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6QW3
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Calcium-bound gelsolin domain 2
分子名称: CALCIUM ION, Gelsolin
著者Scalone, E, Boni, F, Milani, M, Mastrangelo, E, de Rosa, M.
登録日2019-03-05
公開日2019-08-28
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献High-resolution crystal structure of gelsolin domain 2 in complex with the physiological calcium ion.
Biochem.Biophys.Res.Commun., 518, 2019
4S10
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Gelsolin nanobody shielding mutant plasma gelsolin from furin proteolysis
分子名称: CALCIUM ION, GELSOLIN NANOBODY, Gelsolin
著者Wongsantichon, J, Robinson, R.C, Gettemans, J.
登録日2015-01-07
公開日2015-06-03
実験手法X-RAY DIFFRACTION (2.614 Å)
主引用文献An ER-directed gelsolin nanobody targets the first step in amyloid formation in a gelsolin amyloidosis mouse model.
Hum.Mol.Genet., 24, 2015
7P2B
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Crystal structure of human gelsolin amyloid mutant A551P
分子名称: CHLORIDE ION, GLYCEROL, Gelsolin, ...
著者Bollati, M, de Rosa, M.
登録日2021-07-05
公開日2022-05-18
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献A novel hotspot of gelsolin instability triggers an alternative mechanism of amyloid aggregation.
Comput Struct Biotechnol J, 19, 2021
5ZZ0
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HUMAN GELSOLIN FROM RESIDUES GLU28 TO ARG161 WITH CALCIUM
分子名称: 2-(2-METHOXYETHOXY)ETHANOL, CALCIUM ION, Gelsolin
著者Sharma, P, Badmalia, M, Yadav, S.P.S, Singh, S.
登録日2018-05-29
公開日2019-06-05
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.635 Å)
主引用文献Bonsai Gelsolin Survives Heat Induced Denaturation by Forming beta-Amyloids which Leach Out Functional Monomer.
Sci Rep, 8, 2018
2LLF
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Sixth Gelsolin-like domain of villin in 5 mM CaCl2
分子名称: Villin-1
著者Pfaff, D.A, Brockerman, J, Fedechkin, S, Burns, L, Zhang, F, Mcknight, C, Smirnov, S.L.
登録日2011-11-07
公開日2012-11-07
最終更新日2015-04-15
実験手法SOLUTION NMR
主引用文献Gelsolin-like activation of villin: calcium sensitivity of the long helix in domain 6.
Biochemistry, 52, 2013
6H1F
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Structure of the nanobody-stabilized gelsolin D187N variant (second domain)
分子名称: Gelsolin, THIOCYANATE ION, gelsolin nanobody, ...
著者Hassan, A, Milani, M, Mastrangelo, E, de Rosa, M.
登録日2018-07-11
公開日2019-01-23
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Nanobody interaction unveils structure, dynamics and proteotoxicity of the Finnish-type amyloidogenic gelsolin variant.
Biochim Biophys Acta Mol Basis Dis, 1865, 2019
1D0N
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THE CRYSTAL STRUCTURE OF CALCIUM-FREE EQUINE PLASMA GELSOLIN.
分子名称: HORSE PLASMA GELSOLIN
著者Burtnick, L.D, Robinson, R, Li, C.
登録日1999-09-13
公開日1999-09-15
最終更新日2019-08-14
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献The crystal structure of plasma gelsolin: implications for actin severing, capping, and nucleation.
Cell(Cambridge,Mass.), 90, 1997
6Q9Z
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Crystal structure of the pathological G167R variant of calcium-free human gelsolin,
分子名称: GLYCEROL, Gelsolin, SULFATE ION
著者Boni, F, Scalone, E, Milani, M, Eloise, M, de Rosa, M.
登録日2018-12-18
公開日2019-11-27
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (3.8 Å)
主引用文献The structure of N184K amyloidogenic variant of gelsolin highlights the role of the H-bond network for protein stability and aggregation properties.
