PDB: 42 件ウェブページステータス検索Chemie searchBIRD

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3TB8	Crystal structure of full-length myristoylated HIV-1 Nef 分子名称: Protein Nef 著者 Dennis, C.A, Harris, M, Jaeger, J. 登録日 2011-08-05 公開日 2012-10-03 最終更新日 2022-12-21 実験手法 X-RAY DIFFRACTION (3.71 Å) 主引用文献 Crystal structure of full-length myristoylated HIV-1 Nef To be Published
2XI1	Crystal structure of the HIV-1 Nef sequenced from a patient's sample 分子名称: NEF 著者 Yadav, G.P, Singh, P, Gupta, S, Tripathi, A.K, Tripathi, R.K, Ramachandran, R. 登録日 2010-06-25 公開日 2011-08-10 最終更新日 2011-11-23 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 A Novel Dimer-Tetramer Transition Captured by the Crystal Structure of the HIV-1 Nef. Plos One, 6, 2011
6K6N	Crystal structure of SIVmac239 Nef protein 分子名称: Protein Nef 著者 Hirao, K, Andrews, S, Kuroki, K, Kusaka, H, Tadokoro, T, Kita, S, Ose, T, Rowland-Jones, S, Maenaka, K. 登録日 2019-06-04 公開日 2020-03-25 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.0002 Å) 主引用文献 Structure of HIV-2 Nef Reveals Features Distinct from HIV-1 Involved in Immune Regulation. Iscience, 23, 2020
2NEF	HIV-1 NEF (REGULATORY FACTOR), NMR, 40 STRUCTURES 分子名称: NEGATIVE FACTOR (F-PROTEIN) 著者 Grzesiek, S, Bax, A, Clore, G.M, Gronenborn, A.M, Hu, J.S, Kaufman, J, Palmer, I, Stahl, S.J, Tjandra, N, Wingfield, P.T. 登録日 1997-02-12 公開日 1997-07-07 最終更新日 2017-11-29 実験手法 SOLUTION NMR 主引用文献 Refined solution structure and backbone dynamics of HIV-1 Nef. Protein Sci., 6, 1997
1AVV	HIV-1 NEF PROTEIN, UNLIGANDED CORE DOMAIN 分子名称: NEGATIVE FACTOR 著者 Arold, S, Franken, P, Dumas, C. 登録日 1997-09-21 公開日 1998-03-25 最終更新日 2023-08-02 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 The crystal structure of HIV-1 Nef protein bound to the Fyn kinase SH3 domain suggests a role for this complex in altered T cell receptor signaling. Structure, 5, 1997
5NUI	Crystal structure of SIVmac239 Nef in an ExxxLM endocytic sorting motif bound state 分子名称: Protein Nef, SER-GLN-ILE-LYS-ARG-LEU-LEU-SER 著者 Manrique, S, Horenkamp, F.A, Anand, K, Geyer, M. 登録日 2017-04-30 公開日 2017-08-16 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Endocytic sorting motif interactions involved in Nef-mediated downmodulation of CD4 and CD3. Nat Commun, 8, 2017
6B72	A novel HIV-1 Nef dimer interface induced by a single octyl-glucoside molecule 分子名称: Protein Nef, octyl beta-D-glucopyranoside 著者 Wu, M, Augelli-Szafran, C.E, Ptak, R.G, Smithgall, T.E. 登録日 2017-10-03 公開日 2018-02-21 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 A single beta-octyl glucoside molecule induces HIV-1 Nef dimer formation in the absence of partner protein binding. PLoS ONE, 13, 2018
6URI	HIV-1 Nef in complex with the CD4 cytoplasmic domain and the AP2 clathrin adaptor complex 分子名称: AP-2 complex subunit alpha, AP-2 complex subunit beta, AP-2 complex subunit mu, ... 著者 Jia, X, Kwon, Y. 登録日 2019-10-23 公開日 2020-07-29 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structural basis of CD4 downregulation by HIV-1 Nef. Nat.Struct.Mol.Biol., 27, 2020
6OWT	Structure of SIVsmm Nef and SMM tetherin bound to the clathrin adaptor AP-2 complex 分子名称: AP-2 complex subunit alpha, AP-2 complex subunit beta, AP-2 complex subunit sigma, ... 著者 Buffalo, C.Z, Ren, X, Hurley, J.H. 登録日 2019-05-10 公開日 2019-09-25 最終更新日 2019-12-18 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Structural Basis for Tetherin Antagonism as a Barrier to Zoonotic Lentiviral Transmission. Cell Host Microbe, 26, 2019
