Loading
PDBj
メニューPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

1HK7
DownloadVisualize
BU of 1hk7 by Molmil
Middle Domain of HSP90
分子名称: CADMIUM ION, HEAT SHOCK PROTEIN HSP82, MAGNESIUM ION
著者Meyer, P, Prodromou, C, Roe, S.M, Pearl, L.H.
登録日2003-03-06
公開日2004-01-29
最終更新日2019-05-08
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural and Functional Analysis of the Middle Segment of Hsp90. Implications for ATP Hydrolysis and Client Protein and Cochaperone Interactions
Mol.Cell, 11, 2003
6KSQ
DownloadVisualize
BU of 6ksq by Molmil
Middle Domain of Human HSP90 Alpha
分子名称: Heat shock protein HSP 90-alpha
著者Su, H.X, Zhou, C, Zhang, N.X, Xu, Y.C.
登録日2019-08-25
公開日2020-02-26
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.202 Å)
主引用文献Allosteric Regulation of Hsp90 alpha's Activity by Small Molecules Targeting the Middle Domain of the Chaperone.
Iscience, 23, 2020
5HPH
DownloadVisualize
BU of 5hph by Molmil
Structure of TRAP1 fragment
分子名称: GLYCEROL, Heat shock protein 75 kDa, mitochondrial, ...
著者Sung, N, Chang, C, Lee, S, Tsai, F.T.F.
登録日2016-01-20
公開日2016-08-10
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.429 Å)
主引用文献2.4 angstrom resolution crystal structure of human TRAP1NM, the Hsp90 paralog in the mitochondrial matrix.
Acta Crystallogr D Struct Biol, 72, 2016
7C05
DownloadVisualize
BU of 7c05 by Molmil
Crystal structure of human Trap1 with DN203495
分子名称: 1-[(4-bromanyl-2-fluoranyl-phenyl)methyl]-4-chloranyl-pyrazolo[3,4-d]pyrimidin-6-amine, Heat shock protein 75 kDa, mitochondrial
著者Kim, D, Kim, D, Kim, S.Y, Lee, J.H, Kang, B.H, Kang, S, Lee, C.
登録日2020-04-30
公開日2020-07-08
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.59 Å)
主引用文献Development of pyrazolo[3,4-d]pyrimidine-6-amine-based TRAP1 inhibitors that demonstrate in vivo anticancer activity in mouse xenograft models.
Bioorg.Chem., 101, 2020
7C7C
DownloadVisualize
BU of 7c7c by Molmil
Crystal structure of human TRAP1 with SJT104
分子名称: 2-azanyl-9-[(4-bromanyl-2-fluoranyl-phenyl)methyl]-6-chloranyl-purin-8-ol, Heat shock protein 75 kDa, mitochondrial
著者Kim, D, Yang, S, Yoon, N.G, Park, E, Kim, S.Y, Kang, B.H, Lee, C, Kang, S.
登録日2020-05-24
公開日2021-05-26
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Design and Synthesis of TRAP1 Selective Inhibitors: H-Bonding with Asn171 Residue in TRAP1 Increases Paralog Selectivity.
Acs Med.Chem.Lett., 12, 2021
5Y3N
DownloadVisualize
BU of 5y3n by Molmil
Structure of TRAP1 complexed with DN401
分子名称: 1-[(6-bromanyl-1,3-benzodioxol-5-yl)methyl]-4-chloranyl-pyrazolo[3,4-d]pyrimidin-6-amine, Heat shock protein 75 kDa, mitochondrial
著者Jeong, H, Park, H.K, Kang, S, Kang, B.H, Lee, C.
登録日2017-07-29
公開日2017-08-30
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Paralog Specificity Determines Subcellular Distribution, Action Mechanism, and Anticancer Activity of TRAP1 Inhibitors.
