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7Q6C
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BU of 7q6c by Molmil
complement C6 FIM1-2 bound to CP010 antibody
Descriptor: ACETATE ION, CP010 heavy chain, CP010 light chain, ...
Authors:Olesen, H.G, Andersen, G.R.
Deposit date:2021-11-06
Release date:2022-05-25
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.29274 Å)
Cite:Development, Characterization, and in vivo Validation of a Humanized C6 Monoclonal Antibody that Inhibits the Membrane Attack Complex.
J Innate Immun, 2022
2N17
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BU of 2n17 by Molmil
NMR structure of a Kazal-type serine protease inhibitor from the subterranean termite defense gland of Coptotermes formosanus Shiraki soldiers
Descriptor: Lysozyme-Protease Inhibitor Protein
Authors:Negulescu, H, Guo, Y, Garner, T.P, Goodwin, O.Y, Henderson, G, Laine, R.A, Macnaughtan, M.A.
Deposit date:2015-03-23
Release date:2015-05-06
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:A Kazal-Type Serine Protease Inhibitor from the Defense Gland Secretion of the Subterranean Termite Coptotermes formosanus Shiraki.
Plos One, 10, 2015
3PIS
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BU of 3pis by Molmil
Crystal Structure of Carcinoscorpius rotundicauda Serine Protease Inhibitor Domain 1
Descriptor: Kazal-type serine protease inhibitor SPI-1
Authors:Giri, P.K, Tang, X.H, Sivaraman, J.
Deposit date:2010-11-08
Release date:2010-12-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Modifying the Substrate Specificity of Carcinoscorpius rotundicauda Serine Protease Inhibitor Domain 1 to Target Thrombin
To be Published
6JZA
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BU of 6jza by Molmil
Structure of Fstl1
Descriptor: Follistatin-related protein 1
Authors:Liu, X, Ning, W.
Deposit date:2019-04-30
Release date:2019-08-21
Last modified:2019-09-25
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural and functional study of FK domain of Fstl1.
Protein Sci., 28, 2019
2KCX
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BU of 2kcx by Molmil
Solution NMR Structure of Kazal-1 Domain of Human Follistatin-related protein 3 (FSTL-3). Northeast Structural Genomics Target HR6186A.
Descriptor: Follistatin-related protein 3
Authors:Rossi, P, Chiang, Y, Anderson, S, Montelione, G.T, Northeast Structural Genomics Consortium (NESG)
Deposit date:2008-12-30
Release date:2009-03-10
Last modified:2022-03-16
Method:SOLUTION NMR
Cite:Solution NMR Structure of Kazal-1 Domain of Human Follistatin-related protein 3 (FSTL-3). Northeast Structural Genomics Target HR6186A.
To be Published
7KBU
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BU of 7kbu by Molmil
Structure of Hevin FS-EC
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, CHLORIDE ION, ...
Authors:Machius, M, Fan, S, Rudenko, G.
Deposit date:2020-10-03
Release date:2021-02-10
Last modified:2021-07-14
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Interplay between hevin, SPARC, and MDGAs: Modulators of neurexin-neuroligin transsynaptic bridges.
Structure, 29, 2021
1LR7
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BU of 1lr7 by Molmil
Crystal structure of Fs1, the heparin-binding domain of follistatin, complexed with the heparin analogue sucrose octasulphate (SOS)
Descriptor: SULFATE ION, follistatin
Authors:Innis, C.A, Hyvonen, M.
Deposit date:2002-05-15
Release date:2003-07-29
Last modified:2022-12-21
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal Structures of the Heparan Sulfate-binding Domain of Follistatin: Insights into ligand binding.
J.Biol.Chem., 278, 2003
1LR8
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BU of 1lr8 by Molmil
Crystal structure of Fs1, the heparin-binding domain of follistatin, complexed with the heparin analogue D-myo-inositol hexasulphate (Ins6S)
Descriptor: D-MYO-INOSITOL-HEXASULPHATE, Follistatin
Authors:Innis, C.A, Hyvonen, M.
