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5OEN
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Crystal Structure of STAT2 in complex with IRF9
分子名称: Interferon regulatory factor 9, Signal transducer and activator of transcription
著者Rengachari, S, Panne, D.
登録日2017-07-09
公開日2018-01-24
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.919 Å)
主引用文献Structural basis of STAT2 recognition by IRF9 reveals molecular insights into ISGF3 function.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
1YVL
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BU of 1yvl by Molmil
Structure of Unphosphorylated STAT1
分子名称: 5-residue peptide, GOLD ION, Signal transducer and activator of transcription 1-alpha/beta
著者Mao, X, Ren, Z, Parker, G.N, Sondermann, H, Pastorello, M.A, Wang, W, McMurray, J.S, Demeler, B, Darnell Jr, J.E, Chen, X.
登録日2005-02-16
公開日2005-03-22
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structural bases of unphosphorylated STAT1 association and receptor binding.
Mol.Cell, 17, 2005
6WCZ
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BU of 6wcz by Molmil
CryoEM structure of full-length ZIKV NS5-hSTAT2 complex
分子名称: Non-structural protein 5, Signal transducer and activator of transcription 2, ZINC ION
著者Boxiao, W, Stephanie, T, Kang, Z, Maria, T.S, Jian, F, Jiuwei, L, Linfeng, G, Wendan, R, Yanxiang, C, Ethan, C.V, HeaJin, H, Matthew, J.E, Sean, E.O, Adolfo, G.S, Hong, Z, Rong, H, Jikui, S.
登録日2020-03-31
公開日2020-07-08
最終更新日2021-08-25
実験手法ELECTRON MICROSCOPY (4 Å)
主引用文献Structural basis for STAT2 suppression by flavivirus NS5.
Nat.Struct.Mol.Biol., 27, 2020
6QHD
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BU of 6qhd by Molmil
Lysine acetylated and tyrosine phosphorylated STAT3 in a complex with DNA
分子名称: DNA (5'-D(*AP*AP*GP*AP*TP*TP*TP*AP*CP*GP*GP*GP*AP*AP*AP*TP*GP*C)-3'), DNA (5'-D(*TP*GP*CP*AP*TP*TP*TP*CP*CP*CP*GP*TP*AP*AP*AP*TP*CP*T)-3'), Signal transducer and activator of transcription 3
著者Arbely, E, Belo, Y, Shahar, A, Zarivach, R.
登録日2019-01-16
公開日2019-06-19
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献Unexpected implications of STAT3 acetylation revealed by genetic encoding of acetyl-lysine.
Biochim Biophys Acta Gen Subj, 1863, 2019
5D39
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BU of 5d39 by Molmil
Transcription factor-DNA complex
分子名称: DNA (5'-D(P*AP*TP*GP*GP*AP*TP*TP*TP*CP*CP*TP*GP*GP*AP*AP*GP*AP*CP*AP*GP*A)-3'), DNA (5'-D(P*TP*CP*TP*GP*TP*CP*TP*TP*CP*CP*AP*GP*GP*AP*AP*AP*TP*CP*CP*AP*T)-3'), Signal transducer and activator of transcription 6
著者Li, J, Niu, F, Ouyang, S, Liu, Z.
登録日2015-08-06
公開日2016-08-10
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Structural basis for DNA recognition by STAT6
Proc.Natl.Acad.Sci.USA, 113, 2016
8D3F
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BU of 8d3f by Molmil
Crystal structure of human STAT1 in complex with the repeat region from Toxoplasma protein TgIST
分子名称: Signal transducer and activator of transcription 1-alpha/beta,Inhibitor of STAT1-dependent transcription TgIST
著者Huang, Z, Liu, H, Nix, J.C, Amarasinghe, G.K, Sibley, L.D.
登録日2022-06-01
公開日2022-07-06
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.97 Å)
主引用文献The intrinsically disordered protein TgIST from Toxoplasma gondii inhibits STAT1 signaling by blocking cofactor recruitment.
Nat Commun, 13, 2022
3CWG
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BU of 3cwg by Molmil
Unphosphorylated mouse STAT3 core fragment
分子名称: Signal transducer and activator of transcription 3
著者Ren, Z, Mao, X, Mertens, C, Krishnaraj, R, Qin, J, Mandal, P.K, Romanowshi, M.J, McMurray, J.S.
登録日2008-04-21
公開日2008-07-01
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (3.05 Å)
主引用文献Crystal structure of unphosphorylated STAT3 core fragment.
Biochem.Biophys.Res.Commun., 374, 2008
7NUF
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BU of 7nuf by Molmil
Vaccinia virus protein 018 in complex with STAT1
分子名称: ACETYL GROUP, SULFATE ION, Signal transducer and activator of transcription 1-alpha/beta, ...
著者Pantelejevs, T, Talbot-Cooper, C, Smith, G.L, Hyvonen, M.
登録日2021-03-12
公開日2021-07-28
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.0004015 Å)
主引用文献Poxviruses and paramyxoviruses use a conserved mechanism of STAT1 antagonism to inhibit interferon signaling.