Eur.Biophys.J., 49, 2020
6QBF
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Crystal structure of the pathological D187N variant of calcium-free human gelsolin.
分子名称: GLYCEROL, Gelsolin, SODIUM ION, ...
著者Scalone, E, Boni, F, Milani, M, Eloise, M, de Rosa, M.
登録日2018-12-21
公開日2019-11-27
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (3.499 Å)
主引用文献The structure of N184K amyloidogenic variant of gelsolin highlights the role of the H-bond network for protein stability and aggregation properties.
Eur.Biophys.J., 49, 2020
6Q9R
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Crystal structure of the pathological N184K variant of calcium-free human gelsolin
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, GLYCEROL, ...
著者Scalone, E, Boni, F, Milani, M, Eloise, M, de Rosa, M.
登録日2018-12-18
公開日2019-11-27
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.73 Å)
主引用文献The structure of N184K amyloidogenic variant of gelsolin highlights the role of the H-bond network for protein stability and aggregation properties.
Eur.Biophys.J., 49, 2020
5A1M
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Crystal structure of calcium-bound human adseverin domain A3
分子名称: ADSEVERIN, CALCIUM ION
著者Chumnarnsilpa, S, Robinson, R.C, Grimes, J.M, Leyrat, C.
登録日2015-05-01
公開日2015-09-16
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.81 Å)
主引用文献Calcium-Controlled Conformational Choreography in the N-Terminal Half of Adseverin.
Nat.Commun., 6, 2015
5A1K
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Crystal structure of calcium-free human adseverin domains A1-A3
分子名称: ADSEVERIN
著者Chumnarnsilpa, S, Robinson, R.C, Grimes, J.M, Leyrat, C.
登録日2015-04-30
公開日2015-09-16
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Calcium-Controlled Conformational Choreography in the N-Terminal Half of Adseverin.
Nat.Commun., 6, 2015
5FAE
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N184K pathological variant of gelsolin domain 2 (trigonal form)
分子名称: CALCIUM ION, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ...
著者Boni, F, Milani, M, Ricagno, S, Bolognesi, M, de Rosa, M.
登録日2015-12-11
公開日2016-10-05
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Molecular basis of a novel renal amyloidosis due to N184K gelsolin variant.
Sci Rep, 6, 2016
5FAF
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N184K pathological variant of gelsolin domain 2 (orthorhombic form)
分子名称: ACETATE ION, CALCIUM ION, CHLORIDE ION, ...
著者Boni, F, Milani, M, Ricagno, s, Bolognesi, M, de Rosa, M.
登録日2015-12-11
公開日2016-10-05
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.05 Å)
主引用文献Molecular basis of a novel renal amyloidosis due to N184K gelsolin variant.
Sci Rep, 6, 2016
5O2Z
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Domain swap dimer of the G167R variant of gelsolin second domain
分子名称: ACETATE ION, CALCIUM ION, CITRATE ANION, ...
著者Boni, F, Milani, M, Mastrangelo, E, de Rosa, M.
登録日2017-05-23
公開日2017-11-08
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Gelsolin pathogenic Gly167Arg mutation promotes domain-swap dimerization of the protein.
Hum. Mol. Genet., 27, 2018
5H3N
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BU of 5h3n by Molmil
Solution structure of human Gelsolin protein domain 1 at pH 7.3
分子名称: Gelsolin
著者Fan, J.S, Yang, D.
登録日2016-10-26
公開日2017-11-01
最終更新日2023-06-14
実験手法SOLUTION NMR
主引用文献Structural Basis for pH-mediated Regulation of F-actin Severing by Gelsolin Domain 1.
Sci Rep, 7, 2017
5H3M
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Solution structure of human Gelsolin protein domain 1 at pH 5.0
分子名称: Gelsolin
著者Fan, J.S, Yang, D.
登録日2016-10-26
公開日2017-11-01
最終更新日2023-06-14
実験手法SOLUTION NMR
主引用文献Structural Basis for pH-mediated Regulation of F-actin Severing by Gelsolin Domain 1.
