PDB: 54 件ウェブページステータス検索Chemie searchBIRD

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7RTG	Crystal Structure of the Human Adenosine Deaminase 1 分子名称: Adenosine deaminase, ZINC ION 著者 Ma, M.T, Lieberman, R.L, Blazeck, J, Jennings, M.R. 登録日 2021-08-13 公開日 2022-01-12 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.591 Å) 主引用文献 Catalytically active holo Homo sapiens adenosine deaminase I adopts a closed conformation. Acta Crystallogr D Struct Biol, 78, 2022
3T1G	Engineering of organophosphate hydrolase by computational design and directed evolution 分子名称: CALCIUM ION, ZINC ION, organophosphate hydrolase 著者 Takeuchi, R, Stoddard, B.L. 登録日 2011-07-21 公開日 2012-02-08 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Computational redesign of a mononuclear zinc metalloenzyme for organophosphate hydrolysis. Nat.Chem.Biol., 8, 2012
4GXW	Crystal structure of a cog1816 amidohydrolase (target EFI-505188) from Burkhoderia ambifaria, with bound Zn 分子名称: Adenosine deaminase, CHLORIDE ION, ZINC ION 著者 Vetting, M.W, Goble, A.M, Morisco, L.L, Wasserman, S.R, Sojitra, S, Imker, H.J, Raushel, F.M, Gerlt, J.A, Almo, S.C, Enzyme Function Initiative (EFI) 登録日 2012-09-04 公開日 2012-09-12 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Crystal structure of a cog1816 amidohydrolase (target EFI-505188) from Burkhoderia ambifaria, with bound Zn To be Published
2Z7G	Crystal structure of adenosine deaminase ligated with EHNA 分子名称: (2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-2-ol, Adenosine deaminase, ZINC ION 著者 Kinoshita, T. 登録日 2007-08-20 公開日 2008-07-01 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.52 Å) 主引用文献 Conformational change of adenosine deaminase during ligand-exchange in a crystal Biochem.Biophys.Res.Commun., 373, 2008
1O5R	Crystal structure of adenosine deaminase complexed with a potent inhibitor 分子名称: 1-[(1R)-3-(6-{[(BENZYLAMINO)CARBONYL]AMINO}-1H-INDOL-1-YL)-1-(HYDROXYMETHYL)PROPYL]-1H-IMIDAZOLE-4-CARBOXAMIDE, Adenosine deaminase, ZINC ION 著者 Kinoshita, T. 登録日 2003-10-05 公開日 2004-09-21 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Structure-based design, synthesis, and structure-activity relationship studies of novel non-nucleoside adenosine deaminase inhibitors J.Med.Chem., 47, 2004
1FKX	MURINE ADENOSINE DEAMINASE (D296A) 分子名称: 6-HYDROXY-1,6-DIHYDRO PURINE NUCLEOSIDE, ADENOSINE DEAMINASE, ZINC ION 著者 Wilson, D.K, Quiocho, F.A. 登録日 1996-02-29 公開日 1996-08-01 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Probing the functional role of two conserved active site aspartates in mouse adenosine deaminase. Biochemistry, 35, 1996
1FKW	MURINE ADENOSINE DEAMINASE (D295E) 分子名称: ADENOSINE DEAMINASE, PURINE RIBOSIDE, ZINC ION 著者 Wilson, D.K, Quiocho, F.A. 登録日 1996-02-29 公開日 1996-08-01 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Probing the functional role of two conserved active site aspartates in mouse adenosine deaminase. Biochemistry, 35, 1996
1QXL	Crystal structure of Adenosine deaminase complexed with FR235380 分子名称: 1-((1R)-1-(HYDROXYMETHYL)-3-{6-[(5-PHENYLPENTANOYL)AMINO]-1H-INDOL-1-YL}PROPYL)-1H-IMIDAZOLE-4-CARBOXAMIDE, Adenosine deaminase, ZINC ION 著者 Kinoshita, T. 登録日 2003-09-08 公開日 2004-09-21 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Structure-based design, synthesis, and structure-activity relationship studies of novel non-nucleoside adenosine deaminase inhibitors J.Med.Chem., 47, 2004
3EWC	Crystal Structure of adenosine deaminase from Plasmodial vivax in complex with MT-coformycin 分子名称: (8R)-3-(5-S-methyl-5-thio-beta-D-ribofuranosyl)-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol, Adenosine deaminase, ZINC ION 著者 Schramm, V.L, Almo, S.C, Cassera, M.B, Ho, M.C. 登録日 2008-10-14 公開日 2009-09-22 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.11 Å) 主引用文献 Structural and metabolic specificity of methylthiocoformycin for malarial adenosine deaminases. Biochemistry, 48, 2009
