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7ZMA
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Ketosynthase domain of module 4 from Brevibacillus Brevis orphan BGC11
分子名称: Putative polyketide synthase
著者Tittes, Y.U, Herbst, D.A, Jakob, R.P, Maier, T.
登録日2022-04-19
公開日2022-09-21
最終更新日2023-04-05
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献The structure of a polyketide synthase bimodule core.
Sci Adv, 8, 2022
1B3N
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BETA-KETOACYL CARRIER PROTEIN SYNTHASE AS A DRUG TARGET, IMPLICATIONS FROM THE CRYSTAL STRUCTURE OF A COMPLEX WITH THE INHIBITOR CERULENIN.
分子名称: (2S, 3R)-3-HYDROXY-4-OXO-7,10-TRANS,TRANS-DODECADIENAMIDE, PROTEIN (KETOACYL ACYL CARRIER PROTEIN SYNTHASE 2)
著者Moche, M, Schneider, G, Edwards, P, Dehesh, K, Lindqvist, Y.
登録日1998-12-14
公開日1999-04-06
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Structure of the complex between the antibiotic cerulenin and its target, beta-ketoacyl-acyl carrier protein synthase.
J.Biol.Chem., 274, 1999
4V8L
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Cryo-EM Structure of the Mycobacterial Fatty Acid Synthase
分子名称: FATTY ACID SYNTHASE, FLAVIN MONONUCLEOTIDE
著者Boehringer, D, Ban, N, Leibundgut, M.
登録日2012-12-06
公開日2014-07-09
最終更新日2019-12-11
実験手法ELECTRON MICROSCOPY (7.5 Å)
主引用文献7.5-A Cryo-Em Structure of the Mycobacterial Fatty Acid Synthase.
J.Mol.Biol., 425, 2013
3E60
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Crystal structure of 3-oxoacyl-(acyl carrier protein) synthase II from Bartonella henselae
分子名称: 3-oxoacyl-[acyl-carrier-protein ] synthase II, POTASSIUM ION
著者Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日2008-08-14
公開日2008-08-26
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Crystal structure of 3-oxoacyl-(acyl carrier protein) synthase II from Bartonella henselae
To be Published
7CPX
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Lovastatin nonaketide synthase
分子名称: Lovastatin nonaketide synthase, polyketide synthase component, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
著者Wang, J, Wang, Z.
登録日2020-08-08
公開日2021-01-13
最終更新日2021-12-15
実験手法ELECTRON MICROSCOPY (2.91 Å)
主引用文献Structural basis for the biosynthesis of lovastatin.
Nat Commun, 12, 2021
1TQY
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The Actinorhodin Ketosynthase/Chain Length Factor
分子名称: ACETYL GROUP, Actinorhodin polyketide putative beta-ketoacyl synthase 1, Actinorhodin polyketide putative beta-ketoacyl synthase 2, ...
著者Keatinge-Clay, A.T, Maltby, D.A, Medzihradszky, K.F, Khosla, C, Stroud, R.M.
登録日2004-06-18
公開日2004-07-27
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献An antibiotic factory caught in action.
Nat.Struct.Mol.Biol., 11, 2004
1J3N
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Crystal Structure of 3-oxoacyl-(acyl-carrier protein) Synthase II from Thermus thermophilus HB8
分子名称: 3-oxoacyl-(acyl-carrier protein) synthase II, CITRIC ACID, MAGNESIUM ION
著者Bagautdinov, B, Miyano, M, Tahirov, T.H, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
登録日2003-02-10
公開日2003-03-11
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structure of 3-oxoacyl-(acyl-carrier protein) synthase II from Thermus thermophilus HB8.
Acta Crystallogr.,Sect.F, 64, 2008
1OXH
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The crystal structure of beta-ketoacyl-[acyl carrier protein] synthase II from Streptococcus Pneumoniae, Triclinic form
分子名称: Beta ketoacyl-acyl carrier protein synthase, MAGNESIUM ION
著者Price, A.C, Rock, C.O, White, S.W.
登録日2003-04-02
公開日2003-04-22
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.09 Å)
主引用文献The 1.3-Angstrom-Resolution Crystal Structure of beta-Ketoacyl-Acyl Carrier Protein Synthase II from Streptococcus pneumoniae.
J.Bacteriol., 185, 2003
1OX0
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The crystal structure of beta-ketoacyl-[acyl carrier protein] synthase II from Streptococcus pneumoniae
分子名称: Beta ketoacyl-acyl carrier protein synthase, MAGNESIUM ION
著者Price, A.C, Rock, C.O, White, S.W.
