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2GDG
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Crystal structure of covalently modified macrophage inhibitory factor
分子名称: Macrophage migration inhibitory factor
著者Golubkov, P.A, Hackert, M.L.
登録日2006-03-16
公開日2006-07-04
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Inactivation of the phenylpyruvate tautomerase activity of macrophage migration inhibitory factor by 2-oxo-4-phenyl-3-butynoate.
Bioorg.Chem., 34, 2006
1UIZ
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Crystal Structure Of Macrophage Migration Inhibitory Factor From Xenopus Laevis.
分子名称: Macrophage Migration Inhibitory Factor
著者Suzuki, M, Takamura, Y, Maeno, M, Tochinai, S, Iyaguchi, D, Tanaka, I, Nishihira, J, Ishibashi, T.
登録日2003-07-24
公開日2004-05-25
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Xenopus laevis Macrophage Migration Inhibitory Factor Is Essential for Axis Formation and Neural Development.
J.Biol.Chem., 279, 2004
1P1G
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MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF) WITH PRO-1 MUTATED TO GLY-1
分子名称: PROTEIN (MACROPHAGE MIGRATION INHIBITORY FACTOR)
著者Lubetsky, J.B, Lolis, E.
登録日1999-03-24
公開日1999-06-07
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Pro-1 of macrophage migration inhibitory factor functions as a catalytic base in the phenylpyruvate tautomerase activity.
Biochemistry, 38, 1999
5EIZ
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Crystal structure of Y99A mutant of human macrophage migration inhibitory factor
分子名称: GLYCEROL, ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, ...
著者Pantouris, G, Lolis, E.
登録日2015-10-30
公開日2015-11-11
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.96 Å)
主引用文献Nanosecond Dynamics Regulate the MIF-Induced Activity of CD74.
Angew. Chem. Int. Ed. Engl., 2018
8IMR
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Structure of ligand-free human macrophage migration inhibitory factor
分子名称: 1,2-ETHANEDIOL, ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, ...
著者Sugishima, K, Noguchi, K, Yohda, M, Odaka, M, Matsumura, H.
登録日2023-03-07
公開日2024-03-13
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Identification of methotrexate as an inhibitor of macrophage migration inhibitory factor by high-resolution crystal structure analysis
To Be Published
1CA7
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MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF) WITH HYDROXPHENYLPYRUVATE
分子名称: 3-(4-HYDROXY-PHENYL)PYRUVIC ACID, PROTEIN (MACROPHAGE MIGRATION INHIBITORY FACTOR)
著者Lubetsky, J.B, Lolis, E.
登録日1999-02-25
公開日1999-06-30
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Pro-1 of macrophage migration inhibitory factor functions as a catalytic base in the phenylpyruvate tautomerase activity.
Biochemistry, 38, 1999
1CGQ
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MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF) WITH ALANINE INSERTED BETWEEN PRO-1 AND MET-2
分子名称: PROTEIN (MACROPHAGE MIGRATION INHIBITORY FACTOR)
著者Lubetsky, J.B, Lolis, E.
登録日1999-03-25
公開日1999-06-07
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Pro-1 of macrophage migration inhibitory factor functions as a catalytic base in the phenylpyruvate tautomerase activity.
Biochemistry, 38, 1999
4TRF
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Crystal structure of Macrophage Migration Inhibitory Factor in complex with N-(pyridin-3-ylmethyl)thioformamide
分子名称: GLYCEROL, ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, ...
著者Pantouris, G, Lolis, E.
登録日2014-06-16
公開日2015-09-30
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.63 Å)
主引用文献An Analysis of MIF Structural Features that Control Functional Activation of CD74.
Chem.Biol., 22, 2015
1DPT
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D-DOPACHROME TAUTOMERASE
分子名称: D-DOPACHROME TAUTOMERASE
著者Sugimoto, H, Taniguchi, M, Nakagawa, A, Tanaka, I.
登録日1998-05-11
公開日1999-03-30
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.54 Å)
主引用文献Crystal structure of human D-dopachrome tautomerase, a homologue of macrophage migration inhibitory factor, at 1.54 A resolution.
