PDB: 264 件ウェブページステータス検索Chemie searchBIRD

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6XBU	polymerase domain of polymerase-theta 分子名称: 2'-3'-DIDEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA (5'-D(P*GP*TP*CP*AP*TP*TP*G)-3'), DNA polymerase theta, ... 著者 Chen, X, Pomerantz, R, Zhao, J. 登録日 2020-06-07 公開日 2021-06-09 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.29 Å) 主引用文献 Pol theta reverse transcribes RNA and promotes RNA-templated DNA repair. Sci Adv, 7, 2021
4UQG	A new bio-isosteric base pair based on reversible bonding 分子名称: 5'-D(*AP*GP*GP*GP*A SAYP*GP*GP*TP*CP)-3', 5'-D(*GP*AP*CP*C T0TP*TP*CP*CP*CP*TP)-3', DNA POLYMERASE, ... 著者 Tomas-Gamasa, M, Serdjukov, S, Su, M, Mueller, M, Carell, T. 登録日 2014-06-23 公開日 2014-12-03 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 "Post-it" type connected DNA created with a reversible covalent cross-link. Angew. Chem. Int. Ed. Engl., 54, 2015
4X0P	Ternary complex of human DNA polymerase theta C-terminal domain binding ddATP opposite a tetrahydrofuran AP site analog 分子名称: 2',3'-dideoxyadenosine triphosphate, CALCIUM ION, DNA (5'-D(*CP*GP*TP*TP*GP*AP*AP*TP*GP*AP*CP*AP*GP*CP*CP*GP*CP*G)-3'), ... 著者 Zahn, K.E, Doublie, S. 登録日 2014-11-21 公開日 2015-03-18 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.911 Å) 主引用文献 Human DNA polymerase theta grasps the primer terminus to mediate DNA repair. Nat.Struct.Mol.Biol., 22, 2015
3BDP	DNA POLYMERASE I/DNA COMPLEX 分子名称: DNA (5'-D(*AP*GP*CP*AP*TP*CP*AP*TP*GP*C)-3'), DNA (5'-D(*GP*CP*AP*TP*GP*AP*TP*GP*CP*2DT)-3'), PROTEIN (DNA POLYMERASE I), ... 著者 Kiefer, J.R, Mao, C, Beese, L.S. 登録日 1997-11-17 公開日 1999-01-13 最終更新日 2023-08-02 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Visualizing DNA replication in a catalytically active Bacillus DNA polymerase crystal. Nature, 391, 1998
2BDP	CRYSTAL STRUCTURE OF BACILLUS DNA POLYMERASE I FRAGMENT COMPLEXED TO 9 BASE PAIRS OF DUPLEX DNA 分子名称: DNA (5'-D(*GP*CP*AP*TP*GP*AP*TP*GP*C)-3'), DNA (5'-D(P*AP*GP*CP*AP*TP*CP*AP*TP*GP*C)-3'), MAGNESIUM ION, ... 著者 Kiefer, J.R, Mao, C, Beese, L.S. 登録日 1997-11-17 公開日 1999-01-13 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Visualizing DNA replication in a catalytically active Bacillus DNA polymerase crystal. Nature, 391, 1998
4O0I	Crystal structure of fragment DNA polymerase I from Bacillus stearothermophilus with 2'-MeSe-arabino-guanosine derivatized DNA 分子名称: 5'-D(*C*(1TW)P*CP*GP*AP*AP*TP*TP*CP*GP*CP*G)-3', DNA polymerase I, GLYCEROL, ... 著者 Jiang, S, Gan, J, Sun, H, Huang, Z. 登録日 2013-12-13 公開日 2014-12-17 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.203 Å) 主引用文献 Crystal structure of fragment DNA polymerase I from Bacillus stearothermophilus with 2'-MeSe-arabino-guanosine derivatized DNA TO BE PUBLISHED
7ZUS	Crystal structure of ternary complex of Pol theta polymerase domain 分子名称: 2'-3'-DIDEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA (5'-D(*GP*CP*GP*GP*CP*TP*GP*TP*CP*AP*TP*TP*(DDG))-3'), DNA (5'-D(P*TP*TP*CP*CP*AP*AP*TP*GP*AP*CP*AP*GP*CP*CP*GP*C)-3'), ... 著者 Krajewski, W.W, Turnbull, A.P, Willis, S, Charles, M, Stockley, M, Heald, R.A. 登録日 2022-05-13 公開日 2022-10-12 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.26 Å) 主引用文献 Discovery, Characterization, and Structure-Based Optimization of Small-Molecule In Vitro and In Vivo Probes for Human DNA Polymerase Theta. J.Med.Chem., 65, 2022