Sci Rep, 7, 2017
2VIK
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BU of 2vik by Molmil
REFINED STRUCTURE OF THE ACTIN-SEVERING DOMAIN VILLIN 14T, DETERMINED BY SOLUTION NMR, MINIMIZED AVERAGE STRUCTURE
分子名称: VILLIN 14T
著者Markus, M.A, Matsudaira, P, Wagner, G.
登録日1997-01-16
公開日1997-04-01
最終更新日2017-11-29
実験手法SOLUTION NMR
主引用文献Refined structure of villin 14T and a detailed comparison with other actin-severing domains.
Protein Sci., 6, 1997
2VIL
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REFINED STRUCTURE OF THE ACTIN-SEVERING DOMAIN VILLIN 14T, DETERMINED BY SOLUTION NMR, 11 STRUCTURES
分子名称: VILLIN 14T
著者Markus, M.A, Matsudaira, P, Wagner, G.
登録日1997-01-16
公開日1997-04-01
最終更新日2017-11-29
実験手法SOLUTION NMR
主引用文献Refined structure of villin 14T and a detailed comparison with other actin-severing domains.
Protein Sci., 6, 1997
1J72
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Crystal Structure of Mutant Macrophage Capping Protein (Cap G) with Actin-severing Activity in the Ca2+-Free Form
分子名称: Macrophage capping protein
著者Vorobiev, S.M, Southwick, F.S, Storokopytov, B, Almo, S.C.
登録日2001-05-15
公開日2003-06-24
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal Structure of Mutant Human Macrophage Capping Protein
To be Published
1JHW
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Ca2+-binding Mimicry in the Crystal Structure of the Eu3+-Bound Mutant Human Macrophage Capping Protein Cap G
分子名称: EUROPIUM (III) ION, MACROPHAGE CAPPING PROTEIN
著者Vorobiev, S.M, Southwick, F.S, Almo, S.C.
登録日2001-06-28
公開日2002-06-28
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal Structure of Mutant Human Macrophage Capping Protein
To be Published
1KCQ
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Human Gelsolin Domain 2 with a Cd2+ bound
分子名称: CADMIUM ION, GELSOLIN
著者Kazmirski, S.L, Isaacson, R.L, An, C, Buckle, A, Johnson, C.M, Daggett, V, Fersht, A.R.
登録日2001-11-09
公開日2002-01-04
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Loss of a metal-binding site in gelsolin leads to familial amyloidosis-Finnish type.
Nat.Struct.Biol., 9, 2002
2FH3
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C-terminal half of gelsolin soaked in low calcium at pH 8
分子名称: CALCIUM ION, Gelsolin
著者Chumnarnsilpa, S, Loonchanta, A, Xue, B, Choe, H, Urosev, D, Wang, H, Burtnick, L.D, Robinson, R.C.
登録日2005-12-23
公開日2006-06-13
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.87 Å)
主引用文献Calcium ion exchange in crystalline gelsolin
J.Mol.Biol., 357, 2006
2FGH
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ATP bound gelsolin
分子名称: ADENOSINE-5'-TRIPHOSPHATE, gelsolin
著者Ma, Q, Robinson, R.C, Burtnick, L.D, Urosev, D.
登録日2005-12-22
公開日2006-04-18
最終更新日2017-12-20
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献The structure of gelsolin bound to ATP
J.Mol.Biol., 357, 2006
2FH2
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C-terminal half of gelsolin soaked in EGTA at pH 4.5
分子名称: CALCIUM ION, Gelsolin
著者Chumnarnsilpa, S, Loonchanta, A, Xue, B, Choe, H, Urosev, D, Wang, H, Burtnick, L.D, Robinson, R.C.
登録日2005-12-23
公開日2006-06-13
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Calcium ion exchange in crystalline gelsolin
J.Mol.Biol., 357, 2006

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