Biochemistry, 38, 1999
4TRU
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Crystal structure of Q24A Q25A mutant of human macrophage migration inhibitory factor
分子名称: GLYCEROL, ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, ...
著者Pantouris, G, Lolis, E.
登録日2014-06-17
公開日2015-09-30
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.81 Å)
主引用文献An Analysis of MIF Structural Features that Control Functional Activation of CD74.
Chem.Biol., 22, 2015
4WRB
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Macrophage Migration Inhibitory Factor in complex with a biaryltriazole inhibitor (3b-190)
分子名称: 4-{4-[6-(2-methoxyethoxy)quinolin-2-yl]-1H-1,2,3-triazol-1-yl}phenol, GLYCEROL, ISOPROPYL ALCOHOL, ...
著者Robertson, M.J, Baxter, R.H.G, Jorgensen, W.L.
登録日2014-10-23
公開日2015-03-11
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.81 Å)
主引用文献Design, synthesis, and protein crystallography of biaryltriazoles as potent tautomerase inhibitors of macrophage migration inhibitory factor.
J.Am.Chem.Soc., 137, 2015
8AP3
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Structure of A. thaliana MIF/D-DT-like protein-2 (MDL2)
分子名称: MIF homologue
著者Manjula, R, Basquin, J, Lolis, E.
登録日2022-08-09
公開日2023-08-23
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Structure of A. thaliana MIF/D-DT-like protein-2 (MDL2)
To Be Published
4WR8
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Macrophage Migration Inhibitory Factor in complex with a biaryltriazole inhibitor (3b-180)
分子名称: 4-[4-(quinolin-2-yl)-1H-1,2,3-triazol-1-yl]phenol, Macrophage migration inhibitory factor, SODIUM ION, ...
著者Robertson, M.J, Baxter, R.H.G, Jorgensen, W.L.
登録日2014-10-23
公開日2015-03-11
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Design, synthesis, and protein crystallography of biaryltriazoles as potent tautomerase inhibitors of macrophage migration inhibitory factor.
J.Am.Chem.Soc., 137, 2015
6FVE
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Macrophage Migration Inhibitory Factor (MIF) with Covalently Bound FITC
分子名称: 2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)-5-[(E)-(sulfanylmethylidene)amino]benzoic acid, Macrophage migration inhibitory factor, SULFATE ION
著者Samygina, V.R, Bourenkov, G, Sokolov, A.V.
登録日2018-03-02
公開日2018-06-06
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.41 Å)
主引用文献Structural Study of the Complex Formed by Ceruloplasmin and Macrophage Migration Inhibitory Factor.
Biochemistry Mosc., 83, 2018
8CA0
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Macrophage inhibitory factor (MIF) in complex with small molecule PAV174
分子名称: 1-ethyl-9-methyl-3,7-dipyrrolidin-1-yl-phenothiazine, Macrophage migration inhibitory factor
著者Mueller, A, Torres, F, Roland, R, Korth, C.
登録日2023-01-24
公開日2024-02-07
実験手法SOLUTION NMR
主引用文献Oxidized MIF is a drug target at the molecular intersection between immune activation and tau cellular pathology
To Be Published
6FVH
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Macrophage Migration Inhibitory Factor (MIF) with Covalently Bound PITC
分子名称: Macrophage migration inhibitory factor, N-phenylthioformamide, SULFATE ION
著者Samygina, V.R, Bourenkov, G, Sokolov, A.V.
登録日2018-03-02
公開日2018-06-06
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Structural Study of the Complex Formed by Ceruloplasmin and Macrophage Migration Inhibitory Factor.
Biochemistry Mosc., 83, 2018
7XTX
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High resolution crystal structure of human macrophage migration inhibitory factor in complex with methotrexate
分子名称: 1,2-ETHANEDIOL, ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, ...
著者Sugishima, K, Noguchi, K, Yohda, M, Odaka, M, Matsumura, H.
登録日2022-05-18
公開日2023-05-24
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.28 Å)
主引用文献Identification of methotrexate as an inhibitor of macrophage migration inhibitory factor by high-resolution crystal structure analysis
To Be Published
7XVX
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Neutron crystal structure of human macrophage migration inhibitory factor
分子名称: Macrophage migration inhibitory factor
著者Ezawa, T, Tamada, T, Odaka, M, Matsumura, H.
