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4WW3
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Crystal structure of the lumi intermediate of squid rhodopsin
分子名称: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, DOCOSANE, PALMITIC ACID, ...
著者Murakami, M, Kouyama, T.
登録日2014-11-10
公開日2015-06-17
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystallographic Study of the LUMI Intermediate of Squid Rhodopsin
Plos One, 10, 2015
3KJ6
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Crystal structure of a Methylated beta2 Adrenergic Receptor-Fab complex
分子名称: Beta-2 adrenergic receptor, Fab heavy chain, Fab light chain, ...
著者Bokoch, M.P, Zou, Y, Rasmussen, S.G.F, Liu, C.W, Nygaard, R, Rosenbaum, D.M, Fung, J.J, Choi, H.-J, Thian, F.S, Kobilka, T.S, Puglisi, J.D, Weis, W.I, Pardo, L, Prosser, S, Mueller, L, Kobilka, B.K.
登録日2009-11-02
公開日2010-02-16
最終更新日2021-10-13
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor.
Nature, 463, 2010
2R4S
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Crystal structure of the human beta2 adrenoceptor
分子名称: Beta-2 adrenergic receptor, antibody for beta2 adrenoceptor, heavy chain, ...
著者Rasmussen, S.G.F, Choi, H.J, Rosenbaum, D.M, Kobilka, T.S, Thian, F.S, Edwards, P.C, Burghammer, M, Ratnala, V.R, Sanishvili, R, Fischetti, R.F, Schertler, G.F, Weis, W.I, Kobilka, B.K.
登録日2007-08-31
公開日2007-11-06
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献Crystal structure of the human beta2 adrenergic G-protein-coupled receptor.
Nature, 450, 2007
2R4R
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Crystal structure of the human beta2 adrenoceptor
分子名称: Beta-2 adrenergic receptor, antibody for beta2 adrenoceptor, heavy chain, ...
著者Rasmussen, S.G.F, Choi, H.J, Rosenbaum, D.M, Kobilka, T.S, Thian, F.S, Edwards, P.C, Burghammer, M, Ratnala, V.R, Sanishvili, R, Fischetti, R.F, Schertler, G.F, Weis, W.I, Kobilka, B.K.
登録日2007-08-31
公開日2007-11-06
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献Crystal structure of the human beta2 adrenergic G-protein-coupled receptor.
Nature, 450, 2007
2VT4
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TURKEY BETA1 ADRENERGIC RECEPTOR WITH STABILISING MUTATIONS AND BOUND CYANOPINDOLOL
分子名称: 4-{[(2S)-3-(tert-butylamino)-2-hydroxypropyl]oxy}-3H-indole-2-carbonitrile, BETA1 ADRENERGIC RECEPTOR, DECANE, ...
著者Warne, A, Serrano-Vega, M.J, Baker, J.G, Moukhametzianov, R, Edwards, P.C, Henderson, R, Leslie, A.G.W, Tate, C.G, Schertler, G.F.X.
登録日2008-05-09
公開日2008-06-24
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structure of a Beta1-Adrenergic G-Protein-Coupled Receptor.
Nature, 454, 2008
4UG2
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Thermostabilised HUMAN A2a Receptor with CGS21680 bound
分子名称: (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 2-[P-(2-CARBOXYETHYL)PHENYLETHYL-AMINO]-5'-N-ETHYLCARBOXAMIDO ADENOSINE, THERMOSTABILISED HUMAN A2A RECEPTOR
著者Lebon, G, Edwards, P.C, Leslie, A.G.W, Tate, C.G.
登録日2015-03-21
公開日2015-04-08
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Molecular Determinants of Cgs21680 Binding to the Human Adenosine A2A Receptor.
Mol.Pharmacol., 87, 2015
4UHR
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Thermostabilised HUMAN A2a Receptor with CGS21680 bound
分子名称: 2-[P-(2-CARBOXYETHYL)PHENYLETHYL-AMINO]-5'-N-ETHYLCARBOXAMIDO ADENOSINE, THERMOSTABILISED HUMAN A2A RECEPTOR
著者Lebon, G, Edwards, P.C, Leslie, A.G.W, Tate, C.G.
登録日2015-03-25
公開日2015-04-08
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Molecular Determinants of Cgs21680 Binding to the Human Adenosine A2A Receptor.
