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1L3E
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NMR Structures of the HIF-1alpha CTAD/p300 CH1 Complex
Descriptor: ZINC ION, hypoxia inducible factor-1 alpha subunit, p300 protein
Authors:Freedman, S.J, Sun, Z.J, Poy, F, Kung, A.L, Livingston, D.M, Wagner, G, Eck, M.J.
Deposit date:2002-02-26
Release date:2002-04-24
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha.
Proc.Natl.Acad.Sci.USA, 99, 2002
1L8C
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STRUCTURAL BASIS FOR HIF-1ALPHA/CBP RECOGNITION IN THE CELLULAR HYPOXIC RESPONSE
Descriptor: CREB-binding protein, Hypoxia-inducible factor 1 alpha, ZINC ION
Authors:Dames, S.A, Martinez-Yamout, M, De Guzman, R.N, Dyson, H.J, Wright, P.E.
Deposit date:2002-03-19
Release date:2002-04-10
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:Structural basis for Hif-1 alpha /CBP recognition in the cellular hypoxic response.
Proc.Natl.Acad.Sci.USA, 99, 2002
1H2M
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Factor Inhibiting HIF-1 alpha in complex with HIF-1 alpha fragment peptide
Descriptor: FACTOR INHIBITING HIF1, HYPOXIA-INDUCIBLE FACTOR 1 ALPHA, N-OXALYLGLYCINE, ...
Authors:Elkins, J.M, Hewitson, K.S, McNeill, L.A, Schlemminger, I, Seibel, J.F, Schofield, C.J.
Deposit date:2002-08-12
Release date:2002-11-28
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of Factor-Inhibiting Hypoxia-Inducible Factor (Hif) Reveals Mechanism of Oxidative Modification of Hif-1Alpha
J.Biol.Chem., 278, 2003
1H2K
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Factor Inhibiting HIF-1 alpha in complex with HIF-1 alpha fragment peptide
Descriptor: FACTOR INHIBITING HIF1, FE (II) ION, HYPOXIA-INDUCIBLE FACTOR 1 ALPHA, ...
Authors:Elkins, J.M, Hewitson, K.S, McNeill, L.A, Schlemminger, I, Seibel, J.F, Schofield, C.J.
Deposit date:2002-08-12
Release date:2002-11-28
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structure of Factor-Inhibiting Hypoxia-Inducible Factor (Hif) Reveals Mechanism of Oxidative Modification of Hif-1Alpha
J.Biol.Chem., 278, 2003
1H2L
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Factor Inhibiting HIF-1 alpha in complex with HIF-1 alpha fragment peptide
Descriptor: 2-OXOGLUTARIC ACID, FACTOR INHIBITING HIF1, FE (II) ION, ...
Authors:Elkins, J.M, Hewitson, K.S, McNeill, L.A, Schlemminger, I, Seibel, J.F, Schofield, C.J.
Deposit date:2002-08-12
Release date:2002-11-28
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structure of Factor-Inhibiting Hypoxia-Inducible Factor (Hif) Reveals Mechanism of Oxidative Modification of Hif-1Alpha
J.Biol.Chem., 278, 2003
2ILM
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Factor Inhibiting HIF-1 Alpha D201A Mutant in Complex with FE(II), Alpha-Ketoglutarate and HIF-1 Alpha 35mer
Descriptor: 2-OXOGLUTARIC ACID, BICARBONATE ION, FE (II) ION, ...
Authors:Mcdonough, M.A, Schofield, C.J.
Deposit date:2006-10-03
Release date:2007-08-14
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Evidence that two enzyme-derived histidine ligands are sufficient for iron binding and catalysis by factor inhibiting HIF (FIH).
J.Biol.Chem., 283, 2008
5JWP
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Crystal structure of human FIH D201E variant in complex with Zn, alpha-ketoglutarate, and HIF1 alpha peptide.
Descriptor: 2-OXOGLUTARIC ACID, GLYCEROL, Hypoxia-inducible factor 1-alpha, ...
Authors:Taabazuing, C.Y, Garman, S.C, Eron, S, Knapp, M.J.
Deposit date:2016-05-12
Release date:2016-11-23
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The facial triad in the alpha-ketoglutarate dependent oxygenase FIH: A role for sterics in linking substrate binding to O2 activation.
J.Inorg.Biochem., 166, 2016
7LVS
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The CBP TAZ1 Domain in Complex with a CITED2-HIF-1-Alpha Fusion Peptide
Descriptor: Cbp/p300-interacting transactivator 2,Hypoxia-inducible factor 1-alpha, Histone lysine acetyltransferase CREBBP, ZINC ION
Authors:Appling, F.D, Berlow, R.B, Stanfield, R.L, Dyson, H.J, Wright, P.E.
Deposit date:2021-02-26
Release date:2021-07-28
Last modified:2021-12-15
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:The molecular basis of allostery in a facilitated dissociation process.
Structure, 29, 2021
7QGS
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Crystal structure of p300 CH1 domain in complex with CITIF (a CITED2-HIF-1alpha hybrid)
Descriptor: Cbp/p300-interacting transactivator 2,Hypoxia-inducible factor 1-alpha, Histone acetyltransferase, ZINC ION
Authors:Hegedus, Z, Wilson, A.J, Edwards, T.A.
Deposit date:2021-12-10
Release date:2022-05-11
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2 Å)
Cite:Understanding p300-transcription factor interactions using sequence variation and hybridization.
Rsc Chem Biol, 3, 2022

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PDB entries from 2024-03-27

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