PDB: 283 件ウェブページステータス検索Chemie searchBIRD

---

1B3N	BETA-KETOACYL CARRIER PROTEIN SYNTHASE AS A DRUG TARGET, IMPLICATIONS FROM THE CRYSTAL STRUCTURE OF A COMPLEX WITH THE INHIBITOR CERULENIN. 分子名称: (2S, 3R)-3-HYDROXY-4-OXO-7,10-TRANS,TRANS-DODECADIENAMIDE, PROTEIN (KETOACYL ACYL CARRIER PROTEIN SYNTHASE 2) 著者 Moche, M, Schneider, G, Edwards, P, Dehesh, K, Lindqvist, Y. 登録日 1998-12-14 公開日 1999-04-06 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Structure of the complex between the antibiotic cerulenin and its target, beta-ketoacyl-acyl carrier protein synthase. J.Biol.Chem., 274, 1999
4V8L	Cryo-EM Structure of the Mycobacterial Fatty Acid Synthase 分子名称: FATTY ACID SYNTHASE, FLAVIN MONONUCLEOTIDE 著者 Boehringer, D, Ban, N, Leibundgut, M. 登録日 2012-12-06 公開日 2014-07-09 最終更新日 2019-12-11 実験手法 ELECTRON MICROSCOPY (7.5 Å) 主引用文献 7.5-A Cryo-Em Structure of the Mycobacterial Fatty Acid Synthase. J.Mol.Biol., 425, 2013
8SMS	Crosslinked Crystal Structure of Type II Fatty Acid Synthase, FabB, and cerulenin crosslinker-crypto Acyl Carrier Protein, AcpP 分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 1, Acyl carrier protein, N~3~-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-N-{2-[(2R)-2-hydroxy-4-oxododecanamido]ethyl}-beta-alaninamide 著者 Jiang, Z, Chen, A, Chen, J, Sekhon, A, Louie, G.V, Noel, J.P, La Clair, J.J, Burkart, M.D. 登録日 2023-04-26 公開日 2023-09-27 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.93 Å) 主引用文献 Masked cerulenin enables a dual-site selective protein crosslink. Chem Sci, 14, 2023
3E60	Crystal structure of 3-oxoacyl-(acyl carrier protein) synthase II from Bartonella henselae 分子名称: 3-oxoacyl-[acyl-carrier-protein ] synthase II, POTASSIUM ION 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2008-08-14 公開日 2008-08-26 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Crystal structure of 3-oxoacyl-(acyl carrier protein) synthase II from Bartonella henselae To be Published
6C9U	Crystal structure of [KS3][AT3] didomain from module 3 of 6-deoxyerthronolide B synthase in complex with antibody fragment (Fab) 分子名称: 6-deoxyerythronolide-B synthase EryA2, modules 3 and 4, Heavy chain of Fab 1B2, ... 著者 Deis, L.N, Li, X, Mathews, I.I, Khosla, C. 登録日 2018-01-28 公開日 2018-05-23 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.09 Å) 主引用文献 Structure-Function Analysis of the Extended Conformation of a Polyketide Synthase Module. J. Am. Chem. Soc., 140, 2018
6Y2I	Crystal structure of M. tuberculosis KasA in complex with N-(1H-indazol-5-yl)butane-1-sulfonamide 分子名称: 1,2-ETHANEDIOL, 3-oxoacyl-[acyl-carrier-protein] synthase 1, SODIUM ION, ... 著者 Chung, C. 登録日 2020-02-16 公開日 2020-04-08 最終更新日 2020-05-20 実験手法 X-RAY DIFFRACTION (1.533 Å) 主引用文献 Exploring the SAR of the beta-Ketoacyl-ACP Synthase Inhibitor GSK3011724A and Optimization around a Genotoxic Metabolite. Acs Infect Dis., 6, 2020
1TQY	The Actinorhodin Ketosynthase/Chain Length Factor 分子名称: ACETYL GROUP, Actinorhodin polyketide putative beta-ketoacyl synthase 1, Actinorhodin polyketide putative beta-ketoacyl synthase 2, ... 著者 Keatinge-Clay, A.T, Maltby, D.A, Medzihradszky, K.F, Khosla, C, Stroud, R.M. 登録日 2004-06-18 公開日 2004-07-27 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 An antibiotic factory caught in action. Nat.Struct.Mol.Biol., 11, 2004
6Y2J	Crystal structure of M. tuberculosis KasA in complex with 4,4,4-trifluoro-N-(isoquinolin-6-yl)butane-1-sulfonamide 分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 1, 4,4,4-tris(fluoranyl)-~{N}-isoquinolin-6-yl-butane-1-sulfonamide, SODIUM ION, ... 著者 Chung, C. 登録日 2020-02-16 公開日 2020-04-08 最終更新日 2020-05-20 実験手法 X-RAY DIFFRACTION (2.886 Å) 主引用文献 Exploring the SAR of the beta-Ketoacyl-ACP Synthase Inhibitor GSK3011724A and Optimization around a Genotoxic Metabolite. Acs Infect Dis., 6, 2020