3EWD	Crystal structure of adenosine deaminase mutant (delta Asp172) from Plasmodium vivax in complex with MT-coformycin 分子名称: (8R)-3-(5-S-methyl-5-thio-beta-D-ribofuranosyl)-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol, Adenosine deaminase, ZINC ION 著者 Schramm, V.L, Almo, S.C, Cassera, M.B, Ho, M.C. 登録日 2008-10-14 公開日 2009-09-22 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural and metabolic specificity of methylthiocoformycin for malarial adenosine deaminases. Biochemistry, 48, 2009
1A4L	ADA STRUCTURE COMPLEXED WITH DEOXYCOFORMYCIN AT PH 7.0 分子名称: 2'-DEOXYCOFORMYCIN, ADENOSINE DEAMINASE, ZINC ION 著者 Wang, Z, Quiocho, F.A. 登録日 1998-01-31 公開日 1998-10-14 最終更新日 2023-08-02 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Complexes of adenosine deaminase with two potent inhibitors: X-ray structures in four independent molecules at pH of maximum activity. Biochemistry, 37, 1998
1A4M	ADA STRUCTURE COMPLEXED WITH PURINE RIBOSIDE AT PH 7.0 分子名称: 6-HYDROXY-1,6-DIHYDRO PURINE NUCLEOSIDE, ADENOSINE DEAMINASE, ZINC ION 著者 Wang, Z, Quiocho, F.A. 登録日 1998-01-31 公開日 1998-10-14 最終更新日 2023-08-02 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Complexes of adenosine deaminase with two potent inhibitors: X-ray structures in four independent molecules at pH of maximum activity. Biochemistry, 37, 1998
1ADD	A PRE-TRANSITION STATE MIMIC OF AN ENZYME: X-RAY STRUCTURE OF ADENOSINE DEAMINASE WITH BOUND 1-DEAZA-ADENOSINE AND ZINC-ACTIVATED WATER 分子名称: 1-DEAZA-ADENOSINE, ADENOSINE DEAMINASE, ZINC ION 著者 Wilson, D.K, Quiocho, F.A. 登録日 1992-12-22 公開日 1994-01-31 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 A pre-transition-state mimic of an enzyme: X-ray structure of adenosine deaminase with bound 1-deazaadenosine and zinc-activated water. Biochemistry, 32, 1993
2PGF	Crystal structure of adenosine deaminase from Plasmodium vivax in complex with adenosine 分子名称: ACETONITRILE, ADENOSINE, ZINC ION, ... 著者 Larson, E.T, Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP) 登録日 2007-04-09 公開日 2007-04-24 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.89 Å) 主引用文献 Structures of substrate- and inhibitor-bound adenosine deaminase from a human malaria parasite show a dramatic conformational change and shed light on drug selectivity. J.Mol.Biol., 381, 2008
2PGR	Crystal structure of adenosine deaminase from Plasmodium vivax in complex with pentostatin 分子名称: 2'-DEOXYCOFORMYCIN, ACETONITRILE, ZINC ION, ... 著者 Larson, E.T, Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP) 登録日 2007-04-10 公開日 2007-04-24 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structures of substrate- and inhibitor-bound adenosine deaminase from a human malaria parasite show a dramatic conformational change and shed light on drug selectivity. J.Mol.Biol., 381, 2008
2QVN	Crystal structure of adenosine deaminase from Plasmodium vivax in complex with guanosine 分子名称: 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, Adenosine deaminase, GUANOSINE 著者 Larson, E.T, Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP) 登録日 2007-08-08 公開日 2007-09-04 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.19 Å) 主引用文献 Structures of substrate- and inhibitor-bound adenosine deaminase from a human malaria parasite show a dramatic conformational change and shed light on drug selectivity. J.Mol.Biol., 381, 2008
2ADA	ATOMIC STRUCTURE OF ADENOSINE DEAMINASE COMPLEXED WITH A TRANSITION-STATE ANALOG: UNDERSTANDING CATALYSIS AND IMMUNODEFICIENCY MUTATIONS 分子名称: 6-HYDROXY-7,8-DIHYDRO PURINE NUCLEOSIDE, ADENOSINE DEAMINASE, ZINC ION 著者 Wilson, D.K, Quiocho, F.A. 登録日 1994-12-02 公開日 1995-03-31 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Atomic structure of adenosine deaminase complexed with a transition-state analog: understanding catalysis and immunodeficiency mutations. Science, 252, 1991
