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5MR1
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Crystal structure of the Pleckstrin homology domain of Interactor protein for cytohesin exchange factors 1 (IPCEF1)
分子名称: Interactor protein for cytohesin exchange factors 1
著者Newman, J.A, Aitkenhead, H, Wang, D, Burgess-Brown, N, Williams, E, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O.
登録日2016-12-21
公開日2017-01-11
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献Crystal structure of the Pleckstrin homology domain of Interactor protein for cytohesin exchange factors 1 (IPCEF1)
To be published
7MYX
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Crystal structure of the PH domain (R86A) of Akt1
分子名称: RAC-alpha serine/threonine-protein kinase
著者Bae, H, Park, E, Cole, P.A, Eck, M.J.
登録日2021-05-22
公開日2022-11-09
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.39 Å)
主引用文献PH domain-mediated autoinhibition and oncogenic activation of Akt.
Elife, 11, 2022
7VS3
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The crystal structure of rat calcium-dependent activator protein for secretion (CAPS) C2PH
分子名称: Calcium-dependent secretion activator 1, SULFATE ION
著者Zhou, H, Wei, Z.Q, Zhang, L, Ren, Y.J, Ma, C.
登録日2021-10-25
公開日2023-02-15
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.595 Å)
主引用文献The C 2 and PH domains of CAPS constitute an effective PI(4,5)P2-binding unit essential for Ca 2+ -regulated exocytosis.
Structure, 31, 2023
7YIR
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Crystal structure of N-terminal PH domain of ARAP3 protein from human
分子名称: Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3, DI(HYDROXYETHYL)ETHER
著者Zhang, Y.J, Liu, Y.R, Wu, B.
登録日2022-07-18
公開日2023-05-03
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.099 Å)
主引用文献Structural Insights Uncover the Specific Phosphoinositide Recognition by the PH1 Domain of Arap3.
Int J Mol Sci, 24, 2023
7YIS
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Crystal structure of N-terminal PH domain of ARAP3 protein in complex with inositol 1,3,4,5-tetrakisphosphate
分子名称: (2R)-3-{[(S)-{[(2S,3R,5S,6S)-2,6-DIHYDROXY-3,4,5-TRIS(PHOSPHONOOXY)CYCLOHEXYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-2-(1-HYDROXY BUTOXY)PROPYL BUTYRATE, Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3
著者Zhang, Y.J, Liu, Y.R, Wu, B.
登録日2022-07-18
公開日2023-05-03
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Structural Insights Uncover the Specific Phosphoinositide Recognition by the PH1 Domain of Arap3.
Int J Mol Sci, 24, 2023
1BAK
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BU of 1bak by Molmil
SIGNAL TRANSDUCTION PLECKSTRIN HOMOLOGY DOMAIN OF G-PROTEIN COUPLED RECEPTOR KINASE 2 (BETA-ADRENERGIC RECEPTOR KINASE 1), C-TERMINAL EXTENDED, NMR, 20 STRUCTURES
分子名称: G-PROTEIN COUPLED RECEPTOR KINASE 2
著者Fushman, D, Cowburn, D.
登録日1997-11-21
公開日1998-02-25
最終更新日2022-02-16
実験手法SOLUTION NMR
主引用文献The solution structure and dynamics of the pleckstrin homology domain of G protein-coupled receptor kinase 2 (beta-adrenergic receptor kinase 1). A binding partner of Gbetagamma subunits.
J.Biol.Chem., 273, 1998
1AWE
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HUMAN SOS1 PLECKSTRIN HOMOLOGY (PH) DOMAIN, NMR, 20 STRUCTURES
分子名称: SOS1
著者Zheng, J, Cowburn, D.
登録日1997-10-01
公開日1998-02-25
最終更新日2022-02-16
実験手法SOLUTION NMR
主引用文献The solution structure of the pleckstrin homology domain of human SOS1. A possible structural role for the sequential association of diffuse B cell lymphoma and pleckstrin homology domains.
J.Biol.Chem., 272, 1997
7KJZ
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crystal structure of PLEKHA7 PH domain biding inositol-tetraphosphate
分子名称: 1,2-ETHANEDIOL, INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE, Pleckstrin homology domain-containing family A member 7
著者Marassi, F.M, Aleshin, A.E, Liddington, R.C.
登録日2020-10-26
公開日2021-04-07
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.43 Å)
主引用文献Structural basis for the association of PLEKHA7 with membrane-embedded phosphatidylinositol lipids.