7ZX1	Crystal structure of Pol theta polymerase domain in complex with compound 22 分子名称: (2~{S},3~{R})-1-[3-cyano-6-methyl-4-(trifluoromethyl)pyridin-2-yl]-~{N}-methyl-~{N}-(3-methylphenyl)-3-oxidanyl-pyrrolidine-2-carboxamide, 2'-3'-DIDEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA (5'-D(*GP*CP*GP*GP*CP*TP*GP*TP*CP*AP*TP*TP*(DDG))-3'), ... 著者 Krajewski, W.W, Turnbull, A.P, Willis, S, Charles, M, Stockley, M, Heald, R.A. 登録日 2022-05-19 公開日 2022-10-12 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.829 Å) 主引用文献 Discovery, Characterization, and Structure-Based Optimization of Small-Molecule In Vitro and In Vivo Probes for Human DNA Polymerase Theta. J.Med.Chem., 65, 2022
7ZX0	Crystal structure of Pol theta polymerase domain in complex with compound 5 分子名称: 2'-3'-DIDEOXYGUANOSINE-5'-TRIPHOSPHATE, 2-[5-bromanyl-3-cyano-6-methyl-4-(trifluoromethyl)pyridin-2-yl]oxy-~{N}-ethyl-~{N}-(3-methylphenyl)ethanamide, DNA (5'-D(*GP*CP*GP*GP*CP*TP*GP*TP*CP*AP*TP*TP*(DDG))-3'), ... 著者 Krajewski, W.W, Turnbull, A.P, Willis, S, Charles, M, Stockley, M, Heald, R.A. 登録日 2022-05-19 公開日 2022-10-12 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.99 Å) 主引用文献 Discovery, Characterization, and Structure-Based Optimization of Small-Molecule In Vitro and In Vivo Probes for Human DNA Polymerase Theta. J.Med.Chem., 65, 2022
3EYZ	Cocrystal structure of Bacillus fragment DNA polymerase I with duplex DNA (open form) 分子名称: 5'-D(*DAP*DTP*DGP*DCP*DGP*DAP*DGP*DTP*DCP*DAP*DGP*DGP*DA)-3', 5'-D(*DCP*DCP*DTP*DGP*DAP*DCP*DTP*DCP*DGP*DC)-3', DNA polymerase I, ... 著者 Warren, J.J, Wu, E.Y, Golosov, A.A, Karplus, M, Beese, L.S. 登録日 2008-10-22 公開日 2009-11-10 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 The Mechanism of the Translocation Step in DNA Replication by DNA Polymerase I: A Computer Simulation Analysis. Structure, 18, 2010
3EZ5	Cocrystal structure of Bacillus fragment DNA polymerase I with duplex DNA , dCTP, and zinc (closed form). 分子名称: 2',3'-DIDEOXYADENOSINE-5'-TRIPHOSPHATE, 5'-D(*DAP*DTP*DTP*DCP*DGP*DAP*DGP*DTP*DCP*DAP*DGP*DG)-3', 5'-D(*DCP*DCP*DTP*DGP*DAP*DCP*DTP*DCP*DG)-3', ... 著者 Warren, J.J, Wu, E.Y, Golosov, A.A, Karplus, M, Beese, L.S. 登録日 2008-10-22 公開日 2009-11-10 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 The Mechanism of the Translocation Step in DNA Replication by DNA Polymerase I: A Computer Simulation Analysis. Structure, 18, 2010
6P5C	Bacillus Fragment DNA polymerase mutant I716M 分子名称: DNA (5'-D(*CP*GP*AP*TP*CP*AP*CP*GP*C)-3'), DNA (5'-D(P*GP*CP*GP*TP*GP*AP*TP*CP*G)-3'), DNA polymerase I, ... 著者 Wu, E.Y. 登録日 2019-05-30 公開日 2020-03-25 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 The importance of Ile716 toward the mutagenicity of 8-Oxo-2'-deoxyguanosine with Bacillus fragment DNA polymerase. DNA Repair (Amst.), 89, 2020
3HP6	Crystal structure of fragment DNA polymerase I from Bacillus stearothermophilus F710Y mutant bound to G:T mismatch 分子名称: 2',3'-DIDEOXY-THYMIDINE-5'-TRIPHOSPHATE, 5'-D(*AP*CP*GP*CP*CP*GP*TP*GP*AP*TP*CP*G)-3', 5'-D(*CP*GP*AP*TP*CP*AP*CP*GP*(DDG))-3', ... 著者 Wu, E.Y, Beese, L.S. 登録日 2009-06-03 公開日 2010-06-23 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.81 Å) 主引用文献 The structure of a high fidelity DNA polymerase bound to a mismatched nucleotide reveals an "ajar" intermediate conformation in the nucleotide selection mechanism. J.Biol.Chem., 286, 2011
