7CIO
| Molecular interactions of cytoplasmic region of CTLA-4 with SH2 domains of PI3-kinase | 分子名称: | Cytotoxic T-lymphocyte protein 4, Phosphatidylinositol 3-kinase regulatory subunit alpha | 著者 | Iiyama, M, Numoto, N, Ogawa, S, Kuroda, M, Morii, H, Abe, R, Ito, N, Oda, M. | 登録日 | 2020-07-08 | 公開日 | 2020-12-09 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | 主引用文献 | Molecular interactions of the CTLA-4 cytoplasmic region with the phosphoinositide 3-kinase SH2 domains. Mol.Immunol., 131, 2021
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2VIF
| Crystal structure of SOCS6 SH2 domain in complex with a c-KIT phosphopeptide | 分子名称: | 1,2-ETHANEDIOL, MAST/STEM CELL GROWTH FACTOR RECEPTOR, SUPPRESSOR OF CYTOKINE SIGNALLING 6 | 著者 | Bullock, A, Pike, A.C.W, Savitsky, P, Keates, T, Pilka, E.S, von Delft, F, Edwards, A, Weigelt, J, Arrowsmith, C.H, Knapp, S. | 登録日 | 2007-11-30 | 公開日 | 2007-12-25 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Structural Basis for C-Kit Inhibition by the Suppressor of Cytokine Signaling 6 (Socs6) Ubiquitin Ligase. J.Biol.Chem., 286, 2011
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2YU7
| Solution structure of the SHP-1 C-terminal SH2 domain complexed with a tyrosine-phosphorylated peptide from NKG2A | 分子名称: | Tyrosine-protein phosphatase non-receptor type 6, natural killer group 2A | 著者 | Kasai, T, Koshiba, S, Inoue, M, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | 登録日 | 2007-04-05 | 公開日 | 2008-04-15 | 最終更新日 | 2022-03-16 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure of the SHP-1 C-terminal SH2 domain complexed with a tyrosine-phosphorylated peptide from NKG2A To be Published
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2YSX
| Solution structure of the human SHIP SH2 domain | 分子名称: | Signaling inositol polyphosphate phosphatase SHIP II | 著者 | Kasai, T, Koshiba, S, Watanabe, S, Harada, T, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | 登録日 | 2007-04-04 | 公開日 | 2008-04-08 | 最終更新日 | 2022-03-16 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure of the human SHIP SH2 domain To be Published
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6PXC
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5MTN
| Monobody Mb(Lck_1) bound to Lck-Sh2 | 分子名称: | Monobody Mb(Lck_1), SULFATE ION, Tyrosine-protein kinase Lck | 著者 | Pojer, F, Kukenshoner, T, Koide, S, Hantschel, O. | 登録日 | 2017-01-10 | 公開日 | 2017-04-05 | 最終更新日 | 2019-10-16 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | Selective Targeting of SH2 Domain-Phosphotyrosine Interactions of Src Family Tyrosine Kinases with Monobodies. J. Mol. Biol., 429, 2017
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5MTJ
| Yes1-SH2 in complex with monobody Mb(Yes_1) | 分子名称: | 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, Monobody Mb(Yes_1), SULFATE ION, ... | 著者 | Sha, F, Kukenshoner, T, Koide, S, Hantschel, O. | 登録日 | 2017-01-09 | 公開日 | 2017-04-05 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.949 Å) | 主引用文献 | Selective Targeting of SH2 Domain-Phosphotyrosine Interactions of Src Family Tyrosine Kinases with Monobodies. J. Mol. Biol., 429, 2017
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5MTM
| Monobody Mb(Lck_3) bound to Lck-SH2 domain | 分子名称: | Monobody Mb(Lck_3), Tyrosine-protein kinase Lck, ZINC ION | 著者 | Pojer, F, Kukenshoner, T, Koide, S, Hantschel, O. | 登録日 | 2017-01-10 | 公開日 | 2017-04-05 | 最終更新日 | 2019-10-16 | 実験手法 | X-RAY DIFFRACTION (2.405 Å) | 主引用文献 | Selective Targeting of SH2 Domain-Phosphotyrosine Interactions of Src Family Tyrosine Kinases with Monobodies. J. Mol. Biol., 429, 2017
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4EIH
| Crystal structure of Arg SH2 domain | 分子名称: | Abelson tyrosine-protein kinase 2, CHLORIDE ION | 著者 | Liu, W, MacGrath, S.M, Koleske, A.J, Boggon, T.J. | 登録日 | 2012-04-05 | 公開日 | 2013-04-10 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | Two Amino Acid Residues Confer Different Binding Affinities of Abelson Family Kinase Src Homology 2 Domains for Phosphorylated Cortactin. J.Biol.Chem., 289, 2014
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6PXB
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4QSY