Structure, 29, 2021
7KK7
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crystal structure of ligand-free PLEKHA7 PH domain
分子名称: 1,2-ETHANEDIOL, GLYCEROL, Pleckstrin homology domain-containing family A member 7
著者Marassi, F.M, Aleshin, A.E, Liddington, R.C.
登録日2020-10-27
公開日2021-04-07
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structural basis for the association of PLEKHA7 with membrane-embedded phosphatidylinositol lipids.
Structure, 29, 2021
7KJO
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crystal structure of PLEKHA7 PH domain biding SO4
分子名称: GLYCEROL, Pleckstrin homology domain-containing family A member 7, SULFATE ION
著者Marassi, F.M, Aleshin, A.E, Liddington, R.C.
登録日2020-10-26
公開日2021-04-07
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Structural basis for the association of PLEKHA7 with membrane-embedded phosphatidylinositol lipids.
Structure, 29, 2021
6F24
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PH domain from PfAPH
分子名称: C-terminal PH domain from PfAPH
著者Darvill, N, Liu, B, Matthews, S, Soldati-Favre, D, Rouse, S, Benjamin, S, Blake, T, Dubois, D.J, Hammoudi, P.M, Pino, P.
登録日2017-11-23
公開日2018-12-12
最終更新日2023-06-14
実験手法SOLUTION NMR
主引用文献C-terminal PH domain from P. falciparum acylated plekstrin homology domain containing protein (APH)
To Be Published
5C79
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PH domain of ASAP1 in complex with diC4-PtdIns(4,5)P2
分子名称: (2R)-3-{[(R)-HYDROXY{[(1R,2R,3S,4R,5R,6S)-2,3,6-TRIHYDROXY-4,5-BIS(PHOSPHONOOXY)CYCLOHEXYL]OXY}PHOSPHORYL]OXY}PROPANE-1 ,2-DIYL DIBUTANOATE, Arf-GAP, CHLORIDE ION
著者Xia, D, Tang, W.K.
登録日2015-06-24
公開日2015-10-07
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Molecular Basis for Cooperative Binding of Anionic Phospholipids to the PH Domain of the Arf GAP ASAP1.
Structure, 23, 2015
5C6R
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Crystal structure of PH domain of ASAP1
分子名称: Arf-GAP, PHOSPHATE ION, TRIETHYLENE GLYCOL
著者Xia, D, Tang, W.K.
登録日2015-06-23
公開日2015-10-07
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Molecular Basis for Cooperative Binding of Anionic Phospholipids to the PH Domain of the Arf GAP ASAP1.
Structure, 23, 2015
4A5K
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Structural analyses of Slm1-PH domain demonstrate ligand binding in the non-canonical site
分子名称: PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE-BINDING PROTEIN SLM 1, SULFATE ION
著者Anand, K, Gavin, A.C.
登録日2011-10-25
公開日2012-06-13
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.76 Å)
主引用文献Structural Analyses of Slm1-Ph Domain Demonstrate Ligand Binding in the Non-Canonical Site
Plos One, 7, 2012
6BNM
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BU of 6bnm by Molmil
Crystal Structure of the P-Rex2 PH domain
分子名称: CHLORIDE ION, Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein
著者Cash, J.N, Sharma, P.V, Tesmer, J.J.G.
登録日2017-11-17
公開日2018-11-21
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural and biochemical characterization of the pleckstrin homology domain of the RhoGEF P-Rex2 and its regulation by PIP3.
J.Struct.Biol., 1, 2019
5U78
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Crystal structure of ORP8 PH domain in P1211 space group
分子名称: Oxysterol-binding protein-related protein 8
著者Ghai, R, Yang, H.
登録日2016-12-12
公開日2017-10-18
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.978 Å)
主引用文献ORP5 and ORP8 bind phosphatidylinositol-4, 5-biphosphate (PtdIns(4,5)P 2) and regulate its level at the plasma membrane.
Nat Commun, 8, 2017
5U77
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Crystal structure of ORP8 PH domain
分子名称: FORMIC ACID, N-(2-hydroxyethyl)-N,N-dimethyl-3-sulfopropan-1-aminium, Oxysterol-binding protein-related protein 8
著者Ghai, R, Yang, H.
登録日2016-12-11
公開日2017-10-18
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.157 Å)
主引用文献ORP5 and ORP8 bind phosphatidylinositol-4, 5-biphosphate (PtdIns(4,5)P 2) and regulate its level at the plasma membrane.
Nat Commun, 8, 2017
1P6S
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Solution Structure of the Pleckstrin Homology Domain of Human Protein Kinase B beta (Pkb/Akt)
分子名称: RAC-beta serine/threonine protein kinase
著者Auguin, D, Barthe, P, Auge-Senegas, M.T, Stern, M.H, Noguchi, M, Roumestand, C.
