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5K3Y
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BU of 5k3y by Molmil
Crystal structure of AuroraB/INCENP in complex with BI 811283
Descriptor: Aurora kinase B-A, Inner centromere protein A, N-methyl-N-(1-methylpiperidin-4-yl)-4-{[4-({(1R,2S)-2-[(propan-2-yl)carbamoyl]cyclopentyl}amino)-5-(trifluoromethyl)pyrimidin-2-yl]amino}benzamide
Authors:Bader, G, Zahn, S.K, Zoephel, A.
Deposit date:2016-05-20
Release date:2016-08-17
Last modified:2022-12-07
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Pharmacological Profile of BI 847325, an Orally Bioavailable, ATP-Competitive Inhibitor of MEK and Aurora Kinases.
Mol.Cancer Ther., 15, 2016
5EYK
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BU of 5eyk by Molmil
CRYSTAL STRUCTURE OF AURORA B IN COMPLEX WITH BI 847325
Descriptor: 3-[(3~{Z})-3-[[[4-[(dimethylamino)methyl]phenyl]amino]-phenyl-methylidene]-2-oxidanylidene-1~{H}-indol-6-yl]-~{N}-ethyl-prop-2-ynamide, Aurora kinase B-A, Inner centromere protein A
Authors:Bader, G, Zoephel, A.
Deposit date:2015-11-25
Release date:2016-08-17
Last modified:2016-10-19
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Pharmacological Profile of BI 847325, an Orally Bioavailable, ATP-Competitive Inhibitor of MEK and Aurora Kinases.
Mol.Cancer Ther., 15, 2016
3ZTX
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BU of 3ztx by Molmil
Aurora kinase selective inhibitors identified using a Taxol-induced checkpoint sensitivity screen.
Descriptor: 2-((4-(4-HYDROXYPIPERIDIN-1-YL)PHENYL)AMINO)-5,11-DIMETHYL-5H-BENZO[E]PYRIMIDO [5,4-B][1,4]DIAZEPIN-6(11H)-ONE, INNER CENTROMERE PROTEIN A, SERINE/THREONINE-PROTEIN KINASE 12-A
Authors:Kwiatkowski, N, Villa, F, Musacchio, A, Gray, N.
Deposit date:2011-07-12
Release date:2012-02-01
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Selective Aurora Kinase Inhibitors Identified Using a Taxol- Induced Checkpoint Sensitivity Screen.
Acs Chem.Biol., 7, 2012
6GR8
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BU of 6gr8 by Molmil
Human AURKC INCENP complex bound to BRD-7880
Descriptor: 1-[(2~{R},3~{S})-2-[[1,3-benzodioxol-5-ylmethyl(methyl)amino]methyl]-3-methyl-6-oxidanylidene-5-[(2~{S})-1-oxidanylpropan-2-yl]-3,4-dihydro-2~{H}-1,5-benzoxazocin-8-yl]-3-(4-methoxyphenyl)urea, Aurora kinase C, Inner centromere protein
Authors:Abdul Azeez, K.R, Sorrell, F.J, von Delft, F, Bountra, C, Knapp, S, Edwards, A.M, Arrowsmith, C, Elkins, J.M.
Deposit date:2018-06-10
Release date:2019-05-15
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:AURKC INCENP complex bound to BRD-7880
To Be Published
6GR9
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BU of 6gr9 by Molmil
Human AURKC INCENP complex bound to VX-680
Descriptor: Aurora kinase C, CYCLOPROPANECARBOXYLIC ACID {4-[4-(4-METHYL-PIPERAZIN-1-YL)-6-(5-METHYL-2H-PYRAZOL-3-YLAMINO)-PYRIMIDIN-2-YLSULFANYL]-PHENYL}-AMIDE, Inner centromere protein, ...
Authors:Abdul Azeez, K.R, Sorrell, F.J, von Delft, F, Bountra, C, Knapp, S, Edwards, A.M, Arrowsmith, C, Elkins, J.M.
Deposit date:2018-06-10
Release date:2019-05-15
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:AURKC INCENP complex bound to BRD-7880
To Be Published
2BFY
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BU of 2bfy by Molmil
Complex of Aurora-B with INCENP and Hesperadin.
Descriptor: AURORA KINASE B-A, INNER CENTROMERE PROTEIN A, N-[2-OXO-3-((E)-PHENYL{[4-(PIPERIDIN-1-YLMETHYL)PHENYL]IMINO}METHYL)-2,6-DIHYDRO-1H-INDOL-5-YL]ETHANESULFONAMIDE
Authors:Sessa, F, Mapelli, M, Ciferri, C, Tarricone, C, Areces, L.B, Schneider, T.R, Stukenberg, P.T, Musacchio, A.
Deposit date:2004-12-15
Release date:2005-05-03
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Mechanism of Aurora B Activation by Incenp and Inhibition by Hesperadin
Mol.Cell, 18, 2005
2BFX
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BU of 2bfx by Molmil
Mechanism of Aurora-B activation by INCENP and inhibition by Hesperadin.
Descriptor: AURORA KINASE B-A, INNER CENTROMERE PROTEIN A
Authors:Sessa, F, Mapelli, M, Ciferri, C, Tarricone, C, Areces, L.B, Schneider, T.R, Stukenberg, P.T, Musacchio, A.