J. Med. Chem., 60, 2017
5Y3O
DownloadVisualize
BU of 5y3o by Molmil
Structure of TRAP1 complexed with DN320
分子名称: 4-chloranyl-1-[(4-methoxy-3,5-dimethyl-pyridin-2-yl)methyl]pyrazolo[3,4-d]pyrimidin-6-amine, Heat shock protein 75 kDa, mitochondrial
著者Jeong, H, Park, H.K, Kang, S, Kang, B.H, Lee, C.
登録日2017-07-29
公開日2017-08-30
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Paralog Specificity Determines Subcellular Distribution, Action Mechanism, and Anticancer Activity of TRAP1 Inhibitors.
J. Med. Chem., 60, 2017
3HJC
DownloadVisualize
BU of 3hjc by Molmil
Crystal structure of the carboxy-terminal domain of HSP90 from Leishmania major, LmjF33.0312
分子名称: Heat shock protein 83-1, SULFATE ION
著者Wernimont, A.K, Tempel, W, Walker, J, Lin, Y.H, Hutchinson, A, Mackenzie, F, Fairlamb, A, Kozieradzki, I, Cossar, D, Zhao, Y, Schapira, M, Bochkarev, A, Arrowsmith, C.H, Bountra, C, Weigelt, J, Edwards, A.M, Ferguson, M.A.J, Hui, R, Pizarro, J.C, Hills, T, Structural Genomics Consortium (SGC)
登録日2009-05-21
公開日2009-06-02
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal Structure of the middle and carboxy-terminal domain of HSP90 from Leishmania major, LMJF33.0312
To be Published
8OXU
DownloadVisualize
BU of 8oxu by Molmil
Crystal Structure of the Hsp90-LA1011 Complex
分子名称: ATP-dependent molecular chaperone HSP82, dimethyl 2,6-bis[2-(dimethylamino)ethyl]-1-methyl-4-[4-(trifluoromethyl)phenyl]-4~{H}-pyridine-3,5-dicarboxylate
著者Roe, S.M, Prodromou, C.
登録日2023-05-02
公開日2023-07-12
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (2.94 Å)
主引用文献The Crystal Structure of the Hsp90-LA1011 Complex and the Mechanism by Which LA1011 May Improve the Prognosis of Alzheimer's Disease.
Biomolecules, 13, 2023
2CGE
DownloadVisualize
BU of 2cge by Molmil
Crystal structure of an Hsp90-Sba1 closed chaperone complex
分子名称: ATP-DEPENDENT MOLECULAR CHAPERONE HSP82
著者Ali, M.M.U, Roe, S.M, Prodromou, C, Pearl, L.H.
登録日2006-03-01
公開日2006-04-12
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Crystal Structure of an Hsp90-Nucleotide-P23/Sba1 Closed Chaperone Complex
Nature, 440, 2006
7RY1
DownloadVisualize
BU of 7ry1 by Molmil
human Hsp90_MC domain structure
分子名称: Heat shock protein HSP 90-alpha, N-[2-(1-MALEIMIDYL)ETHYL]-7-DIETHYLAMINOCOUMARIN-3-CARBOXAMIDE
著者Peng, S, Deng, J, Matts, R.
登録日2021-08-24
公開日2022-05-11
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.523 Å)
主引用文献Crystal structure of the middle and C-terminal domains of Hsp90 alpha labeled with a coumarin derivative reveals a potential allosteric binding site as a drug target.
Acta Crystallogr D Struct Biol, 78, 2022
7RY0
DownloadVisualize
BU of 7ry0 by Molmil
human Hsp90_MC domain structure
分子名称: DIMETHYL SULFOXIDE, GLYCEROL, Heat shock protein HSP 90-alpha
著者Peng, S, Deng, J, Matts, R.
登録日2021-08-24
公開日2022-12-28
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural basis of the key residue W320 responsible for Hsp90 conformational change.
J.Biomol.Struct.Dyn., 2022
7RXZ
DownloadVisualize
BU of 7rxz by Molmil
human Hsp90_MC domain structure
分子名称: Heat shock protein HSP 90-alpha
著者Peng, S, Deng, J, Matts, R.
