1TOH
| |
4V06
| Crystal structure of human tryptophan hydroxylase 2 (TPH2), catalytic domain | 分子名称: | FE (III) ION, IMIDAZOLE, TRYPTOPHAN 5-HYDROXYLASE 2 | 著者 | Kopec, J, Oberholzer, A, Fitzpatrick, F, Newman, J, Tallant, C, Kiyani, W, Shrestha, L, Burgess-Brown, N, von Delft, F, Arrowsmith, C, Edwards, A, Bountra, C, Yue, W.W. | 登録日 | 2014-09-11 | 公開日 | 2014-10-15 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.63 Å) | 主引用文献 | Crystal Structure of Human Tryptophane Hydroxylase 2 (Tph2), Catalytic Domain To be Published
|
|
5TPG
| Optimization of spirocyclic proline tryptophanhydroxylase-1 inhibitors | 分子名称: | (3S)-8-(2-amino-6-{(1R)-1-[5-chloro-3'-(methylsulfonyl)[1,1'-biphenyl]-2-yl]-2,2,2-trifluoroethoxy}pyrimidin-4-yl)-2,8-diazaspiro[4.5]decane-3-carboxylic acid, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ACETONITRILE, ... | 著者 | Stein, A.J, Goldberg, D.R, De Lombaert, S, Holt, M.C. | 登録日 | 2016-10-20 | 公開日 | 2017-01-25 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Optimization of spirocyclic proline tryptophan hydroxylase-1 inhibitors. Bioorg. Med. Chem. Lett., 27, 2017
|
|
5PAH
| |
1DMW
| CRYSTAL STRUCTURE OF DOUBLE TRUNCATED HUMAN PHENYLALANINE HYDROXYLASE WITH BOUND 7,8-DIHYDRO-L-BIOPTERIN | 分子名称: | 7,8-DIHYDROBIOPTERIN, FE (III) ION, PHENYLALANINE HYDROXYLASE | 著者 | Erlandsen, H, Stevens, R.C, Flatmark, T. | 登録日 | 1999-12-15 | 公開日 | 2000-03-24 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal structure and site-specific mutagenesis of pterin-bound human phenylalanine hydroxylase. Biochemistry, 39, 2000
|
|
6PAH
| HUMAN PHENYLALANINE HYDROXYLASE CATALYTIC DOMAIN DIMER WITH BOUND L-DOPA (3,4-DIHYDROXYPHENYLALANINE) INHIBITOR | 分子名称: | 3,4-DIHYDROXYPHENYLALANINE, FE (III) ION, PHENYLALANINE 4-MONOOXYGENASE | 著者 | Erlandsen, H, Flatmark, T, Stevens, R.C. | 登録日 | 1998-08-20 | 公開日 | 1999-04-27 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Crystallographic analysis of the human phenylalanine hydroxylase catalytic domain with bound catechol inhibitors at 2.0 A resolution. Biochemistry, 37, 1998
|
|
2XSN
| Crystal Structure of Human Tyrosine Hydroxylase Catalytic Domain | 分子名称: | TYROSINE 3-MONOOXYGENASE, ZINC ION | 著者 | Muniz, J.R.C, Cooper, C.D.O, Yue, W.W, Krysztofinska, E, von Delft, F, Knapp, S, Gileadi, O, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bountra, C, Kavanagh, K.L, Oppermann, U. | 登録日 | 2010-10-29 | 公開日 | 2010-11-17 | 最終更新日 | 2018-01-24 | 実験手法 | X-RAY DIFFRACTION (2.68 Å) | 主引用文献 | Crystal Structure of Human Tyrosine Hydroxylase Catalytic Domain To be Published
|
|
3PAH
| HUMAN PHENYLALANINE HYDROXYLASE CATALYTIC DOMAIN DIMER WITH BOUND ADRENALINE INHIBITOR | 分子名称: | 4-[(1S)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol, FE (III) ION, PHENYLALANINE HYDROXYLASE | 著者 | Erlandsen, H, Flatmark, T, Stevens, R.C. | 登録日 | 1998-08-20 | 公開日 | 1999-04-27 | 最終更新日 | 2013-03-20 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystallographic analysis of the human phenylalanine hydroxylase catalytic domain with bound catechol inhibitors at 2.0 A resolution. Biochemistry, 37, 1998
|
|
3E2T
| The catalytic domain of chicken tryptophan hydroxylase 1 with bound tryptophan | 分子名称: | FE (III) ION, IMIDAZOLE, SULFATE ION, ... | 著者 | Windahl, M.S, Petersen, C.R, Christensen, H.E.C, Harris, P. | 登録日 | 2008-08-06 | 公開日 | 2008-11-04 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Crystal structure of tryptophan hydroxylase with bound amino acid substrate Biochemistry, 47, 2008
|
|
4JPY
| |
4JPX
| |
3HFB
| |
3HF8
| Crystal structure of human tryoptophan hydroxylase type 1 with bound LP-533401 and Fe | 分子名称: | 4-{2-amino-6-[(1R)-2,2,2-trifluoro-1-(3'-fluorobiphenyl-4-yl)ethoxy]pyrimidin-4-yl}-L-phenylalanine, FE (III) ION, Tryptophan 5-hydroxylase 1 | 著者 | Tari, L.W, Swanson, R.V, Hunter, M.J. | 登録日 | 2009-05-11 | 公開日 | 2010-04-21 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Mechanism of Inhibition of Novel Tryptophan Hydroxylase Inhibitors Revealed by Co-crystal Structures and Kinetic Analysis. Curr Chem Genomics, 4, 2010
|
|
3HF6