登録日2022-05-25
公開日2023-05-31
最終更新日2024-04-03
実験手法NEUTRON DIFFRACTION (1.6 Å), X-RAY DIFFRACTION
主引用文献Neutron crystal structure of human macrophage migration inhibitory factor
To Be Published
8DBB
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Crystal structure of DDT with the selective inhibitor 2,5-Pyridinedicarboxylic Acid
分子名称: CITRIC ACID, D-dopachrome decarboxylase, pyridine-2,5-dicarboxylic acid
著者Parkins, A, Banumathi, S, Pantouris, G.
登録日2022-06-14
公開日2023-03-08
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献2,5-Pyridinedicarboxylic acid is a bioactive and highly selective inhibitor of D-dopachrome tautomerase.
Structure, 31, 2023
8DQA
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Structure of A. thaliana MIF/D-DT-like protein-3 (MDL3)
分子名称: LS1-like protein
著者Manjula, R, Basquin, J, Lolis, E.
登録日2022-07-18
公開日2023-07-26
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structure of A. thaliana MIF/D-DT-like protein-3 (MDL3)
To Be Published
8DQ6
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Structure of A. thaliana MIF/D-DT-like protein-1 (MDL1)
分子名称: CALCIUM ION, MIF/D-DT-like protein-1
著者Manjula, R, Basquin, J, Lolis, E.
登録日2022-07-18
公開日2023-07-26
実験手法X-RAY DIFFRACTION (1.56 Å)
主引用文献Structure of A. thaliana MIF/D-DT-like protein-1 (AtMDL1)
To Be Published
2WKF
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Crystal Structure of Macrophage Migration Inhibitory Factor from Plasmodium falciparum
分子名称: GLYCEROL, MACROPHAGE MIGRATION INHIBITORY FACTOR
著者Dobson, S.E, Augustijn, K.D, Brannigan, J.A, Dodson, E.J, Waters, A.P, Wilkinson, A.J.
登録日2009-06-11
公開日2009-10-27
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献The crystal structures of macrophage migration inhibitory factor from Plasmodium falciparum and Plasmodium berghei.
Protein Sci., 18, 2009
2XCZ
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Crystal Structure of macrophage migration inhibitory factor homologue from Prochlorococcus marinus
分子名称: DI(HYDROXYETHYL)ETHER, POSSIBLE ATLS1-LIKE LIGHT-INDUCIBLE PROTEIN
著者Wasiel, A.A, Rozeboom, H.J, Hauke, D, Baas, B.J, Zandvoort, E, Quax, W.J, Thunnissen, A.M.W.H, Poelarends, G.J.
登録日2010-04-27
公開日2010-09-01
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.64 Å)
主引用文献Structural and Functional Characterization of a Macrophage Migration Inhibitory Factor Homologue from the Marine Cyanobacterium Prochlorococcus Marinus.
Biochemistry, 49, 2010
3RF4
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Ancylostoma ceylanicum mif in complex with furosemide
分子名称: 5-(AMINOSULFONYL)-4-CHLORO-2-[(2-FURYLMETHYL)AMINO]BENZOIC ACID, ACETATE ION, IMIDAZOLE, ...
著者Cho, Y, Lolis, E.
登録日2011-04-05
公開日2011-10-12
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Drug Repositioning and Pharmacophore Identification in the Discovery of Hookworm MIF Inhibitors.
Chem.Biol., 18, 2011
3RF5
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Ancylostoma ceylanicum mif in complex with n-(2,3,4,5,6-pentafluoro-benzyl)-4-sulfamoyl-benzamide
分子名称: 2-[(furan-2-ylmethyl)amino]benzoic acid, ACETATE ION, IMIDAZOLE, ...
著者Cho, Y, Lolis, E.
登録日2011-04-05
公開日2011-10-12
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Drug Repositioning and Pharmacophore Identification in the Discovery of Hookworm MIF Inhibitors.
Chem.Biol., 18, 2011

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