Mol.Pharmacol., 87, 2015
2LNL
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Structure of human CXCR1 in phospholipid bilayers
分子名称: C-X-C chemokine receptor type 1
著者Park, S, Das, B.B, Casagrande, F, Nothnagel, H, Chu, M, Kiefer, H, Maier, K, De Angelis, A, Marassi, F.M, Opella, S.J.
登録日2011-12-31
公開日2012-10-17
最終更新日2016-04-27
実験手法SOLID-STATE NMR
主引用文献Structure of the chemokine receptor CXCR1 in phospholipid bilayers.
Nature, 491, 2012
4GPO
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Oligomeic Turkey Beta1-Adrenergic G Protein-Coupled Receptor
分子名称: Beta-1 adrenergic receptor
著者Huang, J.J, Chen, S, Zhang, J.J, Huang, X.Y.
登録日2012-08-21
公開日2013-02-27
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献Crystal structure of oligomeric beta-1-adrenergic G protein-coupled receptors in ligand-free basal state.
Nat.Struct.Mol.Biol., 20, 2013
4MQS
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Structure of active human M2 muscarinic acetylcholine receptor bound to the agonist iperoxo
分子名称: 4-(4,5-dihydro-1,2-oxazol-3-yloxy)-N,N,N-trimethylbut-2-yn-1-aminium, Muscarinic acetylcholine receptor M2, Nanobody 9-8
著者Kruse, A.C, Ring, A.M, Manglik, A, Hu, J, Hu, K, Eitel, K, Huebner, H, Pardon, E, Valant, C, Sexton, P.M, Christopoulos, A, Felder, C.C, Gmeiner, P, Steyaert, J, Weis, W.I, Garcia, K.C, Wess, J, Kobilka, B.K.
登録日2013-09-16
公開日2013-11-27
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献Activation and allosteric modulation of a muscarinic acetylcholine receptor.
Nature, 504, 2013
4MQT
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Structure of active human M2 muscarinic acetylcholine receptor bound to the agonist iperoxo and allosteric modulator LY2119620
分子名称: 3-amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methylpiperazin-1-yl)-2-oxoethoxy]thieno[2,3-b]pyridine-2-carboxamide, 4-(4,5-dihydro-1,2-oxazol-3-yloxy)-N,N,N-trimethylbut-2-yn-1-aminium, Muscarinic acetylcholine receptor M2, ...
著者Kruse, A.C, Ring, A.M, Manglik, A, Hu, J, Hu, K, Eitel, K, Huebner, H, Pardon, E, Valant, C, Sexton, P.M, Christopoulos, A, Felder, C.C, Gmeiner, P, Steyaert, J, Weis, W.I, Garcia, K.C, Wess, J, Kobilka, B.K.
登録日2013-09-16
公開日2013-11-27
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (3.7 Å)
主引用文献Activation and allosteric modulation of a muscarinic acetylcholine receptor.
Nature, 504, 2013
4BV0
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High Resolution Structure of Evolved Agonist-bound Neurotensin Receptor 1 Mutant without Lysozyme Fusion
分子名称: NEUROTENSIN RECEPTOR TYPE 1, NEUROTENSIN/NEUROMEDIN N
著者Egloff, P, Hillenbrand, M, Scott, D.J, Schlinkmann, K.M, Heine, P, Balada, S, Batyuk, A, Mittl, P, Schuetz, M, Plueckthun, A.
登録日2013-06-24
公開日2014-01-29
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Structure of Signaling-Competent Neurotensin Receptor 1 Obtained by Directed Evolution in Escherichia Coli
Proc.Natl.Acad.Sci.USA, 111, 2014
4BVN
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Ultra-thermostable beta1-adrenoceptor with cyanopindolol bound
分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (CARBAMOYLMETHYL-CARBOXYMETHYL-AMINO)-ACETIC ACID, 4-{[(2S)-3-(tert-butylamino)-2-hydroxypropyl]oxy}-3H-indole-2-carbonitrile, ...
著者Miller, J, Nehme, R, Warne, T, Edwards, P.C, Leslie, A.G.W, Schertler, G, Tate, C.G.
