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3QTE
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Crystal structure of human alpha-defensin 6 (H27W mutant)
分子名称: CHLORIDE ION, Defensin-6, GLYCEROL
著者Pazgier, M, Lu, W.
登録日2011-02-22
公開日2012-01-11
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.949 Å)
主引用文献Human alpha-defensin 6 promotes mucosal innate immunity through self-assembled peptide nanonets.
Science, 337, 2012
7YOA
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High-resolution crystal structure of the mouse alpha-defensin cryptdin 14
分子名称: Alpha-defensin 14, SULFATE ION
著者Yang, Y, Lu, W.
登録日2022-08-01
公開日2022-11-30
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.67 Å)
主引用文献Mouse alpha-Defensins: Structural and Functional Analysis of the 17 Cryptdin Isoforms Identified from a Single Jejunal Crypt.
Infect.Immun., 91, 2023
6KRA
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Solution NMR Structure of RMAD4 alpha Defensin
分子名称: Neutrophil defensin 4
著者Agadi, N, Kumar, A, Shukla, V.K.
登録日2019-08-21
公開日2020-08-26
実験手法SOLUTION NMR
主引用文献Solution NMR Structure of RMAD4 alpha Defensin.
To Be Published
1DFN
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CRYSTAL STRUCTURE OF DEFENSIN HNP-3, AN AMPHIPHILIC DIMER: MECHANISMS OF MEMBRANE PERMEABILIZATION
分子名称: DEFENSIN HNP-3
著者Hill, C.P, Yee, J, Selsted, M.E, Eisenberg, D.
登録日1991-01-18
公開日1992-07-15
最終更新日2017-11-29
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal structure of defensin HNP-3, an amphiphilic dimer: mechanisms of membrane permeabilization.
Science, 251, 1991
4DU0
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Crystal structure of human alpha-defensin 1, HNP1 (G17A mutant)
分子名称: CHLORIDE ION, GLYCEROL, Neutrophil defensin 1
著者Wu, X, Lu, W, Pazgier, M.
登録日2012-02-21
公開日2012-04-11
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Invariant gly residue is important for alpha-defensin folding, dimerization, and function: a case study of the human neutrophil alpha-defensin HNP1
J.Biol.Chem., 287, 2012
2K1I
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Synthesis, Structure and Activities of an Oral Mucosal Alpha-Defensin from Rhesus Macaque
分子名称: Mucosal Alpha-Defensin
著者Vasudevan, S.V, Yuan, J, Osapay, G, Tran, P, Tai, K, Selsted, M, Cocco, M.J.
登録日2008-03-05
公開日2008-10-28
最終更新日2018-01-24
実験手法SOLUTION NMR
主引用文献Synthesis, structure, and activities of an oral mucosal alpha-defensin from rhesus macaque.
J.Biol.Chem., 283, 2008
6DMQ
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Crystal structure of the T27A mutant of human alpha defensin HNP4.
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, Neutrophil defensin 4
著者Gohain, N, Tolbert, W.D, Pazgier, M.
登録日2018-06-05
公開日2019-01-30
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Systematic mutational analysis of human neutrophil alpha-defensin HNP4.
Biochim Biophys Acta Biomembr, 1861, 2019
6DMM
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Crystal structure of the G23A mutant of human alpha defensin HNP4.
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, Neutrophil defensin 4, SULFATE ION
著者Gohain, N, Tolbert, W.D, Pazgier, M.
登録日2018-06-05
公開日2019-01-30
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.67 Å)
主引用文献Systematic mutational analysis of human neutrophil alpha-defensin HNP4.
Biochim Biophys Acta Biomembr, 1861, 2019
4RBW
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Crystal structure of human alpha-defensin 5, HD5 (Thr7Arg Glu21Arg mutant)
分子名称: CHLORIDE ION, Defensin-5, SULFATE ION
著者Pazgier, M, Gohain, N, Tolbert, W.D.
登録日2014-09-13
公開日2015-07-29
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Design of a potent antibiotic peptide based on the active region of human defensin 5.
J.Med.Chem., 58, 2015
4RBX
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Crystal structure of human alpha-defensin 5, HD5 (Glu21Arg mutant)
分子名称: Defensin-5, SULFATE ION
著者Pazgier, M, Gohain, N, Tolbert, W.D.
登録日2014-09-13
公開日2015-07-29
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.1 Å)
主引用文献Design of a potent antibiotic peptide based on the active region of human defensin 5.
J.Med.Chem., 58, 2015
4E86
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Crystal structure of human alpha-defensin 5, HD5 (Leu29Aba mutant)
分子名称: CHLORIDE ION, Defensin-5
著者Wu, X, Pazgier, M.
登録日2012-03-19
公開日2012-05-16
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Functional determinants of human enteric {alpha}-defensin HD5: crucial role for hydrophobicity at dimer interface.
J.Biol.Chem., 287, 2012
4E82
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Crystal structure of monomeric variant of human alpha-defensin 5, HD5 (Glu21EMe mutant)
分子名称: Defensin-5
著者Pazgier, M.
登録日2012-03-19
公開日2012-05-16
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Functional determinants of human enteric {alpha}-defensin HD5: crucial role for hydrophobicity at dimer interface.
J.Biol.Chem., 287, 2012
4E83
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Crystal structure of human alpha-defensin 5, HD5 (Leu29NLe mutant)
分子名称: CHLORIDE ION, Defensin-5
著者Pazgier, M.
登録日2012-03-19
公開日2012-05-16
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Functional determinants of human enteric {alpha}-defensin HD5: crucial role for hydrophobicity at dimer interface.