| Crystal structure of human tryptophan hydroxylase type 1 with bound LP-521834 and FE | 分子名称: | 4-(4-amino-6-{[(1R)-1-naphthalen-2-ylethyl]amino}-1,3,5-triazin-2-yl)-L-phenylalanine, FE (III) ION, Tryptophan 5-hydroxylase 1 | 著者 | Tari, L.W, Swanson, R.V, Hunter, M.J. | 登録日 | 2009-05-11 | 公開日 | 2009-11-24 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Mechanism of Inhibition of Novel Tryptophan Hydroxylase Inhibitors Revealed by Co-crystal Structures and Kinetic Analysis Curr Chem Genomics, 4, 2010
|
|
3TCY
| Crystallographic structure of phenylalanine hydroxylase from Chromobacterium violaceum (cPAH) bound to phenylalanine in a site distal to the active site | 分子名称: | 1,2-ETHANEDIOL, COBALT (II) ION, PHENYLALANINE, ... | 著者 | Ronau, J.A, Abu-Omar, M.M, Das, C. | 登録日 | 2011-08-09 | 公開日 | 2012-08-22 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | An additional substrate binding site in a bacterial phenylalanine hydroxylase. Eur.Biophys.J., 42, 2013
|
|
3TK2
| |
3TK4
| |
4ANP
| Crystal structure of human phenylalanine hydroxylase in complex with a pharmacological chaperone | 分子名称: | 5,6-DIMETHYL-3-(4-METHYL-2-PYRIDINYL)-2-THIOXO-2,3-DIHYDROTHIENO[2,3- D]PYRIMIDIN-4(1H)-ONE, FE (III) ION, PHENYLALANINE-4-HYDROXYLASE | 著者 | Torreblanca, R, Lira-Navarrete, E, Sancho, J, Hurtado-Guerrero, R. | 登録日 | 2012-03-21 | 公開日 | 2012-04-11 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.11 Å) | 主引用文献 | Structural and Mechanistic Basis of the Interaction between a Pharmacological Chaperone and Human Phenylalanine Hydroxylase. Chembiochem, 13, 2012
|
|
4BPT
| |
1PAH
| |
6ZZU
| Partial structure of the substrate-free tyrosine hydroxylase (apo-TH). | 分子名称: | FE (III) ION, Tyrosine 3-monooxygenase | 著者 | Bueno-Carrasco, M.T, Cuellar, J, Santiago, C, Valpuesta, J.M, Martinez, A, Flydal, M.I. | 登録日 | 2020-08-05 | 公開日 | 2021-11-17 | 最終更新日 | 2022-06-22 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Structural mechanism for tyrosine hydroxylase inhibition by dopamine and reactivation by Ser40 phosphorylation. Nat Commun, 13, 2022
|
|
4ETL
| Crystallographic structure of phenylalanine hydroxylase from Chromobacterium violaceum F258A mutation | 分子名称: | COBALT (II) ION, Phenylalanine-4-hydroxylase | 著者 | Ronau, J.A, Paul, L.P, Corn, I.R, Wagner, K.T, Abu-Omar, M.M, Das, C. | 登録日 | 2012-04-24 | 公開日 | 2013-05-08 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.49 Å) | 主引用文献 | An additional substrate binding site in a bacterial phenylalanine hydroxylase. Eur.Biophys.J., 42, 2013
|
|
4ESM
| Crystallographic structure of phenylalanine hydroxylase from Chromobacterium violaceum Y155A mutation | 分子名称: | COBALT (II) ION, Phenylalanine-4-hydroxylase | 著者 | Ronau, J.A, Paul, L.P, Corn, I.R, Wagner, K.T, Abu-Omar, M.M, Das, C. | 登録日 | 2012-04-23 | 公開日 | 2013-05-08 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | 主引用文献 | An additional substrate binding site in a bacterial phenylalanine hydroxylase. Eur.Biophys.J., 42, 2013
|
|
1TG2
| Crystal structure of phenylalanine hydroxylase A313T mutant with 7,8-dihydrobiopterin bound | 分子名称: | 2-AMINO-6-(1,2-DIHYDROXY-PROPYL)-7,8-DIHYDRO-6H-PTERIDIN-4-ONE, FE (III) ION, Phenylalanine-4-hydroxylase | 著者 | Erlandsen, H, Pey, A.L, Gamez, A, Perez, B, Desviat, L.R, Aguado, C, Koch, R, Surendran, S, Tyring, S, Matalon, R, Scriver, C.R, Ugarte, M, Martinez, A, Stevens, R.C. | 登録日 | 2004-05-28 | 公開日 | 2004-11-30 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Correction of kinetic and stability defects by tetrahydrobiopterin in phenylketonuria patients with certain phenylalanine hydroxylase mutations. Proc.Natl.Acad.Sci.Usa, 101, 2004
|
|
1TDW
| Crystal structure of double truncated human phenylalanine hydroxylase BH4-responsive PKU mutant A313T. | 分子名称: | FE (III) ION, Phenylalanine-4-hydroxylase | 著者 | Erlandsen, H, Pey, A.L, Gamez, A, Perez, B, Desviat, L.R, Aguado, C, Koch, R, Surendran, S, Tyring, S, Matalon, R, Scriver, C.R, Ugarte, M, Martinez, A, Stevens, R.C. | 登録日 | 2004-05-24 | 公開日 | 2004-11-30 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Correction of kinetic and stability defects by tetrahydrobiopterin in phenylketonuria patients with certain phenylalanine hydroxylase mutations. Proc.Natl.Acad.Sci.Usa, 101, 2004
|
|