登録日2021-08-24
公開日2022-12-28
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (3.152 Å)
主引用文献Structural basis of the key residue W320 responsible for Hsp90 conformational change.
J.Biomol.Struct.Dyn., 2022
2GQ0
DownloadVisualize
BU of 2gq0 by Molmil
Crystal Structure of the Middle Domain of HtpG, the E. coli Hsp90
分子名称: Chaperone protein htpG
著者Harris, S.F, Shiau, A.K, Agard, D.A.
登録日2006-04-19
公開日2006-10-31
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural Analysis of E. coli hsp90 reveals dramatic nucleotide-dependent conformational rearrangements.
Cell(Cambridge,Mass.), 127, 2006
3PRY
DownloadVisualize
BU of 3pry by Molmil
Crystal structure of the middle domain of human HSP90-beta refined at 2.3 A resolution
分子名称: 1,2-ETHANEDIOL, GLYCEROL, Heat shock protein HSP 90-beta, ...
著者Chaikuad, A, Pilka, E, Sharpe, T.D, Cooper, C.D.O, Phillips, C, Berridge, G, Ayinampudi, V, Fedorov, O, Keates, T, Thangaratnarajah, C, Zimmermann, T, Vollmar, M, Yue, W.W, Che, K.H, Krojer, T, Muniz, J.R.C, von Delft, F, Bountra, C, Arrowsmith, C.H, Weigelt, J, Edwards, A, Bullock, A, Structural Genomics Consortium (SGC)
登録日2010-11-30
公開日2010-12-15
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.28 Å)
主引用文献Crystal structure of the middle domain of human HSP90-beta refined at 2.3 A resolution
To be Published
3Q6N
DownloadVisualize
BU of 3q6n by Molmil
Crystal Structure of Human MC-HSP90 in P21 space group
分子名称: Heat shock protein HSP 90-alpha, SULFATE ION
著者Lee, C.C, Lin, T.W, Ko, T.P, Wang, A.H.-J.
登録日2011-01-03
公開日2011-06-01
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (3.05 Å)
主引用文献The hexameric structures of human heat shock protein 90
Plos One, 6, 2011
3Q6M
DownloadVisualize
BU of 3q6m by Molmil
Crystal Structure of Human MC-HSP90 in C2221 Space Group
分子名称: Heat shock protein HSP 90-alpha, SULFATE ION
著者Lee, C.C, Lin, T.W, Ko, T.P, Wang, A.H.-J.
登録日2011-01-03
公開日2011-06-01
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献The hexameric structures of human heat shock protein 90
Plos One, 6, 2011
2O1T
DownloadVisualize
BU of 2o1t by Molmil
Structure of Middle plus C-terminal domains (M+C) of GRP94
分子名称: Endoplasmin
著者Dollins, D.E, Warren, J.J, Immormino, R.M, Gewirth, D.T.
登録日2006-11-29
公開日2007-10-23
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Structures of GRP94-Nucleotide Complexes Reveal Mechanistic Differences between the hsp90 Chaperones.
Mol.Cell, 28, 2007
4Z1H
DownloadVisualize
BU of 4z1h by Molmil
Crystal structure of human Trap1 with SMTIN-P01
分子名称: 8-[(6-iodo-1,3-benzodioxol-5-yl)sulfanyl]-9-[6-(triphenyl-lambda~5~-phosphanyl)hexyl]-9H-purin-6-amine, Heat shock protein 75 kDa, mitochondrial
著者Lee, C, Park, H.K, Ryu, J.H, Kang, B.H.
登録日2015-03-27
公開日2015-04-22
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Development of a Mitochondria-Targeted Hsp90 Inhibitor Based on the Crystal Structures of Human TRAP1
J.Am.Chem.Soc., 137, 2015
4Z1I
DownloadVisualize
BU of 4z1i by Molmil
Crystal structure of human Trap1 with AMPPNP
分子名称: Heat shock protein 75 kDa, mitochondrial, MAGNESIUM ION, ...