登録日2013-06-26
公開日2014-04-02
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献The 2.1 A Resolution Structure of Cyanopindolol-Bound Beta1- Adrenoceptor Identifies an Intramembrane Na+ Ion that Stabilises the Ligand-Free Receptor.
Plos One, 9, 2014
4BUO
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High Resolution Structure of Thermostable Agonist-bound Neurotensin Receptor 1 Mutant without Lysozyme Fusion
分子名称: GLYCINE, NEUROTENSIN RECEPTOR TYPE 1, NEUROTENSIN/NEUROMEDIN N
著者Egloff, P, Hillenbrand, M, Schlinkmann, K.M, Batyuk, A, Mittl, P, Plueckthun, A.
登録日2013-06-21
公開日2014-01-29
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Structure of Signaling-Competent Neurotensin Receptor 1 Obtained by Directed Evolution in Escherichia Coli
Proc.Natl.Acad.Sci.USA, 111, 2014
6VI4
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Nanobody-Enabled Monitoring of Kappa Opioid Receptor States
分子名称: (3R)-7-hydroxy-N-{(2S)-1-[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]-3-methylbutan-2-yl}-1,2,3,4-tetrahydroisoquinoline-3-carboxamide, CHOLESTEROL, Kappa opioid receptor, ...
著者Che, T, Roth, B.L.
登録日2020-01-11
公開日2020-03-18
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Nanobody-enabled monitoring of kappa opioid receptor states.
Nat Commun, 11, 2020
4BWB
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Structure of Evolved Agonist-bound Neurotensin Receptor 1 Mutant without Lysozyme Fusion
分子名称: NEUROTENSIN, NEUROTENSIN RECEPTOR TYPE 1
著者Egloff, P, Hillenbrand, M, Scott, D.J, Schlinkmann, K.M, Heine, P, Balada, S, Batyuk, A, Mittl, P, Plueckthun, A.
登録日2013-07-01
公開日2014-01-29
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (3.57 Å)
主引用文献Structure of Signaling-Competent Neurotensin Receptor 1 Obtained by Directed Evolution in Escherichia Coli
Proc.Natl.Acad.Sci.USA, 111, 2014
5F8U
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Ligand occupancy in crystal structure of beta1-adrenergic receptor previously submitted by Huang et al
分子名称: 4-{[(2S)-3-(tert-butylamino)-2-hydroxypropyl]oxy}-3H-indole-2-carbonitrile, Beta-1 adrenergic receptor
著者Leslie, A.G.W, Warne, A, Tate, C.G.
登録日2015-12-09
公開日2015-12-23
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (3.35 Å)
主引用文献Ligand occupancy in crystal structure of Beta1 adrenergic G protein coupled receptor
Nat.Struct.Mol.Biol., 22, 2015
3UZA
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Thermostabilised Adenosine A2A receptor in complex with 6-(2,6-Dimethylpyridin-4-yl)-5-phenyl-1,2,4-triazin-3-amine
分子名称: 6-(2,6-dimethylpyridin-4-yl)-5-phenyl-1,2,4-triazin-3-amine, Adenosine receptor A2a
著者Congreve, M, Andrews, S.P, Dore, A.S, Hollenstein, K, Hurrell, E, Langmead, C.J, Mason, J.S, Ng, I.W, Tehan, B, Zhukov, A, Weir, M, Marshall, F.H.
登録日2011-12-07
公開日2012-03-21
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (3.273 Å)
主引用文献Discovery of 1,2,4-Triazine Derivatives as Adenosine A(2A) Antagonists using Structure Based Drug Design
J.Med.Chem., 55, 2012
3UZC
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Thermostabilised Adenosine A2A receptor in complex with 4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
分子名称: 4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol, Adenosine A2A Receptor
著者Congreve, M, Andrews, S.P, Dore, A.S, Hollenstein, K, Hurrell, E, Langmead, C.J, Mason, J.S, Ng, I.W, Zhukov, A, Weir, M, Marshall, F.H.