登録日2003-03-31
公開日2003-04-22
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献The 1.3-Angstrom-Resolution Crystal Structure of beta-Ketoacyl-Acyl Carrier Protein Synthase II from Streptococcus pneumoniae.
J.Bacteriol., 185, 2003
3U0F
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The structure of Beta-ketoacyl synthase from Brucella melitensis bound to the fragment 7-hydroxycoumarin
分子名称: 7-hydroxy-2H-chromen-2-one, Beta-ketoacyl synthase, CHLORIDE ION, ...
著者Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日2011-09-28
公開日2011-10-12
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.25 Å)
主引用文献Structural characterization of beta-ketoacyl ACP synthase I bound to platencin and fragment screening molecules at two substrate binding sites.
Proteins, 88, 2020
3U0E
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Crystal structure of beta-ketoacyl synthase from Brucella melitensis in complex with fragment 9320
分子名称: 8-methylquinolin-4-amine, Beta-ketoacyl synthase, CHLORIDE ION, ...
著者Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日2011-09-28
公開日2011-10-26
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structural characterization of beta-ketoacyl ACP synthase I bound to platencin and fragment screening molecules at two substrate binding sites.
Proteins, 88, 2020
7F27
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Crystal structure of polyketide ketosynthase
分子名称: 3-oxoacyl-(Acyl-carrier-protein) synthase
著者Kim, Y, Lee, W.C.
登録日2021-06-10
公開日2022-06-15
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.806 Å)
主引用文献Structural basis of the complementary activity of two ketosynthases in aryl polyene biosynthesis.
Sci Rep, 11, 2021
1W0I
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Arabidopsis thaliana Mitochondrial KAS
分子名称: 3-OXOACYL CARRIER PROTEIN SYNTHASE, POTASSIUM ION, SULFATE ION
著者Olsen, J.G, Rasmussen, A.V, von Wettstein-Knowles, P, Henriksen, A.
登録日2004-06-04
公開日2004-11-10
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structure of the mitochondrial beta-ketoacyl-[acyl carrier protein] synthase from Arabidopsis and its role in fatty acid synthesis.
FEBS Lett., 577, 2004
1KAS
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BETA-KETOACYL-ACP SYNTHASE II FROM ESCHERICHIA COLI
分子名称: BETA-KETOACYL ACP SYNTHASE II
著者Huang, W, Jia, J, Edwards, P, Dehesh, K, Schneider, G, Lindqvist, Y.
登録日1997-12-22
公開日1999-03-02
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Crystal structure of beta-ketoacyl-acyl carrier protein synthase II from E.coli reveals the molecular architecture of condensing enzymes.
EMBO J., 17, 1998
6C9U
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Crystal structure of [KS3][AT3] didomain from module 3 of 6-deoxyerthronolide B synthase in complex with antibody fragment (Fab)
分子名称: 6-deoxyerythronolide-B synthase EryA2, modules 3 and 4, Heavy chain of Fab 1B2, ...
著者Deis, L.N, Li, X, Mathews, I.I, Khosla, C.
登録日2018-01-28
公開日2018-05-23
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.09 Å)
主引用文献Structure-Function Analysis of the Extended Conformation of a Polyketide Synthase Module.
J. Am. Chem. Soc., 140, 2018
6WC7
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Acyl carrier protein (ACP) domain bound to dehydratase (DH) domain in fungal fatty acid synthase (FAS)
分子名称: Fatty acid synthase subunit alpha, Fatty acid synthase subunit beta
著者Lou, J.W, Mazhab-Jafari, M.T.
登録日2020-03-29
公開日2020-06-03
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (5.8 Å)
主引用文献Steric occlusion regulates proximal interactions of acyl carrier protein domain in fungal fatty acid synthase.
Commun Biol, 3, 2020
8EE0
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KS-AT didomain from module 2 of the 6-deoxyerythronolide B synthase in complex with antibody fragment 1B2
分子名称: 1B2 antibody heavy chain, 1B2 antibody light chain, 6-deoxyerythronolide B synthase
著者Cogan, D.P, Brodsky, K.L, Guzman, K.M, Mathews, I.I, Khosla, C.
登録日2022-09-06
公開日2023-05-31
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Discovery and Characterization of Antibody Probes of Module 2 of the 6-Deoxyerythronolide B Synthase.