3HPO	Crystal structure of fragment DNA polymerase I from Bacillus stearothermophilus Y714S mutant bound to G:T mismatch 分子名称: 5'-D(*CP*GP*AP*TP*CP*AP*CP*GP*(DOC))-3', 5'-D(P*GP*GP*CP*GP*TP*GP*AP*TP*CP*G)-3', DNA polymerase I, ... 著者 Wu, E.Y, Beese, L.S. 登録日 2009-06-04 公開日 2010-06-23 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 The structure of a high fidelity DNA polymerase bound to a mismatched nucleotide reveals an "ajar" intermediate conformation in the nucleotide selection mechanism. J.Biol.Chem., 286, 2011
3HT3	Crystal structure of fragment DNA polymerase I from Bacillus stearothermophilus V713P mutant bound to G:dCTP 分子名称: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, 5'-D(*AP*CP*GP*GP*CP*GP*TP*GP*AP*TP*CP*G)-3', 5'-D(*CP*GP*AP*TP*CP*AP*CP*GP*(DOC))-3', ... 著者 Wu, E.Y, Beese, L.S. 登録日 2009-06-11 公開日 2010-07-14 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 The structure of a high fidelity DNA polymerase bound to a mismatched nucleotide reveals an "ajar" intermediate conformation in the nucleotide selection mechanism. J.Biol.Chem., 286, 2011
8E23	Human DNA polymerase theta in complex with allosteric inhibitor 分子名称: 2'-3'-DIDEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA (5'-D(*CP*GP*TP*CP*CP*AP*AP*TP*GP*AP*CP*AP*GP*CP*CP*GP*C)-3'), DNA (5'-D(*GP*C*GP*GP*CP*TP*GP*TP*CP*AP*TP*TP*G)-3'), ... 著者 Mader, P, Pau, V.P.T, Sicheri, F. 登録日 2022-08-13 公開日 2022-09-28 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.59 Å) 主引用文献 Identification of RP-6685 , an Orally Bioavailable Compound that Inhibits the DNA Polymerase Activity of Pol theta. J.Med.Chem., 65, 2022
8E24	Human DNA polymerase theta in complex with allosteric inhibitor 分子名称: 2'-3'-DIDEOXYGUANOSINE-5'-TRIPHOSPHATE, 2-[2,4-bis(trifluoromethyl)phenyl]-N-phenyl-N-[3-(pyridazin-3-yl)prop-2-yn-1-yl]acetamide, DNA, ... 著者 Mader, P, Pau, V.P.T, Sicheri, F. 登録日 2022-08-13 公開日 2022-09-28 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.34 Å) 主引用文献 Identification of RP-6685 , an Orally Bioavailable Compound that Inhibits the DNA Polymerase Activity of Pol theta. J.Med.Chem., 65, 2022
8EF9	Structure of Lates calcarifer DNA polymerase theta polymerase domain with long duplex DNA, complex Ia 分子名称: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA (5'-D(*AP*GP*CP*AP*TP*CP*CP*GP*TP*AP*GP*(2DA))-3'), DNA (5'-D(*AP*GP*CP*TP*CP*TP*AP*CP*GP*GP*AP*TP*GP*C)-3'), ... 著者 Li, C, Zhu, H, Sun, J, Gao, Y. 登録日 2022-09-08 公開日 2022-12-14 最終更新日 2023-02-01 実験手法 ELECTRON MICROSCOPY (2.4 Å) 主引用文献 Structural basis of DNA polymerase theta mediated DNA end joining. Nucleic Acids Res., 51, 2023
8EFC	Structure of Lates calcarifer DNA polymerase theta polymerase domain with long duplex DNA, complex Ia 分子名称: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA (5'-D(*AP*CP*TP*GP*TP*GP*AP*GP*GP*CP*AP*TP*CP*CP*GP*TP*AP*GP*(2DA))-3'), DNA (5'-D(*AP*GP*CP*TP*CP*TP*AP*CP*GP*GP*AP*TP*GP*CP*CP*TP*CP*AP*CP*AP*G)-3'), ... 著者 Li, C, Zhu, H, Sun, J, Gao, Y. 登録日 2022-09-08 公開日 2022-12-14 最終更新日 2023-02-01 実験手法 ELECTRON MICROSCOPY (2.8 Å) 主引用文献 Structural basis of DNA polymerase theta mediated DNA end joining. Nucleic Acids Res., 51, 2023