登録日2011-12-07
公開日2012-03-21
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (3.341 Å)
主引用文献Discovery of 1,2,4-Triazine Derivatives as Adenosine A(2A) Antagonists using Structure Based Drug Design
J.Med.Chem., 55, 2012
6Z10
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Crystal structure of a humanized (K18E, K269N) rat succinate receptor SUCNR1 (GPR91) in complex with a nanobody and antagonist
分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 2-[2-[[3-[4-chloranyl-2-fluoranyl-5-[(3~{R})-piperidin-3-yl]oxy-phenyl]-2-fluoranyl-phenyl]carbonylamino]-5-fluoranyl-phenyl]ethanoic acid, CHLORIDE ION, ...
著者Haffke, M, Villard, F.
登録日2020-05-11
公開日2020-09-16
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.269 Å)
主引用文献Discovery and Optimization of Novel SUCNR1 Inhibitors: Design of Zwitterionic Derivatives with a Salt Bridge for the Improvement of Oral Exposure.
J.Med.Chem., 63, 2020
3VG9
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Crystal structure of human adenosine A2A receptor with an allosteric inverse-agonist antibody at 2.7 A resolution
分子名称: 4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenol, Adenosine receptor A2a, DODECYL-BETA-D-MALTOSIDE, ...
著者Hino, T, Arakawa, T, Iwanari, H, Yurugi-Kobayashi, T, Ikeda-Suno, C, Nakada-Nakura, Y, Kusano-Arai, O, Weyand, S, Shimamura, T, Nomura, N, Cameron, A.D, Kobayashi, T, Hamakubo, T, Iwata, S, Murata, T.
登録日2011-08-04
公開日2012-02-01
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献G-protein-coupled receptor inactivation by an allosteric inverse-agonist antibody
Nature, 482, 2012
6Z4Q
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Crystal structure of the neurotensin receptor 1 in complex with the small-molecule inverse agonist SR142948A
分子名称: 2-[[5-(2,6-dimethoxyphenyl)-1-[4-[3-(dimethylamino)propyl-methyl-carbamoyl]-2-propan-2-yl-phenyl]pyrazol-3-yl]carbonylamino]adamantane-2-carboxylic acid, Neurotensin receptor type 1,Neurotensin receptor type 1,DARPin
著者Deluigi, M, Klipp, A, Hilge, M, Merklinger, L, Klenk, C, Plueckthun, A.
登録日2020-05-25
公開日2021-02-10
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.923 Å)
主引用文献Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism.
Sci Adv, 7, 2021
6ZIN
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Crystal structure of the neurotensin receptor 1 in complex with the small molecule inverse agonist SR48692
分子名称: 2-[[1-(7-chloranylquinolin-4-yl)-5-(2,6-dimethoxyphenyl)pyrazol-3-yl]carbonylamino]adamantane-2-carboxylic acid, Neurotensin receptor type 1,DARPin,HRV 3C protease recognition sequence
著者Deluigi, M, Klipp, A, Hilge, M, Merklinger, L, Klenk, C, Plueckthun, A.
登録日2020-06-26
公開日2021-02-10
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.639 Å)
主引用文献Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism.
Sci Adv, 7, 2021
6ZA8
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Crystal structure of the neurotensin receptor 1 in complex with the small-molecule partial agonist RTI-3a
分子名称: (2~{S})-2-[[1-(7-chloranylquinolin-4-yl)-5-(2,6-dimethoxyphenyl)pyrazol-3-yl]carbonylamino]-4-methyl-pentanoic acid, Neurotensin receptor type 1,Neurotensin receptor type 1,Neurotensin receptor 1 (NTSR1),Neurotensin receptor 1 (NTSR1),Neurotensin receptor type 1,Neurotensin receptor 1 (NTSR1),Neurotensin receptor 1 (NTSR1)
著者Deluigi, M, Klipp, A, Hilge, M, Merklinger, L, Klenk, C, Plueckthun, A.
登録日2020-06-05
公開日2021-02-10
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.72 Å)
主引用文献Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism.
Sci Adv, 7, 2021
6Z4V
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Crystal structure of the neurotensin receptor 1 (NTSR1-H4bmx) in complex with NTS8-13
分子名称: ARG-PRO-TYR-ILE-LEU, Neurotensin receptor type 1,Neurotensin receptor type 1,DARPin
著者Deluigi, M, Klipp, A, Hilge, M, Merklinger, L, Klenk, C, Plueckthun, A.
登録日2020-05-25
公開日2021-02-10
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.595 Å)
主引用文献Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism.
Sci Adv, 7, 2021

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