Biochemistry, 62, 2023
8EE1
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KS-AT didomain from module 2 of the 6-deoxyerythronolide B synthase in complex with antibody fragment AA5
分子名称: 6-deoxyerythronolide B synthase, AA5 antibody heavy chain, AA5 antibody light chain
著者Cogan, D.P, Brodsky, K.L, Guzman, K.M, Mathews, I.I, Khosla, C.
登録日2022-09-06
公開日2023-05-31
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Discovery and Characterization of Antibody Probes of Module 2 of the 6-Deoxyerythronolide B Synthase.
Biochemistry, 62, 2023
3MQD
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Crystal structure of beta-ketoacyl synthase from brucella melitensis with FOL 0758, (1-methyl-1h-indazol-3-yl) methanol
分子名称: (5-thiophen-2-ylisoxazol-3-yl)methanol, Beta-ketoacyl synthase, CHLORIDE ION, ...
著者Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日2010-04-28
公開日2010-06-09
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.25 Å)
主引用文献Structural characterization of beta-ketoacyl ACP synthase I bound to platencin and fragment screening molecules at two substrate binding sites.
Proteins, 88, 2020
4B7V
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Structure of wild type Pseudomonas aeruginosa FabF (KASII)
分子名称: 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE 2, POTASSIUM ION
著者Lecker, L, Baum, B, Zoltner, M, Hunter, W.N.
登録日2012-08-22
公開日2013-09-04
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.73 Å)
主引用文献Structures of Pseudomonas Aeruginosa Beta-Keto-Acyl-(Acyl-Carrier-Protein) Synthase II (Fabf) and a C164Q Mutant Provide Templates for Antibacterial Drug Discovery and Identify a Buried Potassium Ion and a Ligand-Binding Site that is an Artefact of the Crystal Form
Acta Crystallogr.,Sect.F, 71, 2015
6Y2I
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Crystal structure of M. tuberculosis KasA in complex with N-(1H-indazol-5-yl)butane-1-sulfonamide
分子名称: 1,2-ETHANEDIOL, 3-oxoacyl-[acyl-carrier-protein] synthase 1, SODIUM ION, ...
著者Chung, C.
登録日2020-02-16
公開日2020-04-08
最終更新日2020-05-20
実験手法X-RAY DIFFRACTION (1.533 Å)
主引用文献Exploring the SAR of the beta-Ketoacyl-ACP Synthase Inhibitor GSK3011724A and Optimization around a Genotoxic Metabolite.
Acs Infect Dis., 6, 2020
8G4U
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Final ketosynthase+acyltransferase of the erythromycin modular polyketide synthase
分子名称: EryAIII
著者Keatinge-Clay, A.T.
登録日2023-02-10
公開日2023-03-01
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Crystal structures reveal the framework of cis -acyltransferase modular polyketide synthases.
Biorxiv, 2023
3O04
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Crystal structure of the beta-keto-acyl carrier protein synthase II (lmo2201) from Listeria monocytogenes
分子名称: beta-keto-acyl carrier protein synthase II
著者Anderson, S.M, Wawrzak, Z, Onopriyenko, O, Anderson, W.F, Savchenko, A, Center for Structural Genomics of Infectious Diseases (CSGID)
登録日2010-07-19
公開日2010-08-04
最終更新日2021-10-06
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Crystal structure of the beta-keto-acyl carrier protein synthase II (lmo2201) from Listeria monocytogenes
To be Published
6Y2J
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Crystal structure of M. tuberculosis KasA in complex with 4,4,4-trifluoro-N-(isoquinolin-6-yl)butane-1-sulfonamide
分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 1, 4,4,4-tris(fluoranyl)-~{N}-isoquinolin-6-yl-butane-1-sulfonamide, SODIUM ION, ...
著者Chung, C.
登録日2020-02-16
公開日2020-04-08
最終更新日2020-05-20
実験手法X-RAY DIFFRACTION (2.886 Å)
主引用文献Exploring the SAR of the beta-Ketoacyl-ACP Synthase Inhibitor GSK3011724A and Optimization around a Genotoxic Metabolite.
Acs Infect Dis., 6, 2020
7BC4
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Cryo-EM structure of fatty acid synthase (FAS) from Pichia pastoris
分子名称: FLAVIN MONONUCLEOTIDE, Fatty acid synthase subunit alpha, Fatty acid synthase subunit beta
著者Snowden, J.S, Alzahrani, J, Sherry, L, Stacey, M, Rowlands, D.J, Ranson, N.A, Stonehouse, N.J.
登録日2020-12-18
公開日2021-05-19
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Structural insight into Pichia pastoris fatty acid synthase.
Sci Rep, 11, 2021

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