PDB: 13 件ウェブページステータス検索Chemie searchBIRD

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1PB5	NMR Structure of a Prototype LNR Module from Human Notch1 分子名称: CALCIUM ION, Neurogenic locus notch homolog protein 1 著者 Vardar, D, North, C.L, Sanchez-Irizarry, C, Aster, J.C, Blacklow, S.C. 登録日 2003-05-14 公開日 2003-06-17 最終更新日 2022-02-23 実験手法 SOLUTION NMR 主引用文献 Nuclear Magnetic Resonance Structure of a Prototype Lin12-Notch Repeat Module from Human Notch1 Biochemistry, 42, 2003
2OO4	Structure of LNR-HD (Negative Regulatory Region) from human Notch 2 分子名称: CALCIUM ION, GLYCEROL, Neurogenic locus notch homolog protein 2, ... 著者 Gordon, W.R, Vardar-Ulu, D, Histen, G, Sanchez-Irizarry, C, Aster, J.C, Blacklow, S.C. 登録日 2007-01-25 公開日 2007-04-03 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.003 Å) 主引用文献 Structural basis for autoinhibition of Notch Nat.Struct.Mol.Biol., 14, 2007
3ETO	2 Angstrom Xray structure of the NOTCH1 Negative Regulatory Region (NRR) 分子名称: CALCIUM ION, CHLORIDE ION, GLYCEROL, ... 著者 Gordon, W.R, Blacklow, S.C. 登録日 2008-10-08 公開日 2008-12-23 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structure of the Notch1-negative regulatory region: implications for normal activation and pathogenic signaling in T-ALL. Blood, 113, 2009
7DXI	Structure of Drosophila melanogaster GlcNAc-1-phosphotransferase 分子名称: CALCIUM ION, FI02838p 著者 Du, S, Xiao, J, Guopeng, W. 登録日 2021-01-19 公開日 2022-02-02 最終更新日 2022-08-17 実験手法 ELECTRON MICROSCOPY (3.53 Å) 主引用文献 Structural insights into how GlcNAc-1-phosphotransferase directs lysosomal protein transport. J.Biol.Chem., 298, 2022
7S06	Cryo-EM structure of human GlcNAc-1-phosphotransferase A2B2 subcomplex 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, N-acetylglucosamine-1-phosphotransferase subunits alpha/beta 著者 Li, H, Li, H. 登録日 2021-08-30 公開日 2022-03-30 最終更新日 2022-04-27 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Structure of the human GlcNAc-1-phosphotransferase alpha beta subunits reveals regulatory mechanism for lysosomal enzyme glycan phosphorylation. Nat.Struct.Mol.Biol., 29, 2022
7S05	Cryo-EM structure of human GlcNAc-1-phosphotransferase A2B2 subcomplex 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... 著者 Li, H, Li, H. 登録日 2021-08-30 公開日 2022-03-30 最終更新日 2022-04-27 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structure of the human GlcNAc-1-phosphotransferase alpha beta subunits reveals regulatory mechanism for lysosomal enzyme glycan phosphorylation. Nat.Struct.Mol.Biol., 29, 2022
6XSW	Structure of the Notch3 NRR in complex with an antibody Fab Fragment 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Anti-N3 Fab Heavy Chain, ... 著者 Bard, J. 登録日 2020-07-16 公開日 2021-07-21 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.98 Å) 主引用文献 NOTCH3-targeted antibody drug conjugates regress tumors by inducing apoptosis in receptor cells and through transendocytosis into ligand cells. Cell Rep Med, 2, 2021
3I08	Crystal structure of the S1-cleaved Notch1 Negative Regulatory Region (NRR) 分子名称: CALCIUM ION, CHLORIDE ION, Neurogenic locus notch homolog protein 1 著者 Gordon, W.R, Blacklow, S.C. 登録日 2009-06-24 公開日 2009-09-01 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Effects of S1 cleavage on the structure, surface export, and signaling activity of human Notch1 and Notch2. Plos One, 4, 2009
7ABV	Structure of the S1-cleaved mouse Notch1 Negative Regulatory Region (NRR) 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Neurogenic locus notch homolog protein 1 著者 Zeronian, M.R, Janssen, B.J.C. 登録日 2020-09-08 公開日 2021-07-07 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.065 Å) 主引用文献 Notch-Jagged signaling complex defined by an interaction mosaic. Proc.Natl.Acad.Sci.USA, 118, 2021
3L95	Crystal structure of the human Notch1 Negative Regulatory Region (NRR) bound to the fab fragment of an antagonist antibody 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Neurogenic locus notch homolog protein 1, ... 著者 Hymowitz, S.G, de Leon, G.P. 登録日 2010-01-04 公開日 2010-03-09 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.19 Å) 主引用文献 Therapeutic antibody targeting of individual Notch receptors. Nature, 464, 2010
4ZLP	Crystal Structure of Notch3 Negative Regulatory Region 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, CALCIUM ION, ... 著者 Xu, X, Blacklow, S.C. 登録日 2015-05-01 公開日 2015-08-19 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.479 Å) 主引用文献 Insights into Autoregulation of Notch3 from Structural and Functional Studies of Its Negative Regulatory Region. Structure, 23, 2015
5CZX	Crystal structure of Notch3 NRR in complex with 20358 Fab 分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 20358 Fab heavy chain, ... 著者 Hu, T, Fryer, C, Chopra, R, Clark, K. 登録日 2015-08-01 公開日 2016-06-01 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Characterization of activating mutations of NOTCH3 in T-cell acute lymphoblastic leukemia and anti-leukemic activity of NOTCH3 inhibitory antibodies. Oncogene, 35, 2016
5CZV	Crystal structure of Notch3 NRR in complex with 20350 Fab 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Fab 20350 heavy chain, ... 著者 Hu, T, Fryer, C, Chopra, R, Clark, K. 登録日 2015-08-01 公開日 2016-06-01 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.19 Å) 主引用文献 Characterization of activating mutations of NOTCH3 in T-cell acute lymphoblastic leukemia and anti-leukemic activity of NOTCH3 inhibitory antibodies. Oncogene, 35, 2016