Deposit date:2004-12-15
Release date:2005-05-03
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Mechanism of Aurora B Activation by Incenp and Inhibition by Hesperadin
Mol.Cell, 18, 2005
2VGP
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BU of 2vgp by Molmil
Crystal structure of Aurora B kinase in complex with a aminothiazole inhibitor
Descriptor: 4-[(5-bromo-1,3-thiazol-2-yl)amino]-N-methylbenzamide, INNER CENTROMERE PROTEIN A, SERINE/THREONINE-PROTEIN KINASE 12-A
Authors:Andersen, C.B, Wan, Y, Chang, J.W, Lee, C, Liu, Y, Sessa, F, Villa, F, Nallan, L, Musacchio, A, Gray, N.S.
Deposit date:2007-11-15
Release date:2008-02-26
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Discovery of Selective Aminothiazole Aurora Kinase Inhibitors
Acs Chem.Biol., 3, 2008
2VGO
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BU of 2vgo by Molmil
Crystal structure of Aurora B kinase in complex with Reversine inhibitor
Descriptor: INNER CENTROMERE PROTEIN A, N~6~-cyclohexyl-N~2~-(4-morpholin-4-ylphenyl)-9H-purine-2,6-diamine, SERINE/THREONINE-PROTEIN KINASE 12-A
Authors:D'Alise, A.M, Amabile, G, Iovino, M, Di Giorgio, F.P, Bartiromo, M, Sessa, F, Villa, F, Musacchio, A, Cortese, R.
Deposit date:2007-11-15
Release date:2008-10-28
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Reversine, a Novel Aurora Kinases Inhibitor, Inhibits Colony Formation of Human Acute Myeloid Leukemia Cells.
Mol.Cancer Ther., 7, 2008
2VRX
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BU of 2vrx by Molmil
Structure of Aurora B kinase in complex with ZM447439
Descriptor: INNER CENTROMERE PROTEIN A, N-(4-{[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinazolin-4-yl]amino}phenyl)benzamide, SERINE/THREONINE-PROTEIN KINASE 12-A
Authors:Girdler, F, Sessa, F, Patercoli, S, Villa, F, Ridgway, E, Musacchio, A, Taylor, S.S.
Deposit date:2008-04-16
Release date:2008-07-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Molecular Basis of Drug Resistance in Aurora Kinases.
Chem.Biol., 15, 2008
4AF3
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BU of 4af3 by Molmil
Human Aurora B Kinase in complex with INCENP and VX-680
Descriptor: AURORA KINASE B, CYCLOPROPANECARBOXYLIC ACID {4-[4-(4-METHYL-PIPERAZIN-1-YL)-6-(5-METHYL-2H-PYRAZOL-3-YLAMINO)-PYRIMIDIN-2-YLSULFANYL]-PHENYL}-AMIDE, INNER CENTROMERE PROTEIN
Authors:Elkins, J.M, Vollmar, M, Wang, J, Picaud, S, Arrowsmith, C.H, Edwards, A, Bountra, C, von Delft, F, Knapp, S.
Deposit date:2012-01-16
Release date:2012-04-11
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Crystal Structure of Human Aurora B in Complex with Incenp and Vx-680.
J.Med.Chem., 55, 2012
4B8M
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BU of 4b8m by Molmil
Aurora B kinase in complex with VX-680
Descriptor: AURORA KINASE B-A, CYCLOPROPANECARBOXYLIC ACID {4-[4-(4-METHYL-PIPERAZIN-1-YL)-6-(5-METHYL-2H-PYRAZOL-3-YLAMINO)-PYRIMIDIN-2-YLSULFANYL]-PHENYL}-AMIDE, INNER CENTROMERE PROTEIN A
Authors:Sessa, F, Villa, F.
Deposit date:2012-08-28
Release date:2013-07-10
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural and Biochemical Analysis of an Aurora B Kinase Mutant Reveals a Multistep Activation Mechanism
To be Published
4B8L
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BU of 4b8l by Molmil
Aurora B kinase P353G mutant
Descriptor: 9-{5-O-[(R)-hydroxy{[(R)-hydroxy(phosphonoamino)phosphoryl]oxy}phosphoryl]-alpha-L-arabinofuranosyl}-9H-purin-6-amine, AURORA KINASE B-A, INNER CENTROMERE PROTEIN A
Authors:Sessa, F, Villa, F.
Deposit date:2012-08-28
Release date:2013-07-10
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural and Biochemical Analysis of an Aurora B Kinase Mutant Reveals a Multistep Activation Mechanism
To be Published
4C2W
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BU of 4c2w by Molmil
Crystal structure of Aurora B in complex with AMP-PNP
Descriptor: AURORA KINASE B-A, INNER CENTROMERE PROTEIN A, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Sessa, F, Villa, F.
Deposit date:2013-08-20
Release date:2014-02-26
Last modified:2014-03-19
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure of Aurora B-Incenp in Complex with Barasertib Reveals a Potential Transinhibitory Mechanism
Acta Crystallogr.,Sect.F, 70, 2014
4C2V
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BU of 4c2v by Molmil
Aurora B kinase in complex with the specific inhibitor Barasertib
Descriptor: 2-[5-[[7-[3-[ethyl(2-hydroxyethyl)amino]propoxy]quinazolin-4-yl]amino]-1H-pyrazol-3-yl]-N-(3-fluorophenyl)ethanamide, AURORA KINASE B-A, INNER CENTROMERE PROTEIN A
Authors:Sessa, F, Villa, F.
Deposit date:2013-08-20
Release date:2014-02-26
Last modified:2014-03-19
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:Structure of Aurora B-Incenp in Complex with Barasertib Reveals a Potential Transinhibitory Mechanism
Acta Crystallogr.,Sect.F, 70, 2014

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