1J3N	Crystal Structure of 3-oxoacyl-(acyl-carrier protein) Synthase II from Thermus thermophilus HB8 分子名称: 3-oxoacyl-(acyl-carrier protein) synthase II, CITRIC ACID, MAGNESIUM ION 著者 Bagautdinov, B, Miyano, M, Tahirov, T.H, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2003-02-10 公開日 2003-03-11 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structure of 3-oxoacyl-(acyl-carrier protein) synthase II from Thermus thermophilus HB8. Acta Crystallogr.,Sect.F, 64, 2008
1OXH	The crystal structure of beta-ketoacyl-[acyl carrier protein] synthase II from Streptococcus Pneumoniae, Triclinic form 分子名称: Beta ketoacyl-acyl carrier protein synthase, MAGNESIUM ION 著者 Price, A.C, Rock, C.O, White, S.W. 登録日 2003-04-02 公開日 2003-04-22 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.09 Å) 主引用文献 The 1.3-Angstrom-Resolution Crystal Structure of beta-Ketoacyl-Acyl Carrier Protein Synthase II from Streptococcus pneumoniae. J.Bacteriol., 185, 2003
1OX0	The crystal structure of beta-ketoacyl-[acyl carrier protein] synthase II from Streptococcus pneumoniae 分子名称: Beta ketoacyl-acyl carrier protein synthase, MAGNESIUM ION 著者 Price, A.C, Rock, C.O, White, S.W. 登録日 2003-03-31 公開日 2003-04-22 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 The 1.3-Angstrom-Resolution Crystal Structure of beta-Ketoacyl-Acyl Carrier Protein Synthase II from Streptococcus pneumoniae. J.Bacteriol., 185, 2003
7OC0	Structure of Pseudomonas aeruginosa FabF mutant C164Q in complex with a ligand (2S,4R)-2-(thiophen-2-yl)thiazolidine-4-carboxylic acid 分子名称: (2S,4R)-2-(thiophen-2-yl)thiazolidine-4-carboxylic acid, 3-oxoacyl-[acyl-carrier-protein] synthase 2, DIMETHYL SULFOXIDE, ... 著者 Georgiou, C, Brenk, R, Espeland, L.O, Klein, R. 登録日 2021-04-25 公開日 2021-08-25 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.78 Å) 主引用文献 An Experimental Toolbox for Structure-Based Hit Discovery for P. aeruginosa FabF, a Promising Target for Antibiotics. Chemmedchem, 16, 2021
7OC1	Structure of Pseudomonas aeruginosa FabF mutant C164Q in complex with Platensimycin 分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 2, DIMETHYL SULFOXIDE, GLYCEROL, ... 著者 Georgiou, C, Brenk, R, Espeland, L.O, Klein, R. 登録日 2021-04-25 公開日 2021-08-25 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 An Experimental Toolbox for Structure-Based Hit Discovery for P. aeruginosa FabF, a Promising Target for Antibiotics. Chemmedchem, 16, 2021
3U0F	The structure of Beta-ketoacyl synthase from Brucella melitensis bound to the fragment 7-hydroxycoumarin 分子名称: 7-hydroxy-2H-chromen-2-one, Beta-ketoacyl synthase, CHLORIDE ION, ... 著者 Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2011-09-28 公開日 2011-10-12 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.25 Å) 主引用文献 Structural characterization of beta-ketoacyl ACP synthase I bound to platencin and fragment screening molecules at two substrate binding sites. Proteins, 88, 2020
6FIJ	Structure of the loading/condensing region (SAT-KS-MAT) of the cercosporin fungal non-reducing polyketide synthase (NR-PKS) CTB1 分子名称: 1,2-ETHANEDIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, GLYCEROL, ... 著者 Herbst, D.A, Jakob, R.P, Townsend, C.A, Maier, T. 登録日 2018-01-18 公開日 2018-03-21 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.77 Å) 主引用文献 The structural organization of substrate loading in iterative polyketide synthases. Nat. Chem. Biol., 14, 2018
3U0E	Crystal structure of beta-ketoacyl synthase from Brucella melitensis in complex with fragment 9320 分子名称: 8-methylquinolin-4-amine, Beta-ketoacyl synthase, CHLORIDE ION, ... 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2011-09-28 公開日 2011-10-26 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structural characterization of beta-ketoacyl ACP synthase I bound to platencin and fragment screening molecules at two substrate binding sites. Proteins, 88, 2020
6FIK	ACP2 crosslinked to the KS of the loading/condensing region of the CTB1 PKS 分子名称: Polyketide synthase 著者 Herbst, D.A, Huitt-Roehl, C.R, Jakob, R.P, Townsend, C.A, Maier, T. 登録日 2018-01-18 公開日 2018-03-21 最終更新日 2019-12-11 実験手法 ELECTRON MICROSCOPY (7.1 Å) 主引用文献 The structural organization of substrate loading in iterative polyketide synthases. Nat. Chem. Biol., 14, 2018