Cell Host Microbe, 30, 2022
4E68
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BU of 4e68 by Molmil
Unphosphorylated STAT3B core protein binding to dsDNA
分子名称: DNA (5'-D(*TP*GP*CP*AP*TP*TP*TP*CP*CP*CP*GP*TP*AP*AP*AP*TP*CP*T)-3'), Signal transducer and activator of transcription 3
著者Collie, G.W, Parkinson, G.N, Shah, R.
登録日2012-03-15
公開日2013-03-06
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.585 Å)
主引用文献Observation of unphosphorylated STAT3 core protein binding to target dsDNA by PEMSA and X-ray crystallography.
Febs Lett., 587, 2013
1Y1U
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BU of 1y1u by Molmil
Structure of unphosphorylated STAT5a
分子名称: Signal transducer and activator of transcription 5A
著者Neculai, D, Neculai, A.M, Verrier, S, Straub, K, Klumpp, K, Pfitzner, E, Becker, S.
登録日2004-11-19
公開日2005-10-04
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (3.21 Å)
主引用文献Structure of the unphosphorylated STAT5a dimer
J.Biol.Chem., 280, 2005
8T12
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BU of 8t12 by Molmil
Cryo-EM structure of DENV2 NS5 in complex with human STAT2 with the N-terminal domain of STAT2 ordered.
分子名称: Non-structural protein 5, Signal transducer and activator of transcription 2, ZINC ION
著者Biswal, M, Lu, J, Song, J.
登録日2023-06-01
公開日2024-01-17
実験手法ELECTRON MICROSCOPY (3.34 Å)
主引用文献Cryo-EM structure of DENV2 NS5 in complex with human STAT2 with the N-terminal domain of STAT2 ordered.
To Be Published
7ZNN
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BU of 7znn by Molmil
Cryo-EM structure of RCMV-E E27 bound to human DDB1 (deltaBPB) and full-length rat STAT2
分子名称: B27a, DNA damage-binding protein 1, Signal transducer and activator of transcription, ...
著者Lauer, S, Spahn, C.M.T, Schwefel, D.
登録日2022-04-21
公開日2022-11-09
最終更新日2023-03-15
実験手法ELECTRON MICROSCOPY (4.8 Å)
主引用文献Structural mechanism of CRL4-instructed STAT2 degradation via a novel cytomegaloviral DCAF receptor.
Embo J., 42, 2023
8T13
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BU of 8t13 by Molmil
Cryo-EM structure of DENV2 NS5 in complex with human STAT2 with the N-terminal domain of STAT2 disordered
分子名称: Non-structural protein 5, Signal transducer and activator of transcription 2, ZINC ION
著者Biswal, M, Lu, J, Song, J.
登録日2023-06-01
公開日2024-01-17
実験手法ELECTRON MICROSCOPY (3.45 Å)
主引用文献Cryo-EM structure of DENV2 NS5 in complex with human STAT2 with the N-terminal domain of STAT2 disordered
To Be Published
7ZN7
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BU of 7zn7 by Molmil
Cryo-EM structure of RCMV-E E27 bound to human DDB1 (deltaBPB) and rat STAT2 CCD
分子名称: B27a, DNA damage-binding protein 1, Signal transducer and activator of transcription, ...
著者Lauer, S, Spahn, C.M.T, Schwefel, D.
登録日2022-04-20
公開日2022-11-09
最終更新日2023-03-15
実験手法ELECTRON MICROSCOPY (3.78 Å)
主引用文献Structural mechanism of CRL4-instructed STAT2 degradation via a novel cytomegaloviral DCAF receptor.
Embo J., 42, 2023
1BG1
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BU of 1bg1 by Molmil
TRANSCRIPTION FACTOR STAT3B/DNA COMPLEX
分子名称: DNA (5'-D(*TP*GP*CP*AP*TP*TP*TP*CP*CP*CP*GP*TP*AP*AP*AP*TP*CP*T)-3'), PROTEIN (TRANSCRIPTION FACTOR STAT3B)
著者Becker, S, Groner, B, Muller, C.W.
登録日1998-06-03
公開日1999-01-13
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Three-dimensional structure of the Stat3beta homodimer bound to DNA.
Nature, 394, 1998
1BF5
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BU of 1bf5 by Molmil
TYROSINE PHOSPHORYLATED STAT-1/DNA COMPLEX
分子名称: DNA (5'-D(*AP*CP*AP*GP*TP*TP*TP*CP*CP*CP*GP*TP*AP*AP*AP*TP*G P*C)-3'), DNA (5'-D(*TP*GP*CP*AP*TP*TP*TP*AP*CP*GP*GP*GP*AP*AP*AP*CP*T P*G)-3'), SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA
著者Kuriyan, J, Zhao, Y, Chen, X, Vinkemeier, U, Jeruzalmi, D, Darnell Jr, J.E.
登録日1998-05-27
公開日1998-08-12
最終更新日2022-12-21
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA.
