PDB: 14 件ウェブページステータス検索Chemie searchBIRD

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1T36	Crystal structure of E. coli carbamoyl phosphate synthetase small subunit mutant C248D complexed with uridine 5'-monophosphate 分子名称: ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, Carbamoyl-phosphate synthase large chain, ... 著者 Thoden, J.B, Huang, X, Raushel, F.M, Holden, H.M. 登録日 2004-04-24 公開日 2004-09-21 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Long-range allosteric transitions in carbamoyl phosphate synthetase. Protein Sci., 13, 2004
6UEL	CPS1 bound to allosteric inhibitor H3B-193 分子名称: Carbamoyl-phosphate synthase [ammonia], mitochondrial, N~1~-[(4-fluorophenyl)methyl]-N~1~-methyl-N~4~-(4-methyl-1,3-thiazol-2-yl)piperidine-1,4-dicarboxamide, ... 著者 Larsen, N.A, Nguyen, T.V. 登録日 2019-09-21 公開日 2020-03-18 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Small Molecule Inhibition of CPS1 Activity through an Allosteric Pocket. Cell Chem Biol, 27, 2020
5DOU	Crystal Structure of Human Carbamoyl phosphate synthetase I (CPS1), ligand-bound form 分子名称: 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, ... 著者 de Cima, S, Polo, L.M, Fita, I, Rubio, V. 登録日 2015-09-11 公開日 2015-12-09 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structure of human carbamoyl phosphate synthetase: deciphering the on/off switch of human ureagenesis. Sci Rep, 5, 2015
5DOT	Crystal Structure of Human Carbamoyl phosphate synthetase I (CPS1), apo form 分子名称: 1,2-ETHANEDIOL, Carbamoyl-phosphate synthase [ammonia], mitochondrial, ... 著者 Polo, L.M, de Cima, S, Fita, I, Rubio, V. 登録日 2015-09-11 公開日 2015-12-09 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structure of human carbamoyl phosphate synthetase: deciphering the on/off switch of human ureagenesis. Sci Rep, 5, 2015
6W2J	CPS1 bound to allosteric inhibitor H3B-374 分子名称: (2-fluoranyl-4-methoxy-phenyl)-[(3~{R},5~{R})-4-(2-fluoranyl-4-methoxy-phenyl)carbonyl-3,5-dimethyl-piperazin-1-yl]methanone, 1,2-ETHANEDIOL, Carbamoyl-phosphate synthase [ammonia], ... 著者 Larsen, N.A, Nguyen, T.V. 登録日 2020-03-05 公開日 2021-01-13 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.62 Å) 主引用文献 Discovery of 2,6-Dimethylpiperazines as Allosteric Inhibitors of CPS1. Acs Med.Chem.Lett., 11, 2020
1BXR	STRUCTURE OF CARBAMOYL PHOSPHATE SYNTHETASE COMPLEXED WITH THE ATP ANALOG AMPPNP 分子名称: CARBAMOYL-PHOSPHATE SYNTHASE, CHLORIDE ION, L-ornithine, ... 著者 Thoden, J.B, Wesenberg, G, Raushel, F.M, Holden, H.M. 登録日 1998-10-08 公開日 1999-04-20 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Carbamoyl phosphate synthetase: closure of the B-domain as a result of nucleotide binding. Biochemistry, 38, 1999
1CE8	CARBAMOYL PHOSPHATE SYNTHETASE FROM ESCHERICHIS COLI WITH COMPLEXED WITH THE ALLOSTERIC LIGAND IMP 分子名称: ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, INOSINIC ACID, ... 著者 Thoden, J.B, Raushel, F.M, Holden, H.M. 登録日 1999-03-18 公開日 1999-07-26 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 The binding of inosine monophosphate to Escherichia coli carbamoyl phosphate synthetase. J.Biol.Chem., 274, 1999
