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2O9K
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WDR5 in Complex with Dimethylated H3K4 Peptide
分子名称: H3 HISTONE, WD repeat protein 5
著者Min, J.R, Schuetz, A, Allali-Hassani, A, Martin, F, Loppnau, P, Vedadi, M, Weigelt, J, Sundstrom, M, Edwards, A.M, Arrowsmith, C.H, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC)
登録日2006-12-13
公開日2006-12-19
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural Basis for Molecular Recognition and Presentation of Histone H3 by Wdr5.
Embo J., 25, 2006
1NR0
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BU of 1nr0 by Molmil
Two Seven-Bladed Beta-Propeller Domains Revealed By The Structure Of A C. elegans Homologue Of Yeast Actin Interacting Protein 1 (AIP1).
分子名称: Actin interacting protein 1, MANGANESE (II) ION
著者Vorobiev, S.M, Mohri, K, Ono, S, Almo, S.C, Burley, S.K, New York SGX Research Center for Structural Genomics (NYSGXRC)
登録日2003-01-23
公開日2003-07-01
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Identification of Functional Residues on Caenorhabditis elegans Actin-interacting Protein 1 (UNC-78) for Disassembly of Actin Depolymerizing Factor/Cofilin-bound Actin Filaments
J.Biol.Chem., 279, 2004
1ERJ
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CRYSTAL STRUCTURE OF THE C-TERMINAL WD40 DOMAIN OF TUP1
分子名称: TRANSCRIPTIONAL REPRESSOR TUP1
著者Sprague, E.R, Redd, M.J, Johnson, A.D, Wolberger, C.
登録日2000-04-06
公開日2000-07-26
最終更新日2022-12-21
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structure of the C-terminal domain of Tup1, a corepressor of transcription in yeast.
EMBO J., 19, 2000
1YFQ
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High resolution S. cerevisiae Bub3 mitotic checkpoint protein
分子名称: ACETATE ION, CALCIUM ION, Cell cycle arrest protein BUB3
著者Wilson, D.K, Cerna, D, Chew, E.
登録日2005-01-03
公開日2005-01-11
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.1 Å)
主引用文献The 1.1-a structure of the spindle checkpoint protein bub3p reveals functional regions.
J.Biol.Chem., 280, 2005
1GXR
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WD40 Region of Human Groucho/TLE1
分子名称: CALCIUM ION, TRANSDUCIN-LIKE ENHANCER PROTEIN 1
著者Pearl, L.H, Roe, S.M, Pickles, L.M.
登録日2002-04-10
公開日2002-06-13
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Crystal Structure of the C-Terminal Wd40 Repeat Domain of the Human Groucho/Tle1 Transcriptional Corepressor
Structure, 10, 2002
5OV3
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Structure of the RbBP5 beta-propeller domain
分子名称: Retinoblastoma-binding protein 5, TETRAETHYLENE GLYCOL, TRIETHYLENE GLYCOL
著者Mittal, A, Zhang, Y, Gamblin, S.J, Wilson, J.R.
登録日2017-08-27
公開日2018-03-28
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献The structure of the RbBP5 beta-propeller domain reveals a surface with potential nucleic acid binding sites.
Nucleic Acids Res., 46, 2018
5SXM
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WDR5 in complex with MLL Win motif peptidomimetic
分子名称: ACE-ALA-ARG-THR-GLU-VAL-TYR-NH2, WD repeat-containing protein 5
著者Alicea-Velazquez, N.L, Shinsky, S.A, Cosgrove, M.S.
登録日2016-08-09
公開日2016-09-07
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Targeted Disruption of the Interaction between WD-40 Repeat Protein 5 (WDR5) and Mixed Lineage Leukemia (MLL)/SET1 Family Proteins Specifically Inhibits MLL1 and SETd1A Methyltransferase Complexes.
J.Biol.Chem., 291, 2016
1PEV
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Crystal Structure of the Actin Interacting Protein from Caenorhabditis Elegans
分子名称: Actin interacting protein 1
著者Vorobiev, S, Mohri, K, Fedorov, A.A, Ono, S, Almo, S.C, Burley, S.K, New York SGX Research Center for Structural Genomics (NYSGXRC)
登録日2003-05-22
公開日2003-07-01
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Identification of functional residues on Caenorhabditis elegans actin-interacting protein 1 (UNC-78) for disassembly of actin depolymerizing factor/cofilin-bound actin filaments.