著者Lee, C, Park, H.K, Ryu, J.H, Kang, B.H.
登録日2015-03-27
公開日2015-04-29
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Development of a Mitochondria-Targeted Hsp90 Inhibitor Based on the Crystal Structures of Human TRAP1
J.Am.Chem.Soc., 137, 2015
4Z1G
DownloadVisualize
BU of 4z1g by Molmil
Crystal structure of human Trap1 with BIIB-021
分子名称: 6-chloro-9-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]-9H-purin-2-amine, Heat shock protein 75 kDa, mitochondrial
著者Lee, C, Park, H.K, Ryu, J.H, Kang, B.H.
登録日2015-03-27
公開日2015-04-22
最終更新日2022-10-05
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Development of a Mitochondria-Targeted Hsp90 Inhibitor Based on the Crystal Structures of Human TRAP1
J.Am.Chem.Soc., 137, 2015
4Z1F
DownloadVisualize
BU of 4z1f by Molmil
Crystal structure of human Trap1 with PU-H71
分子名称: 8-[(6-IODO-1,3-BENZODIOXOL-5-YL)THIO]-9-[3-(ISOPROPYLAMINO)PROPYL]-9H-PURIN-6-AMINE, Heat shock protein 75 kDa, mitochondrial
著者Lee, C, Park, H.K, Ryu, J.H, Kang, B.H.
登録日2015-03-27
公開日2015-04-22
実験手法X-RAY DIFFRACTION (2.703 Å)
主引用文献Development of a Mitochondria-Targeted Hsp90 Inhibitor Based on the Crystal Structures of Human TRAP1
J.Am.Chem.Soc., 137, 2015
1Y6Z
DownloadVisualize
BU of 1y6z by Molmil
Middle domain of Plasmodium falciparum putative heat shock protein PF14_0417
分子名称: heat shock protein, putative
著者Lunin, V.V, Botchkareva, E, Loppnau, P, Amani, M, Bray, J, Vedadi, M, Edwards, A, Arrowsmith, C, Sundstrom, M, Bochkarev, A, Hui, R, Plotnikova, O, Structural Genomics Consortium (SGC)
登録日2004-12-07
公開日2005-02-08
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.88 Å)
主引用文献Genome-scale protein expression and structural biology of Plasmodium falciparum and related Apicomplexan organisms.
Mol.Biochem.Parasitol., 151, 2007
7U8X
DownloadVisualize
BU of 7u8x by Molmil
hTRAP1 with inhibitors
分子名称: Heat shock protein 75 kDa, mitochondrial, [5-(4-fluoro-2H-isoindole-2-carbonyl)-2-hydroxyphenyl](5-methoxy-2H-isoindol-2-yl)methanone
著者Deng, J, Matts, R, Peng, S.
登録日2022-03-09
公開日2023-08-16
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Elucidation of novel TRAP1-Selective inhibitors that regulate mitochondrial processes.
Eur.J.Med.Chem., 258, 2023
7U8W
DownloadVisualize
BU of 7u8w by Molmil
hTRAP1 with inhibitors
分子名称: Heat shock protein 75 kDa, mitochondrial, [5-(4-fluoro-2H-isoindole-2-carbonyl)-2-hydroxyphenyl](5-fluoro-2H-isoindol-2-yl)methanone
著者Deng, J, Matts, R, Peng, S.
登録日2022-03-09
公開日2023-08-16
実験手法X-RAY DIFFRACTION (1.706 Å)
主引用文献Elucidation of novel TRAP1-Selective inhibitors that regulate mitochondrial processes.
Eur.J.Med.Chem., 258, 2023

 

1234>

217705

件を2024-03-27に公開中

PDB statisticsPDBj update infoContact PDBjnumon