1W0I	Arabidopsis thaliana Mitochondrial KAS 分子名称: 3-OXOACYL CARRIER PROTEIN SYNTHASE, POTASSIUM ION, SULFATE ION 著者 Olsen, J.G, Rasmussen, A.V, von Wettstein-Knowles, P, Henriksen, A. 登録日 2004-06-04 公開日 2004-11-10 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structure of the mitochondrial beta-ketoacyl-[acyl carrier protein] synthase from Arabidopsis and its role in fatty acid synthesis. FEBS Lett., 577, 2004
1KAS	BETA-KETOACYL-ACP SYNTHASE II FROM ESCHERICHIA COLI 分子名称: BETA-KETOACYL ACP SYNTHASE II 著者 Huang, W, Jia, J, Edwards, P, Dehesh, K, Schneider, G, Lindqvist, Y. 登録日 1997-12-22 公開日 1999-03-02 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Crystal structure of beta-ketoacyl-acyl carrier protein synthase II from E.coli reveals the molecular architecture of condensing enzymes. EMBO J., 17, 1998
3MQD	Crystal structure of beta-ketoacyl synthase from brucella melitensis with FOL 0758, (1-methyl-1h-indazol-3-yl) methanol 分子名称: (5-thiophen-2-ylisoxazol-3-yl)methanol, Beta-ketoacyl synthase, CHLORIDE ION, ... 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2010-04-28 公開日 2010-06-09 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.25 Å) 主引用文献 Structural characterization of beta-ketoacyl ACP synthase I bound to platencin and fragment screening molecules at two substrate binding sites. Proteins, 88, 2020
4B7V	Structure of wild type Pseudomonas aeruginosa FabF (KASII) 分子名称: 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE 2, POTASSIUM ION 著者 Lecker, L, Baum, B, Zoltner, M, Hunter, W.N. 登録日 2012-08-22 公開日 2013-09-04 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.73 Å) 主引用文献 Structures of Pseudomonas Aeruginosa Beta-Keto-Acyl-(Acyl-Carrier-Protein) Synthase II (Fabf) and a C164Q Mutant Provide Templates for Antibacterial Drug Discovery and Identify a Buried Potassium Ion and a Ligand-Binding Site that is an Artefact of the Crystal Form Acta Crystallogr.,Sect.F, 71, 2015
3O04	Crystal structure of the beta-keto-acyl carrier protein synthase II (lmo2201) from Listeria monocytogenes 分子名称: beta-keto-acyl carrier protein synthase II 著者 Anderson, S.M, Wawrzak, Z, Onopriyenko, O, Anderson, W.F, Savchenko, A, Center for Structural Genomics of Infectious Diseases (CSGID) 登録日 2010-07-19 公開日 2010-08-04 最終更新日 2021-10-06 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Crystal structure of the beta-keto-acyl carrier protein synthase II (lmo2201) from Listeria monocytogenes To be Published
3OYT	1.84 Angstrom resolution crystal structure of 3-oxoacyl-(acyl carrier protein) synthase I (fabB) from Yersinia pestis CO92 分子名称: 1,2-ETHANEDIOL, 3-oxoacyl-[acyl-carrier-protein] synthase I, DI(HYDROXYETHYL)ETHER, ... 著者 Halavaty, A.S, Wawrzak, Z, Onopriyenko, O, Peterson, S, Savchenko, A, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) 登録日 2010-09-23 公開日 2011-01-12 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.84 Å) 主引用文献 1.84 Angstrom resolution crystal structure of 3-oxoacyl-(acyl carrier protein) synthase I (fabB) from Yersinia pestis CO92 To be Published
4CW4	Crystal structure of the noncanonical ketosynthase FabY from P. aeruginosa 分子名称: BETA-KETOACYL SYNTHASE, CHLORIDE ION, SULFATE ION 著者 Bukhari, H.S.T, Jakob, R.P, Maier, T. 登録日 2014-04-01 公開日 2014-12-17 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.349 Å) 主引用文献 Evolutionary Origins of the Multienzyme Architecture of Giant Fungal Fatty Acid Synthase. Structure, 22, 2014
4DDO	Crystal structure of 3-oxoacyl-[acyl-carrier-protein] synthase ii from burkholderia vietnamiensis 分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 2, SODIUM ION 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2012-01-19 公開日 2012-05-23 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Combining functional and structural genomics to sample the essential Burkholderia structome. Plos One, 8, 2013

 

123456789101112>