Cell(Cambridge,Mass.), 93, 1998
4Y5U
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BU of 4y5u by Molmil
Transcription factor
分子名称: NICKEL (II) ION, Signal transducer and activator of transcription 6
著者Li, J, Niu, F, Ouyang, S, Liu, Z.
登録日2015-02-12
公開日2016-02-17
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.708 Å)
主引用文献Structural basis for DNA recognition by STAT6
Proc.Natl.Acad.Sci.USA, 113, 2016
4Y5W
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BU of 4y5w by Molmil
Transcription factor-DNA complex
分子名称: DNA (5'-D(P*AP*TP*GP*GP*AP*TP*TP*TP*CP*CP*TP*AP*GP*GP*AP*AP*GP*AP*CP*AP*A)-3'), DNA (5'-D(P*TP*TP*GP*TP*CP*TP*TP*CP*CP*TP*AP*GP*GP*AP*AP*AP*TP*CP*CP*AP*T)-3'), Signal transducer and activator of transcription 6
著者Li, J, Niu, F, Ouyang, S, Liu, Z.
登録日2015-02-12
公開日2016-02-17
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (3.104 Å)
主引用文献Structural basis for DNA recognition by STAT6
Proc.Natl.Acad.Sci.USA, 113, 2016
6TLC
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BU of 6tlc by Molmil
Unphosphorylated human STAT3 in complex with MS3-6 monobody
分子名称: Monobody, Signal transducer and activator of transcription 3
著者La Sala, G, Lau, K, Reynaud, A, Pojer, F, Hantschel, O.
登録日2019-12-02
公開日2020-07-22
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Selective inhibition of STAT3 signaling using monobodies targeting the coiled-coil and N-terminal domains.
Nat Commun, 11, 2020
6UX2
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BU of 6ux2 by Molmil
Crystal structure of ZIKV RdRp in complex with STAT2
分子名称: Nonstructural Protein 5, SULFATE ION, Signal transducer and activator of transcription 2, ...
著者Wang, B, Song, J.
登録日2019-11-06
公開日2020-07-08
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.01 Å)
主引用文献Structural basis for STAT2 suppression by flavivirus NS5.
Nat.Struct.Mol.Biol., 27, 2020
6MBZ
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Structure of Transcription Factor
分子名称: Signal transducer and activator of transcription 5B
著者Seo, H.-S, Dhe-Paganon, S.
登録日2018-08-30
公開日2019-06-19
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.21 Å)
主引用文献Structural and functional consequences of the STAT5BN642Hdriver mutation.
Nat Commun, 10, 2019
6MBW
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BU of 6mbw by Molmil
Structure of Transcription Factor
分子名称: Signal transducer and activator of transcription 5B
著者Seo, H.-S, Dhe-Paganon, S.
登録日2018-08-30
公開日2019-06-19
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.29 Å)
主引用文献Structural and functional consequences of the STAT5BN642H driver mutation.
Nat Commun, 10, 2019
6NJS
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BU of 6njs by Molmil
Stat3 Core in complex with compound SD36
分子名称: Signal transducer and activator of transcription 3, [(2-{[(5S,8S,10aR)-3-acetyl-8-({(2S)-5-amino-1-[(diphenylmethyl)amino]-1,5-dioxopentan-2-yl}carbamoyl)-6-oxodecahydropyrrolo[1,2-a][1,5]diazocin-5-yl]carbamoyl}-1H-indol-5-yl)(difluoro)methyl]phosphonic acid (non-preferred name)
著者Meagher, J.L, Stuckey, J.A.
登録日2019-01-04
公開日2019-12-04
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo.
Cancer Cell, 36, 2019
6NUQ
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Stat3 Core in complex with compound SI109
分子名称: Signal transducer and activator of transcription 3, [(2-{[(5S,8S,10aR)-3-acetyl-8-({(2S)-5-amino-1-[(diphenylmethyl)amino]-1,5-dioxopentan-2-yl}carbamoyl)-6-oxodecahydropyrrolo[1,2-a][1,5]diazocin-5-yl]carbamoyl}-1H-indol-5-yl)(difluoro)methyl]phosphonic acid (non-preferred name)
著者Meagher, J.L, Stuckey, J.A.
登録日2019-02-01
公開日2019-12-04
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.15 Å)
主引用文献A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo.
Cancer Cell, 36, 2019
7UC6
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BU of 7uc6 by Molmil
Stat5a Core in complex with Compound 12
分子名称: N-{5-[difluoro(phosphono)methyl]-1-benzothiophene-2-carbonyl}-3-methyl-L-valyl-L-prolyl-N~3~-(4-bromophenyl)-N,N-dimethyl-beta-alaninamide, Signal transducer and activator of transcription 5A
著者Meagher, J.L, Stuckey, J.A.
登録日2022-03-16
公開日2023-02-15
最終更新日2023-03-08
実験手法X-RAY DIFFRACTION (3.101 Å)
主引用文献Discovery of a Potent and Selective STAT5 PROTAC Degrader with Strong Antitumor Activity In Vivo in Acute Myeloid Leukemia.
J.Med.Chem., 66, 2023

 

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