7ZMA
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1B3N
| BETA-KETOACYL CARRIER PROTEIN SYNTHASE AS A DRUG TARGET, IMPLICATIONS FROM THE CRYSTAL STRUCTURE OF A COMPLEX WITH THE INHIBITOR CERULENIN. | 分子名称: | (2S, 3R)-3-HYDROXY-4-OXO-7,10-TRANS,TRANS-DODECADIENAMIDE, PROTEIN (KETOACYL ACYL CARRIER PROTEIN SYNTHASE 2) | 著者 | Moche, M, Schneider, G, Edwards, P, Dehesh, K, Lindqvist, Y. | 登録日 | 1998-12-14 | 公開日 | 1999-04-06 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Structure of the complex between the antibiotic cerulenin and its target, beta-ketoacyl-acyl carrier protein synthase. J.Biol.Chem., 274, 1999
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4V8L
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3E60
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7CPX
| Lovastatin nonaketide synthase | 分子名称: | Lovastatin nonaketide synthase, polyketide synthase component, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | 著者 | Wang, J, Wang, Z. | 登録日 | 2020-08-08 | 公開日 | 2021-01-13 | 最終更新日 | 2021-12-15 | 実験手法 | ELECTRON MICROSCOPY (2.91 Å) | 主引用文献 | Structural basis for the biosynthesis of lovastatin. Nat Commun, 12, 2021
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1TQY
| The Actinorhodin Ketosynthase/Chain Length Factor | 分子名称: | ACETYL GROUP, Actinorhodin polyketide putative beta-ketoacyl synthase 1, Actinorhodin polyketide putative beta-ketoacyl synthase 2, ... | 著者 | Keatinge-Clay, A.T, Maltby, D.A, Medzihradszky, K.F, Khosla, C, Stroud, R.M. | 登録日 | 2004-06-18 | 公開日 | 2004-07-27 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | An antibiotic factory caught in action. Nat.Struct.Mol.Biol., 11, 2004
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1J3N
| Crystal Structure of 3-oxoacyl-(acyl-carrier protein) Synthase II from Thermus thermophilus HB8 | 分子名称: | 3-oxoacyl-(acyl-carrier protein) synthase II, CITRIC ACID, MAGNESIUM ION | 著者 | Bagautdinov, B, Miyano, M, Tahirov, T.H, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | 登録日 | 2003-02-10 | 公開日 | 2003-03-11 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structure of 3-oxoacyl-(acyl-carrier protein) synthase II from Thermus thermophilus HB8. Acta Crystallogr.,Sect.F, 64, 2008
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1OXH
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1OX0
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3U0F
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3U0E
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7F27
| Crystal structure of polyketide ketosynthase | 分子名称: | 3-oxoacyl-(Acyl-carrier-protein) synthase | 著者 | Kim, Y, Lee, W.C. | 登録日 | 2021-06-10 | 公開日 | 2022-06-15 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.806 Å) | 主引用文献 | Structural basis of the complementary activity of two ketosynthases in aryl polyene biosynthesis. Sci Rep, 11, 2021
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1W0I
| Arabidopsis thaliana Mitochondrial KAS | 分子名称: | 3-OXOACYL CARRIER PROTEIN SYNTHASE, POTASSIUM ION, SULFATE ION | 著者 | Olsen, J.G, Rasmussen, A.V, von Wettstein-Knowles, P, Henriksen, A. | 登録日 | 2004-06-04 | 公開日 | 2004-11-10 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structure of the mitochondrial beta-ketoacyl-[acyl carrier protein] synthase from Arabidopsis and its role in fatty acid synthesis. FEBS Lett., 577, 2004
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1KAS
| BETA-KETOACYL-ACP SYNTHASE II FROM ESCHERICHIA COLI | 分子名称: | BETA-KETOACYL ACP SYNTHASE II | 著者 | Huang, W, Jia, J, Edwards, P, Dehesh, K, Schneider, G, Lindqvist, Y. | 登録日 | 1997-12-22 | 公開日 | 1999-03-02 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Crystal structure of beta-ketoacyl-acyl carrier protein synthase II from E.coli reveals the molecular architecture of condensing enzymes. EMBO J., 17, 1998
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6C9U