3IK5	SIVmac239 Nef in complex with TCR zeta ITAM 1 polypeptide (A63-R80) 分子名称: Protein Nef, T-cell surface glycoprotein CD3 zeta chain 著者 Kim, W.M, Sigalov, A.B, Stern, L.J. 登録日 2009-08-05 公開日 2010-02-02 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Pseudo-merohedral twinning and noncrystallographic symmetry in orthorhombic crystals of SIVmac239 Nef core domain bound to different-length TCRzeta fragments. Acta Crystallogr.,Sect.D, 66, 2010
4NEE	crystal structure of AP-2 alpha/simga2 complex bound to HIV-1 Nef 分子名称: AP-2 complex subunit alpha-2, AP-2 complex subunit sigma, Protein Nef 著者 Hurley, J.H, Bonifacino, J.S, Ren, X, Park, S.Y. 登録日 2013-10-29 公開日 2014-01-29 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.8841 Å) 主引用文献 How HIV-1 Nef hijacks the AP-2 clathrin adaptor to downregulate CD4. Elife, 3, 2014
3IOZ	SIVmac239 Nef in complex with a TCR zeta polypeptide DP1 (L51-D93) 分子名称: Protein Nef, T-cell surface glycoprotein CD3 zeta chain 著者 Kim, W.M, Sigalov, A.B, Stern, L.J. 登録日 2009-08-15 公開日 2010-02-02 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (3.699 Å) 主引用文献 Pseudo-merohedral twinning and noncrystallographic symmetry in orthorhombic crystals of SIVmac239 Nef core domain bound to different-length TCRzeta fragments. Acta Crystallogr.,Sect.D, 66, 2010
4EN2	HIV-1 Nef in complex with MHC-I cytoplasmic domain and Mu1 adaptin subunit of AP1 adaptor (second domain) 分子名称: AP-1 complex subunit mu-1, MHC-I, Protein Nef 著者 Jia, X, Xiong, Y. 登録日 2012-04-12 公開日 2012-06-20 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.58 Å) 主引用文献 Structural basis of evasion of cellular adaptive immunity by HIV-1 Nef. Nat.Struct.Mol.Biol., 19, 2012
4EMZ	HIV-1 Nef in complex with MHC-I cytoplasmic domain and Mu1 adaptin subunit of AP1 adaptor (second domain) 分子名称: AP-1 complex subunit mu-1, MHC-I, Protein Nef 著者 Jia, X, Xiong, Y. 登録日 2012-04-12 公開日 2012-06-20 最終更新日 2012-07-25 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structural basis of evasion of cellular adaptive immunity by HIV-1 Nef. Nat.Struct.Mol.Biol., 19, 2012
7UX3	Asymmetric unit of AP-1, Arf1, Nef lattice on MHC-I lipopeptide incorporated narrow membrane tubes 分子名称: ADP-ribosylation factor 1, AP-1 complex subunit beta-1, AP-1 complex subunit gamma-1, ... 著者 Hooy, R.M, Hurley, J.H. 登録日 2022-05-04 公開日 2023-05-10 最終更新日 2023-06-14 実験手法 ELECTRON MICROSCOPY (9.6 Å) 主引用文献 Self-assembly and structure of a clathrin-independent AP-1:Arf1 tubular membrane coat. Sci Adv, 8, 2022
1EFN	HIV-1 NEF PROTEIN IN COMPLEX WITH R96I MUTANT FYN SH3 DOMAIN 分子名称: FYN TYROSINE KINASE, HIV-1 NEF PROTEIN, TRIMETHYL LEAD ION 著者 Lee, C.-H, Kuriyan, J. 登録日 1996-06-29 公開日 1997-01-11 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal structure of the conserved core of HIV-1 Nef complexed with a Src family SH3 domain. Cell(Cambridge,Mass.), 85, 1996
8F2P	Nef SF2 dimerization mutant bound to Hck SH3 分子名称: C-terminal core protein, Tyrosine-protein kinase HCK 著者 Thomas, C.E, Alvarado, J.J, Smithgall, T.E. 登録日 2022-11-08 公開日 2023-02-22 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.63 Å) 主引用文献 Neutron Reflectometry and Molecular Simulations Demonstrate HIV-1 Nef Homodimer Formation on Model Lipid Bilayers. J.Mol.Biol., 435, 2023