8EFK	Structure of Lates calcarifer DNA polymerase theta polymerase domain with hairpin DNA 分子名称: 2',3'-dideoxyadenosine triphosphate, DNA (5'-D(P*TP*TP*TP*TP*GP*GP*CP*TP*TP*TP*TP*GP*CP*CP*(2DA))-3'), Lates calcarifer DNA polymerase theta, ... 著者 Li, C, Zhu, H, Sun, J, Gao, Y. 登録日 2022-09-08 公開日 2022-12-14 最終更新日 2023-02-01 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Structural basis of DNA polymerase theta mediated DNA end joining. Nucleic Acids Res., 51, 2023
2XY7	Crystal structure of a salicylic aldehyde base in the pre-insertion site of fragment DNA polymerase I from Bacillus stearothermophilus 分子名称: 5'-D(*GP*CP*CP*TP*GP*AP*CP*TP*CP*GP)-3', 5'-D(*SAYP*CP*GP*AP*GP*TP*CP*AP*GP*GP*CP)-3', DNA POLYMERASE I, ... 著者 Kaul, C, Mueller, M, Wagner, M, Schneider, S, Carell, T. 登録日 2010-11-15 公開日 2011-07-27 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (3.05 Å) 主引用文献 Reversible Bond Formation Enables the Replication and Amplification of a Crosslinking Salen Complex as an Orthogonal Base Pair. Nature Chem., 3, 2011
2Y1I	Crystal structure of a S-diastereomer analogue of the spore photoproduct in complex with fragment DNA polymerase I from Bacillus stearothermophilus 分子名称: 5'-D(*AP*GP*GP*GP*PBTP*THM*GP*GP*TP*CP)-3', 5'-D(*GP*AP*CP*CP*AP*AP*CP*CP*CP*TP)-3', DNA POLYMERASE I, ... 著者 Heil, K, Schneider, S, Mueller, M, Kneuttinger, A.C, Carell, T. 登録日 2010-12-08 公開日 2011-07-27 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.78 Å) 主引用文献 Crystal Structures and Repair Studies Reveal the Identity and the Base-Pairing Properties of the Uv-Induced Spore Photoproduct DNA Lesion. Chemistry, 17, 2011
2XY5	Crystal structure of an artificial salen-copper basepair in complex with fragment DNA polymerase I from Bacillus stearothermophilus 分子名称: (4R)-2-METHYLPENTANE-2,4-DIOL, 5'-D(*AP*GP*GP*GP*AP*SAYP*GP*GP*TP*CP)-3', 5'-D(*GP*AP*CP*CP*SAYP*TP*CP*CP*CP*TP)-3', ... 著者 Kaul, C, Mueller, M, Wagner, M, Schneider, S, Carell, T. 登録日 2010-11-15 公開日 2011-07-27 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.22 Å) 主引用文献 Reversible Bond Formation Enables the Replication and Amplification of a Crosslinking Salen Complex as an Orthogonal Base Pair. Nature Chem., 3, 2011
2Y1J	CRYSTAL STRUCTURE OF A R-DIASTEREOMER ANALOGUE OF THE SPORE PHOTOPRODUCT IN COMPLEX WITH FRAGMENT DNA POLYMERASE I FROM BACILLUS STEAROTHERMOPHILUS 分子名称: 5'-D(*AP*GP*GP*GP*QBTP*THM*GP*GP*TP*CP)-3', 5'-D(*GP*AP*CP*CP*AP*AP*CP*CP*CP*TP)-3', DNA POLYMERASE I, ... 著者 Heil, K, Schneider, S, Mueller, M, Kneuttinger, A.C, Carell, T. 登録日 2010-12-08 公開日 2011-07-27 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Crystal Structures and Repair Studies Reveal the Identity and the Base-Pairing Properties of the Uv-Induced Spore Photoproduct DNA Lesion. Chemistry, 17, 2011
2XO7	Crystal structure of a dA:O-allylhydroxylamine-dC basepair in complex with fragment DNA polymerase I from Bacillus stearothermophilus 分子名称: 5'-D(*AP*GP*GP*AP*AP*TP*GP*GP*TP*CP*A)-3', 5'-D(*GP*AP*CP*CP*AP*TP*47C*CP*CP*T)-3', DNA POLYMERASE I, ... 著者 Muenzel, M, Lercher, L, Mueller, M, Carell, T. 登録日 2010-08-10 公開日 2010-09-15 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 Chemical Discrimination between Dc and 5Medc Via Their Hydroxylamine Adducts Nucleic Acids Res., 38, 2010

 

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