| Crystal structure of [KS3][AT3] didomain from module 3 of 6-deoxyerthronolide B synthase in complex with antibody fragment (Fab) | 分子名称: | 6-deoxyerythronolide-B synthase EryA2, modules 3 and 4, Heavy chain of Fab 1B2, ... | 著者 | Deis, L.N, Li, X, Mathews, I.I, Khosla, C. | 登録日 | 2018-01-28 | 公開日 | 2018-05-23 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | 主引用文献 | Structure-Function Analysis of the Extended Conformation of a Polyketide Synthase Module. J. Am. Chem. Soc., 140, 2018
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6WC7
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8EE0
| KS-AT didomain from module 2 of the 6-deoxyerythronolide B synthase in complex with antibody fragment 1B2 | 分子名称: | 1B2 antibody heavy chain, 1B2 antibody light chain, 6-deoxyerythronolide B synthase | 著者 | Cogan, D.P, Brodsky, K.L, Guzman, K.M, Mathews, I.I, Khosla, C. | 登録日 | 2022-09-06 | 公開日 | 2023-05-31 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Discovery and Characterization of Antibody Probes of Module 2 of the 6-Deoxyerythronolide B Synthase. Biochemistry, 62, 2023
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8EE1
| KS-AT didomain from module 2 of the 6-deoxyerythronolide B synthase in complex with antibody fragment AA5 | 分子名称: | 6-deoxyerythronolide B synthase, AA5 antibody heavy chain, AA5 antibody light chain | 著者 | Cogan, D.P, Brodsky, K.L, Guzman, K.M, Mathews, I.I, Khosla, C. | 登録日 | 2022-09-06 | 公開日 | 2023-05-31 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Discovery and Characterization of Antibody Probes of Module 2 of the 6-Deoxyerythronolide B Synthase. Biochemistry, 62, 2023
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3MQD
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4B7V
| Structure of wild type Pseudomonas aeruginosa FabF (KASII) | 分子名称: | 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE 2, POTASSIUM ION | 著者 | Lecker, L, Baum, B, Zoltner, M, Hunter, W.N. | 登録日 | 2012-08-22 | 公開日 | 2013-09-04 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | 主引用文献 | Structures of Pseudomonas Aeruginosa Beta-Keto-Acyl-(Acyl-Carrier-Protein) Synthase II (Fabf) and a C164Q Mutant Provide Templates for Antibacterial Drug Discovery and Identify a Buried Potassium Ion and a Ligand-Binding Site that is an Artefact of the Crystal Form Acta Crystallogr.,Sect.F, 71, 2015
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6Y2I
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8G4U
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3O04
| Crystal structure of the beta-keto-acyl carrier protein synthase II (lmo2201) from Listeria monocytogenes | 分子名称: | beta-keto-acyl carrier protein synthase II | 著者 | Anderson, S.M, Wawrzak, Z, Onopriyenko, O, Anderson, W.F, Savchenko, A, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2010-07-19 | 公開日 | 2010-08-04 | 最終更新日 | 2021-10-06 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Crystal structure of the beta-keto-acyl carrier protein synthase II (lmo2201) from Listeria monocytogenes To be Published
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6Y2J
| Crystal structure of M. tuberculosis KasA in complex with 4,4,4-trifluoro-N-(isoquinolin-6-yl)butane-1-sulfonamide | 分子名称: | 3-oxoacyl-[acyl-carrier-protein] synthase 1, 4,4,4-tris(fluoranyl)-~{N}-isoquinolin-6-yl-butane-1-sulfonamide, SODIUM ION, ... | 著者 | Chung, C. | 登録日 | 2020-02-16 | 公開日 | 2020-04-08 | 最終更新日 | 2020-05-20 | 実験手法 | X-RAY DIFFRACTION (2.886 Å) | 主引用文献 | Exploring the SAR of the beta-Ketoacyl-ACP Synthase Inhibitor GSK3011724A and Optimization around a Genotoxic Metabolite. Acs Infect Dis., 6, 2020
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7BC4
| Cryo-EM structure of fatty acid synthase (FAS) from Pichia pastoris | 分子名称: | FLAVIN MONONUCLEOTIDE, Fatty acid synthase subunit alpha, Fatty acid synthase subunit beta | 著者 | Snowden, J.S, Alzahrani, J, Sherry, L, Stacey, M, Rowlands, D.J, Ranson, N.A, Stonehouse, N.J. | 登録日 | 2020-12-18 | 公開日 | 2021-05-19 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural insight into Pichia pastoris fatty acid synthase. Sci Rep, 11, 2021
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