登録日2003-04-30
公開日2004-05-18
最終更新日2022-02-23
実験手法SOLUTION NMR
主引用文献Solution structure and backbone dynamics of the pleckstrin homology domain of the human protein kinase B (PKB/Akt). Interaction with inositol phosphates.
J.BIOMOL.NMR, 28, 2004
1PLS
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BU of 1pls by Molmil
SOLUTION STRUCTURE OF A PLECKSTRIN HOMOLOGY DOMAIN
分子名称: PLECKSTRIN HOMOLOGY DOMAIN
著者Yoon, H.S, Hajduk, P.J, Petros, A.M, Olejniczak, E.T, Meadows, R.P, Fesik, S.W.
登録日1994-05-03
公開日1995-06-03
最終更新日2017-11-29
実験手法SOLUTION NMR
主引用文献Solution structure of a pleckstrin-homology domain.
Nature, 369, 1994
2I5F
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Crystal structure of the C-terminal PH domain of pleckstrin in complex with D-myo-Ins(1,2,3,5,6)P5
分子名称: (1R,2R,3R,4R,5S,6S)-6-HYDROXYCYCLOHEXANE-1,2,3,4,5-PENTAYL PENTAKIS[DIHYDROGEN (PHOSPHATE)], Pleckstrin
著者Jackson, S.G, Haslam, R.J, Junop, M.S.
登録日2006-08-24
公開日2007-08-07
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.35 Å)
主引用文献Structural analysis of the carboxy terminal PH domain of pleckstrin bound to D-myo-inositol 1,2,3,5,6-pentakisphosphate.
Bmc Struct.Biol., 7, 2007
2I5C
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Crystal structure of the C-terminal PH domain of pleckstrin in complex with D-myo-Ins(1,2,3,4,5)P5
分子名称: (1R,2S,3R,4S,5S,6R)-6-HYDROXYCYCLOHEXANE-1,2,3,4,5-PENTAYL PENTAKIS[DIHYDROGEN (PHOSPHATE)], Pleckstrin
著者Jackson, S.G, Haslam, R.J, Junop, M.S.
登録日2006-08-24
公開日2007-08-07
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Structural analysis of the carboxy terminal PH domain of pleckstrin bound to D-myo-inositol 1,2,3,5,6-pentakisphosphate.
Bmc Struct.Biol., 7, 2007
1PMS
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PLECKSTRIN HOMOLOGY DOMAIN OF SON OF SEVENLESS 1 (SOS1) WITH GLYCINE-SERINE ADDED TO THE N-TERMINUS, NMR, 20 STRUCTURES
分子名称: SOS 1
著者Koshiba, S, Kigawa, T, Kim, J, Shirouzu, M, Bowtell, D, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
登録日1997-02-18
公開日1997-05-15
最終更新日2021-11-03
実験手法SOLUTION NMR
主引用文献The solution structure of the pleckstrin homology domain of mouse Son-of-sevenless 1 (mSos1).
J.Mol.Biol., 269, 1997
2KCJ
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solution structure of FAPP1 PH domain
分子名称: Pleckstrin homology domain-containing family A member 3
著者Lenoir, M, Coskun, U, James, J, Simons, K, Overduin, M.
登録日2008-12-22
公開日2009-12-22
最終更新日2021-10-20
実験手法SOLUTION NMR
主引用文献Structural basis of wedging the Golgi membrane by FAPP pleckstrin homology domains.
Embo Rep., 11, 2010
2LG1
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Solution structure of the human AKAP13 PH domain and stabilizing DH helix
分子名称: A-kinase anchor protein 13
著者Lenoir, M, Sugawara, M, Ball, L, Overduin, M.
登録日2011-07-19
公開日2011-08-03
最終更新日2023-06-14
実験手法SOLUTION NMR
主引用文献Structural Insights into the Activation of the RhoA GTPase by the Lbc Oncoprotein.
J.Biol.Chem., 3, 2014
1U5F
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Crystal Structure of the PH Domain of SKAP-Hom with 8 Vector-derived N-terminal Residues
分子名称: SULFATE ION, Src-associated adaptor protein
著者Tang, Y, Swanson, K.D, Neel, B.G, Eck, M.J.
登録日2004-07-27
公開日2005-07-26
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural Basis for the Dimerization and Phosphoinositide Specificity of the Src Kinase-associated Phosphoproteins SKAP55 and SKAP-Hom
To be Published

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件を2024-04-17に公開中

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