4U5W	Crystal Structure of HIV-1 Nef-SF2 Core Domain in Complex with the Src Family Kinase Hck SH3-SH2 Tandem Regulatory Domains 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, IODIDE ION, Protein Nef, ... 著者 Alvarado, J.J, Yeh, J.I, Smithgall, T.E. 登録日 2014-07-25 公開日 2014-08-20 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.86 Å) 主引用文献 Interaction with the Src Homology (SH3-SH2) Region of the Src-family Kinase Hck Structures the HIV-1 Nef Dimer for Kinase Activation and Effector Recruitment. J.Biol.Chem., 289, 2014
7D7S	HIV-1 SF2 Nef in complex with the Fyn SH3 R96I mutant 分子名称: Protein Nef, Tyrosine-protein kinase Fyn 著者 Aldehaiman, A, Shahul Hamed, U.F, Arold, S.T. 登録日 2020-10-05 公開日 2020-11-18 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (3.32 Å) 主引用文献 Synergy and allostery in ligand binding by HIV-1 Nef. Biochem.J., 478, 2021
1AVZ	V-1 NEF PROTEIN IN COMPLEX WITH WILD TYPE FYN SH3 DOMAIN 分子名称: FYN TYROSINE KINASE, NEGATIVE FACTOR 著者 Arold, S, Franken, P, Dumas, C. 登録日 1997-09-23 公開日 1998-03-25 最終更新日 2023-08-02 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 The crystal structure of HIV-1 Nef protein bound to the Fyn kinase SH3 domain suggests a role for this complex in altered T cell receptor signaling. Structure, 5, 1997
5NUH	Crystal structure of SIVmac239 Nef bound to an engineered Hck SH3 domain 分子名称: Protein Nef, Tyrosine-protein kinase HCK,Tyrosine-protein kinase HCK 著者 Horenkamp, F.A, Anand, K, Geyer, M. 登録日 2017-04-30 公開日 2017-08-16 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.78 Å) 主引用文献 Endocytic sorting motif interactions involved in Nef-mediated downmodulation of CD4 and CD3. Nat Commun, 8, 2017
4ORZ	HIV-1 Nef protein in complex with single domain antibody sdAb19 and an engineered Hck SH3 domain 分子名称: Protein Nef, Tyrosine-protein kinase HCK, single domain antibody sdAb19 著者 Geyer, M, Lulf, S. 登録日 2014-02-12 公開日 2014-03-26 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural basis for the inhibition of HIV-1 Nef by a high-affinity binding single-domain antibody. Retrovirology, 11, 2014
4D8D	Crystal structure of HIV-1 NEF Fyn-SH3 R96W variant 分子名称: GLYCEROL, Protein Nef, Tyrosine-protein kinase Fyn 著者 Arold, S.T, Hoh, F, Dumas, C. 登録日 2012-01-10 公開日 2013-01-16 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.5201 Å) 主引用文献 Synergy and allostery in ligand binding by HIV-1 Nef. Biochem.J., 478, 2021
3REB	HIV-1 Nef protein in complex with engineered Hck-SH3 domain 分子名称: Protein Nef, Tyrosine-protein kinase HCK 著者 Schulte, A, Blankenfeldt, W, Geyer, M. 登録日 2011-04-04 公開日 2011-06-01 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (3.45 Å) 主引用文献 Molecular design, functional characterization and structural basis of a protein inhibitor against the HIV-1 pathogenicity factor Nef. PLoS ONE, 6, 2011
3RBB	HIV-1 NEF protein in complex with engineered HCK SH3 domain 分子名称: 1,2-ETHANEDIOL, Protein Nef, Tyrosine-protein kinase HCK 著者 Horenkamp, F.A, Schulte, A, Weyand, M, Geyer, M. 登録日 2011-03-29 公開日 2011-04-27 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Conformation of the Dileucine-Based Sorting Motif in HIV-1 Nef Revealed by Intermolecular Domain Assembly. Traffic, 12, 2011

 

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