Deposit date:2002-05-15
Release date:2003-07-29
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structures of the Heparan Sulfate-binding Domain of Follistatin: Insights into ligand binding.
J.Biol.Chem., 278, 2003
1LR9
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BU of 1lr9 by Molmil
STRUCTURE OF Fs1, THE HEPARIN-BINDING DOMAIN OF FOLLISTATIN
Descriptor: Follistatin
Authors:Innis, C.A, Hyvonen, M.
Deposit date:2002-05-15
Release date:2003-07-29
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal Structures of the Heparan Sulfate-binding Domain of Follistatin: Insights into ligand binding.
J.Biol.Chem., 278, 2003
3B4V
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BU of 3b4v by Molmil
X-Ray structure of Activin in complex with FSTL3
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Inhibin beta A chain, ...
Authors:Thompson, T.B.
Deposit date:2007-10-24
Release date:2008-09-02
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:The structure of FSTL3.activin A complex. Differential binding of N-terminal domains influences follistatin-type antagonist specificity.
J.Biol.Chem., 283, 2008
7EEB
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BU of 7eeb by Molmil
Structure of the CatSpermasome
Descriptor: (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Wu, J.P, Ke, M.
Deposit date:2021-03-18
Release date:2021-07-28
Last modified:2021-08-11
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structure of a mammalian sperm cation channel complex.
Nature, 595, 2021
3HH2
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BU of 3hh2 by Molmil
Crystal structure of the myostatin:follistatin 288 complex
Descriptor: CITRIC ACID, Follistatin, Growth/differentiation factor 8, ...
Authors:Cash, J.N, Thompson, T.B.
Deposit date:2009-05-14
Release date:2009-08-04
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:The structure of myostatin:follistatin 288: insights into receptor utilization and heparin binding
Embo J., 28, 2009
5JHW
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BU of 5jhw by Molmil
Crystal Structure of the GDF11:Follistatin 288 complex
Descriptor: CITRATE ANION, Follistatin, Growth/differentiation factor 11, ...
Authors:Walker, R.G, Thompson, T.B.
Deposit date:2016-04-21
Release date:2017-03-22
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structural basis for potency differences between GDF8 and GDF11.
BMC Biol., 15, 2017
1TBQ
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BU of 1tbq by Molmil
CRYSTAL STRUCTURE OF INSECT DERIVED DOUBLE DOMAIN KAZAL INHIBITOR RHODNIIN IN COMPLEX WITH THROMBIN
Descriptor: RHODNIIN, THROMBIN
Authors:Van De Locht, A, Lamba, D, Bode, W.
Deposit date:1995-03-02
Release date:1996-10-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Two heads are better than one: crystal structure of the insect derived double domain Kazal inhibitor rhodniin in complex with thrombin.
EMBO J., 14, 1995
8TZP
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BU of 8tzp by Molmil
Structure of human Wnt7a bound to WLS and RECK
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, PALMITOLEIC ACID, Protein Wnt-7a, ...
Authors:Qi, X, Hu, Q, Li, X.
Deposit date:2023-08-27
Release date:2023-10-18
Method:ELECTRON MICROSCOPY (3.23 Å)
Cite:Structure of human Wnt7a bound to WLS and RECK
To Be Published
8S9P
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BU of 8s9p by Molmil
1:1:1 agrin/LRP4/MuSK complex
Descriptor: Agrin, Low-density lipoprotein receptor-related protein 4, Muscle, ...
Authors:Xie, T, Xu, G.J, Liu, Y, Quade, B, Lin, W.C, Bai, X.C.
Deposit date:2023-03-29
Release date:2023-05-17
Last modified:2023-06-14
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structural insights into the assembly of the agrin/LRP4/MuSK signaling complex.
Proc.Natl.Acad.Sci.USA, 120, 2023
1TBR
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BU of 1tbr by Molmil
CRYSTAL STRUCTURE OF INSECT DERIVED DOUBLE DOMAIN KAZAL INHIBITOR RHODNIIN IN COMPLEX WITH THROMBIN
Descriptor: RHODNIIN, THROMBIN
Authors:Van De Locht, A, Lamba, D, Bode, W.