2AMX	Crystal structure of Plasmodium Yoelii Adenosine deaminase (PY02076) 分子名称: COBALT (II) ION, UNKNOWN ATOM OR ION, adenosine deaminase 著者 Dong, A, Vedadi, M, Wasney, G, Zhao, Y, Lew, J, Alam, Z, Melone, M, Koeieradzki, I, Edwards, A.M, Arrowsmith, C.H, Weigelt, J, Sundstrom, M, Bochkarev, A, Hui, R, Amani, M, Structural Genomics Consortium (SGC) 登録日 2005-08-10 公開日 2005-09-20 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.02 Å) 主引用文献 Genome-scale protein expression and structural biology of Plasmodium falciparum and related Apicomplexan organisms. Mol.Biochem.Parasitol., 151, 2007
3IAR	The crystal structure of human adenosine deaminase 分子名称: (2R,3S,5R)-5-(6-amino-9H-purin-9-yl)-tetrahydro-2-(hydroxymethyl)furan-3-ol, Adenosine deaminase, GLYCEROL, ... 著者 Ugochukwu, E, Zhang, Y, Hapka, E, Yue, W.W, Bray, J.E, Muniz, J, Burgess-Brown, N, Chaikuad, A, von Delft, F, Bountra, C, Arrowsmith, C.H, Weigelt, J, Edwards, A, Kavanagh, K.L, Oppermann, U, Structural Genomics Consortium (SGC) 登録日 2009-07-14 公開日 2009-08-11 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.52 Å) 主引用文献 The crystal structure of human adenosine deaminase To be Published
3KM8	Crystal structuore of adenosine deaminase from mus musculus complexed with 9-deazainosine 分子名称: 9-DEAZAINOSINE, Adenosine deaminase, ZINC ION 著者 Fan, X, Gao, Y. 登録日 2009-11-10 公開日 2010-10-20 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 The Catalytic Mechanism of Adenosine Deaminase from Mouse: An Experimental and Theoretical Study To be Published
2E1W	Crystal structure of adenosine deaminase complexed with potent inhibitors 分子名称: 1-{(1R,2S)-2-HYDROXY-1-[2-(1-NAPHTHYL)ETHYL]PROPYL}-1H-IMIDAZOLE-4-CARBOXAMIDE, Adenosine deaminase, ZINC ION 著者 Kinoshita, T. 登録日 2006-10-30 公開日 2006-11-07 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structure-Based Design and Synthesis of Non-Nucleoside, Potent, and Orally Bioavailable Adenosine Deaminase Inhibitors J.Med.Chem., 47, 2004
1KRM	Crystal structure of bovine adenosine deaminase complexed with 6-hydroxyl-1,6-dihydropurine riboside 分子名称: 6-HYDROXY-1,6-DIHYDRO PURINE NUCLEOSIDE, ZINC ION, adenosine deaminase 著者 Kinoshita, T. 登録日 2002-01-10 公開日 2003-01-14 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structure of bovine adenosine deaminase complexed with 6-hydroxy-1,6-dihydropurine riboside. Acta Crystallogr.,Sect.D, 59, 2003
1NDV	Crystal Structure of Adenosine Deaminase complexed with FR117016 分子名称: Adenosine deaminase, N''-(4-(5-((1H-BENZIMIDAZOL-2-YLAMINO)METHYL)-2-THIENYL)-1,3-THIAZOL-2-YL)GUANIDINE, ZINC ION 著者 Kinoshita, T. 登録日 2002-12-09 公開日 2003-12-09 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 A highly potent non-nucleoside adenosine deaminase inhibitor: efficient drug discovery by intentional lead hybridization J.Am.Chem.Soc., 126, 2004
1NDY	Crystal Structure of Adenosine Deaminase Complexed with FR230513 分子名称: 1-((1R)-1-(HYDROXYMETHYL)-3-(1-NAPHTHYL)PROPYL)-1H-IMIDAZOLE-4-CARBOXAMIDE, Adenosine Deaminase, ZINC ION 著者 Kinoshita, T. 登録日 2002-12-09 公開日 2003-12-09 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 A highly potent non-nucleoside adenosine deaminase inhibitor: efficient drug discovery by intentional lead hybridization J.Am.Chem.Soc., 126, 2004
1NDW	Crystal Structure of Adenosine Deaminase Complexed with FR221647 分子名称: 1-((1R)-1-(HYDROXYMETHYL)-3-PHENYLPROPYL)-1H-IMIDAZOLE-4-CARBOXAMIDE, Adenosine Deaminase, ZINC ION 著者 Kinoshita, T. 登録日 2002-12-09 公開日 2003-12-09 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 A highly potent non-nucleoside adenosine deaminase inhibitor: efficient drug discovery by intentional lead hybridization J.Am.Chem.Soc., 126, 2004

 

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