J.Biol.Chem., 279, 2004
1PGU
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YEAST ACTIN INTERACTING PROTEIN 1 (AIP1), Se-Met PROTEIN, MONOCLINIC CRYSTAL FORM
分子名称: Actin interacting protein 1, ZINC ION
著者Voegtli, W.C, Madrona, A.Y, Wilson, D.K.
登録日2003-05-28
公開日2003-07-15
最終更新日2021-10-27
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献The structure of Aip1p, a WD repeat protein that regulates Cofilin-mediated actin depolymerization.
J.Biol.Chem., 278, 2003
1PI6
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YEAST ACTIN INTERACTING PROTEIN 1 (Aip1), ORTHORHOMBIC CRYSTAL FORM
分子名称: Actin interacting protein 1, ZINC ION
著者Voegtli, W.C, Madrona, A.Y, Wilson, D.K.
登録日2003-05-29
公開日2003-07-15
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献The structure of Aip1p, a WD repeat protein that regulates Cofilin-mediated actin depolymerization.
J.Biol.Chem., 278, 2003
1R5M
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Crystal Structure Of The C-Terminal WD40 Domain Of Sif2
分子名称: SIR4-interacting protein SIF2, SULFATE ION
著者Cerna, D, Wilson, D.K.
登録日2003-10-10
公開日2005-03-01
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献The structure of Sif2p, a WD repeat protein functioning in the SET3 corepressor complex.
J.Mol.Biol., 351, 2005
1S4U
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Crystal Structure analysis of the beta-propeller protein Ski8p
分子名称: Antiviral protein SKI8
著者Cheng, Z, Song, H.
登録日2004-01-18
公開日2004-12-28
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal structure of Ski8p, a WD-repeat protein with dual roles in mRNA metabolism and meiotic recombination
Protein Sci., 13, 2004
1SQ9
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Structure of Ski8p, a WD repeat protein involved in mRNA degradation and meiotic recombination
分子名称: Antiviral protein SKI8, SULFATE ION
著者Madrona, A.Y, Wilson, D.K.
登録日2004-03-18
公開日2004-05-25
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献The structure of Ski8p, a protein regulating mRNA degradation: Implications for WD protein structure.
Protein Sci., 13, 2004
1U4C
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Structure of spindle checkpoint protein Bub3
分子名称: Cell cycle arrest protein BUB3
著者Larsen, N.A, Harrison, S.C.
登録日2004-07-23
公開日2004-08-03
最終更新日2019-08-14
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Crystal structure of the spindle assembly checkpoint protein Bub3
J.Mol.Biol., 344, 2004
1TRJ
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Homology Model of Yeast RACK1 Protein fitted into 11.7A cryo-EM map of Yeast 80S Ribosome
分子名称: Guanine nucleotide-binding protein beta subunit-like protein, Helix 39 of 18S rRNA, Helix 40 of 18S rRNA
著者Sengupta, J, Nilsson, J, Gursky, R, Spahn, C.M, Nissen, P, Frank, J.
登録日2004-06-21
公開日2004-09-28
最終更新日2024-02-14
実験手法ELECTRON MICROSCOPY (11.7 Å)
主引用文献Identification of the versatile scaffold protein RACK1 on the eukaryotic ribosome by cryo-EM
Nat.Struct.Mol.Biol., 11, 2004
3ODT
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BU of 3odt by Molmil
Crystal structure of WD40 beta propeller domain of Doa1
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, Protein DOA1
著者Pashkova, N, Gakhar, L, Winistorfer, S.C, Yu, L, Ramaswamy, S, Piper, R.C.
登録日2010-08-11
公開日2010-12-01
最終更新日2019-12-25
実験手法X-RAY DIFFRACTION (1.35 Å)
主引用文献WD40 Repeat Propellers Define a Ubiquitin-Binding Domain that Regulates Turnover of F Box Proteins.
Mol.Cell, 40, 2010
3OW8
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Crystal Structure of the WD repeat-containing protein 61
分子名称: UNKNOWN ATOM OR ION, WD repeat-containing protein 61
著者Tempel, W, Li, Z, Chao, X, Lam, R, Wernimont, A.K, He, H, Seitova, A, Pan, P.W, Li, Y, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Min, J, Structural Genomics Consortium (SGC)
登録日2010-09-17
公開日2010-09-29
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structure and function of WD40 domain proteins.
