, Legrand, P, Ropars, V, Charbonnier, J.B.
登録日2017-10-18
公開日2018-10-17
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献XLF and APLF bind Ku80 at two remote sites to ensure DNA repair by non-homologous end joining.
Nat. Struct. Mol. Biol., 25, 2018
6ERH
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BU of 6erh by Molmil
Complex of XLF and heterodimer Ku bound to DNA
分子名称: DNA (21-MER), DNA (34-MER), Non-homologous end-joining factor 1, ...
著者Nemoz, C, Legrand, P, Ropars, V, Charbonnier, J.B.
登録日2017-10-18
公開日2018-10-17
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献XLF and APLF bind Ku80 at two remote sites to ensure DNA repair by non-homologous end joining.
Nat. Struct. Mol. Biol., 25, 2018
6ERF
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BU of 6erf by Molmil
Complex of APLF factor and Ku heterodimer bound to DNA
分子名称: Aprataxin and PNK-like factor, DNA (34-MER), DNA (5'-D(*GP*TP*TP*TP*TP*TP*AP*GP*TP*TP*TP*AP*TP*TP*GP*GP*GP*CP*GP*CP*G)-3'), ...
著者Nemoz, C, Legrand, P, Ropars, V, Charbonnier, J.B.
登録日2017-10-18
公開日2018-10-17
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (3.01 Å)
主引用文献XLF and APLF bind Ku80 at two remote sites to ensure DNA repair by non-homologous end joining.
Nat.Struct.Mol.Biol., 25, 2018
8ASC
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BU of 8asc by Molmil
Ku70/80 binds to the Ku-binding motif of PAXX
分子名称: DNA (5'-D(P*CP*GP*GP*AP*TP*CP*GP*AP*GP*GP*GP*CP*CP*CP*GP*AP*TP*AP*T)-3'), DNA (5'-D(P*GP*GP*GP*CP*CP*CP*TP*CP*GP*AP*TP*CP*CP*G)-3'), Protein PAXX, ...
著者Seif El Dahan, M, Ropars, V, Charbonnier, J.B.
登録日2022-08-19
公開日2023-06-21
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.95 Å)
主引用文献PAXX binding to the NHEJ machinery explains functional redundancy with XLF.
Sci Adv, 9, 2023
6ZHE
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BU of 6zhe by Molmil
Cryo-EM structure of DNA-PK dimer
分子名称: DNA (25-MER), DNA (26-MER), DNA (27-MER), ...
著者Chaplin, A.K, Hardwick, S.W, Chirgadze, D.Y, Blundell, T.L.
登録日2020-06-23
公開日2020-10-21
最終更新日2021-01-20
実験手法ELECTRON MICROSCOPY (7.24 Å)
主引用文献Dimers of DNA-PK create a stage for DNA double-strand break repair.
Nat.Struct.Mol.Biol., 28, 2021
6ZHA
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BU of 6zha by Molmil
Cryo-EM structure of DNA-PK monomer
分子名称: DNA, DNA-dependent protein kinase catalytic subunit,DNA-dependent protein kinase catalytic subunit,DNA-dependent protein kinase catalytic subunit,DNA-PKcs, X-ray repair cross-complementing protein 5, ...
著者Chaplin, A.K, Hardwick, S.W, Chirgadze, D.Y, Blundell, T.L.
登録日2020-06-21
公開日2020-10-21
最終更新日2021-01-20
実験手法ELECTRON MICROSCOPY (3.91 Å)
主引用文献Dimers of DNA-PK create a stage for DNA double-strand break repair.
Nat.Struct.Mol.Biol., 28, 2021
5Y3R
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BU of 5y3r by Molmil
Cryo-EM structure of Human DNA-PK Holoenzyme
分子名称: DNA (34-MER), DNA (36-MER), DNA-dependent protein kinase catalytic subunit, ...
著者Yin, X, Liu, M, Tian, Y, Wang, J, Xu, Y.
登録日2017-07-29
公開日2017-09-06
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (6.6 Å)
主引用文献Cryo-EM structure of human DNA-PK holoenzyme
Cell Res., 27, 2017
8EZB
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BU of 8ezb by Molmil
NHEJ Long-range complex with ATP
分子名称: ADENOSINE-5'-TRIPHOSPHATE, DNA (30-MER), DNA (31-MER), ...
著者Chen, S, He, Y.
登録日2022-10-31
公開日2023-06-14
実験手法ELECTRON MICROSCOPY (8.9 Å)
主引用文献Cryo-EM visualization of DNA-PKcs structural intermediates in NHEJ.
Sci Adv, 9, 2023
8EZA
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BU of 8eza by Molmil
NHEJ Long-range complex with PAXX
分子名称: ADENOSINE-5'-TRIPHOSPHATE, DNA (30-MER), DNA (31-MER), ...
著者Chen, S, He, Y.