Deposit date:1995-03-03
Release date:1996-10-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Two heads are better than one: crystal structure of the insect derived double domain Kazal inhibitor rhodniin in complex with thrombin.
EMBO J., 14, 1995
4A5W
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BU of 4a5w by Molmil
Crystal structure of C5b6
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, COMPLEMENT C5, ...
Authors:Hadders, M.A, Bubeck, D, Forneris, F, Pangburn, M, Llorca, O, Lea, S.M, Gros, P.
Deposit date:2011-10-28
Release date:2012-03-14
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Assembly and Regulation of the Membrane Attack Complex Based on Structures of C5B6 and Sc5B9.
Cell Rep., 1, 2012
6H03
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BU of 6h03 by Molmil
OPEN CONFORMATION OF THE MEMBRANE ATTACK COMPLEX
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C5,Complement C5, ...
Authors:Menny, A, Serna, M, Boyd, C.M, Gardner, S, Joseph, A.P, Topf, M, Bubeck, D.
Deposit date:2018-07-06
Release date:2018-12-19
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (5.6 Å)
Cite:CryoEM reveals how the complement membrane attack complex ruptures lipid bilayers.
Nat Commun, 9, 2018
6H04
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BU of 6h04 by Molmil
Closed conformation of the Membrane Attack Complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C5,Complement C5, ...
Authors:Menny, A, Serna, M, Boyd, C.M, Gardner, S, Joseph, A.P, Topf, M, Bubeck, D.
Deposit date:2018-07-06
Release date:2018-12-19
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (5.6 Å)
Cite:CryoEM reveals how the complement membrane attack complex ruptures lipid bilayers.
Nat Commun, 9, 2018
2P6A
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BU of 2p6a by Molmil
The structure of the Activin:Follistatin 315 complex
Descriptor: Follistatin, Inhibin beta A chain, probable fragment of follistatin
Authors:Lerch, T.F, Shimasaki, S, Woodruff, T.K, Jardetzky, T.S.
Deposit date:2007-03-16
Release date:2007-04-03
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Structural and biophysical coupling of heparin and activin binding to follistatin isoform functions.
J.Biol.Chem., 282, 2007
4E0S
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BU of 4e0s by Molmil
Crystal Structure of C5b-6
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Complement C5, ...
Authors:Aleshin, A.E, Stec, B, DiScipio, R, Liddington, R.C.
Deposit date:2012-03-05
Release date:2012-04-18
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (4.21 Å)
Cite:Crystal structure of c5b-6 suggests structural basis for priming assembly of the membrane attack complex.
J.Biol.Chem., 287, 2012
3QTL
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BU of 3qtl by Molmil
Structural Basis for Dual-inhibition Mechanism of a Non-classical Kazal-type Serine Protease Inhibitor from Horseshoe Crab in Complex with Subtilisin
Descriptor: Kazal-type serine protease inhibitor SPI-1, Subtilisin-like serin protease
Authors:Shenoy, R.T, Sivaraman, J.
Deposit date:2011-02-23
Release date:2011-06-01
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural basis for dual-inhibition mechanism of a non-classical kazal-type serine protease inhibitor from horseshoe crab in complex with subtilisin.
Plos One, 6, 2011
8B0H
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2C9, C5b9-CD59 cryoEM structure
Descriptor: CD59 glycoprotein, Complement C5, Complement component C6, ...
Authors:Couves, E.C, Gardner, S, Bubeck, D.
Deposit date:2022-09-07
Release date:2023-02-22
Last modified:2023-03-01
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structural basis for membrane attack complex inhibition by CD59.
Nat Commun, 14, 2023
8B0G
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2C9, C5b9-CD59 structure
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CD59 glycoprotein, Complement C5, ...
Authors:Couves, E.C, Gardner, S, Bubeck, D.
Deposit date:2022-09-07
Release date:2023-02-22
Last modified:2023-03-01
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structural basis for membrane attack complex inhibition by CD59.
Nat Commun, 14, 2023

 

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