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8CDG
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Crystal structure of human IL-17A cytokine in complex with macrocycle
Descriptor: (9~{S},12~{R},19~{S})-9-[[4-[[(2~{S})-2-cyclohexyl-2-(2-phenylethanoylamino)ethanoyl]amino]phenyl]methyl]-12-methyl-7,10,13,21-tetrakis(oxidanylidene)-8,11,14,20-tetrazaspiro[4.17]docosane-19-carboxylic acid, Interleukin-17A
Authors:Schulze, M.-S.
Deposit date:2023-01-30
Release date:2023-12-06
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Modulation of IL-17 backbone dynamics reduces receptor affinity and reveals a new inhibitory mechanism.
Chem Sci, 14, 2023
8B7W
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Complex IL-17A/anti-IL-17A-76
Descriptor: CHLORIDE ION, GLYCEROL, Interleukin-17A, ...
Authors:Kostareva, O.S, Svoeglazova, A, Kolyadenko, I.A, Dzhus, U.F, Tishchenko, S.V, Gabdulkhakov, A.G.
Deposit date:2022-10-03
Release date:2022-12-28
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Two Epitope Regions Revealed in the Complex of IL-17A and Anti-IL-17A V H H Domain.
Int J Mol Sci, 23, 2022
8DYG
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IL17A homodimer bound to Compound 7
Descriptor: (5P)-2-hydroxy-5-(6-methylquinolin-5-yl)benzoic acid, Interleukin-17A
Authors:Argiriadi, M.A, Goedken, E.R.
Deposit date:2022-08-04
Release date:2022-09-07
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:Identification and structure-based drug design of cell-active inhibitors of interleukin 17A at a novel C-terminal site.
Sci Rep, 12, 2022
8DYH
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IL17A homodimer bound to Compound 6
Descriptor: (5P)-N-benzyl-6-chloro-5-(quinolin-5-yl)pyridin-3-amine, GLYCEROL, Interleukin-17A
Authors:Argiriadi, M.A, Goedken, E.R.
Deposit date:2022-08-04
Release date:2022-09-07
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Identification and structure-based drug design of cell-active inhibitors of interleukin 17A at a novel C-terminal site.
Sci Rep, 12, 2022
8DYI
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IL17A homodimer bound to Compound 5
Descriptor: (5P)-5-[5-(benzylamino)pyridin-3-yl]-N-[2-(morpholin-4-yl)ethyl]-1H-indazol-3-amine, Interleukin-17A
Authors:Argiriadi, M.A, Goedken, E.R.
Deposit date:2022-08-04
Release date:2022-09-07
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Identification and structure-based drug design of cell-active inhibitors of interleukin 17A at a novel C-terminal site.
Sci Rep, 12, 2022
8DYF
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IL17A homodimer bound to Compound 10
Descriptor: (5M)-3-[({2-[2-(2-{2-[2-({[(5M)-3-carboxy-5-(5,8-dihydroquinolin-4-yl)phenyl]amino}methyl)phenoxy]ethoxy}ethoxy)ethoxy]phenyl}methyl)amino]-5-(quinolin-4-yl)benzoic acid, Interleukin-17A
Authors:Argiriadi, M.A, Goedken, E.R.
Deposit date:2022-08-04
Release date:2022-09-07
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Identification and structure-based drug design of cell-active inhibitors of interleukin 17A at a novel C-terminal site.
Sci Rep, 12, 2022
8DY1
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Crystal Structure of scFv CAT2200 LH in complex with IL-17A
Descriptor: Interleukin-17A, SULFATE ION, scFv CAT2200 LH
Authors:Luo, J, Armstrong, A.A.
Deposit date:2022-08-03
Release date:2023-05-03
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.68 Å)
Cite:"Stapling" scFv for multispecific biotherapeutics of superior properties.
Mabs, 15, 2023
8DY5
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Crystal Structure of spFv CAT2200 LH in complex with IL-17A
Descriptor: CALCIUM ION, CHLORIDE ION, Interleukin-17A, ...
Authors:Luo, J, Boucher, L.E.
Deposit date:2022-08-03
Release date:2023-05-03
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:"Stapling" scFv for multispecific biotherapeutics of superior properties.
Mabs, 15, 2023
7UWL
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Structure of the IL-25-IL-17RB-IL-17RA ternary complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-17 receptor A, ...
Authors:Wilson, S.C, Caveney, N.A, Jude, K.M, Garcia, K.C.