Protein Cell, 2, 2011
3P4F
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Structural and biochemical insights into MLL1 core complex assembly and regulation.
分子名称: Histone-lysine N-methyltransferase MLL, Retinoblastoma-binding protein 5, WD repeat-containing protein 5
著者Avdic, V, Zhang, P, Lanouette, S, Groulx, A, Tremblay, V, Brunzelle, J.B, Couture, J.-F.
登録日2010-10-06
公開日2010-12-08
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Structural and biochemical insights into MLL1 core complex assembly.
Structure, 19, 2011
3PSL
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Fine-tuning the stimulation of MLL1 methyltransferase activity by a histone H3 based peptide mimetic
分子名称: N-alpha acetylated form of histone H3, WD repeat-containing protein 5
著者Avdic, V, Zhang, P, Lanouette, S, Voronova, A, Skerjanc, I, Couture, J.-F.
登録日2010-12-01
公開日2010-12-22
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Fine-tuning the stimulation of MLL1 methyltransferase activity by a histone H3-based peptide mimetic.
Faseb J., 25, 2011
3RFH
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Crystal structure of the yeast RACK1 dimer in space group P21
分子名称: Guanine nucleotide-binding protein subunit beta-like protein
著者Yatime, L, Hein, K.L, Nilsson, J, Nissen, P.
登録日2011-04-06
公開日2011-07-06
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structure of the RACK1 dimer from Saccharomyces cerevisiae
J.Mol.Biol., 411, 2011
3RFG
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Crystal structure of the yeast RACK1 dimer in space group P63
分子名称: Guanine nucleotide-binding protein subunit beta-like protein
著者Yatime, L, Hein, K.L, Nilsson, J, Nissen, P.
登録日2011-04-06
公開日2011-07-06
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (3.9 Å)
主引用文献Structure of the RACK1 dimer from Saccharomyces cerevisiae
J.Mol.Biol., 411, 2011
3SMR
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Crystal structure of human WD repeat domain 5 with compound
分子名称: 1,2-ETHANEDIOL, 2-chloro-N-[2-(4-methylpiperazin-1-yl)-5-nitrophenyl]benzamide, UNKNOWN ATOM OR ION, ...
著者Dong, A, Dombrovski, L, Wasney, G.A, Tempel, W, Senisterra, G, Bolshan, Y, Smil, D, Nguyen, K.T, Hajian, T, Poda, G, Al-Awar, R, Bountra, C, Weigelt, J, Edwards, A.M, Brown, P.J, Schapira, M, Arrowsmith, C.H, Vedadi, M, Wu, H, Structural Genomics Consortium (SGC)
登録日2011-06-28
公開日2011-08-31
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.82 Å)
主引用文献Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5.
Biochem. J., 449, 2013
4WJS
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Crystal structure of Rsa4 from Chaetomium thermophilum
分子名称: Rsa4
著者Holdermann, I, Bassler, J, Hurt, E, Sinning, I.
登録日2014-10-01
公開日2014-11-19
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献A network of assembly factors is involved in remodeling rRNA elements during preribosome maturation.
J.Cell Biol., 207, 2014
4X3E
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Crystal structure of EED in complex with a trimethylated Jarid2 peptide
分子名称: ALA-GLN-ARG-M3L-PHE-ALA-GLN-SER, Polycomb protein EED
著者Justin, N, Gamblin, S.J, Margueron, R.
登録日2014-11-28
公開日2015-01-21
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Jarid2 Methylation via the PRC2 Complex Regulates H3K27me3 Deposition during Cell Differentiation.
Mol.Cell, 57, 2015
2XL2
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WDR5 IN COMPLEX WITH AN RBBP5 PEPTIDE RECRUITED TO NOVEL SITE
分子名称: GLYCEROL, RETINOBLASTOMA-BINDING PROTEIN 5, WD REPEAT-CONTAINING PROTEIN 5
著者Odho, Z, Southall, S.M, Wilson, J.R.
登録日2010-07-19
公開日2010-08-04
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Characterisation of a Novel Wdr5 Binding Site that Recruits Rbbp5 Through a Conserved Motif and Enhances Methylation of H3K4 by Mll1.
J.Biol.Chem., 285, 2010

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