登録日2022-10-31
公開日2023-06-14
実験手法ELECTRON MICROSCOPY (4.39 Å)
主引用文献Cryo-EM visualization of DNA-PKcs structural intermediates in NHEJ.
Sci Adv, 9, 2023
7AXZ
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BU of 7axz by Molmil
Ku70/80 complex apo form
分子名称: X-ray repair cross-complementing protein 5, X-ray repair cross-complementing protein 6
著者Hnizda, A, Tesina, P, Novak, P, Blundell, T.L.
登録日2020-11-10
公開日2021-02-10
最終更新日2021-07-28
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献SAP domain forms a flexible part of DNA aperture in Ku70/80.
Febs J., 288, 2021
1JEY
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BU of 1jey by Molmil
Crystal Structure of the Ku heterodimer bound to DNA
分子名称: DNA (34-MER), DNA (5'-D(*GP*TP*TP*TP*TP*TP*AP*GP*TP*TP*TP*AP*TP*TP*GP*GP*GP*CP*GP*CP*G)-3'), Ku70, ...
著者Walker, J.R, Corpina, R.A, Goldberg, J.
登録日2001-06-19
公開日2001-08-10
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair.
Nature, 412, 2001
1JEQ
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BU of 1jeq by Molmil
Crystal Structure of the Ku Heterodimer
分子名称: KU70, KU80
著者Walker, J.R, Corpina, R.A, Goldberg, J.
登録日2001-06-18
公開日2001-08-15
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair.
Nature, 412, 2001
7SGL
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BU of 7sgl by Molmil
DNA-PK complex of DNA end processing
分子名称: ADENOSINE-5'-TRIPHOSPHATE, DNA-dependent protein kinase catalytic subunit, Hairpin_1, ...
著者Liu, L, Li, J, Chen, X, Yang, W, Gellert, M.
登録日2021-10-06
公開日2022-01-12
最終更新日2022-01-19
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Autophosphorylation transforms DNA-PK from protecting to processing DNA ends.
Mol.Cell, 82, 2022
7SU3
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BU of 7su3 by Molmil
CryoEM structure of DNA-PK complex VII
分子名称: ADENOSINE-5'-TRIPHOSPHATE, DNA (5'-D(*AP*AP*GP*CP*AP*GP*TP*AP*GP*AP*G)-3'), DNA (5'-D(*GP*CP*AP*TP*GP*CP*TP*CP*TP*AP*CP*TP*GP*CP*TP*TP*CP*GP*AP*TP*AP*TP*CP*G)-3'), ...
著者Chen, X, Liu, L, Gellert, M, Yang, W.
登録日2021-11-16
公開日2022-01-12
最終更新日2022-01-19
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Autophosphorylation transforms DNA-PK from protecting to processing DNA ends.
Mol.Cell, 82, 2022
7SUD
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BU of 7sud by Molmil
CryoEM structure of DNA-PK complex VIII
分子名称: ADENOSINE-5'-TRIPHOSPHATE, DNA-dependent protein kinase catalytic subunit, MAGNESIUM ION, ...
著者Chen, X, Liu, L, Gellert, M, Yang, W.
登録日2021-11-16
公開日2022-01-12
最終更新日2022-01-19
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献Autophosphorylation transforms DNA-PK from protecting to processing DNA ends.
Mol.Cell, 82, 2022
7LT3
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BU of 7lt3 by Molmil
NHEJ Long-range synaptic complex
分子名称: ADENOSINE-5'-DIPHOSPHATE, DNA (30-MER), DNA (31-MER), ...
著者He, Y, Chen, S.
登録日2021-02-18
公開日2021-04-14
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (4.6 Å)
主引用文献Structural basis of long-range to short-range synaptic transition in NHEJ.
Nature, 593, 2021
7LSY
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BU of 7lsy by Molmil
NHEJ Short-range synaptic complex
分子名称: DNA (26-MER), DNA (5'-D(P*CP*AP*AP*TP*GP*AP*AP*AP*CP*GP*GP*AP*AP*CP*AP*GP*TP*CP*AP*G)-3'), DNA (5'-D(P*GP*TP*TP*CP*TP*TP*AP*GP*TP*AP*TP*AP*TP*A)-3'), ...
著者He, Y, Chen, S.
登録日2021-02-18
公開日2021-04-14
最終更新日2023-08-16
実験手法ELECTRON MICROSCOPY (8.4 Å)
主引用文献Structural basis of long-range to short-range synaptic transition in NHEJ.
Nature, 593, 2021
7NFC
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BU of 7nfc by Molmil
Cryo-EM structure of NHEJ super-complex (dimer)
分子名称: DNA (27-MER), DNA (28-MER), DNA ligase 4, ...
著者Chaplin, A.K, Hardwick, S.W, Kefala Stavridi, A, Chirgadze, D.Y, Blundell, T.L.
登録日2021-02-05
公開日2021-08-18
最終更新日2021-09-22
実験手法ELECTRON MICROSCOPY (4.14 Å)
主引用文献Cryo-EM of NHEJ supercomplexes provides insights into DNA repair.