1CS0	Crystal structure of carbamoyl phosphate synthetase complexed at CYS269 in the small subunit with the tetrahedral mimic l-glutamate gamma-semialdehyde 分子名称: ADENOSINE-5'-DIPHOSPHATE, CARBAMOYL PHOSPHATE SYNTHETASE: LARGE SUBUNIT, CARBAMOYL PHOSPHATE SYNTHETASE: SMALL SUBUNIT, ... 著者 Thoden, J.B, Huang, X, Raushel, F.M, Holden, H.M. 登録日 1999-08-16 公開日 1999-12-10 最終更新日 2019-11-20 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 The small subunit of carbamoyl phosphate synthetase: snapshots along the reaction pathway. Biochemistry, 38, 1999
1A9X	CARBAMOYL PHOSPHATE SYNTHETASE: CAUGHT IN THE ACT OF GLUTAMINE HYDROLYSIS 分子名称: ADENOSINE-5'-DIPHOSPHATE, CARBAMOYL PHOSPHATE SYNTHETASE (LARGE CHAIN), CARBAMOYL PHOSPHATE SYNTHETASE (SMALL CHAIN), ... 著者 Thoden, J, Holden, H. 登録日 1998-04-14 公開日 1998-10-21 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Carbamoyl phosphate synthetase: caught in the act of glutamine hydrolysis. Biochemistry, 37, 1998
1JDB	CARBAMOYL PHOSPHATE SYNTHETASE FROM ESCHERICHIA COLI 分子名称: ADENOSINE-5'-DIPHOSPHATE, CARBAMOYL PHOSPHATE SYNTHETASE, CHLORIDE ION, ... 著者 Thoden, J.B, Holden, H.M, Wesenberg, G, Raushel, F.M, Rayment, I. 登録日 1997-03-25 公開日 1998-06-17 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 The structure of carbamoyl phosphate synthetase determined to 2.1 A resolution. Acta Crystallogr.,Sect.D, 55, 1999
1KEE	Inactivation of the Amidotransferase Activity of Carbamoyl Phosphate Synthetase by the Antibiotic Acivicin 分子名称: ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, Carbamoyl-phosphate synthetase large chain, ... 著者 Miles, B.W, Thoden, J.B, Holden, H.M, Raushel, F.M. 登録日 2001-11-15 公開日 2001-12-21 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Inactivation of the amidotransferase activity of carbamoyl phosphate synthetase by the antibiotic acivicin. J.Biol.Chem., 277, 2002
1C30	CRYSTAL STRUCTURE OF CARBAMOYL PHOSPHATE SYNTHETASE: SMALL SUBUNIT MUTATION C269S 分子名称: ADENOSINE-5'-DIPHOSPHATE, CARBAMOYL PHOSPHATE SYNTHETASE: LARGE SUBUNIT, CARBAMOYL PHOSPHATE SYNTHETASE: SMALL SUBUNIT, ... 著者 Thoden, J.B, Huang, X, Raushel, F.M, Holden, H.M. 登録日 1999-07-24 公開日 1999-12-10 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 The small subunit of carbamoyl phosphate synthetase: snapshots along the reaction pathway. Biochemistry, 38, 1999
1C3O	CRYSTAL STRUCTURE OF THE CARBAMOYL PHOSPHATE SYNTHETASE: SMALL SUBUNIT MUTANT C269S WITH BOUND GLUTAMINE 分子名称: ADENOSINE-5'-DIPHOSPHATE, CARBAMOYL PHOSPHATE SYNTHETASE: LARGE SUBUNIT, CARBAMOYL PHOSPHATE SYNTHETASE: SMALL SUBUNIT, ... 著者 Thoden, J.B, Huang, X, Raushel, F.M, Holden, H.M. 登録日 1999-07-28 公開日 1999-12-10 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 The small subunit of carbamoyl phosphate synthetase: snapshots along the reaction pathway. Biochemistry, 38, 1999
1M6V	Crystal Structure of the G359F (small subunit) Point Mutant of Carbamoyl Phosphate Synthetase 分子名称: ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, L-ornithine, ... 著者 Thoden, J.B, Huang, X, Raushel, F.M, Holden, H.M. 登録日 2002-07-17 公開日 2002-07-31 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Carbamoyl-phosphate synthetase. Creation of an escape route for ammonia J.Biol.Chem., 277, 2002