Deposit date:2022-05-03
Release date:2022-07-27
Last modified:2022-09-28
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Organizing structural principles of the IL-17 ligand-receptor axis.
Nature, 609, 2022
7UWN
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Structure of the IL-17A-IL-17RA-IL-17RC ternary complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-17 receptor A, ...
Authors:Wilson, S.C, Caveney, N.A, Jude, K.M, Garcia, K.C.
Deposit date:2022-05-03
Release date:2022-07-27
Last modified:2022-09-28
Method:ELECTRON MICROSCOPY (3.01 Å)
Cite:Organizing structural principles of the IL-17 ligand-receptor axis.
Nature, 609, 2022
7UWJ
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Structure of the homodimeric IL-25-IL-17RB binary complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-17 receptor B, Interleukin-25
Authors:Wilson, S.C, Caveney, N.A, Jude, K.M, Garcia, K.C.
Deposit date:2022-05-03
Release date:2022-07-27
Last modified:2022-09-28
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Organizing structural principles of the IL-17 ligand-receptor axis.
Nature, 609, 2022
7UWK
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Structure of the higher-order IL-25-IL-17RB complex
Descriptor: Interleukin-17 receptor B, Interleukin-25
Authors:Wilson, S.C, Caveney, N.A, Jude, K.M, Garcia, K.C.
Deposit date:2022-05-03
Release date:2022-07-27
Last modified:2022-09-28
Method:ELECTRON MICROSCOPY (4.4 Å)
Cite:Organizing structural principles of the IL-17 ligand-receptor axis.
Nature, 609, 2022
7UWM
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BU of 7uwm by Molmil
Structure of the IL-17A-IL-17RA binary complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-17 receptor A, ...
Authors:Wilson, S.C, Caveney, N.A, Jude, K.M, Garcia, K.C.
Deposit date:2022-05-03
Release date:2022-07-27
Last modified:2022-09-28
Method:ELECTRON MICROSCOPY (2.5 Å)
Cite:Organizing structural principles of the IL-17 ligand-receptor axis.
Nature, 609, 2022
7ZAN
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BU of 7zan by Molmil
Crystal Structure of human IL-17A in complex with IL-17RA and IL-17RC
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-17 receptor A, Interleukin-17A, ...
Authors:Rondeau, J.M, Goepfert, A.
Deposit date:2022-03-22
Release date:2022-10-12
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (5.061 Å)
Cite:IL-17-induced dimerization of IL-17RA drives the formation of the IL-17 signalosome to potentiate signaling.
Cell Rep, 41, 2022
7Z2M
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BU of 7z2m by Molmil
Crystal Structure of the 11.003 Fab in complex with human IL-17A
Descriptor: 11.003 Fab heavy-chain, 11.003 Fab light-chain, GLYCEROL, ...
Authors:Rondeau, J.M, Lehmann, S.
Deposit date:2022-02-28
Release date:2023-02-08
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.899 Å)
Cite:"Redirecting an anti-IL-1 beta antibody to bind a new, unrelated and computationally predicted epitope on hIL-17A".
Commun Biol, 6, 2023
7WKX
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IL-17A in complex with the humanized antibody HB0017
Descriptor: ACETIC ACID, Heavy chain of HB0017 Fab, Interleukin-17A, ...
Authors:Xu, J, Zhu, X, He, Y.
Deposit date:2022-01-12
Release date:2022-03-23
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:Structural and functional insights into a novel pre-clinical-stage antibody targeting IL-17A for treatment of autoimmune diseases.
Int.J.Biol.Macromol., 202, 2022
7AMG
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BU of 7amg by Molmil
IL-17A in complex with small molecule modulators
Descriptor: (3~{R})-4-[4-[[(2~{S})-2-[[2,2-bis(fluoranyl)-2-phenyl-ethanoyl]amino]-3-(2-chlorophenyl)propanoyl]amino]phenyl]-3-[[(2~{S})-3-methyl-2-[2-[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethoxy]ethanoylamino]butanoyl]amino]butanoic acid, Interleukin-17A
Authors:Hakansson, M, Kimbung, R, Logan, D, Walse, U.B, de Groot, M.J, Andrews, M.D, Dack, K.N, Lambert, M.
Deposit date:2020-10-08
Release date:2022-04-20
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (3.18 Å)
Cite:Discovery of an Oral, Rule of 5 Compliant, Interleukin 17A Protein-Protein Interaction Modulator for the Potential Treatment of Psoriasis and Other Inflammatory Diseases.