J.Biol.Chem., 287, 2012
5CUJ
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Crystal structure of Human Defensin-5 Y27A mutant crystal form 2.
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, CALCIUM ION, CHLORIDE ION, ...
著者Tolbert, W.D, Gohain, N, Pazgier, M.
登録日2015-07-24
公開日2016-07-27
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.08 Å)
主引用文献Human Enteric alpha-Defensin 5 Promotes Shigella Infection by Enhancing Bacterial Adhesion and Invasion.
Immunity, 2018
5CUI
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Crystal structure of Human Defensin-5 R28A mutant.
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 2-(2-METHOXYETHOXY)ETHANOL, CHLORIDE ION, ...
著者Tolbert, W.D, Gohain, N, Pazgier, M.
登録日2015-07-24
公開日2016-07-27
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.403 Å)
主引用文献Human Enteric alpha-Defensin 5 Promotes Shigella Infection by Enhancing Bacterial Adhesion and Invasion.
Immunity, 2018
5CUM
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Crystal structure of Human Defensin-5 Y27A mutant crystal form 1.
分子名称: CALCIUM ION, CHLORIDE ION, Defensin-5, ...
著者Tolbert, W.D, Gohain, N, Pazgier, M.
登録日2015-07-24
公開日2016-07-27
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.752 Å)
主引用文献Human Enteric alpha-Defensin 5 Promotes Shigella Infection by Enhancing Bacterial Adhesion and Invasion.
Immunity, 2018
4LBF
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Crystal structure of HUMAN ALPHA-DEFENSIN 1 (HNP1) I20A/L25A mutant
分子名称: GLYCEROL, Neutrophil defensin 1
著者Tolbert, W.D, Wu, X, Pazgier, M.
登録日2013-06-20
公開日2013-11-27
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Single, Double and Quadruple Alanine Substitutions at Oligomeric Interfaces Identify Hydrophobicity as the Key Determinant of Human Neutrophil Alpha Defensin HNP1 Function.
Plos One, 8, 2013
4LB1
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Crystal structure of human alpha-defensin 1 (HNP1) Y16A/F28A mutant
分子名称: Neutrophil defensin 1
著者Tolbert, W.D, Wu, X, Pazgier, M.
登録日2013-06-20
公開日2013-11-27
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Single, Double and Quadruple Alanine Substitutions at Oligomeric Interfaces Identify Hydrophobicity as the Key Determinant of Human Neutrophil Alpha Defensin HNP1 Function.
Plos One, 8, 2013
4LBB
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Crystal structure of human alpha-defensin 1 (HNP1) I20A mutant
分子名称: CHLORIDE ION, Neutrophil defensin 1
著者Tolbert, W.D, Wu, X, Pazgier, M.
登録日2013-06-20
公開日2013-11-27
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.719 Å)
主引用文献Single, Double and Quadruple Alanine Substitutions at Oligomeric Interfaces Identify Hydrophobicity as the Key Determinant of Human Neutrophil Alpha Defensin HNP1 Function.
Plos One, 8, 2013
4LB7
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Crystal structure of human alpha-defensin 1 (HNP1) Y16A/I20A/L25A/F28A mutant.
分子名称: Neutrophil defensin 1
著者Tolbert, W.D, Wu, X, Pazgier, M.
登録日2013-06-20
公開日2013-11-27
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.902 Å)
主引用文献Single, Double and Quadruple Alanine Substitutions at Oligomeric Interfaces Identify Hydrophobicity as the Key Determinant of Human Neutrophil Alpha Defensin HNP1 Function.
Plos One, 8, 2013
3GNY
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BU of 3gny by Molmil
Crystal structure of human alpha-defensin 1 (HNP1)
分子名称: CHLORIDE ION, GLYCEROL, Neutrophil defensin 1
著者Pazgier, M, Lu, W.-Y.
登録日2009-03-18
公開日2009-07-28
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.56 Å)
主引用文献Through the looking glass, mechanistic insights from enantiomeric human defensins.
J.Biol.Chem., 284, 2009
3H6C
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Crystal structure of human alpha-defensin 1 (Mutant Gln22Ala)
分子名称: CHLORIDE ION, DI(HYDROXYETHYL)ETHER, Neutrophil defensin 1
著者Pazgier, M, Lu, W.
登録日2009-04-23
公開日2010-03-09
最終更新日2021-10-27
実験手法X-RAY DIFFRACTION (1.63 Å)
主引用文献Trp-26 imparts functional versatility to human alpha-defensin HNP1.
J.Biol.Chem., 285, 2010
3HJ2
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Crystal structure of covalent dimer of HNP1
分子名称: HUMAN NEUTROPHIL PEPTIDE 1
著者Lubkowski, J, Pazgier, M, Lu, W.
登録日2009-05-20
公開日2009-10-20
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献What Dictates the Multifaced Functions of the Human alpha-Defensin HNP1?
To be Published
3HJD
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X-ray structure of monomeric variant of HNP1
分子名称: Human neutrophil peptide 1
著者Lubkowski, J, Pazgier, M, Lu, W.
登録日2009-05-21
公開日2009-10-13
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献What Dictates the Multifaced Functions of the Human alpha-Defensin HNP?
To be Published
3I5W
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Crystal structure of human alpha-defensin 5 (mutant R13H)
分子名称: CHLORIDE ION, CITRATE ANION, Defensin-5
著者Pazgier, M, Lu, W.
登録日2009-07-06
公開日2009-07-28
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.63 Å)
主引用文献Selective arginines are important for the antibacterial activity and host cell interaction of human alpha-defensin 5
Febs Lett., 583, 2009

 

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