Mol.Cell, 81, 2021
7NFE
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BU of 7nfe by Molmil
Cryo-EM structure of NHEJ super-complex (monomer)
分子名称: DNA (5'-D(P*AP*AP*TP*AP*AP*AP*CP*TP*AP*AP*AP*AP*AP*CP*TP*AP*TP*TP*AP*TP*TP*AP*TP*G)-3'), DNA (5'-D(P*TP*AP*AP*TP*AP*AP*TP*AP*GP*TP*TP*TP*TP*TP*AP*GP*TP*TP*TP*AP*TP*TP*AP*G)-3'), DNA ligase 4, ...
著者Chaplin, A.K, Hardwick, S.W, Kefala Stavridi, A, Chirgadze, D.Y, Blundell, T.L.
登録日2021-02-06
公開日2021-08-18
最終更新日2021-09-22
実験手法ELECTRON MICROSCOPY (4.29 Å)
主引用文献Cryo-EM of NHEJ supercomplexes provides insights into DNA repair.
Mol.Cell, 81, 2021
7K0Y
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BU of 7k0y by Molmil
Cryo-EM structure of activated-form DNA-PK (complex VI)
分子名称: DNA (5'-D(*AP*AP*GP*CP*AP*GP*TP*AP*GP*AP*GP*CP*A)-3'), DNA (5'-D(*GP*CP*AP*TP*GP*CP*TP*CP*TP*AP*CP*TP*GP*CP*TP*TP*CP*GP*AP*TP*AP*TP*CP*G)-3'), DNA-dependent protein kinase catalytic subunit, ...
著者Chen, X, Gellert, M, Yang, W.
登録日2020-09-06
公開日2021-01-06
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献Structure of an activated DNA-PK and its implications for NHEJ.
Mol.Cell, 81, 2021
7K1J
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BU of 7k1j by Molmil
CryoEM structure of inactivated-form DNA-PK (Complex III)
分子名称: DNA (5'-D(*AP*AP*GP*CP*AP*GP*TP*AP*GP*AP*GP*CP*A)-3'), DNA (5'-D(*GP*CP*AP*TP*GP*CP*TP*CP*TP*AP*CP*TP*GP*CP*TP*TP*CP*GP*AP*TP*AP*TP*CP*G)-3'), DNA-dependent protein kinase catalytic subunit, ...
著者Chen, X, Gellert, M, Yang, W.
登録日2020-09-07
公開日2021-01-06
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (3.9 Å)
主引用文献Structure of an activated DNA-PK and its implications for NHEJ.
Mol.Cell, 81, 2021
7K1N
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BU of 7k1n by Molmil
CryoEM structure of inactivated-form DNA-PK (Complex V)
分子名称: DNA (5'-D(P*AP*AP*GP*CP*AP*GP*TP*AP*GP*AP*GP*CP*A)-3'), DNA (5'-D(P*GP*CP*AP*TP*GP*CP*TP*CP*TP*AP*CP*TP*GP*CP*TP*TP*CP*GP*AP*TP*AP*TP*CP*G)-3'), DNA-dependent protein kinase catalytic subunit, ...
著者Chen, X, Gellert, M, Yang, W.
登録日2020-09-08
公開日2021-01-06
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (3.9 Å)
主引用文献Structure of an activated DNA-PK and its implications for NHEJ.
Mol.Cell, 81, 2021
7K1K
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BU of 7k1k by Molmil
CryoEM structure of inactivated-form DNA-PK (Complex IV)
分子名称: DNA (5'-D(*AP*AP*GP*CP*AP*GP*TP*AP*GP*AP*GP*CP*A)-3'), DNA (5'-D(*GP*CP*AP*TP*GP*CP*TP*CP*TP*AP*CP*TP*GP*CP*TP*TP*CP*GP*AP*TP*AP*TP*CP*G)-3'), DNA-dependent protein kinase catalytic subunit, ...
著者Chen, X, Gellert, M, Yang, W.
登録日2020-09-07
公開日2021-01-06
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (4.1 Å)
主引用文献Structure of an activated DNA-PK and its implications for NHEJ.
Mol.Cell, 81, 2021
7Z88
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BU of 7z88 by Molmil
DNA-PK in the intermediate state
分子名称: (~{S})-[2-chloranyl-4-fluoranyl-5-(7-morpholin-4-ylquinazolin-4-yl)phenyl]-(6-methoxypyridazin-3-yl)methanol, DNA (26-MER), DNA-dependent protein kinase catalytic subunit, ...
著者Liang, S, Blundell, T.L.
登録日2022-03-16
公開日2023-01-18
最終更新日2023-03-01
実験手法ELECTRON MICROSCOPY (3.33 Å)
主引用文献Human DNA-dependent protein kinase activation mechanism.
Nat.Struct.Mol.Biol., 30, 2023

 

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件を2024-03-27に公開中

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