| SHP2 SH2 domain in complex with GAB1 peptide | 分子名称: | GRB2-associated-binding protein 1, Tyrosine-protein phosphatase non-receptor type 11 | 著者 | Gogl, G, Remenyi, A. | 登録日 | 2014-07-06 | 公開日 | 2015-07-08 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Selective targeting of GAB adapter protein SHP2 tyrosine phosphatase interaction attenuates ERK signaling To be Published
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6R5G
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6ROZ
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4ROJ
| Crystal Structure of the VAV2 SH2 domain in complex with TXNIP phosphorylated peptide | 分子名称: | Guanine nucleotide exchange factor VAV2, Thioredoxin-interacting protein, UNKNOWN ATOM OR ION | 著者 | Liu, Y, Tempel, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | 登録日 | 2014-10-28 | 公開日 | 2014-12-10 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Crystal Structure of the VAV2 SH2 domain in complex with TXNIP phosphorylated peptide TO BE PUBLISHED
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6ROY
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6SM5
| MbC/SHP1-C-SH2 complex | 分子名称: | MbC (monobody targeting SHP1-C-SH2), Tyrosine-protein phosphatase non-receptor type 6 | 著者 | Mann, G, Hantschel, O. | 登録日 | 2019-08-21 | 公開日 | 2021-01-13 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | MbC/SHP1-C-SH2 complex To Be Published
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4TZI
| Structure of unliganded Lyn SH2 domain | 分子名称: | Tyrosine-protein kinase Lyn | 著者 | Wybenga-Groot, L.E. | 登録日 | 2014-07-10 | 公開日 | 2015-01-21 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Tyrosine Phosphorylation of the Lyn Src Homology 2 (SH2) Domain Modulates Its Binding Affinity and Specificity. Mol.Cell Proteomics, 14, 2015
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4U1P
| Human Fyn-SH2 domain in complex with a synthetic high-affinity phospho-peptide | 分子名称: | Middle T antigen, POLYETHYLENE GLYCOL (N=34), SODIUM ION, ... | 著者 | Garcia-Pino, A, Huculeci, R, Lenaerts, T, van Nuland, N.A.J. | 登録日 | 2014-07-16 | 公開日 | 2015-07-29 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Human Fyn-SH2 domain in complex with a synthetic high-affinity phospho-peptide To Be Published
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4U17
| Swapped dimer of the human Fyn-SH2 domain | 分子名称: | 1,2-ETHANEDIOL, PHOSPHATE ION, Tyrosine-protein kinase Fyn | 著者 | Garcia-Pino, A, Huculeci, R, Lenaerts, T, van Nuland, N.A.J. | 登録日 | 2014-07-15 | 公開日 | 2015-07-29 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | 主引用文献 | Swapped dimer of the human Fyn-SH2 domain To Be Published
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7MPH
| GRB2 SH2 Domain with Compound 7 | 分子名称: | (4-{(10R,11E,14S,18S)-18-(2-amino-2-oxoethyl)-14-[(naphthalen-1-yl)methyl]-8,17,20-trioxo-7,16,19-triazaspiro[5.14]icos-11-en-10-yl}phenyl)acetic acid, 1,2-ETHANEDIOL, Growth factor receptor-bound protein 2, ... | 著者 | Sun, L, Schonbrunn, E. | 登録日 | 2021-05-04 | 公開日 | 2021-09-22 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Synthesis and structural characterization of a monocarboxylic inhibitor for GRB2 SH2 domain. Bioorg.Med.Chem.Lett., 51, 2021
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7MP3
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7NXE
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6WAY
| C-terminal SH2 domain of p120RasGAP in complex with p190RhoGAP phosphotyrosine peptide | 分子名称: | Ras GTPase-activating protein 1, Rho GTPase-activating protein 35 | 著者 | Jaber Chehayeb, R, Wang, J, Stiegler, A.L, Boggon, T.J. | 登録日 | 2020-03-26 | 公開日 | 2020-06-17 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | The GTPase-activating protein p120RasGAP has an evolutionarily conserved "FLVR-unique" SH2 domain. J.Biol.Chem., 295, 2020
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3C7I
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6WAX
| C-terminal SH2 domain of p120RasGAP | 分子名称: | 1,2-ETHANEDIOL, Ras GTPase-activating protein 1, SULFATE ION | 著者 | Jaber Chehayeb, R, Wang, J, Stiegler, A.L, Boggon, T.J. | 登録日 | 2020-03-26 | 公開日 | 2020-06-17 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | The GTPase-activating protein p120RasGAP has an evolutionarily conserved "FLVR-unique" SH2 domain. J.Biol.Chem., 295, 2020
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