J.Med.Chem., 65, 2022
7AMA
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BU of 7ama by Molmil
IL-17A in complex with small molecule modulators
Descriptor: Interleukin-17A, ~{N}-[(2~{S})-1,1-dicyclopropyl-3-[[4-(3,5-dimethyl-1~{H}-pyrazol-4-yl)phenyl]amino]-3-oxidanylidene-propan-2-yl]-2-propan-2-yl-pyrazole-3-carboxamide
Authors:Hakansson, M, Kimbung, R, Logan, D, Walse, U.B, de Groot, M.J, Andrews, M.D, Dack, K.N, Lambert, M.
Deposit date:2020-10-08
Release date:2022-04-20
Last modified:2022-08-10
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:Discovery of an Oral, Rule of 5 Compliant, Interleukin 17A Protein-Protein Interaction Modulator for the Potential Treatment of Psoriasis and Other Inflammatory Diseases.
J.Med.Chem., 65, 2022
6WIO
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BU of 6wio by Molmil
Fab antigen complex
Descriptor: Fab Heavy chain, Fab Light chain, Interleukin-17A
Authors:Antonysamy, S.
Deposit date:2020-04-10
Release date:2020-09-23
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.17 Å)
Cite:Rapid and robust antibody Fab fragment crystallization utilizing edge-to-edge beta-sheet packing.
Plos One, 15, 2020
6WIR
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BU of 6wir by Molmil
Fab antigen complex
Descriptor: Fab heavy chain, Fab light chain, Interleukin-17A
Authors:Antonysamy, S.
Deposit date:2020-04-10
Release date:2020-09-23
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.96 Å)
Cite:Rapid and robust antibody Fab fragment crystallization utilizing edge-to-edge beta-sheet packing.
Plos One, 15, 2020
6PPG
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BU of 6ppg by Molmil
Crystal structure of IL17FF bound to Fab fragments of MCAF5352A
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CADMIUM ION, Fab MCAF5352A heavy chain, ...
Authors:Huang, C.S, Yin, J.P, Hymowitz, S.G.
Deposit date:2019-07-06
Release date:2019-12-11
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Dissecting the molecular basis of high viscosity of monospecific and bispecific IgG antibodies.
Mabs, 12
6HG9
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Crystal Structure of the human IL-17RC ECD in complex with human IL-17F, Crystal form II
Descriptor: Interleukin-17 receptor C, Interleukin-17F
Authors:Rondeau, J.M, Goepfert, A.
Deposit date:2018-08-23
Release date:2020-03-18
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.62 Å)
Cite:Structural Analysis Reveals that the Cytokine IL-17F Forms a Homodimeric Complex with Receptor IL-17RC to Drive IL-17RA-Independent Signaling.
Immunity, 52, 2020
6HGO
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Crystal Structure of human IL-17F
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-17F, ...
Authors:Rondeau, J.M, Goepfert, A.
Deposit date:2018-08-23
Release date:2019-11-20
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural Analysis Reveals that the Cytokine IL-17F Forms a Homodimeric Complex with Receptor IL-17RC to Drive IL-17RA-Independent Signaling.
Immunity, 52, 2020
6HG4
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Crystal Structure of the human IL-17RC ECD in complex with human IL-17F
Descriptor: Interleukin-17 receptor C, Interleukin-17F
Authors:Rondeau, J.M, Goepfert, A.
Deposit date:2018-08-22
Release date:2020-03-18
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.32 Å)
Cite:Structural Analysis Reveals that the Cytokine IL-17F Forms a Homodimeric Complex with Receptor IL-17RC to Drive IL-17RA-Independent Signaling.
Immunity, 52, 2020
5VB9
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IL-17A in complex with peptide
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Interleukin-17A, ...
Authors:Antonysamy, S, Russell, M, Zhang, A, Groshong, C, Manglicmot, D, Lu, F, Benach, J, Wasserman, S.R, Zhang, F, Afshar, S, Bina, H, Broughton, H, Chalmers, M, Dodge, J, Espada, A, Jones, S, Ting, J.P, Woodman, M.
Deposit date:2017-03-28
Release date:2018-02-14
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Utilization of peptide phage display to investigate hotspots on IL-17A and what it means for drug discovery.
PLoS ONE, 13, 2018

 

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